LOCUS       NM_178407               7363 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 2 (Arap2), mRNA.
ACCESSION   NM_178407 XM_001001363 XM_132099
VERSION     NM_178407.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7363)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7363)
  AUTHORS   Chaudhari,A., Haversen,L., Mobini,R., Andersson,L., Stahlman,M.,
            Lu,E., Rutberg,M., Fogelstrand,P., Ekroos,K., Mardinoglu,A.,
            Levin,M., Perkins,R. and Boren,J.
  TITLE     ARAP2 promotes GLUT1-mediated basal glucose uptake through
            regulation of sphingolipid metabolism
  JOURNAL   Biochim Biophys Acta 1861 (11), 1643-1651 (2016)
   PUBMED   27476102
  REMARK    GeneRIF: ARAP2 knockdown did not affect fatty acid uptake but
            reduced basal glucose uptake, total levels of the glucose
            transporter GLUT1, and GLUT1 levels in the plasma membrane and the
            lipid micro-domain fraction.
REFERENCE   4  (bases 1 to 7363)
  AUTHORS   Gambardella,L., Hemberger,M., Hughes,B., Zudaire,E., Andrews,S. and
            Vermeren,S.
  TITLE     PI3K signaling through the dual GTPase-activating protein ARAP3 is
            essential for developmental angiogenesis
  JOURNAL   Sci Signal 3 (145), ra76 (2010)
   PUBMED   20978237
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7363)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   6  (bases 1 to 7363)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7363)
  AUTHORS   Vallis,K.A., Chen,Z., Stanford,W.L., Yu,M., Hill,R.P. and
            Bernstein,A.
  TITLE     Identification of radiation-responsive genes in vitro using a gene
            trap strategy predicts for modulation of expression by radiation in
            vivo
  JOURNAL   Radiat Res 157 (1), 8-18 (2002)
   PUBMED   11754636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122231.2, AC124720.3 and AC135359.2.
            
            On or before Jun 7, 2008 this sequence version replaced
            XM_001001363.1, XM_132099.9, NM_178407.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14995048.1511781.1, SRR6116558.17390.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC122231.2         73421-73704         c
            285-1325            AC122231.2         56303-57343         c
            1326-1384           AC124720.3         183217-183275       c
            1385-1461           AC124720.3         182129-182205       c
            1462-1553           AC124720.3         181199-181290       c
            1554-1907           AC124720.3         178750-179103       c
            1908-1977           AC124720.3         162962-163031       c
            1978-2098           AC124720.3         154837-154957       c
            2099-2277           AC124720.3         146470-146648       c
            2278-2393           AC124720.3         133790-133905       c
            2394-2593           AC124720.3         131584-131783       c
            2594-2679           AC124720.3         126174-126259       c
            2680-2862           AC124720.3         125331-125513       c
            2863-3037           AC124720.3         124741-124915       c
            3038-3172           AC124720.3         124181-124315       c
            3173-3317           AC124720.3         119165-119309       c
            3318-3420           AC124720.3         118109-118211       c
            3421-3619           AC124720.3         117256-117454       c
            3620-3683           AC124720.3         117018-117081       c
            3684-3847           AC124720.3         102275-102438       c
            3848-4060           AC124720.3         97918-98130         c
            4061-4166           AC124720.3         94412-94517         c
            4167-4314           AC124720.3         91024-91171         c
            4315-4383           AC124720.3         89557-89625         c
