LOCUS       NM_139206               5266 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 3 (Arap3), transcript variant 1, mRNA.
ACCESSION   NM_139206
VERSION     NM_139206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5266)
  AUTHORS   McCormick B, Craig HE, Chu JY, Carlin LM, Canel M, Wollweber F,
            Toivakka M, Michael M, Astier AL, Norton L, Lilja J, Felton JM,
            Sasaki T, Ivaska J, Hers I, Dransfield I, Rossi AG and Vermeren S.
  TITLE     A Negative Feedback Loop Regulates Integrin Inactivation and
            Promotes Neutrophil Recruitment to Inflammatory Sites
  JOURNAL   J Immunol 203 (6), 1579-1588 (2019)
   PUBMED   31427445
REFERENCE   2  (bases 1 to 5266)
  AUTHORS   Qu X, Harmelink C and Baldwin HS.
  TITLE     Tie2 regulates endocardial sprouting and myocardial trabeculation
  JOURNAL   JCI Insight 5 (13), 96002 (2019)
   PUBMED   31112136
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5266)
  AUTHORS   Sharma PR, Mackey AJ, Dejene EA, Ramadan JW, Langefeld CD, Palmer
            ND, Taylor KD, Wagenknecht LE, Watanabe RM, Rich SS and Nunemaker
            CS.
  TITLE     An Islet-Targeted Genome-Wide Association Scan Identifies Novel
            Genes Implicated in Cytokine-Mediated Islet Stress in Type 2
            Diabetes
  JOURNAL   Endocrinology 156 (9), 3147-3156 (2015)
   PUBMED   26018251
REFERENCE   4  (bases 1 to 5266)
  AUTHORS   Xing YH, Zhang JL, Lu L, Li DG, Wang YY, Huang S, Li CC, Zhang ZB,
            Li JG, Xu GS and Meng AM.
  TITLE     Identification of specific gene modules in mouse lung tissue
            exposed to cigarette smoke
  JOURNAL   Asian Pac J Cancer Prev 16 (10), 4251-4256 (2015)
   PUBMED   26028081
REFERENCE   5  (bases 1 to 5266)
  AUTHORS   Song Y, Jiang J, Vermeren S and Tong W.
  TITLE     ARAP3 functions in hematopoietic stem cells
  JOURNAL   PLoS One 9 (12), e116107 (2014)
   PUBMED   25542002
  REMARK    GeneRIF: Deletion of Arap3 in osteoblasts and mesenchymal stromal
            cells using Prx1-Cre resulted in no discernable phenotypes in
            hematopoietic development or hematopoietic stem cells homeostasis
            in adult mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5266)
  AUTHORS   Gambardella L, Hemberger M, Hughes B, Zudaire E, Andrews S and
            Vermeren S.
  TITLE     PI3K signaling through the dual GTPase-activating protein ARAP3 is
            essential for developmental angiogenesis
  JOURNAL   Sci Signal 3 (145), ra76 (2010)
   PUBMED   20978237
  REMARK    GeneRIF: PI3K signaling through the dual GTPase-activating protein
            ARAP3 is essential for developmental angiogenesis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5266)
  AUTHORS   Samuels AL, Klinken SP and Ingley E.
  TITLE     Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein
            that influences erythropoietin-induced differentiation
  JOURNAL   Blood 113 (16), 3845-3856 (2009)
   PUBMED   19064729
REFERENCE   8  (bases 1 to 5266)
  AUTHORS   Ruusala A, Pawson T, Heldin CH and Aspenstrom P.
  TITLE     Nck adapters are involved in the formation of dorsal ruffles, cell
            migration, and Rho signaling downstream of the platelet-derived
            growth factor beta receptor
  JOURNAL   J Biol Chem 283 (44), 30034-30044 (2008)
   PUBMED   18765673
  REMARK    GeneRIF: the Nck adapters are needed for signaling to Rho GTPases
            and actin dynamics downstream of the PDGFbeta receptor
REFERENCE   9  (bases 1 to 5266)
  AUTHORS   I ST, Nie Z, Stewart A, Najdovska M, Hall NE, He H, Randazzo PA and
            Lock P.
