LOCUS       NM_013476              10063 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus androgen receptor (Ar), mRNA.
ACCESSION   NM_013476
VERSION     NM_013476.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10063)
  AUTHORS   Sakai,H., Uno,H., Yamakawa,H., Tanaka,K., Ikedo,A., Uezumi,A.,
            Ohkawa,Y. and Imai,Y.
  TITLE     The androgen receptor in mesenchymal progenitors regulates skeletal
            muscle mass via Igf1 expression in male mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (39), e2407768121 (2024)
   PUBMED   39292748
  REMARK    GeneRIF: The androgen receptor in mesenchymal progenitors regulates
            skeletal muscle mass via Igf1 expression in male mice.
REFERENCE   2  (bases 1 to 10063)
  AUTHORS   Sucquart,I.E., Coyle,C., Rodriguez Paris,V., Prescott,M.,
            Glendining,K.A., Potapov,K., Begg,D.P., Gilchrist,R.B.,
            Walters,K.A. and Campbell,R.E.
  TITLE     Investigating GABA Neuron-Specific Androgen Receptor Knockout in
            two Hyperandrogenic Models of PCOS
  JOURNAL   Endocrinology 165 (7) (2024)
   PUBMED   38788194
  REMARK    GeneRIF: Investigating GABA Neuron-Specific Androgen Receptor
            Knockout in two Hyperandrogenic Models of PCOS.
REFERENCE   3  (bases 1 to 10063)
  AUTHORS   Dart,D.A., Bevan,C.L., Uysal-Onganer,P. and Jiang,W.G.
  TITLE     Analysis of androgen receptor expression and activity in the mouse
            brain
  JOURNAL   Sci Rep 14 (1), 11115 (2024)
   PUBMED   38750183
  REMARK    GeneRIF: Analysis of androgen receptor expression and activity in
            the mouse brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10063)
  AUTHORS   Matsumoto,T., Sakari,M., Okada,M., Yokoyama,A., Takahashi,S.,
            Kouzmenko,A. and Kato,S.
  TITLE     The androgen receptor in health and disease
  JOURNAL   Annu Rev Physiol 75, 201-224 (2013)
   PUBMED   23157556
  REMARK    Review article
REFERENCE   5  (bases 1 to 10063)
  AUTHORS   Faber,P.W., King,A., van Rooij,H.C., Brinkmann,A.O., de Both,N.J.
            and Trapman,J.
  TITLE     The mouse androgen receptor. Functional analysis of the protein and
            characterization of the gene
  JOURNAL   Biochem J 278 (Pt 1) (Pt 1), 269-278 (1991)
   PUBMED   1883336
REFERENCE   6  (bases 1 to 10063)
  AUTHORS   Charest,N.J., Zhou,Z.X., Lubahn,D.B., Olsen,K.L., Wilson,E.M. and
            French,F.S.
  TITLE     A frameshift mutation destabilizes androgen receptor messenger RNA
            in the Tfm mouse
  JOURNAL   Mol Endocrinol 5 (4), 573-581 (1991)
   PUBMED   1681426
REFERENCE   7  (bases 1 to 10063)
  AUTHORS   Gaspar,M.L., Meo,T. and Tosi,M.
  TITLE     Structure and size distribution of the androgen receptor mRNA in
            wild-type and Tfm/Y mutant mice
  JOURNAL   Mol Endocrinol 4 (10), 1600-1610 (1990)
   PUBMED   2178222
REFERENCE   8  (bases 1 to 10063)
  AUTHORS   He,W.W., Fischer,L.M., Sun,S., Bilhartz,D.L., Zhu,X.P., Young,C.Y.,
            Kelley,D.B. and Tindall,D.J.
  TITLE     Molecular cloning of androgen receptors from divergent species with
            a polymerase chain reaction technique: complete cDNA sequence of
            the mouse androgen receptor and isolation of androgen receptor cDNA
            probes from dog, guinea pig and clawed frog
  JOURNAL   Biochem Biophys Res Commun 171 (2), 697-704 (1990)
   PUBMED   2403358
REFERENCE   9  (bases 1 to 10063)
  AUTHORS   Attardi,B., Geller,L.N. and Ohno,S.
  TITLE     Androgen and estrogen receptors in brain cytosol from male, female,
            and testicular feminized (tfm/y hermaphrodite) mice
  JOURNAL   Endocrinology 98 (4), 864-874 (1976)
   PUBMED   179788
REFERENCE   10 (bases 1 to 10063)
  AUTHORS   Dunn,J.F. and Wilson,J.D.