            4384-4458           AC124720.3         87191-87265         c
            4459-4576           AC124720.3         84181-84298         c
            4577-4705           AC124720.3         78362-78490         c
            4706-4833           AC124720.3         70068-70195         c
            4834-4916           AC124720.3         63233-63315         c
            4917-4952           AC124720.3         62223-62258         c
            4953-5016           AC124720.3         59933-59996         c
            5017-5151           AC135359.2         4961-5095
            5152-7363           AC135359.2         6514-8725
FEATURES             Location/Qualifiers
     source          1..7363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 32.04 cM"
     gene            1..7363
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 2"
                     /db_xref="GeneID:212285"
                     /db_xref="MGI:MGI:2684416"
     exon            1..284
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            285..1325
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..5538
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /note="centaurin, delta 1; cnt-d1; PARX protein"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 2"
                     /protein_id="NP_848494.2"
                     /db_xref="CCDS:CCDS51506.1"
                     /db_xref="GeneID:212285"
                     /db_xref="MGI:MGI:2684416"
                     /translation="MSSVSEVNADIRDFLMSINLEQYLLHFREFGFYTVRDCTSINDS
                     VLHQIGISPTGHRRRILKQLQMIFSKMQDFPIYANVHKAKNGSTTKEQQHSDPSSSTH
                     TGIECSDSITVHRPGPAPSEMVTTSTLSEGNCQSPKSHDKLCLSSHDLLCPEEELHQN
                     VDSSKDSLFGGVNVKIDPLITKRAVEYTAGEEHTEKGNLTSEDSSKALSTNTECLPSG
                     DCPTSGTHSGNGTNGVLESFPPTPFFQFQGEMVVNELYVPSSPVHGPMRSRSKLVSRP
                     SRSFLLRHRPVPEIPGSTKSIPGSYFRDRRSNTTSAGKSLTLKNSNEDNSTSIFPYGE
                     TFLFQRLESSKKRSIKNEFWPHENTVKEEAATTRNSILTQSSIYDNRKEKVSEDKVED
                     IWIPREDKNNLAQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYP
                     LSSTSGNTEPSSTISNAISPYACFYGSSAAKEKCGWLDKLSPQGKRMFQKRWVKFDGL
                     SISYYNNDREMYSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISI
                     LLSALKSPSLASQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKNEQDFKSGLG
                     ITIIPMNVANVKQVDRAVKQSFEIITPYRSFSFTADSEREKQEWIEAVQQSIAETLSD
                     YEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKM
                     DASIWSNELIELFIVIGNKRANDFWAGNLQKDEELQVDSPVEKRKNFITQKYKEGKFR
                     KTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAG
                     QSLQMEFLYHNKFSDFPQYDAHFEGGSSQDAAQSSFLCDFLYQTAAAASRVSSEKKLL
                     EDTNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLAVHKEDFYLNTGPIFVFEIY
                     LPSERVFLFGAETSQIQRKWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQW
                     RKGWFAMDKSSLCFCLQTQEAQEERMNLRRLQELTISTMVQNGEKVDVLLLVEKGRTL
                     YIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLCKNDVPIIVNSCIAFVTQYGLGCKY
                     IYQKDGDPLHISELLESFKKDARSVKLRAGKHQLEDVTGVLKSFLSDIDDALLTKELY
                     PYWVSALDTQDEKERTSKYRAFIRSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNL
                     AMVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQV
                     SQAGDLLIEVFVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPMKGDIWATFEVI
                     ENEELERPLHYTENVLEQVLQWSSLAEPGSAYLVVKRFLTIDSIKQCREKSIKEGILK
                     LKEEPSKILSGNKFQDRCVVLRDGHLFIYKDPKSSKHDKMFPLRAMKFYLGVKKKMKP
                     PTSWGLTVYSEKHHWHLCCDSLQAQMEWMASIFIAQHENDIWPPAGKERKRSITKNPK
                     IGGLPLIPIQHERNATQARKNIETARAELERLRLSEKHDPRDFTDSSLKDRASLIAHC