  TITLE     ARAP3 is transiently tyrosine phosphorylated in cells attaching to
            fibronectin and inhibits cell spreading in a RhoGAP-dependent
            manner
  JOURNAL   J Cell Sci 117 (Pt 25), 6071-6084 (2004)
   PUBMED   15546919
  REMARK    GeneRIF: ARAP3 has a role in integrin-mediated tyrosine kinase
            signalling pathways controlling Rho GTPases and cell spreading
REFERENCE   10 (bases 1 to 5266)
  AUTHORS   Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell
            J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis
            N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK,
            Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P,
            Stephens LR and Hawkins PT.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ046208.1, AK220486.1,
            BC068145.1, CF743699.1 and AA175706.1.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_139206.3.
            
            On Oct 31, 2007 this sequence version replaced NM_139206.1.
            
            Summary: This gene encodes a phosphoinositide binding protein
            containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin
            homology domains. The ARF-GAP and RHO-GAP domains cooperate in
            mediating rearrangements in the cell cytoskeleton and cell shape.
            It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP
            protein. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068145.1, SRR10223969.18528.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CJ046208.1         1-7
            8-12                AK220486.1         1-5
            13-490              BC068145.1         1-478
            491-608             CF743699.1         516-633
            609-5219            BC068145.1         597-5207
            5220-5266           AA175706.1         321-367
FEATURES             Location/Qualifiers
     source          1..5266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.85 cM"
     gene            1..5266
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 3"
                     /db_xref="GeneID:106952"
                     /db_xref="MGI:MGI:2147274"
     exon            1..42
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            43..580
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..4676
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centaurin, delta 3; dual-specificity Rho- and Arf-GTPase
                     activating protein 1; ARF-GAP, RHO-GAP, ankyrin repeat and
                     pleckstrin homology domains-containing protein 3; arf-GAP
                     with Rho-GAP domain, ANK repeat and PH domain-containing
                     protein 3"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 3 isoform 1"
                     /protein_id="NP_631945.2"
                     /db_xref="CCDS:CCDS29196.1"
                     /db_xref="GeneID:106952"
                     /db_xref="MGI:MGI:2147274"
                     /translation="MAAPQDLDIAVWLALVHLEQYADTFRRHGLATAGAAQHLGHEEL
                     RHLGISATGHRKRILRLLRAGSAEGFLDSHLDNTMEPTPSPAPDAQPPKPVPKPRTVF
                     GLSNPATAQRPGLSPIFWDPEVSRNSECTQRSSPLLPSSSEQPSVPNTMEMMPNAIYF
                     GLDLRGRAQAAQDVTPDSSQATVPTPAFRPTTGTVHIMDPGCLYYGVQPVGIPGASDR
                     RDGRGVCQERAEHRQDLETREDAGYASLELPGDSILSLPTQDAETSDDLISPYASFSS
                     TADRPVPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEM
