LOCUS       NM_001163419            3912 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus ARB2 cotranscriptional regulator A (Arb2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001163419
VERSION     NM_001163419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3912)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3912)
  AUTHORS   Sallis,S., Berube-Simard,F.A., Grondin,B., Leduc,E., Azouz,F.,
            Belanger,C. and Pilon,N.
  TITLE     The CHARGE syndrome-associated protein FAM172A controls AGO2
            nuclear import
  JOURNAL   Life Sci Alliance 6 (8), e202302133 (2023)
   PUBMED   37221016
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3912)
  AUTHORS   Belanger,C., Cardinal,T., Leduc,E., Viger,R.S. and Pilon,N.
  TITLE     CHARGE syndrome-associated proteins FAM172A and CHD7 influence male
            sex determination and differentiation through transcriptional and
            alternative splicing mechanisms
  JOURNAL   FASEB J 36 (3), e22176 (2022)
   PUBMED   35129866
  REMARK    GeneRIF: CHARGE syndrome-associated proteins FAM172A and CHD7
            influence male sex determination and differentiation through
            transcriptional and alternative splicing mechanisms.
REFERENCE   4  (bases 1 to 3912)
  AUTHORS   Belanger,C., Berube-Simard,F.A., Leduc,E., Bernas,G., Campeau,P.M.,
            Lalani,S.R., Martin,D.M., Bielas,S., Moccia,A., Srivastava,A.,
            Silversides,D.W. and Pilon,N.
  TITLE     Dysregulation of cotranscriptional alternative splicing underlies
            CHARGE syndrome
  JOURNAL   Proc Natl Acad Sci U S A 115 (4), E620-E629 (2018)
   PUBMED   29311329
  REMARK    GeneRIF: key role in the regulation of cotranscriptional
            alternative splicing in CHARGE syndrome model
REFERENCE   5  (bases 1 to 3912)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 3912)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 3912)
  AUTHORS   Neilan,E.G. and Barsh,G.S.
  TITLE     Gene trap insertional mutagenesis in mice: new vectors and germ
            line mutations in two novel genes
  JOURNAL   Transgenic Res 8 (6), 451-458 (1999)
   PUBMED   10767988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167171.2, BC057380.1 and AW060304.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon and
            uses a downstream start codon, compared to variant 1. The resulting
            isoform (2) has a shorter N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057380.1, AK052419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC167171.2         115380-115411       c
            33-3602             BC057380.1         1-3570
            3603-3893           BC057380.1         3572-3862
            3894-3912           AW060304.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 41.29 cM"
     gene            1..3912
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /note="ARB2 cotranscriptional regulator A"
                     /db_xref="GeneID:68675"
                     /db_xref="MGI:MGI:1915925"
     exon            1..164
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            165..266
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1312
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein FAM172A; cotranscriptional regulator FAM172A;
                     family with sequence similarity 172, member A;
