LOCUS       NM_018790               3059 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus activity regulated cytoskeletal-associated protein
            (Arc), transcript variant 1, mRNA.
ACCESSION   NM_018790
VERSION     NM_018790.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3059)
  AUTHORS   Gora,C., Dudas,A., Vaugrente,O., Drobecq,L., Pecnard,E., Lefort,G.
            and Pellissier,L.P.
  TITLE     Deciphering autism heterogeneity: a molecular stratification
            approach in four mouse models
  JOURNAL   Transl Psychiatry 14 (1), 416 (2024)
   PUBMED   39366951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3059)
  AUTHORS   Wang,D.C., Santos-Valencia,F., Song,J.H., Franks,K.M. and Luo,L.
  TITLE     Embryonically active piriform cortex neurons promote intracortical
            recurrent connectivity during development
  JOURNAL   Neuron 112 (17), 2938-2954 (2024)
   PUBMED   38964330
REFERENCE   3  (bases 1 to 3059)
  AUTHORS   Fatt,M.P., Zhang,M.D., Kupari,J., Altinkok,M., Yang,Y., Hu,Y.,
            Svenningsson,P. and Ernfors,P.
  TITLE     Morphine-responsive neurons that regulate mechanical
            antinociception
  JOURNAL   Science 385 (6712), eado6593 (2024)
   PUBMED   39208104
REFERENCE   4  (bases 1 to 3059)
  AUTHORS   Bjorklund,G.R., Rees,K.P., Balasubramanian,K., Hewitt,L.T.,
            Nishimura,K. and Newbern,J.M.
  TITLE     Hyperactivation of MEK1 in cortical glutamatergic neurons results
            in projection axon deficits and aberrant motor learning
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38826084
REFERENCE   5  (bases 1 to 3059)
  AUTHORS   Wu,J., Petralia,R.S., Kurushima,H., Patel,H., Jung,M.Y., Volk,L.,
            Chowdhury,S., Shepherd,J.D., Dehoff,M., Li,Y., Kuhl,D.,
            Huganir,R.L., Price,D.L., Scannevin,R., Troncoso,J.C., Wong,P.C.
            and Worley,P.F.
  TITLE     Arc/Arg3.1 regulates an endosomal pathway essential for
            activity-dependent beta-amyloid generation
  JOURNAL   Cell 147 (3), 615-628 (2011)
   PUBMED   22036569
  REMARK    GeneRIF: Study reports that the immediate early gene Arc is
            required for activity-dependent generation of Abeta. Arc is a
            postsynaptic protein that recruits endophilin2/3 and dynamin to
            early/recycling endosomes that traffic
REFERENCE   6  (bases 1 to 3059)
  AUTHORS   Maier,B., Medrano,S., Sleight,S.B., Visconti,P.E. and Scrable,H.
  TITLE     Developmental association of the synaptic activity-regulated
            protein arc with the mouse acrosomal organelle and the sperm tail
  JOURNAL   Biol Reprod 68 (1), 67-76 (2003)
   PUBMED   12493697
  REMARK    GeneRIF: highly expressed both at the RNA and protein levels in
            postmeiotic germ cells in the testis of adult mice
REFERENCE   7  (bases 1 to 3059)
  AUTHORS   Nishimura,M., Yamagata,K., Sugiura,H. and Okamura,H.
  TITLE     The activity-regulated cytoskeleton-associated (Arc) gene is a new
            light-inducible early gene in the mouse suprachiasmatic nucleus
  JOURNAL   Neuroscience 116 (4), 1141-1147 (2003)
   PUBMED   12617955
  REMARK    GeneRIF: Arc, an activity-regulated cytoskeletal gene, is expressed
            in suprachiasmatic nucleus neurons and is possibly involved in the
            light-induced phase-shift of circadian rhythm.
REFERENCE   8  (bases 1 to 3059)
  AUTHORS   Waltereit,R., Dammermann,B., Wulff,P., Scafidi,J., Staubli,U.,
            Kauselmann,G., Bundman,M. and Kuhl,D.
  TITLE     Arg3.1/Arc mRNA induction by Ca2+ and cAMP requires protein kinase
            A and mitogen-activated protein kinase/extracellular regulated
            kinase activation
  JOURNAL   J Neurosci 21 (15), 5484-5493 (2001)
   PUBMED   11466419
REFERENCE   9  (bases 1 to 3059)
  AUTHORS   Liu,D., Bei,D., Parmar,H. and Matus,A.
