LOCUS       NM_009702               4854 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus aquarius (Aqr), transcript variant 1, mRNA.
ACCESSION   NM_009702
VERSION     NM_009702.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4854)
  AUTHORS   Sam,M., Wurst,W., Kluppel,M., Jin,O., Heng,H. and Bernstein,A.
  TITLE     Aquarius, a novel gene isolated by gene trapping with an
            RNA-dependent RNA polymerase motif
  JOURNAL   Dev Dyn 212 (2), 304-317 (1998)
   PUBMED   9626505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844569.4 and AC133157.1.
            
            On Feb 21, 2023 this sequence version replaced NM_009702.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042479.1, AK145547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AL844569.4         167679-167894       c
            217-273             AL844569.4         165278-165334       c
            274-314             AL844569.4         162614-162654       c
            315-350             AL844569.4         158780-158815       c
            351-471             AL844569.4         154151-154271       c
            472-612             AL844569.4         151457-151597       c
            613-681             AL844569.4         150127-150195       c
            682-782             AL844569.4         148834-148934       c
            783-859             AL844569.4         147552-147628       c
            860-924             AL844569.4         144106-144170       c
            925-1041            AL844569.4         142986-143102       c
            1042-1155           AL844569.4         141526-141639       c
            1156-1259           AL844569.4         139476-139579       c
            1260-1362           AL844569.4         138215-138317       c
            1363-1483           AL844569.4         135575-135695       c
            1484-1625           AL844569.4         133456-133597       c
            1626-1804           AL844569.4         129457-129635       c
            1805-1972           AL844569.4         127239-127406       c
            1973-2142           AL844569.4         125554-125723       c
            2143-2384           AL844569.4         123122-123363       c
            2385-2531           AL844569.4         120100-120246       c
            2532-2601           AL844569.4         119543-119612       c
            2602-2712           AL844569.4         118478-118588       c
            2713-2822           AL844569.4         113792-113901       c
            2823-2958           AL844569.4         112497-112632       c
            2959-3180           AL844569.4         111264-111485       c
            3181-3318           AL844569.4         109110-109247       c
            3319-3390           AL844569.4         107167-107238       c
            3391-3578           AL844569.4         105806-105993       c
            3579-3750           AL844569.4         105069-105240       c
            3751-3921           AL844569.4         102471-102641       c
            3922-4007           AL844569.4         100691-100776       c
            4008-4182           AC133157.1         1851-2025
            4183-4296           AC133157.1         3708-3821
            4297-4854           AC133157.1         6096-6653
FEATURES             Location/Qualifiers
     source          1..4854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.57 cM"
     gene            1..4854
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /note="aquarius"
                     /db_xref="GeneID:11834"
                     /db_xref="MGI:MGI:1276102"
     exon            1..216
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..4587
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /EC_number="3.6.4.13"
                     /note="isoform a is encoded by transcript variant 1;
                     intron-binding protein aquarius; intron-binding protein of
                     160 kDa; RNA helicase aquarius"
                     /codon_start=1
                     /product="RNA helicase aquarius isoform a"
                     /protein_id="NP_033832.2"
                     /db_xref="CCDS:CCDS16565.1"
                     /db_xref="GeneID:11834"
                     /db_xref="MGI:MGI:1276102"
                     /translation="MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIK
                     VIEEIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKF
                     RENVPAWETFKKKPDHFPFFFKCILKAALAETDGEFSLHEQTLLLLFLDHCFNSLEVD
                     LIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQE
                     RRFLSRLIQKFISVLKSIPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDD
                     SHLLVHCYLSSLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRI
                     TSLQRAAFAHFPELYDFALSNVAEVDARDSLVKFFGPLSSNTLHQVASYLCLLPTLPK
                     NEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCL
                     ALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWA
                     RMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLIT
                     VRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRT
                     FRVFLDPNQYQQDMTNTIQNGAEDVYDTFNVIMRRKPKENNFKAVLETIRNLMNTDCV
                     VPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVSDP
                     ALQIPPFRITFPVRSGKGKKRKDADGEEDDTEEAKTLIVEPHVIPNRGPYPYNQPKRN
                     TIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSN
                     QALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKR
                     LQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYMSRVKNSGTACPDAAPDAAQVATFF
                     PFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKY
                     LLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDG
                     FSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARAS
                     LCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQN
                     LGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVT
                     TVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFEL
                     TPAFSQLTARPLHLHIIPTEPFPTSRKNGERPPHEVQVIKNMPQMANFVYNMYMHLIQ
                     TTHHYHQTFLQLPPAMVEEGEEGQSQETEMEAEEETVSAQGNLTPSPADASLSQETPA
                     AQPDCSSQTEDTSAPCDIATAAEPVSAAAEAATPQDAESVPTETE"
     exon            217..273
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            274..314
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            315..350
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            351..471
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            472..612
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            613..681
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            682..782
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            783..859
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            860..924
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1041
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1155
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1259
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1362
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1483
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1625
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1804
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1972
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2142
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2384
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2531
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2601
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2712
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2822
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2958
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3180
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3318
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3390
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3578
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3750
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3921
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4007
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4182
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4296
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     exon            4297..4854
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4833..4838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /note="hexamer: ATTAAA"
     polyA_site      4854
                     /gene="Aqr"
                     /gene_synonym="mKIAA0560"
                     /note="major polyA site"
ORIGIN      
        1 aggttccggg aggaaccgtg ggagcccagc gtgtctgtgc cgggcgctct ggcacctcgg
       61 ggctgggtcg ccgccgctgc ttgaaagctt tcgagagtcg ccgctacgag cctctggtca
      121 gcttcagtgg cgatcgctgc gatggcggct cctgcgcagc ccaagaaaat cgtggccccc
      181 acggtgtccc agatcaacgc ggagttcgtc actcagctag catgtaaata ctgggctcct
      241 catatcaaga agaaatcacc gtttgatata aaagtaattg aagaaatata tgaaaaagag
      301 atcgtcaaat cacggtttgc catcaggaaa ataatgctgc tggaatttag ccaatacctt
      361 gaaaattatc tttggatgaa ttattctccg gaagtttcca gcaaggccta tttaatgtcc
      421 atctgctgta tggtgaatga gaagttcaga gaaaatgtcc cagcctggga gacctttaag
      481 aagaaaccag accacttccc attctttttt aagtgcatct tgaaagcggc cttagctgag
      541 actgacggcg agttctccct ccacgagcag acactgctcc tgcttttcct ggatcactgc
      601 ttcaatagct tggaagtaga cttgataagg agtcaggtgc agcagcttat ctcgctcccg
      661 atgtggatgg gcttgcagcc tgcacgattg gaattagaat tgaaaaagac accaaagcta
      721 agaaaattct ggaacctgat taaaaagaat gatgaaaaga tggacccaga agcaagagag
      781 caggcctacc aagaaagaag gtttctctcc cggctcatcc agaagttcat ctccgtgttg
      841 aagtccatcc cgctttctga gcctgtcacc atggacaagg ttcattactg tgaaagattc