  TITLE     Developmental study of androgen responsiveness in the submandibular
            gland of the mouse
  JOURNAL   Endocrinology 96 (6), 1571-1578 (1975)
   PUBMED   123850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL844866.17, AK133647.1,
            M37890.1 and AL683800.9.
            
            On May 7, 2015 this sequence version replaced NM_013476.3.
            
            Summary: This gene encodes a nuclear hormone receptor containing
            zinc finger and DNA-binding domains. The encoded protein is a key
            regulator of signalling by androgens, a class of steroid hormones
            involved in male reproductive development. The protein responds to
            hormone signalling by translocating to the nucleus, forming dimers,
            and binding to androgen response elements (AREs) in the promoters
            of target genes, which are subsequently transcriptionally
            activated. Activity of this protein is negatively regulated by
            nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as
            Dax1). Mutations in this gene result in feminized genitals and
            infertility in male animals. Loss of function in female animals
            also causes problems in reproductive development and function.
            [provided by RefSeq, May 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133647.1, X59592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-964               AL844866.17        170469-171432
            965-2421            AK133647.1         2-1458
            2422-2422           M37890.1           1397-1397
            2423-4962           AK133647.1         1459-3998
            4963-10063          AL683800.9         23421-28521
FEATURES             Location/Qualifiers
     source          1..10063
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.82 cM"
     gene            1..10063
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /note="androgen receptor"
                     /db_xref="GeneID:11835"
                     /db_xref="MGI:MGI:88064"
     exon            1..2578
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     CDS             1026..3725
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /note="dihydrotestosterone receptor; nuclear receptor
                     subfamily 3 group C member 4; testicular feminization"
                     /codon_start=1
                     /product="androgen receptor"
                     /protein_id="NP_038504.1"
                     /db_xref="CCDS:CCDS30294.1"
                     /db_xref="GeneID:11835"
                     /db_xref="MGI:MGI:88064"
                     /translation="MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEA
                     ANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAAS
                     EGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADI
                     KDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSY
                     LGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTP
                     CAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEI
                     PSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAW
                     AAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSS
                     PSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWME
                     NYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRA
                     AEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGE
                     NSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLS
                     SLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSR
                     MLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPV
                     DGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQF
                     TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ"
     exon            2579..2730
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2847
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3135
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3280
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3411
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3569
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..10063
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10030..10035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /note="hexamer: ATTAAA"
     polyA_site      10060
                     /gene="Ar"
                     /gene_synonym="Tfm"
                     /note="major polyA site"
ORIGIN      
        1 cagcgccccc tcggagatcc ctaggagcca gcctgctggg agaaccagag ggtccggagc
       61 aaacctggag gctgagaggg catcagaggg gaaaagactg agctagccac tccagtgcca
      121 tacagaagct taagggacgc accacgccag ccccagccca gcgacagcca acgcctgttg
      181 cagagcggcg gcttcgaagc cgccgcccag gagctgccct ttcctcttcg gtgaagtttc
      241 taaaagctgc gggagactca gaggaagcaa ggaaagtgtc cggtaggact acggctgcct
      301 ttgtcctctt cccctctacc cttaccccct cctgggtccc ctctccagga gctgactagg
      361 caggctttct ggccaaccct ctcccctaca cccccagctc tgccagccag tttgcacaga
      421 ggtaaactcc ctttggctga gagtagggga gcttgttgca cattgcaagg aaggcttttg
      481 ggagcccaga gactgaggag caacagcacg cccaggagag tccctggttc caggttctcg
      541 cccctgcacc tcctcctgcc cgcccctcac cctgtgtgtg gtgttagaaa tgaaaagatg
      601 aaaaggcagc tagggtttca gtagtcgaaa gcaaaacaaa agctaaaaga aaacaaaaag
      661 aaaatagccc agttcttatt tgcacctgct tcagtggact ttgaatttgg aaggcagagg
      721 atttcccctt ttccctcccg tcaaggtttg agcatctttt aatctgttct tcaagtattt
      781 agagacaaac tgtgtaagta gcagggcaga tcctgtcttg cgcgtgcctt cctttactgg
      841 agactttgag gttatctggg cactcccccc acccaccccc cctcctgcaa gttttcttcc
      901 ccggagcttc ccgcaggtgg gcagctagct gcagatacta catcatcagt caggagaact
      961 cttcagagca agagacgagg aggcaggata agggaattcg gtggaagcta cagacaagct
     1021 caaggatgga ggtgcagtta gggctgggaa gggtctaccc acggccccca tccaagacct
     1081 atcgaggagc gttccagaat ctgttccaga gcgtgcgcga agcgatccag aacccgggcc
     1141 ccaggcaccc tgaggccgct aacatagcac ctcccggcgc ctgtttacag cagaggcagg
     1201 agactagccc ccggcggcgg cggcggcagc agcacactga ggatggttct cctcaagccc
     1261 acatcagagg ccccacaggc tacctggccc tggaggagga acagcagcct tcacagcagc
     1321 aggcagcctc cgagggccac cctgagagca gctgcctccc cgagcctggg gcggccaccg
     1381 ctcctggcaa ggggctgccg cagcagccac cagctcctcc agatcaggat gactcagctg
     1441 ccccatccac gttgtccctg ctgggcccca ctttcccagg cttaagcagc tgctccgccg
     1501 acattaaaga cattttgaac gaggccggca ccatgcaact tcttcagcag cagcaacaac
     1561 agcagcagca ccaacagcag caccaacagc accaacagca gcaggaggta atctccgaag
     1621 gcagcagcgc aagagccagg gaggccacgg gggctccctc ttcctccaag gatagttacc
     1681 tagggggcaa ttcaaccata tctgacagtg ccaaggagtt gtgtaaagca gtgtctgtgt
     1741 ccatgggatt gggtgtggaa gcattggaac atctgagtcc aggggaacag cttcggggag
     1801 actgcatgta cgcgtcgctc ctgggaggtc cacccgcggt gcgtcccact ccttgtgcgc