  TITLE     Activity-regulated, cytoskeleton-associated protein (Arc) is
            essential for visceral endoderm organization during early
            embryogenesis
  JOURNAL   Mech Dev 92 (2), 207-215 (2000)
   PUBMED   10727859
REFERENCE   10 (bases 1 to 3059)
  AUTHORS   Letts,V.A., Valenzuela,A., Kirley,J.P., Sweet,H.O., Davisson,M.T.
            and Frankel,W.N.
  TITLE     Genetic and physical maps of the stargazer locus on mouse
            chromosome 15
  JOURNAL   Genomics 43 (1), 62-68 (1997)
   PUBMED   9226373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118022.12 and AF162777.1.
            
            On Feb 21, 2013 this sequence version replaced NM_018790.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            CCDS Note: This CCDS ID represents the protein described in PMIDs:
            10727859 and 22036569. This protein is encoded by two splice
            variants which are supported by AK157822.1 and AF162777.1. It
            should be noted this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously in PMID: 22036569.
            It is likely that the majority of transcripts representing this
            variant will undergo NMD, while some low level of NMD escape may
            allow for the expression of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF162777.1, SRR7652917.469492.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 22036569
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC118022.12        102374-102391       c
            19-3057             AF162777.1         10-3048
            3058-3059           AC118022.12        98902-98903         c
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.25 cM"
     gene            1..3059
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /note="activity regulated cytoskeletal-associated protein"
                     /db_xref="GeneID:11838"
                     /db_xref="MGI:MGI:88067"
     exon            1..2006
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1389
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /note="ARC/ARG3.1; activity-regulated gene 3.1 protein
                     homolog"
                     /codon_start=1
                     /product="activity-regulated cytoskeleton-associated
                     protein"
                     /protein_id="NP_061260.1"
                     /db_xref="CCDS:CCDS37102.1"
                     /db_xref="GeneID:11838"
                     /db_xref="MGI:MGI:88067"
                     /translation="MELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRR
                     THRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETI
                     ANLERWVKREMHVWREVFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQ
                     EADGYDYTVSPYAITPPPAAGELPEQESVEAQQYQSWGPGEDGQPSPGVDTQIFEDPR
                     EFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSE
                     GTLSREAIQRELELPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKLK
                     RFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSGTPLPTEDETEALTPALTSESVASDR
                     TQPE"
     exon            2007..2146
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..3059
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /note="hexamer: AATAAA"
     polyA_site      3057
                     /gene="Arc"
                     /gene_synonym="Arc3.1; arg3.1; mArc"
                     /note="major polyA site"
ORIGIN      
        1 gcagagctca agcgagttct cccgcagccg cagtctctgg gcctctctag cttcagcggc
       61 gacgagcctg ccacactcgc taagctcctc cggcaccgca cacctgccac tgccgctgca
      121 gccgccggct ctgctccctt ccggcttctg cctcagagga gttcttagcc tgttcggagc