      901 atcgaactga tgattgatct agaggctcta ctccccacga ggcgctggtt taacaccatc
      961 ctggatgact cccaccttct ggttcactgc tacctctcca gtcttgttca cagagaagag
     1021 gacggccatc tgttttccca gcttttagac atgctgaagt tctatactgg ctttgagatt
     1081 aacgaccaga ctggaaatgc tctgacagag aacgagatga ccacgattca ctatgacaga
     1141 attacatctc tgcagagggc tgccttcgca cacttccccg agctctatga ctttgccctc
     1201 tccaatgtgg cagaagtaga tgcccgagat tccttggtca agttttttgg gcctctcagt
     1261 tcaaacacac tccaccaggt ggcatcatac ctctgcctct tgccaacgct ccctaaaaat
     1321 gaagacacaa cttttgataa agagtttctt ctagaattgc tggtgtctcg ccacgaacgc
     1381 cgcatctctc aaattcagca actgaatcag atgcctttgt atccaactga gaaaattata
     1441 tgggatgaga acatcgtccc tactgagtac tattctgggg aaggctgcct tgctctcccc
     1501 aagttgaatc tgcagttttt gactctgcac gactatctcc tgaggaactt caatctcttc
     1561 cgcttagagt caacttacga aattagacaa gacatcgagg acagtgtcag cagaatgaag
     1621 ccctggcagt ctgagtatgg tggcgtagtg ttcggtggtt gggcacggat ggcccagccc
     1681 attgtggctt tcactgtagt cgaggttgcc aaacccaaca tcggtgaaaa ctggccaacc
     1741 cgagttcgtg cagatgtcac catcaatctg aatgtcagag accacatcaa ggatgagtgg
     1801 gaaggtcttc gaaagcacga tgtatgcttt ttaattactg tgcgtccaac aaaaccttac
     1861 ggcactaagt ttgacaggag gagacctttt attgagcaag ttggtctggt gtacgtcaga
     1921 ggctgtgaaa tccagggcat gctggatgac aaagggcgag tcatcgaaga cggacctgaa
     1981 cccagaccca atcttagagg agagtcaagg acatttcgag tatttttgga tccaaaccag
     2041 tatcaacagg atatgaccaa tacgatacaa aacggagccg aagatgtgta tgacactttc
     2101 aatgtcataa tgaggaggaa accgaaggag aataacttca aggctgtgtt ggagacgatt
     2161 cggaatctga tgaatactga ctgcgtggta ccggactggc tgcatgacat cattttgggc
     2221 tatggggacc caagtagtgc ccattattca aaaatgccca atcagattgc caccctggat
     2281 ttcaatgaca cttttctctc cattgaacat ttaaaggcca gctttcctgg tcataatgtc
     2341 aaagtgactg tgagtgaccc agcactccaa atcccccctt tcagaataac gttcccagta
     2401 agaagtggaa aggggaagaa aagaaaagat gcagacgggg aagaagatga cacagaagaa
     2461 gcaaagacct taattgtgga gcctcatgtt attcctaata gaggccctta tccttacaac
     2521 cagcccaaac gtaatacaat ccagttcact catacacaga tagaggccat ccgggccgga
     2581 atgcagcctg gactcaccat ggttgtgggc ccacctggta caggaaaaac agatgttgca
     2641 gtccagatca tatccaacat ttaccacaat ttcccagaac agaggacttt aattgttact
     2701 cattccaatc aggctctgaa ccagctgttt gagaaaatca tggctttaga cattgatgag
     2761 cgccatctcc tgcgtctggg tcatggagaa gaagagctag agacagagaa agactttagc
     2821 aggtatggaa gagttaatta tgtcctagct cgaagaatag aacttttaga agaagtcaaa
     2881 cggttacaaa agagtctggg ggttcccgga gatgcttcgt atacctgtga aactgccggc
     2941 tatttcttct tatatcaggt gatgtcccgc tgggaagaat acatgagcag agtgaagaac
     3001 tcggggactg cctgcccgga cgctgccccg gacgctgcac aggtcgccac gttcttcccc
     3061 ttccatgagt attttgccaa tgctcctcag cccatcttta aaggcagatc ttatgaggaa
     3121 gacatggaaa tcgctgaagg gtgcttcagg cacattaaga aaatcttcac ccaacttgag
     3181 gagttcagag cctcggagct gcttcgcagt ggactggaca gatccaaata cctcttggta
     3241 aaagaagcca aaatcatcgc tatgacatgt actcatgctg ccttgaaacg acacgacttg
     3301 gtcaagttgg gtttcaagta tgacaacatt ttaatggaag aggctgctca gattctggag
     3361 atcgaaacct ttatccctct acttctgcag aatcctcaag acggattcag ccgattgaaa
     3421 cggtggatta tgattggcga tcaccaccaa ttgcctccag tcattaagaa catggccttt
     3481 cagaagtatt ccaacatgga gcagtctctt ttcactcgct tcgtccgggt tggagttcct
     3541 actgtggacc ttgatgctca agggagagcc agggcaagct tgtgtaacct ctacaactgg
     3601 cgctacaaaa acctagggaa tttgccccat gtgcagctcc tgccagagtt cagcacagcc
     3661 aacgcgggcc tgctgtatga cttccagctc atcaacgtgg aagactttca gggcgtggga
     3721 gagtcggagc ctaaccctta cttctaccag aaccttggag aggcagagta tgtagtggcg
     3781 ctcttcatgt acatgtgctt gcttggttac cctgcagaca agatcagtat tctaacaacc
     3841 tacaatggac agaagcatct gattcgggac atcatcaata ggcgctgtgg gaataatcca
     3901 ctgattggaa ggccaaacaa agtgacaaca gttgacagat tccagggtca gcagaacgat
     3961 tatatcctcc tttcgctagt gcggaccagg gctgtgggtc atctgaggga tgtgcgtcgc
     4021 ttggtggtag ccatgtcaag agccaggctt ggcctttaca tcttcgctcg agtgtccctc
     4081 ttccagaact gctttgaact gactcctgct ttcagccagc tcactgcccg cccactgcat
     4141 ttgcatatca ttccaacaga acccttccca acctccagaa agaatggaga gagaccacct
     4201 catgaagtgc aggtaattaa gaacatgccc cagatggcga actttgtgta caacatgtat
     4261 atgcatctga tacagactac ccatcattat catcagactt tcttacaact gccacctgcc
     4321 atggtggaag aaggtgagga aggtcagagc caagaaacag aaatggaagc agaagaagaa
     4381 accgtgtctg ctcaaggtaa cctcacaccc agtccagcgg atgccagcct gagtcaagag
     4441 accccagccg ctcagcctga ctgctccagt cagacagaag acacctctgc cccgtgtgac
     4501 attgctactg cagctgagcc tgtctctgca gcagcagaag ctgccacccc acaagatgca
     4561 gagtctgtcc ccacagagac cgagtagcct atctgcagca cagcctggga cattccattt
     4621 ataaactcta agtgaggtta ccttttgaat ttcatactta gttactgtat gactttaata
     4681 acaccagcta atttcagtac ttatggtttt tagctggttt ccttattttg tatatttttt
     4741 atttgtaaat attaaaaata actctagttt catttgttca ttcagaagag aaaataattt
     4801 tgattgctga atgtatctga ggtaatccct gcattaaaat cattttctat caaa
//