     1861 cgctgcccga atgcaaaggt cttcccctgg acgaaggccc aggcaaaagc actgaagaga
     1921 ctgctgagta ttcctctttc aagggaggtt acgccaaagg attggaaggt gagagcttgg
     1981 ggtgctctgg cagcagtgaa gcaggtagct ctgggacact tgagatcccg tcctctctgt
     2041 ctctgtataa atctggagca ctagacgagg cagcagcata ccagaatcgc gactactaca
     2101 actttccgct ggctctgtcc gggccgccgc accccccgcc ccctacccat ccacacgccc
     2161 gtatcaagct ggagaaccca ttggactacg gcagcgcctg ggctgcggcg gcagcgcaat
     2221 gccgctatgg ggacttgggt agtctacatg gagggagtgt agccgggccc agcactggat
     2281 cgcccccagc caccacctct tcttcctggc atactctctt cacagctgaa gaaggccaat
     2341 tatatgggcc aggaggcggg ggcggcagca gcagcccaag cgatgccggg cctgtagccc
     2401 cctatggcta cactcggccc cctcaggggc tgacaagcca ggagagtgac tactctgcct
     2461 ccgaagtgtg gtatcctggt ggagttgtga acagagtacc ctatcccagt cccaattgtg
     2521 tcaaaagtga aatgggacct tggatggaga actactccgg accttatggg gacatgcgtt
     2581 tggacagtac cagggaccat gttttaccca tcgactatta ctttccaccc cagaagacct
     2641 gcctgatctg tggagatgaa gcttctggct gtcactacgg agctctcact tgtggcagct
     2701 gcaaggtctt cttcaaaaga gccgctgaag ggaaacagaa gtatctatgt gccagcagaa
     2761 acgattgtac cattgataaa tttcggagga aaaattgccc atcttgtcgt ctccggaaat
     2821 gttatgaagc agggatgact ctgggagctc gtaagctgaa gaaacttgga aatctaaaac
     2881 tacaggagga aggagaaaac tccaatgctg gcagccccac tgaggaccca tcccagaaga
     2941 tgactgtatc acacattgaa ggctatgaat gtcagcctat ctttcttaac gtcctggaag
     3001 ccattgagcc aggagtggtg tgtgccggac atgacaacaa ccaaccagat tcctttgctg
     3061 ccttgttatc tagcctcaat gagcttggag agaggcagct tgtgcatgtg gtcaagtggg
     3121 ccaaggcctt gcctggcttc cgcaacttgc atgtggatga ccagatggcg gtcattcagt
     3181 attcctggat gggactgatg gtatttgcca tgggttggcg gtccttcact aatgtcaact
     3241 ccaggatgct ctactttgca cctgacttgg ttttcaatga gtaccgcatg cacaagtctc
     3301 ggatgtacag ccagtgtgtg aggatgaggc acctgtctca agagtttgga tggctccaaa
     3361 taacccccca ggaattcctg tgcatgaaag cactgctgct cttcagcatt attccagtgg
     3421 atgggctgaa aaatcaaaaa ttctttgatg aacttcgaat gaactacatc aaggaactcg
     3481 atcgcatcat tgcatgcaaa agaaagaatc ccacatcctg ctcaaggcgc ttctaccagc
     3541 tcaccaagct cctggattct gtgcagccta ttgcaagaga gctgcatcag ttcacttttg
     3601 acctgctaat caagtcccat atggtgagcg tggactttcc tgaaatgatg gcagagatca
     3661 tctctgtgca agtgcccaag atcctttctg ggaaagtcaa gcccatctat ttccacacac
     3721 agtgaagatt tggaaaccct aatacccaaa acccaccttg ttccctttcc agatgtcttc
     3781 tgcctgttat ataactctgc actacttctc tgcagtgcct tgggggaaat tcctctactg
     3841 atgtacagtc tgtcgtgaac aggttcctca gttctatttc ctgggcttct ccttcttttt
     3901 ttttcttctt ccctccctct ttcaccctcc catggcacat tttgaatctg ctgcgtattg
     3961 tggctcctgc ctttgttttg atttctgttg tatttctttg aatctgtgat gatcctcttg
     4021 tggcccagtg tcaattgtgc ttgtttatag cactgtgctg tgtgccaacc aagcaaatgt
     4081 ttactcacct tatgccatgg caaatttaga gagctataag tatctggaga agaaacaaac
     4141 agagagaata aaaagcaaaa acaaaaccaa aaaataaaaa aaacacaaac aaaaaacaaa
     4201 accaacaaac aaaacatgct aggtttgttt cttcgtggta tacaaataaa cacataggat
     4261 tcccaaagaa gccgacagtg actagaagaa agtaaaaaat tacaaatcca cgaggagtca
     4321 ctgtttttgt tcatcctgtt tctctgtggg aaacttcagt tgttgttaat ggctattgcc
     4381 attaaagagc aggttgaccc caaagcttta ctgatagggt agagagaaaa gaggacaagg
     4441 agggcagatg gataaccatt acctccccac agcctttgtc cctgagtcct agagtgctca
     4501 gttgcagtgt agttccttgt actgaaatgt gcttcttgtt tgaaaacttg tctgcatgtg