                     TRSSKDNKFQVITGQRVFVFRTESEAQRDLWCSTLQSCLKEQRLLGHPRPPHPPRPLR
                     TGTLELRGHKAKVFAALIPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLL
                     TPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKVWSNPANRHCADCRASRPD
                     WAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANCFW
                     AGALPPGEGLHPDSAPGPRGEFISRKYKLGLFRKPHPRHPDHSQLLQALCAAMAGPNL
                     LKNMAQLLCVETSEGEEPLSPSALNGSLLSLLPSDSPGVYNEVVVPATYRGFLYCGSI
                     SNKAGAPPLRRGRDAPPRLWCVLGAALEMFASESSPEPLSLLQPQDIVCLGVSPPPAD
                     PGDLDRFPFSFELILTGGRIQHFATDGADSLEAWISAVGKWFSPLSCHQLLGPGLLRM
                     GRLWLRSPSHAGLAPGLWLSGFGLLRGDHLFLCPAPGPGPPAPEDMVHLRRLQEISVV
                     SAADTPDKKEHLVLVETGRTLYLQGEGRLDFAAWNTAIGGAAGGGGTGLQEQQMSRGD
                     IPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPREHFVEDV
                     TDTLKRFFRELDDPVTSARLLPRWREAAELSQKNQRLEKYKEVISCLPRVNRRTLATL
                     IGHLYRVQKCASLNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDS
                     DQAAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQ
                     VLEMRGAASGTDLWVTFEILEHGELERPLHPKEKVLEQALQWCQLPEPCSASLLLRKV
                     SMAHAGCLFTGVRRESPRVGLLRCREEPPRLLGNRFQERFFLVRGRCLLLLKEKKSSK
                     PEREWSLEGAKVYLGIRKKLKPPTLWGFTLILEKMHLCLSCMDEEEMWDWTTSILKAQ
                     HDDQQSVVLRRRSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMF
                     FPMKSPQGSVEEQDELEEPVYEEPVYEEVGAFPELTKDTTFSSTWEWSAKSDPSLTSQ
                     RSFDQPPLSKASMLGHEERIPDPPPGPPSKSSSQARGSLEEQLLQELNNLILRKGEPA
                     SCPESSSQPTSPQAPSPTSLPTPTPSLPTQPPCTSNPPSSQPLT"
     exon            581..642
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..754
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            755..946
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1016
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1137
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1322
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1429
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1629
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1715
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1898
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2034
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2148
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2296
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2399
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2619
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2683
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2847
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3060
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3166
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3314
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3383
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3458
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3573
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3702
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3836
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3919
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..3955
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4019
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4157
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4196
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..5225
