LOCUS       NM_001407803            5850 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH
            domain 1 (Arap1), transcript variant 6, mRNA.
ACCESSION   NM_001407803 XM_006508186
VERSION     NM_001407803.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5850)
  AUTHORS   Li,X., Guo,L., Wang,J. and Yang,X.
  TITLE     Pro-fibrotic and apoptotic activities of circARAP1 in myocardial
            ischemia-reperfusion injury
  JOURNAL   Eur J Med Res 28 (1), 84 (2023)
   PUBMED   36803446
  REMARK    GeneRIF: Pro-fibrotic and apoptotic activities of circARAP1 in
            myocardial ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5850)
  AUTHORS   Shao,A., Lopez,A.J., Chen,J., Tham,A., Javier,S., Quiroz,A.,
            Frick,S., Levine,E.M., Lloyd,K.C.K., Leonard,B.C., Murphy,C.J.,
            Glaser,T.M. and Moshiri,A.
  TITLE     Arap1 loss causes retinal pigment epithelium phagocytic dysfunction
            and subsequent photoreceptor death
  JOURNAL   Dis Model Mech 15 (7) (2022)
   PUBMED   35758026
  REMARK    GeneRIF: Arap1 loss causes retinal pigment epithelium phagocytic
            dysfunction and subsequent photoreceptor death.
REFERENCE   4  (bases 1 to 5850)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5850)
  AUTHORS   Voisinne,G., Kersse,K., Chaoui,K., Lu,L., Chaix,J., Zhang,L.,
            Goncalves Menoita,M., Girard,L., Ounoughene,Y., Wang,H.,
            Burlet-Schiltz,O., Luche,H., Fiore,F., Malissen,M., Gonzalez de
            Peredo,A., Liang,Y., Roncagalli,R. and Malissen,B.
  TITLE     Quantitative interactomics in primary T cells unveils TCR signal
            diversification extent and dynamics
  JOURNAL   Nat Immunol 20 (11), 1530-1541 (2019)
   PUBMED   31591574
REFERENCE   6  (bases 1 to 5850)
  AUTHORS   Gambardella,L., Hemberger,M., Hughes,B., Zudaire,E., Andrews,S. and
            Vermeren,S.
  TITLE     PI3K signaling through the dual GTPase-activating protein ARAP3 is
            essential for developmental angiogenesis
  JOURNAL   Sci Signal 3 (145), ra76 (2010)
   PUBMED   20978237
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5850)
  AUTHORS   Miyata,M., Rikitake,Y., Takahashi,M., Nagamatsu,Y., Yamauchi,Y.,
            Ogita,H., Hirata,K. and Takai,Y.
  TITLE     Regulation by afadin of cyclical activation and inactivation of
            Rap1, Rac1, and RhoA small G proteins at leading edges of moving
            NIH3T3 cells
  JOURNAL   J Biol Chem 284 (36), 24595-24609 (2009)
   PUBMED   19589776
  REMARK    GeneRIF: afadin regulates the cyclical activation and inactivation
            of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
REFERENCE   8  (bases 1 to 5850)
  AUTHORS   Guo,D.F., Chenier,I., Tardif,V., Orlov,S.N. and Inagami,T.
  TITLE     Type 1 angiotensin II receptor-associated protein ARAP1 binds and
            recycles the receptor to the plasma membrane
  JOURNAL   Biochem Biophys Res Commun 310 (4), 1254-1265 (2003)
   PUBMED   14559250
REFERENCE   9  (bases 1 to 5850)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 5850)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129079.5.