                     cotranscriptional regulator ARB2A"
                     /codon_start=1
                     /product="cotranscriptional regulator ARB2A isoform 2"
                     /protein_id="NP_001156891.1"
                     /db_xref="CCDS:CCDS49318.1"
                     /db_xref="GeneID:68675"
                     /db_xref="MGI:MGI:1915925"
                     /translation="MKKDEPPFDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDL
                     HRWNQKRYEALGEIITRYVYELLESDCNLKKISIPVDATESEPKSFIFMSEDALTNPQ
                     KLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAMDEGYGVIVLNPNENYIEV
                     EKQKMHKQSSSSDGTDEPAGKRERRDKVSKETKKRRDFYEKYRNPQKEKEMMQLFIRE
                     NGSPEEHAVYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKSKVTAVALTD
                     SVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSW
                     KSFPSIFKFFAEASEAKSSSQKPALTRRSHRIKHEEL"
     exon            267..367
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            368..433
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            434..625
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            626..847
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            848..967
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1084
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1169
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..3897
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3875..3880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /note="hexamer: AATAAA"
     polyA_site      3893
                     /gene="Arb2a"
                     /gene_synonym="1110033M05Rik; 2610318O14Rik; 53-E6;
                     9430037D06Rik; Fam172a; pEN87"
                     /note="major polyA site"
ORIGIN      
        1 gtttaaattc cctgcagacc cggaagtgca atcgaacttg gtcggggcgc ggatcttgag
       61 agagaaagtc cgagccaggg cgcaagggag ttcgcccaga gatctggaag gccacgcctc
      121 ctcgcaccta ccctctcagc attgcagctg gggacagagc tcagatttgc tgtctaggat
      181 cgatttggat gaactcatga aaaaggacga accacctttt gattttccag atacactgga
      241 aggctttgaa tatgctttta atgaaaaggg gcagttaaga cacataaaaa ctggggaacc
      301 atttgttttt aactaccgag aagacttaca caggtggaac cagaaaagat atgaagctct
      361 gggcgagatc atcacaagat atgtttatga gctcctggaa agtgactgta atttgaaaaa
      421 aatctctatt ccagtagatg ccactgagag tgaaccaaag agttttatct ttatgagtga
      481 ggatgctttg acaaatccac agaaactgat ggttttaatt catggtagtg gtgttgtcag
      541 ggcaggtcag tgggctagaa ggcttattat taatgaagat ctggacagtg gcacacagat
      601 accttttatt aagagagcta tggatgaagg gtatggagtc atcgtcctga acccaaatga
      661 aaactatata gaagtggaaa agcagaaaat gcataaacag tcatcatctt ctgatggtac
      721 agatgagcca gcagggaagc gggaaaggag agataaggtc tccaaggaaa caaagaagcg
      781 tcgtgatttc tatgagaagt accgcaaccc tcaaaaggag aaagaaatga tgcagttgtt
      841 tatcagggaa aatggttctc ctgaagagca tgcggtctat gtgtgggacc atttcatagc
      901 ccaggctgct gctgagaatg tgttctttgt ggctcatagc tatggaggac ttgcttttgt
      961 tgaactgatg attcaacgag aagcagatgt aaaaagtaag gtgactgctg tggcattgac
     1021 agactctgtt cacaatgtgt ggcatcaaga agctggcaaa accatccgag aatggatgag
     1081 agagaactgt tgtaactggg tctccagctc agaaccatta gatacatcgg tggaatccat
     1141 gctgcctgac tgtcccagag tgtctgcagg caccgaccgt cacgagctca cttcctggaa
     1201 gagcttcccg tctatcttca agttcttcgc ggaagcctcg gaggccaaga gcagctcgca