     4561 aatgcctctt ccttccaatc cttttctctc ttaacctctg cttccaccct caattgactt
     4621 tcaatagctt ttctcagagc tttgtactat atgctctctt tagccaaaac ttggccactt
     4681 tcactgaagt tatgtcagtg agaagaaagt ggaaaggtct gactctttgg aaggctctat
     4741 tcagatttat gttcatattt ccatgtgtga gccatagcgg agctttgtga ctggagtcag
     4801 aggaaaagga agtgatggct tagccattct cccattagag atagtgaatg atgatgccat
     4861 agtgcaatca tcctttcctc tgcttttaaa ggacctagag accccatgca gccacattct
     4921 ccctgcacaa gtcttcagtg ttcagtggcc ctgaacttca ccaaaatgca tttaagccaa
     4981 ggtggtaaag cttgtacact tctttggacg tgtttgtaga cactgctaag atctccctct
     5041 caccaccacc acaaaggcta gcaggccagc agccacagca tctatgttta gatgttaata
     5101 gcataaaaga catctcactc aatgtctttc atcaacagta aatttctgga gcccttagaa
     5161 aaattggaaa gaaagcatca aagggaccag acaaaatggg catcttgccc ttgtcctcca
     5221 gagacaatat attcctccca agtggagaaa tgtcaatttc ctcctcagaa caattaaagg
     5281 ggctacccag accatggtgg aagagaaaac taagtaaccc agctgagaaa aatgaagaca
     5341 ctagaaccag aaagcacagg actttttcct ttccatccag catacccatt ggcagaaata
     5401 atggaaggaa aagagaaggc cagaagaaaa tacagactgc tgaagtcttc agaggcaaag
     5461 tctaaagcca gatgaatacc atctggctag atgggcatca gtttgctcat cctcctctat
     5521 tgccattgct gggctgactt tggccaaagt tacttcgaat ctccaccata gttgtcccct
     5581 ctcagtcaga gggtgcagga ccactgaaac attctatcca ccgtgactct cattggacag
     5641 atctggccgg tgtggctaca aatagactgc acccataaac tcagggcaag ccctgggtca
     5701 ctggtttcat gtagtctgtt gacagccttc tttactgtgg actctgttcc tcaaccttga
     5761 gtgcaggagg aatgcacatc tacttttgcc tttgtatcat tcctcctcac tcagctcttc
     5821 acctccctgc agaccttaag aaatcagggg ccagctgcca agctgactct tttggttggt
     5881 actatgttaa ctgaaaaggt gatttccgaa ggacaggttt tcttccctga tttctttgtt
     5941 gctattaata gcaaaaacaa acttgcaaaa caacttcttt aacaaggaag ggaggatata
     6001 tacaatgggt gatatggtaa tccaaccctg cttgacaaaa actgaagctg acaggttaca
     6061 tttaaaaaca aaacaaaaca aaacgggaca gtttctgatt tgctttgtga caacaccatc
     6121 tggcttatgt acaggagctc tcttagctgt tccttaaaca gaaaaaaaat cattactcct
     6181 tttagttaaa tttggttaca ttttaatagt ttctttacat ctattctgaa gcaatttttg
     6241 tcttctgtgg tacatggatt ttattataac attctaatat ttgtctttgt aaatactaga
     6301 gactctttga tccatttctc taggaagttt ttcatcttat ggagttctga atcatgactt
     6361 ttatctttat gaatgtatat gctttttact tgcaaaagcc aaaaagagtg aaacagcagt
     6421 gcaattaaag caacaccaac taaactccaa atttccaagt gacaatatta gagaaaaaca
     6481 gcatacacat ggctttatgc ctactgcttc tgcggtgggg tttgggtgcg caatggaaac
     6541 tgtagcttgg ctgtgttctc ccacacaagt gaagaagaga ttggtttttg cttttttgga
     6601 ttttgtgttt cttttctgtt ttgttttgtt ttgttttgtt ttgctttgct ttctttggcc
     6661 atcaatgttc caactaatat gattggcgga gcacgtgctc tgctcagtag agtgaatgtt
     6721 gctggtgcac tatgctcacc tgtgaacggc tggccatttc tccattcata tggttaagat
     6781 ggaagatgag gatcacttac cagagaagtc aaggtgatca tctccaaaga ggtttacagt
     6841 gcttggtagg aatggaaaat gaggacaaga aaaagaggag aaccatggag aaggcccaac
     6901 tgggcaggac agcagccagc tgccaaagtc acgaactctg ggattcaaga agagtcgtgt
     6961 agtgctttca actctcatcc gcaggcagct cactgtgtgt ggactctgag ctgacacggg
     7021 agttggcttc tttgttccat agattttcta tgccacaggc aatattattg ttcttggaaa
     7081 gttcattatt tttttaaatt accttactct cagaaaggga tttttttgaa ggattctgtc
     7141 atatatcttt ggaaaacaga aaatcagtaa tatgtatatt tttatgtatg ttcactggca
     7201 ctaaaaaaaa aaaaaaaaag aaaagaaaaa aaagagaaaa aaaaaagctt cactctgtcc
     7261 tttgggtagt tgctgaggtt aattgtccag gttgagaaat gtgcttctgc taacatcctt