            
            On Jun 7, 2022 this sequence version replaced XM_006508186.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ621558.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC129079.5         125787-125897       c
            112-189             AC129079.5         106888-106965       c
            190-735             AC129079.5         100485-101030       c
            736-914             AC129079.5         88946-89124         c
            915-979             AC129079.5         88370-88434         c
            980-1104            AC129079.5         87713-87837         c
            1105-1254           AC129079.5         87445-87594         c
            1255-1324           AC129079.5         87127-87196         c
            1325-1445           AC129079.5         86760-86880         c
            1446-1648           AC129079.5         85797-85999         c
            1649-1755           AC129079.5         85266-85372         c
            1756-1955           AC129079.5         83723-83922         c
            1956-2041           AC129079.5         82065-82150         c
            2042-2224           AC129079.5         80357-80539         c
            2225-2399           AC129079.5         79078-79252         c
            2400-2534           AC129079.5         77791-77925         c
            2535-2670           AC129079.5         75555-75690         c
            2671-2773           AC129079.5         75188-75290         c
            2774-2969           AC129079.5         74312-74507         c
            2970-3021           AC129079.5         73952-74003         c
            3022-3185           AC129079.5         73695-73858         c
            3186-3398           AC129079.5         73382-73594         c
            3399-3504           AC129079.5         72998-73103         c
            3505-3652           AC129079.5         72449-72596         c
            3653-3739           AC129079.5         72277-72363         c
            3740-3808           AC129079.5         72126-72194         c
            3809-3926           AC129079.5         71810-71927         c
            3927-4040           AC129079.5         69908-70021         c
            4041-4186           AC129079.5         69561-69706         c
            4187-4219           AC129079.5         69021-69053         c
            4220-4302           AC129079.5         65857-65939         c
            4303-4353           AC129079.5         64822-64872         c
            4354-4417           AC129079.5         64632-64695         c
            4418-4567           AC129079.5         62917-63066         c
            4568-5850           AC129079.5         61400-62682         c
FEATURES             Location/Qualifiers
     source          1..5850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.56 cM"
     gene            1..5850
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /note="ArfGAP with RhoGAP domain, ankyrin repeat and PH
                     domain 1"
                     /db_xref="GeneID:69710"
                     /db_xref="MGI:MGI:1916960"
     exon            1..111
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            112..189
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            190..735
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..4585
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /note="isoform 5 is encoded by transcript variant 6;
                     centaurin, delta 2; arf-GAP with Rho-GAP domain, ANK
                     repeat and PH domain-containing protein 1; cnt-d2"
                     /codon_start=1
                     /product="arf-GAP with Rho-GAP domain, ANK repeat and PH
                     domain-containing protein 1 isoform 5"
                     /protein_id="NP_001394732.1"
                     /db_xref="GeneID:69710"
                     /db_xref="MGI:MGI:1916960"
                     /translation="MAEGYDAALSVAEWLRALHLEQYTALFEQHGLVWATECQGLSDA