     1261 gaagccggcc ctgacgcggc gctcgcaccg gatcaagcac gaggagctgt gagcgcgcag
     1321 ccgcccgccc gccgcccgta gcctcctggc ccccattaga ttgctttctt tctccagcgc
     1381 agggtcgtga tgtgtccgtc taaatagcgt tttgcattat ttctagatga gtgcaactgt
     1441 caaagcaata tggcttcagc ggccgagttg cctgcggctg agccgggcct cgcactgtgg
     1501 gccccggcga ccgaggctga aagcgccggg agtgccagcg ccgggcgctc ctaattgccc
     1561 ggctgatccg cgggcgcggc tggccgagcg gcgtctgcgc ggtcctaccg cccgctgcag
     1621 cgcggtcgcc gctgcccagc ctcaattgtg cccattttta atccccttta aacccagcaa
     1681 gcttttattc taaacctcaa acttgatttt aaccaggttt tttcctcagg tcatctaatg
     1741 agcctctgtc ttttacacaa agccacacac tcgagtccta aaaatgccaa ctttaaattc
     1801 agaacatgat ggactatgta gtttggggag tacaagttct ttctccctat aacgacttat
     1861 tttcacttca accccccccc ccaaaaaaaa aaaaactgta catgaagtac cgaatccgaa
     1921 tcctcatttg tgcccagttg aactccagtc tttatgtctc tgatttcagg agggaatgtc
     1981 gaaaggaaaa tataaacaga tcttttagat gtaggtataa gtctccatgt tcagtgaatt
     2041 ttccagttac ttataagaac tgaccttact attaaaatat ataacacgat gtgtgcgcca
     2101 atgcagggtg atggtggtgg ctgttgatcc ttacaacctg tactttcacc tttcttgtag
     2161 cgtgccctgt cagatgcagg acttttttac tatcatcaag aaaataaaac tacataacct
     2221 ctttcttcca aaagtccaag tagggttaat gtgcttcagt tttcatctgc agtaggaaaa
     2281 gagaggcgta gtgtgaatgg gttgctcttt tgaggccaaa atgtttactg ttctcttcct
     2341 gtgatagggc gctgccctgt aattccaaca gtaaggccaa cgcggaagat aaaataagtt
     2401 gacattttac tggcttttga attaaagcat tagacattaa ttacttgaaa tttttaatta
     2461 gtgaaggtta tatccagtgc atggtgagat tgtgatttaa tacatccatc ctttttaaaa
     2521 tgaatgcaat aagtaatttg tctaccttgt ttgagacctt gagacagtat aagcaaaatg
     2581 agtctgagtt gctaatgaca gggaagaaaa cctgagctca gccacctcat gaggaatact
     2641 ctcatcccat gaactgattt tagcaaggtt taaactggta acatgtcatg ctctttgcac
     2701 atgcatacat tcagtaattc tgtaaggaca gtaaagtcct cagtgccatg gctgggcatc
     2761 tcctgacatt acttaggcag aagtacctta ggaaaaacca aaatggggct ttctccagct
     2821 tttgggcagt ttaaatatgt tactccaaca gtgtcaagca cattgaactg tcatagtggc
     2881 cctttacatt tctgctttta gaaggattgg tgaactctgt gaaaataata tctttccagt
     2941 tactgggctt gaaacactgg tgtgcattga ttatatttta ccaaatgtta taaattgtct
     3001 ggtgttttca gtatgtgaaa atgttcacaa gaaagtgagt ttgcaacatg tagaggttgg
     3061 aaaaacctat gcagggctaa atttgctaga cttctgcagc taaattaaag cagagttaaa
     3121 gtgctcagct tatgaaccaa acaaaagtat cctgctcctg ccctccgggt tcctctctgc
     3181 aactcttaaa ccttattcag agaaagtctc tgtttccttg ggatgagtac tttactgtca
     3241 ctggattgta accttgtctt ctgtctagca gagagctatt tacaaagtta cattttgtaa
     3301 atgtctgtta ctacttttga atctgtgcta tagcaaccca gagggagcca ggcgcagcac
     3361 cccagatcac cagctgatga gtgacaaatg attctttaca atgtaggatt tcttgacctg
     3421 ttgattgggt tgctgttggt atatgtgtaa ggatgttatt cacctcagct ttcttgggat
     3481 aacaacaagc acttggcagt accctgccta cagggaggcc agggttaata tttctcatct
     3541 ggccttctcc ctatttttat tctaggcaca cagtggtaga aaggtaaggt gtgagctttt
     3601 ttaaaaataa atcttatact tagttcttaa agtaaataga tggaaagaga cataaattgg
     3661 aaattcaaaa tagtctgatt caagctttgg agctttttcg ggtacctaac acacagtcct
     3721 tggaagtcat catggatgtt tgctagacca tctacgtgta ataattgttc ttttctcaca
     3781 attctgcctt gtgcttcctg aaatgcattt ttgtttgttt atatgtcaaa aataataaag
     3841 tgtggacctc ctataatctt gtttaccatt ttaaaataaa attttccaac aaagcaaaaa
     3901 aaaaaaaaaa aa
//