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5200..5205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
     polyA_site      5225
                     /gene="Arap3"
                     /gene_synonym="Centd3; cnt-d3; Drag1; E030006K04Rik"
ORIGIN      
        1 ggattacgat gtccaccctg aacctctgct ctggaaacca gtcaatggcc tgaaagccca
       61 tggctgcccc tcaggacctg gacatcgctg tgtggttggc cctggtgcat ctggagcagt
      121 atgcggacac tttccgacgg catggcctag ctacagctgg tgcggcccaa cacctgggcc
      181 acgaggagct gaggcacttg ggcatcagtg ctacaggaca ccggaaacgc atcttgcgcc
      241 tgttgcgggc aggctctgct gagggtttcc tggattctca tctggataat accatggagc
      301 caactcccag cccagcccct gatgcccaac cccccaagcc tgtgcctaag cccaggacgg
      361 tgtttgggct cagcaaccct gccactgccc agaggcctgg actgagccca atcttctggg
      421 atccagaagt atccaggaac tcagagtgta cgcaaagatc ctctcctctc cttccttcct
      481 cctctgaaca gccttcagtc ccgaatacca tggagatgat gcctaatgcc atctactttg
      541 gcctggactt aagaggtcgg gcccaggcag ctcaggacgt gactccagat agttctcagg
      601 cgactgtccc aacccctgcc ttcaggccca caacaggcac agtgcacatc atggatcctg
      661 gttgcctgta ctacggtgtc cagcctgtgg ggatcccagg agcctctgac aggagagacg
      721 gcaggggtgt ctgtcaggaa agggcagaac acagacagga tctggagaca cgggaggatg
      781 ctggttatgc cagcctcgag ctacctggag actccattct ttcgctaccc acccaggatg
      841 cagagaccag tgatgacctc atttcgccct atgccagctt ctcctccaca gcagatcgtc
      901 ccgtgcctct gctcagtggc tggctggaca agctctcacc tcagggaaac tatgtgttcc
      961 agagacgttt tgtgcagttc aatggaagga gtctaatgta ctttggcagt gacaaggacc
     1021 ccttccccaa aggtgtgatc cctctgactg ccatcgagat gacccgaagc agcaaggaca
     1081 acaaattcca ggtcattacc ggccagagag tatttgtgtt ccgcacagag agtgaggctc
     1141 agcgtgacct atggtgctcc acgctgcaat cctgcctgaa ggaacagcgc ctcctgggcc
     1201 acccccggcc ccctcaccca ccacgacccc tccgcacggg cacgttagag ttgcgtggac
     1261 acaaggccaa ggtgtttgct gccttgatcc ctggagagct ggcactgtac aagagtgagc
     1321 aggccttctc actgggcatc gggatctgct tcattgaact gcaaggctgc agtgtccggg
     1381 agaccaagag tcgaagcttc gatctgctca caccccatcg ctgcttcagc ttcacagccg
     1441 agtctggggg ggctcgacag agctgggcag ccgctctgca agaagcagta accgagacac
     1501 tgtctgacta cgaggtggct gagaaggtct ggtccaaccc ggcaaaccgg cattgtgcgg
     1561 actgcagggc ctcccggccg gattgggctg ccgtcaacct gggggtcgtc atctgcaagc
     1621 agtgtgcagg tcagcacagg gccctgggct ctgggatctc caaggtgcag agcctgaagc
     1681 tggacacgag tgtctggagt aatgagatag tgcagctgtt cattgtcctg ggaaatgatc
     1741 gtgccaattg cttctgggca ggggcacttc ccccaggtga agggctgcat ccagattcag
     1801 cccctggccc tcgaggagag ttcatctccc gaaagtataa gctgggtctc ttccggaagc
     1861 cccaccctcg gcatccagat catagccagc ttctccaggc actgtgtgca gctatggcag
     1921 gacccaacct gctcaagaac atggcccagc ttctctgtgt cgaaacctct gagggagagg
     1981 aacccttgtc cccttcagcc ctcaatggca gcttgcttag ccttctacct tcagactccc
     2041 ctggagtata caatgaggtg gtagtgcctg ccacttacag aggtttcctg tactgtggct
     2101 ccatcagcaa caaggctgga gccccacccc ttcgcagggg ccgggatgct cctccccgct
     2161 tgtggtgtgt gctgggagct gccctggaaa tgtttgcatc agagagcagc cctgaacccc
     2221 tcagccttct ccagccccag gatattgtat gtctgggtgt aagcccccca cctgctgatc
     2281 caggtgacct tgacaggttc cccttttcct ttgaactcat cctcactggg ggaagaatcc
     2341 agcattttgc cactgatgga gcagacagtc tagaggcctg gatcagtgca gtgggcaagt
     2401 ggttctcccc gctcagctgc caccagctgc tgggccctgg gttgctgcgg atgggtcgcc
     2461 tgtggctacg gtccccctcc cacgcaggcc tggcccctgg tctctggctg tcgggcttcg