                     GLLDMGMHLPGHRRRILAGLHRAHAPPVPLPRPAPRPVPMKRHIFRSPPVPVTPPEPP
                     PTAGEDEGLPAAPPIPPRRSCLPPACFTPTSTAAPDPVLPPLPAKRHLVEPSVPPVPP
                     RTGPPYPQASLLAKEELLLPSVSPRSQPEPAETPSTLLPAFPQGPLQPPSPPPCPPVI
                     PPKPPRLLPEFDDSDYDDVPEEGPGAPASVMTKEEPLPSRVPRAVRVASLLSEGEELS
                     GDDSEDDDDHAYEGIPNGGWPTSGLNPPLRSLIPDLPLHPMDELPGGPTPITPVIKAG
                     WLDKNPPQGSYIYQKRWVRLDADYLRYFDSNKDAYSKRFVPVACICRVAPIGDQKFEV
                     ITNNRTFAFRAESDVERNEWMQALQQAVVEHRARFRLSSASVLGVRGSEQPDRAGSLE
                     LRGFKNKLYVAVTGDKVQLYKNLEEFHLGIGITFIDMNVGNVKEVDRRSFDLTTPYRI
                     FSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAAQPDWASIN
                     LCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTEALIQLFLHLGNGPGNHFWAANVP
                     PSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQA
                     LLGCGAGVSCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPRLDSVKPLEKHYS
                     VTLPTVSHSGFLYKTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEI
                     RASEIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAFVPPLA
                     EDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGSELRAVFPEGPWEEPLQLRKLQEL
                     SIQGDSENQVLVLVERRRTLYIQGERRLDFMAWLGVIQKAAASLGDTLSEQQLGDSDI
                     PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVS
                     SALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALI
                     SHLYCVQCFSDTNQMNTHNLAIVFGPTLFQTDGQDYKAGKVVEDLINHYVVVFSVDEE
                     ELRKQREEVTAIVKMRVAGTASGTQHAGDFICTVYLEEKKVETEQHVKIPASMTAEEL
                     TLEILDRRNVSIREKDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGIDSHLVVKKYQ
                     SMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR
                     SQRPWSGAPETSHRPEKEWPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYL
                     CCDTQMELREWFATFLSVQHDGLVWPSEPSRVSRAVPEVRMGSVSLIPLRGSENEMRR
                     SVAAFTADPLSLLRHV"
     exon            736..914
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            915..979
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1104
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1254
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1324
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1445
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1648
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1755
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1955
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2041
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2224
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2399
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2534
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2670
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2773
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2969
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3021
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3185
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3398
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3504
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3652
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3739
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3808
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3926
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4040
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4041..4186
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4219
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4302
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4353
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4417
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4418..4567
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..5850