     7321 ctctgtccac actctatttc taagtacata taggcatata taggaagata tattcaacac
     7381 actttaagaa aaaagtatgt ccaccatcca catgataacc acaatgatac tccacaaatt
     7441 acatgacttt aagcttcaag caacttctaa ctgattcatt catttatagc cttgccctct
     7501 tctttccctt aaatttggcc cagcacaaag acccaagcca cccttatacc tccctaagac
     7561 ttaagccagc accagacttc agaaggtttt ctgaagacaa ctgacttgct atccctgcat
     7621 gaccctagca tggtcctgca aacacaagag actaattata attctcctcc actaattgcc
     7681 tgggtcacag gtcattgggc caaggccatg attcttatgc ttacgaacca ctaatgctaa
     7741 cctactagat taaatcctga actgaaagtt aaaagaagcc atttagcatg tgaaacttct
     7801 tggagtaaga agtttctgtc ccggctgcct ttgcaaacag gtttgctttc accacttatc
     7861 tccttgaaaa tctttgaagg cctttttttt ttaagtagaa aaggagatga aagcattata
     7921 ttatgtaacc aaagattata ttgtatctaa gataccaaat tttttaaggg cagggaagga
     7981 gcaagcatta gtgcctcttt ggtaaattat ccaaagacag actgaaggac ttttctgatg
     8041 attgacttag aagactttgt ggggaggggt tgtctcacaa tatacatatt tagaagtgtt
     8101 gagaataatt tggggggaaa tgggattata gtgtccttca ctaactgatt ttataagcag
     8161 aactagcttt cctttttttt ttttttaaag tagttacaaa gcaaattctt aaagctccat
     8221 ctttgcatgg ttagaaatgg agctggtctt ggccactgtg tttactagtg cccatgttag
     8281 cttatttgaa gatgtgaagc ccttgataag aaggggtaca tttaaaggat tagatttttg
     8341 cactagaagg agggcaggca gaaaccctca tttctgccca gtttggacag cacaaaaagt
     8401 tctctgcagt ttaaggcaga aagttgaaat atattgtaaa tgagtatttg tatccatgtt
     8461 tcaaaactga attctatata tagatgtaat gtgttctgat agctttacct ttctctgcac
     8521 ctttatattt ggttccaggt catatctgat gccatgtact tgtaagagag gttgcagtta
     8581 catttttgga tgctctctca gaatggataa gacacctgga ttgatcagat aactgagatc
     8641 tcttcccttc ttgggcctgg tgttgaggcc ttgcaaaggg gtggaagagg aaagggtagg
     8701 gtacatgatg tattgcactt tactagctta agacggatga atgtggaaag ggtggtgaaa
     8761 tttcattgaa aatgcctagg aattgcaata gggagaaatc cagatgtggg gccaggtgcc
     8821 cacccaaagg actggccagc agcctcttca tgggatctga ggcattggga aaaggaaggc
     8881 tatttccttg gttttcacca tccttgttag agaagggcag ttgcctggtc ttgggaacct
     8941 ggagcaaacg ctccttctgt cacatcaatt ctttcccctg caattgaggt gctcttgcta
     9001 ctgggtgtcc gtgtgctcta attctggttc tggatatgtt ctgtaaagat tttgataatt
     9061 gctaatgtat ttttctctgt taaaaatttg ttagtgtgtt agaagtcata tctctgtagg
     9121 tacagatcct ttgctaccca tgagtagagg gatttttttt cttcaattaa gagtttgacc
     9181 ctggggtctg ttgcccagag cccatccaga aaaaaaaatc cacatttgtc acaatttttc
     9241 tgaaatttca gtcaaggtaa cagatcgctg ggagttctct ttaccccccc aaaaaagcag
     9301 ataattgaat ttagcaggtg gtgttttaga gcaaaaaaca aaacagcctt tgacccagct
     9361 ttaatatgac ccaatttaat ctggccagga agcaggtaat gtgtattaat tggcttccaa
     9421 tcctggttga gtgtagcaag gttctacttt gtttcctagt tccttttgtt acatggcctt
     9481 tcacagaaag gattgactgg gtttgcagta tatcttatgg ccttagcacc tattgctaac
     9541 tgtcctgaag ggaattgcct atggggttgt cctataagcc acttctatca ttaaaagcag
     9601 ccaccaatgg aatctcccag gtttgaaaaa aaaaaaaaaa aacagatggt cctttaccat
     9661 tcattgacac acatccctgc tttcctgtag acagattgac tggacattga ttagggaata
     9721 catggcaaat gacatgctta cactaccctg gagattaatt tggcagtagg agggaataga
     9781 caatgtaacc aagaatgtaa tgtaattctt atagagataa gaattaaatc tggatgtgga
     9841 gagagcaaag agagaaagca ttcaattttt ttttcaaaag aaaccaattt attttgcttg
     9901 aaacttcttt cgctggggct tcagttctca cagcggctct tggtctccac tgggcagcag
     9961 gaccagcccc aagcgctagt gttctgttct ctttttgtaa tcttggaatc ttttgttgct
    10021 ctaaatacaa ttaaaaatgg cagaaacttg tttgttggaa tac
//