     2521 gcctccttcg tggtgatcat ctcttcctgt gcccagcgcc tggccctggt ccccctgctc
     2581 cggaggacat ggtgcattta cgacgtctac aggagatcag tgtggtctcg gcagctgaca
     2641 ctccagacaa aaaggagcat ttggtccttg tagagacagg aaggaccctg tatttgcagg
     2701 gggaaggcag gctagacttt gcagcgtgga acacggccat tggaggtgct gccggagggg
     2761 gtggcacggg cctgcaggag cagcagatga gccggggaga catccctatc attgtggacg
     2821 cttgcatcag ttttgtcacg cagcatgggc tccggctgga aggtgtatat cggaaaggag
     2881 gcgctcgagc ccgcagcctg cgactcttgg ctgagtttag gcgggatgcc cggtcagtga
     2941 agcttagacc acgggaacac tttgtagaag atgttactga cacactcaaa cgcttctttc
     3001 gagagcttga tgaccccgtg acctctgcta ggttgctgcc tcgatggaga gaagctgcag
     3061 agctttccca gaagaatcag cgcctggaga agtacaaaga agtgattagc tgcctgcctc
     3121 gagtcaaccg cagaacactg gccaccctca tcgggcatct gtaccgggtg cagaagtgtg
     3181 cgtctctaaa ccagatgtgc acgcggaacc tggccctact gtttgcacct agtgtgttcc
     3241 agacagatgg gcggggagag catgaggttc gggtactgca ggagctcatc gatggctaca
     3301 tctctgtttt tgatattgac tcggaccagg cagctcagat tgacttggag gtcagtctca
     3361 ttaccacctg gaaggatgtg cagttgtccc aggctggaga cctcatcatg gaggtttaca
     3421 tagaacagca gctcccggac aactgtgtca ccctaaaggt atccccaaca ctgactgctg
     3481 aggagttgac taaccaggtg ctggagatgc gaggggcggc atcggggaca gacttgtggg
     3541 tgacatttga aattcttgaa cacggagagc ttgagaggcc actgcacccc aaagaaaagg
     3601 ttctagagca ggccttgcag tggtgccagc ttccagagcc ctgctcagcc tctctgcttc
     3661 tgagaaaagt ctctatggca cacgctggct gcctcttcac aggagtccgg cgtgagagcc
     3721 cacgagtggg gctgctacgg tgtcgtgagg agccacctcg attgctggga aaccgtttcc
     3781 aggagaggtt ctttttggtg cgtggccgat gcctgctgct gctcaaggag aagaagagct
     3841 ctaagccaga acgggagtgg tctctggaag gtgccaaggt ctacctggga atccgcaaga
     3901 agttaaaacc tccaacactg tggggtttca cattaatatt ggaaaagatg cacctctgtc
     3961 tgtcctgcat ggatgaggag gagatgtggg actggaccac aagcatcctt aaagcccagc
     4021 atgatgacca acagtccgtg gttttacgtc gccgttcctc ctctgacctt gctcgtcaga
     4081 agtttggcac tatgcccttg ctgcccatcc gaggggatga cagtggagcc acccttctct
     4141 ctgccaatca gaccctgcgg cgactacaca accggaggac cttatccatg ttctttccaa
     4201 tgaagtcacc ccagggatct gtggaagagc aagatgagct ggaggagcct gtgtatgaag
     4261 agccagtata tgaggaggtc ggggccttcc ctgagcttac caaggacacg accttctctt
     4321 ccacatggga gtggtcagcc aagtcagatc catcccttac cagccagagg tcctttgatc
     4381 aaccccccct ctccaaggca agcatgttgg gccacgaaga gaggatacct gaccctcctc
     4441 cgggcccccc ttcaaaaagc agttctcagg cacgagggtc cctagaggaa cagctgcttc
     4501 aggaactcaa caacctcatc ctgaggaaag gagagcctgc ctcgtgccca gaaagctctt
     4561 cccagcccac cagtccccaa gccccaagcc ccaccagcct tccaacaccg acccccagct
     4621 tacccaccca accgccctgc acttccaatc caccctccag ccagcctctc acatgacccc
     4681 agggcccgca gttgaggagg taggtaacca gaggcgaagc caggctctca ccatggcaga
     4741 ttactgctgg gagctgcttc tgccctggat ggatgactct ggaatccagt atggtaccat
     4801 ggaaggagca ctggactgag agccctggag actgtgtgtc tcagggaaga tcatggcccc
     4861 tctctgggcc cagcccattt gtctgtacta tgaagtcact aaaagaagga gaggggtgaa
     4921 caccgaactg tttctgagct aggagccctg atatttcccc tcaataaggg cagctcctag
     4981 ttgatatatt tgatataggg gttcagtgag agctttgtgg cctaagaatg gttttactac
     5041 attataggaa agtgaaggtt tggaagctag agatgggcat gatatctaaa tctatgttat
     5101 tccgcttcct atgtactgga actgccttga ggccctagag tggctgattg ggattgggag
     5161 ctggggcaaa ggggagtcga agaggaatgg atcactatta ataaaatttg gaaccaaaag
     5221 gctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