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5135..5140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /note="hexamer: AATATA"
     polyA_site      5158
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /note="major polyA site"
     regulatory      5832..5837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
                     /note="hexamer: TATAAA"
     polyA_site      5850
                     /gene="Arap1"
                     /gene_synonym="2410002L19Rik; Centd2; mKIAA0782"
ORIGIN      
        1 gagcgaggtg ggcgcgcccg gaccgctgcc gcgagttggc tgcggccgcg tgtgacagac
       61 ggtaccggga ccccgagtcc cacctcgtgg agttctcttc gctcaaaaca gctcccacct
      121 cagagcatca tgaggagccc ttgggactag gaacaacctc cttggaggac caggtgtcct
      181 tggtggcagg tctgagccta gccctgggcc tctgctgaca gaagccatgg cagagggtta
      241 cgatgccgca ctgtctgtag ctgagtggct gcgggcactt cacctggagc agtacacggc
      301 actctttgag cagcacggac tggtgtgggc caccgagtgc caaggcctca gcgatgctgg
      361 cctgctagac atgggcatgc acctccccgg ccaccgccgc cgcatcctgg ctggtcttca
      421 ccgcgcccat gcacccccag tccctctgcc tcgccccgcc ccacggcccg tgccgatgaa
      481 gcgacacatc ttccgttcac cacctgtgcc cgtcactcca ccagagccgc cgcccacagc
      541 tggagaggat gagggtctgc ctgccgctcc acctatccca ccccgcagga gctgcctccc
      601 acctgcctgc ttcactccga catccacagc cgccccagat cctgtgctgc ccccactgcc
      661 tgccaagaga cacttggtag aacccagcgt tcctcctgtc cctcctcgaa ccggaccccc
      721 ctacccacag gccagccttc ttgctaagga ggagttactg ctgccatcag tgtcaccccg
      781 gtcccaacca gagcctgcag agactccgtc caccctcctg cctgcctttc cccaggggcc
      841 cctgcagcct ccgtctcctc ctccctgtcc tcctgtgatc cctcccaagc ctcctcgcct
      901 gctccctgag tttgacgact ctgactatga tgatgtcccg gaggaggggc caggggcccc
      961 agccagtgtg atgaccaagg aggagcccct gccgagccga gtcccacggg ctgtgcgtgt
     1021 ggctagtctg ctgagcgagg gggaggagct gtctggggat gattcggaag atgacgatga
     1081 ccatgcctat gagggtatcc ccaatggtgg gtggccaacg agtggcctga atccaccctt
     1141 acgcagcctg atccctgatc tcccactgca ccccatggat gagttgcctg ggggtcccac
     1201 ccccatcaca cctgtcatca aggctggctg gctggacaag aacccaccac aggggtctta
     1261 tatctatcag aagcgatggg tgagactgga cgctgattac ctgcgatact ttgacagtaa
     1321 caaggacgcc tactctaagc gctttgttcc tgtggcctgc atctgccgag tagctcctat
     1381 tggagaccag aagtttgaag tgatcacaaa taatcggacc ttcgccttcc gggcagagag
     1441 tgatgtggag cggaacgagt ggatgcaggc cctgcagcag gcagtagttg agcatcgagc
     1501 ccgttttcgg ctttctagtg cttctgtgtt gggagtccga ggctccgagc agcctgaccg
     1561 tgctggcagc ctggagctac gaggcttcaa gaataagctt tacgtggctg tgactgggga
     1621 caaagtacag ctctataaga atctggagga attccatctg ggcattggta tcacctttat
     1681 cgacatgaat gtgggcaatg tcaaggaagt ggatcggcgc agctttgacc tcactacccc
     1741 ctaccgcatc ttcagcttct cggctgattc agagttagag aaggaacagt ggctggaggc
     1801 catgcaggga gccatcgcag aggccctatc tacctcagag gtggctgagc gcatctgggc
     1861 cgcagccccc aacaggttct gtgccgactg tggggccgcc cagcctgact gggcctccat
     1921 caacctctgc gttgtcatct gcaagcgctg tgcaggggag caccgcggcc tgggtgcagg
     1981 agtgtccaag gtgcggagtt tgaagatgga caggaaggtg tggacagaag cactcatcca
     2041 gctcttctta catctgggca atggccccgg gaaccacttc tgggctgcta atgtgcctcc
     2101 tagtgaggcc ctggagccca gcagcagccc tggtgcccgg cggtatcacc tggaggccaa
     2161 gtacagagag ggcaagtacc gccgctacca tccgctcttt ggcaaccaag aggaactgga
     2221 caaggccctg tgtgctgcag ttactaccac tgacctggct gagacccagg cactcctggg
     2281 ctgtggggct ggggtcagct gcttctcagg ggacccagca gctcccacac ccctggctct
     2341 tgctgagcag gccggacaga ctctgcagat ggagtttcta cggaataatc agagtacaga
     2401 ggtccctcgg ttggactcag tgaagccctt ggaaaagcac tactccgtta ccctgccaac
     2461 tgtgagccac agcggcttcc tgtacaaaac tgcttctgcc ggcaaacctc tgcaggaccg
     2521 ccgtgcccgg gaagagttca gccggcgctg gtgtgtcctg agtgatgggg tcctgagcta
     2581 ctatgaaaac gaacgggcag tgacacccaa tggggagatt cgggccagcg agatagtatg
     2641 cctagcagtt tcccctctgg acacccatgg ctttgagcac acctttgagg tgtacacaga