                     LEHKDEKLRNRARKHRSFNCLEDTEAEGPHGLPKAYKGPKTLKKTEERNSKATLDADP
                     KLPSKVIEELSVVLQRSRPLHKELPDEQTLQKEVK"
     exon            1326..1384
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1461
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1553
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1907
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1977
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2098
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2277
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2393
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2593
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2679
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2862
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3037
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3172
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3317
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3420
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3619
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3683
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3847
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..4060
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4166
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4314
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4383
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4384..4458
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4576
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4705
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4833
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..4916
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4917..4952
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            4953..5016
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..5151
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     exon            5152..7363
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7335..7340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /note="hexamer: ATTAAA"
     polyA_site      7363
                     /gene="Arap2"
                     /gene_synonym="Centd1; Gm148; mKIAA0580"
                     /note="major polyA site"
ORIGIN      
        1 gcgctcgccc gcggagccca gccgcgctcc cgcctccagg tgcggcgcgg ggtccgcccg
       61 ctcgccgccg gggacagcgc cccacgggga cgagccggcg ctgcgctgcc ggggctcgcg
      121 ggccgcgcgc gagcgaggcg agtccccggg gtgcgctggc cgcggtccgg tcccgggtgc
      181 gagaacgcag cgcttcggga cgcgtggagt gctcgggcgg ctctggattg tgtcgctcgg
      241 attgcgcgtc ccgcgagtgg gcgtcggaag agaaaccaaa ggcggtttga gcacatgaac
      301 agaaaataac attctaaaga ctttgtcaga agtgataggg aggaaaaaaa cccataagaa
      361 gtacttcctt gtgtgtgtgt ctcatggtgc agcttttaac actcacatag taatgaagcc
      421 accattatgt cctcagtcag cgaagtaaat gcggacatca gagatttcct gatgagcatc
      481 aatttggagc agtacctctt acatttccgt gaattcggtt tttataccgt gagggactgc
      541 acgtcgataa atgacagcgt actccatcag attggaatat cacctactgg acaccgtagg
      601 aggatactga aacagttaca aatgatcttt tcaaaaatgc aagacttccc catatatgca
      661 aatgtgcata aggcaaagaa cggcagcacc acaaaagagc aacaacacag tgatccatct
      721 tccagcaccc acaccggcat agagtgttcc gattccatta ctgtccatag acctggcccg
      781 gcaccatcag agatggttac aaccagtacc cttagtgaag gaaactgtca gtctccgaaa
      841 tcacatgata agctatgtct ttcttcacat gacctgctct gtccagaaga agaactacac
      901 cagaacgtgg attcttcgaa agattcttta tttggtggtg taaatgtcaa aatagatcct
      961 ttgattacca agagggctgt ggagtacaca gctggagaag aacacacaga aaaaggcaat
     1021 ttgacctcag aagattccag caaggcactt agtacaaaca ctgaatgtct tccctctggg
     1081 gactgtccaa catcaggcac acattctgga aacgggacga atggcgtatt agaaagcttc
     1141 ccgccaaccc cgttctttca gtttcagggc gagatggttg tgaatgaact gtacgttccg
     1201 tcctcaccag tccacggccc catgagaagc cggagcaagt tggtttccag accttctcga