      181 cgcagcaccg acgaccagat ggagctggac catatgacca ccggcggcct ccacgcctac
      241 cctgccccgc ggggtgggcc ggccgccaaa cccaatgtga tcctgcagat tggtaagtgc
      301 cgagctgaga tgctggaaca cgtacggagg acccaccggc atctgttgac cgaagtgtcc
      361 aagcaggtgg agcgagagct gaaagggttg cacaggtcgg tgggcaagct ggagaacaac
      421 ttggacggct acgtgcccac cggcgactca cagcgctgga agaagtccat caaggcctgt
      481 ctttgccgct gccaggagac catcgccaac ctggagcgct gggtcaagcg tgagatgcac
      541 gtgtggaggg aggtcttcta ccgtctggag aggtgggctg accgcctgga gtccatgggc
      601 ggcaaatacc cagtgggcag cgagccggcc cgccacactg tctctgtagg tgtggggggt
      661 ccagagccct actgccagga agctgatggc tatgactata ccgttagccc ctatgccatc
      721 accccgccac ctgccgcagg agaactgcct gaacaggagt cagttgaggc tcagcaatat
      781 cagtcttggg ggccaggtga ggatgggcaa ccgagccctg gtgtggatac acagatcttc
      841 gaggacccac gggagttcct gagccacctg gaagagtacc tgcggcaggt gggtggctct
      901 gaagaatatt ggctgtccca gatccagaac cacatgaatg ggccagccaa gaagtggtgg
      961 gagttcaagc agggctcggt gaagaactgg gtggagttca agaaggagtt tctgcaatac
     1021 agtgagggta cactctcccg tgaagccatt cagcgggagc tggagctgcc gcagaagcag
     1081 ggtgaaccac tcgaccagtt cctctggcgc aagcgggacc tgtaccagac actgtatgtg
     1141 gacgctgagg aggaggagat cattcagtat gtggtgggca ccctgcagcc caaactcaag
     1201 cgctttctgc gccacccact ccccaagacc ctggagcagc ttatccagag gggtatggaa
     1261 gtgcaggacg gcctggagca ggcagctgag ccttctggca ccccactgcc cacagaggat
     1321 gagacggagg cactcacacc tgctcttacc agcgagtcag tagccagtga caggacccag
     1381 cctgaataga ggggccagcc cagggtcccc agcccgcctg ccacacccag cctgtggctt
     1441 ttgccaacta ggacttgagc tggggctgac tcccaaaggg atgccctgtc cagccagaca
     1501 tctactcacc cactgacctg gcctgactca caactgccac acaaccatgc tacatggact
     1561 gaacatcaag aagccccttt cccatagggc tcccacctgc cgcctacccc tcatctgtct
     1621 gccctggtcc tggcccccag ccccattggc ctcaccctct acactctcag accatcacag
     1681 aacacgatct ggcttcctca ttctgctcca gtgtccaggg ctctttgggt aatcaagaaa
     1741 ccaagtgtct gaaaggcaac aaaaagtagg caccaaaacc caggggacat cctagggcag
     1801 atgctaaagc agagatgctg agggaacctc aacttccggg gatgcagccc actcctgcag
     1861 acacagcaga tccagctggt accctagctg ccgcccaggg caaccggcca gtcttgggca
     1921 gcatagctcc cctcccaggg gtgagctgaa gccacaaatg cagctgaagc agcagacctg
     1981 acatcctggc acctcctggc ccccagcagt gattcatacc agtgaagaag agcagagctc
     2041 agctccgtga ctcagccatg gcaggcggag ggtccccgag gggctgagtc ctcacaccca
     2101 gccgaggcag cggctggagc ctacagagcc aggagaatga caccaggtct caaggctgct
     2161 gagaagtctt tgctgccatg tctggaaagg gcatcaccac accaccagca ccagcaccat
     2221 cctctcttct cctgaagctg cctacatggg ttccaagaca ctttcaaggc agagaaaaca
     2281 agattacaga gaggaggtgc ctggcagggg gcagcacccc agctcagccc aagagctgaa
     2341 ggtgaagaca agccagcatg aaaccacggg tctgccatga tgcccgcccc gctggccgct
     2401 cactagctgc ctgccattag cctctgcagc ttgagcaggg tctgtaccct tggtcctctt
     2461 ggcacagagc ccagctcgct gcatggcctt tggctccccg accagaccct tgcaggagcc
     2521 ttaaggcttg ggcccctgcc cagcctgatc tttcctgctg tgccctgcct gccaggtcaa
     2581 gcccagtccc aggagacccc aggccttggc tcctaggctg ttccatgaac ctccctgacc
     2641 tgcctggtga ttgcccagct gaaacctcag ccaagcccca gctccaatta ccttgtgctg
     2701 gtagctgctt gtgtctgcag tctgagtagg ccttgttgcg gttcctccat ctgcctggtc
     2761 tattggtgtt ctgagaccaa ttccactgat gttctgacag atcctccacc ctgtgcccct
     2821 gccagccccc acaagtttat ttttgcacaa aagccatgac ccatactcat ttggctggca
     2881 tagggtgtgt aggtaggccc tggggactag ggagaccctg gagatctcaa gagagtgtgg
     2941 ctatccccta ttttcaccaa gccttgaata tccagccagg ctgtctgccc ataccatctt
     3001 acctcaaaga cagatatata tctatatatg attttgttaa taaaactatg aaacttatt
//