     2701 gggagaacgg ctgtacctgt ttgggctgga gaatgcagag ctggctcatg agtgggtcaa
     2761 gtgcattgcc aaggcgttcg tgcctcccct ggctgaggac ctgctagccc gggactttga
     2821 acgtcttggg cgcctaccct gtaaagctgg cctgagcctt cagcaggctc aggaaggctg
     2881 gtttgccttg actggctctg agctccgggc tgtcttccca gaggggccct gggaagagcc
     2941 gctgcagctc cggaaactgc aagagctttc tatccaagga gacagcgaga accaagtgct
     3001 ggtgctggtg gagcggagga ggacactgta catccagggt gagcggcggc tggacttcat
     3061 ggcttggcta ggggtcatcc agaaagcagc agccagcttg ggagacacac tatcagaaca
     3121 acagcttggg gactcggaca tcccagtgat tgtgtaccgc tgtgtggact acatcacgca
     3181 gtgtggcttg acctcagagg gtatctatcg aaagtgtggt cagacctcca agactcagag
     3241 actgctagac agcctccggc aggacgcacg ctctgtgcac ctaaaggagg gagaacagca
     3301 cgtggacgac gtctcctctg cactcaaacg cttcctcagg gacctgcccg atgggctctt
     3361 cacgcgtgcg cagcgcctgg cctggctgga ggcctctgag atcgaggatg aggaagaaaa
     3421 gatctccagg tatcgagagc tcttggtgca tctgccccct gtcaaccggg ccactgtgaa
     3481 ggcccttatc agccatctgt actgtgtaca gtgcttctca gacacaaacc aaatgaacac
     3541 acacaacctg gctatcgtgt ttgggcctac actcttccag acagacgggc aggactacaa
     3601 ggccggcaag gtggtggaag acctcatcaa ccactacgtg gtggtgttca gtgtggacga
     3661 ggaggagctg aggaagcaga gggaggaagt cacggccatc gtgaagatgc gagtggctgg
     3721 cactgccagt gggacccagc atgctggcga cttcatctgc acagtctacc tggaggagaa
     3781 gaaggtggag actgaacagc atgttaagat cccagcatcc atgactgcag aggagcttac
     3841 tctggagatt ctggaccgcc gcaatgtgag catcagggag aaggactact ggacttgctt
     3901 tgaggtcaac gagaaggagg aggcagagcg cccgctgcac tttgcagaga aggtgctgcc
     3961 cattgtccat gggctgggca tagacagcca tctggtggtg aagaagtacc agtccatgga
     4021 ggccatgctg ttgtacttgg ccagccgtgt gggtgacacc aagcatggta tgatgaagtt
     4081 ccgtgaagac cgcagcctcc tgggtctggg gctaccttcg ggtggcttcc acgatcgcta
     4141 cttcattctc aacagcagct gcctacggct ctacaaggag gtccggagcc agaggccgtg
     4201 gagcggggcc cctgagacca gtcaccggcc tgagaaggag tggcctgtca agagcctcaa
     4261 agtctacctg ggtgtaaaga agaaactgcg gccacctact tgctggggct tcacggtggt
     4321 gcacgagaca gaaaagcacg agaagcagca gtggtacctc tgctgtgaca cgcagatgga
     4381 acttcgagag tggtttgcca ccttcctctc tgtgcagcac gatggcctgg tgtggccctc
     4441 cgagccatct cgagtgtccc gggcagtgcc tgaggtccgg atgggcagtg tatcgctgat
     4501 ccctctacga ggcagtgaaa atgaaatgcg ccggagtgtg gcagccttca ctgctgaccc
     4561 cctttccctt ctccgccatg tctgagcaca ggagtcgttc tgactctggg acaccatcac
     4621 tgccaccagg aagctttcct gttcagacgc cctcgtgctc tgcgtgtttg gtgtgagcca
     4681 acagaacaca cggggaagcc atacccacat cccatatcct gactgcagca caggcttctt
     4741 ggctgggcag gaatgggctg gcaatgggga tttcccagga gggacccttc cttttcctgc
     4801 aggcaagcaa tgctcttgac ctggcttgct tacctagggt catgctcttt gaatccgtgg
     4861 aattggaaag atggacagaa atcaggagct gtgcaggaga agggtttggg gccccgctgg
     4921 gagggagccc acccccttcc cacaggctcc caaatggaaa gggtgacact ctgaacgtac
     4981 tcccgggggt ctacaaggga gctcgtggga agcttctgca gggtgatttc tggacttggg
     5041 gacatcagcc ctcttctggt gtgtgctggc agggaggccc aggctgtggc tgtctgctat
     5101 cccttcccca ctttggatac tttttgataa tataaatata tctgtatatt ttaccctatg
     5161 gtgctgaggc ctgtgatggt ttgtgggcac tggtgtccta ggctaagggt acagttggct
     5221 gtgaagccca gaggtgaatg ctggggcttt gaagccagga gcctgagtct accctctgca
     5281 tgtttactga gctatttacc ctccactgtc ctggcagagg cctggcctgg ccctgtacct
     5341 actgtgccac tgtacagcca ggctatggaa tttctgattc aggacaaggc agaccccagc
     5401 tagtctgagt cccggtccct gcaaccatct gagctggggc ctagatctgt gttagtgacc
     5461 ccggcacagc tactcagagc ctcgtgctgg agacacgagg ccacagtgca taccacaagc
     5521 tttggaggac tgtgaagggg gctttaccct gggcactatg cgtgtgcttc cagagtggag
     5581 tctgcctctc acatcacagg gcatcgcctt cagagggaag tgctgaccta cagaggtcac
     5641 cagctactca aagacagact ggagacttct gggaaagtgc taagcttctg ccttctctgg
     5701 agtctcattg ccaccctatc tcaaaggctt agtgagcaga cttgctggtg tcctgtcctt
     5761 agcctcgaaa ggggcagagc agagctggat aagactgggg tacctgtgcc atctgtgacc
     5821 cccccatcac ctataaagct ctgaaccccg
//