     1261 tcatttctac tgagacatcg ccctgtacca gagatcccag ggtctacaaa atcaattcca
     1321 gggagctatt tccgtgacag aagaagtaat actacctcag ctggaaagtc tttgacactg
     1381 aaaaattcaa atgaggataa ttcaacttcc atctttcctt acggagagac atttctcttc
     1441 cagagactag aaagttccaa gaagcgatct ataaagaatg agttttggcc gcatgagaac
     1501 acagttaaag aggaagcagc cactacaaga aactctatcc taacccagtc aagcatatat
     1561 gataacagga aggaaaaagt gagtgaagac aaagtcgaag acatttggat accccgcgag
     1621 gataaaaata accttgcaca ggattcggct tctgagtcag aatactccac agtagaggaa
     1681 tgcttccaga gtttaagaag aaaaaattct aaagcgtcca agtctaggac tcaaaaagcc
     1741 ttctacttgg accccttcaa taggcacagt tatcctttaa gctccacgag tggaaatact
     1801 gaaccgtcat caaccatctc aaatgccatc tctccctatg cctgcttcta tggatcttca
     1861 gcagccaagg agaaatgtgg atggctggac aaactctctc ctcaaggaaa acgcatgttt
     1921 cagaagagat gggtgaaatt tgatggcctt agcatttctt actacaataa tgacagagag
     1981 atgtactcaa aaggaataat tcccctcacg gcgatatcca cagtccgggc tcaaggagac
     2041 aacaaatttg aaattgttac aacacaaagg acttttgttt ttagagtaga aaaagaagaa
     2101 gagagaaatg attggattag catattatta agtgcactga agtcaccatc acttgcatca
     2161 cagttgcaag cagctgtagc ccctgagaaa tgtggatatc ttgaattgag agggtataaa
     2221 gccaaaattt ttaccgtgtt aaggggcaac agtgtgtggc tttgcaaaaa tgaacaggat
     2281 tttaagagtg gactcggtat taccataatt cccatgaatg ttgcaaatgt gaagcaagta
     2341 gatcgagctg tgaaacagtc ttttgagata attactccct accggagttt cagcttcaca
     2401 gcagattcgg agagagagaa acaggagtgg attgaagctg tgcagcagtc aatagcagag
     2461 actctctctg attatgaagt ggcggagaag atttggttta atgagtccaa caggagctgt
     2521 gcagattgta aagccccaga tcctgactgg gcatccatca atctctgtgt cgtcatctgt
     2581 aagaagtgtg caggacaaca tagatcgttg ggaccaaaag actctaaagt tagaagtctg
     2641 aaaatggatg ccagtatttg gagcaatgag ctcattgagc tatttattgt cattggaaac
     2701 aagagagcaa atgacttttg ggctggaaac cttcaaaaag acgaagaatt acaggtggat
     2761 tccccagtgg aaaagagaaa aaactttatt acccagaaat acaaagaagg aaaatttaga
     2821 aagactctct tagcatctct gactaaagaa gagttaaata aggctctgtg tgctgcagtt
     2881 gtgaagccag atgtgctgga aacaatggcc ctgctgttca gtggagcaga tgtcatgtgt
     2941 gcgacaggag accccgtgca cagtaccccc tacctgctgg ccaagaaggc tgggcagagt
     3001 ctgcagatgg aatttctcta ccataacaag ttctcagatt ttcctcagta cgatgctcat
     3061 tttgagggag ggtcaagtca ggatgctgcc caatcctcct tcctctgcga cttcttatac
     3121 cagactgctg ccgctgcctc tcgggtctcc tcggagaaga agcttcttga agacacaaat
     3181 aaaaaatggt gtgttttgga aggcggcttc ttgagttact atgaaaacga caggtgcacc
     3241 acacctaatg gtaccattaa tatcagtgaa gttatctgcc tggctgtcca taaggaggac
     3301 ttctatctga atactgggcc catctttgtc tttgaaatct acttaccatc agaacgtgtc
     3361 tttttgtttg gagctgaaac atctcagatt caaagaaaat ggacagagac aatagccaag
     3421 cgttttgttc cctttgttgc tgaaaactta acagaagctg actatgatct gattggtcaa
     3481 ctcttctaca aagactgcca tgccctggac cagtggagaa aaggctggtt tgctatggac
     3541 aagtctagct tgtgtttttg ccttcaaacg caagaagctc aggaagagag gatgaaccta
     3601 agaagactgc aggagctaac aatcagcaca atggttcaaa atggagaaaa agtagatgtg
     3661 ttactcttgg tagaaaaggg gagaacactg tacatccatg ggcacaccaa gttggatttc
     3721 acagtctggc atactgcaat tgaaaaagca gcaggtacag atggtaacgc attacaagat
     3781 cagcagctct gcaagaatga cgtccccatt attgtgaaca gctgcatagc atttgttaca
     3841 cagtatgggt taggatgcaa atacatttat caaaaggatg gtgatccttt gcacataagt
     3901 gaactcctgg agagtttcaa gaaggatgcc aggagtgtta agttgcgagc tgggaaacat
     3961 caacttgaag atgtgacagg cgtgctgaag agttttctgt cggacattga tgacgctctc
     4021 ctcacgaagg agctctatcc atactgggtc tctgcattag atacacaaga tgaaaaggag
     4081 agaactagca agtacagagc ctttatacgc tctcttcctg gggtcaacag agcaacactt
     4141 gcggctctaa ttgaacacct ttacagggtt cagaaatgct cagaaatcaa tcacatgaat
     4201 gcccataact tggcaatggt cttttcatcc tgcttatttc aaactaaggg acaaactagt
     4261 gaagaagtca atgtaattga agatctaatt aataattacg tggagatatt tgaggttaaa
     4321 gaagaccaag tcaaacaaat ggacatagaa aatagcttta taaccaagtg gaaagacact
     4381 caagtgtccc aggctggaga cttgttaatt gaagtgtttg tggaaagaaa ggagccagac
     4441 tgtagtatta taatccggat atctcctgtg atggaagctg aagagttaac gaatgatata
     4501 ttagcgataa aaaatatcat tcctatgaaa ggggatattt gggccacctt tgaagtcatt
     4561 gaaaatgaag agctagaacg tccacttcac tacacagaga atgtgttgga gcaggtgctt
     4621 cagtggagtt cattagctga gcctggttct gcgtatcttg tggtgaagag attcttaacc
     4681 attgacagca ttaaacagtg cagagagaaa agtatcaaag aaggcatctt aaaactcaaa
     4741 gaagaaccat ctaaaatact gtctgggaat aaatttcaag atcgatgtgt tgttttacga
     4801 gatgggcatc tctttattta caaggatcca aagagcagca aacacgacaa gatgtttcct
     4861 cttagggcga tgaagtttta tcttggtgta aaaaagaaaa tgaaaccccc aacaagttgg
     4921 ggattgactg tgtattctga aaaacatcac tggcacctgt gttgtgacag tttacaagcc
     4981 cagatggagt ggatggccag tatcttcatt gctcagcatg agaatgatat atggccgcca
     5041 gctggaaagg aacggaaacg ttcaataacc aaaaatccca agattggagg tttacctctg
     5101 attcctatcc aacatgagag aaatgcgacc caggcccgta agaatattga gacggccaga
     5161 gcagagcttg aaaggctgcg gctgagtgaa aagcacgatc ctcgagactt tacggactcc
     5221 agcttaaaag accgagcctc cctcatagcc cactgcttgg agcacaagga tgagaaactc
     5281 cgaaatcgtg ccagaaaaca tcgcagtttc aactgcctgg aagacaccga ggcagagggc
     5341 ccacatggcc tgccaaaggc ctataaaggt ccgaagacac tgaagaagac agaggaaaga
     5401 aacagcaaag ctaccttaga cgcagatcct aagctgccat cgaaggtcat cgaggaactc
     5461 agtgtggttc tccagaggtc acgacccctt cacaaagagc taccggatga acagacgcta
     5521 cagaaagaag taaaataaat cattgcacaa gttatttttt taacattgta tacaacatgt
     5581 gcaggacaga aatcaagctg caattcttga gtttctgtat ctcgatcaat ttgtctgtat
     5641 ttaagcaagt tgtttgtcta tacctaagca tcaaaagagc attttaaaat atgtatatat
     5701 gtggttatgt gtaagagcaa ctttattttg gtttggaaac ttgtaaagtt caattgtatt
     5761 aactttaata agtctttggg tcacttaaag tggccagccc tttgaaagta gatgtgtaag
     5821 tgggttaatt tatgagcaga aatctgtact ttattgtata aaatgctatg tgtatatgaa
     5881 tcttatgaaa ttgtatcata atttgcactt tgagaggctt gagaggcttg taaattaagt
     5941 tgttttgtgt ttttaggtta atatagggtc cgtcttaggg agaagaaagg gaagtgagtt
     6001 cgaaaaggga atgatattac agtggctgct tgataaacat tgggaagaga ggcaagaaat
     6061 taaaaacatt ccactaccca tggaggtggc ctaattcacc aaaaatcaaa cctttttatg
     6121 gagatcctac ttgttaaaaa aaaaaaattc tgtcttgaat gaaacaaaaa tattgatctg
     6181 gcctatgtta gtaatggcac tggctgctgc catttatggt gtcagtagat aagccccagg
     6241 gcatattcac tacatcagtg caactttttg tcagtgtctg ctcagaggaa cttactctgc
     6301 actgaagagt gtgtgcatgg gcccagcacg gatatcattt gcactgttgc tgtatgcagg
     6361 cagtccttta gggctccaaa ctgtattttt ggtacgaatc aaatttatca caatggggtc
     6421 ttttgctctt ttgttgttgt tgttctattt ttttgtttca tttcttaatg taacataatg
     6481 tttacttctg cactgtcagt aactgttgga agtgggcaat ctgtggctac ttatacaaca
     6541 catttgcagg caggcagttc acattccatt taactttttc tttctatctg tggaaatgac
     6601 agagccctgc attttttgtt gccacacaat gattgggaac agatttgaca attttcataa
     6661 ctcagactac attagcttat aatagttcat gttaaagatg gcgcttttta tagattgctt
     6721 ccaagtcaag ttggtttgtt gactcttaca actggaagtc atataggtga tctttattct
     6781 caacatttct ttgtcctctt ctgtatattt ttcctattta tgacatgtct ggtctatgag
     6841 ttcaagcctt tgtttcactt attcacagga aggcaccatg ctatgaatta ctagggctga
     6901 cttcactcag atatgctaac cccatgtact tgttgaagat agcggagttt accaggagtt
     6961 ggtggaattt attctttaca tccaaataaa ttgtaatgga aataataagt aaaactgcag
     7021 gacagtttta ggatttggtg gcactaccga agatccttcc ttcaaagcaa gatattgtgt
     7081 tttgagggaa gaaaagctta atttttagta aacttgtttc taatatgtaa tcatatttat
     7141 atttttatgc tgtaaagagt cgtatggaac tgatgttatt ggcctcgttg agaatgtgtc
     7201 atgtgctttg gcatacctta ctggaattcc tcctgagagt tgagtgtaaa aactgctccc
     7261 atctgttcct cttcttttca taaacaattg tcacataagg gctaatggtt acatctcaca
     7321 tattttgagt aacaattaaa atagttttac aagtccagtg aaa
//
