LOCUS       NM_022026               2660 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus aquaporin 9 (Aqp9), transcript variant 1, mRNA.
ACCESSION   NM_022026 XM_001003981 XM_980183
VERSION     NM_022026.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Hirako,S., Wakayama,Y., Kim,H., Iizuka,Y., Wada,N., Kaibara,N.,
            Okabe,M., Arata,S. and Matsumoto,A.
  TITLE     Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in
            db/db Mice
  JOURNAL   Zoolog Sci 40 (6), 455-462 (2023)
   PUBMED   38064372
  REMARK    GeneRIF: Association of Aquaporin 7 and 9 with Obesity and Fatty
            Liver in db/db Mice.
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Ma,N., Liu,B., Jin,Y., Wang,J., Qin,W., Zheng,F., Qin,R., Li,J.,
            Hang,F. and Qin,A.
  TITLE     Aquaporin 9 causes recurrent spontaneous abortion by inhibiting
            trophoblast cell epithelial-mesenchymal transformation and invasion
            through the PI3K/AKT pathwaydagger
  JOURNAL   Biol Reprod 109 (5), 736-748 (2023)
   PUBMED   37602667
  REMARK    GeneRIF: Aquaporin 9 causes recurrent spontaneous abortion by
            inhibiting trophoblast cell epithelial-mesenchymal transformation
            and invasion through the PI3K/AKT pathwaydagger.
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Murai,Y., Mori,S., Okuda,M., Kusuhara,S., Kurimoto,T. and
            Nakamura,M.
  TITLE     Effects of Elevated Intraocular Pressure on Retinal Ganglion Cell
            Density and Expression and Interaction of Retinal Aquaporin 9 and
            Monocarboxylate Transporters
  JOURNAL   Ophthalmic Res 66 (1), 1222-1229 (2023)
   PUBMED   37647868
  REMARK    GeneRIF: Effects of Elevated Intraocular Pressure on Retinal
            Ganglion Cell Density and Expression and Interaction of Retinal
            Aquaporin 9 and Monocarboxylate Transporters.
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Rojek,A.M., Skowronski,M.T., Fuchtbauer,E.M., Fuchtbauer,A.C.,
            Fenton,R.A., Agre,P., Frokiaer,J. and Nielsen,S.
  TITLE     Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3609-3614 (2007)
   PUBMED   17360690
  REMARK    GeneRIF: AQP9 is important for hepatic glycerol metabolism and may
            play a role in glycerol and glucose metabolism in diabetes
            mellitus.
REFERENCE   6  (bases 1 to 2660)
  AUTHORS   Aharon,R. and Bar-Shavit,Z.
  TITLE     Involvement of aquaporin 9 in osteoclast differentiation
  JOURNAL   J Biol Chem 281 (28), 19305-19309 (2006)
   PUBMED   16698796
  REMARK    GeneRIF: AQP9 has a role in osteoclast differentiation,
            specifically in the fusion process
REFERENCE   7  (bases 1 to 2660)
  AUTHORS   Kuriyama,H., Shimomura,I., Kishida,K., Kondo,H., Furuyama,N.,
            Nishizawa,H., Maeda,N., Matsuda,M., Nagaretani,H., Kihara,S.,
            Nakamura,T., Tochino,Y., Funahashi,T. and Matsuzawa,Y.
  TITLE     Coordinated regulation of fat-specific and liver-specific glycerol
            channels, aquaporin adipose and aquaporin 9
  JOURNAL   Diabetes 51 (10), 2915-2921 (2002)
   PUBMED   12351427
  REMARK    GeneRIF: Coordinated regulation of fat-specific and liver-specific
            glycerol channels, aquaporin adipose and aquaporin 9.
REFERENCE   8  (bases 1 to 2660)
  AUTHORS   Offenberg,H., Barcroft,L.C., Caveney,A., Viuff,D., Thomsen,P.D. and
            Watson,A.J.
  TITLE     mRNAs encoding aquaporins are present during murine preimplantation
            development
  JOURNAL   Mol Reprod Dev 57 (4), 323-330 (2000)
   PUBMED   11066060
REFERENCE   9  (bases 1 to 2660)
  AUTHORS   Kishida,K., Kuriyama,H., Funahashi,T., Shimomura,I., Kihara,S.,
            Ouchi,N., Nishida,M., Nishizawa,H., Matsuda,M., Takahashi,M.,
            Hotta,K., Nakamura,T., Yamashita,S., Tochino,Y. and Matsuzawa,Y.
  TITLE     Aquaporin adipose, a putative glycerol channel in adipocytes
  JOURNAL   J Biol Chem 275 (27), 20896-20902 (2000)
   PUBMED   10777495
REFERENCE   10 (bases 1 to 2660)
  AUTHORS   Edashige,K., Sakamoto,M. and Kasai,M.
  TITLE     Expression of mRNAs of the aquaporin family in mouse oocytes and
            embryos
  JOURNAL   Cryobiology 40 (2), 171-175 (2000)
   PUBMED   10788316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK050042.1 and AI789806.1.
            
            On Dec 5, 2012 this sequence version replaced NM_022026.2.
            
            Summary: This gene encodes a member of the aquaglyceroporin
            subfamily of aquaporins. This protein transports water, glycerol,
            urea, purines and pyrimidines and plays a role in glycerol
            metabolism and osteoclast differentiation. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050042.1, BB611054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2644              AK050042.1         1-2644
            2645-2660           AI789806.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.85 cM"
     gene            1..2660
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /note="aquaporin 9"
                     /db_xref="GeneID:64008"
                     /db_xref="MGI:MGI:1891066"
     exon            1..317
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1094
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aquaglyceroporin-9"
                     /codon_start=1
                     /product="aquaporin-9 isoform 1"
                     /protein_id="NP_071309.1"
                     /db_xref="CCDS:CCDS23325.1"
                     /db_xref="GeneID:64008"
                     /db_xref="MGI:MGI:1891066"
                     /translation="MPSEKDRAKKNLVQRLALKSCLAKETLSEFLGTFIMIVLGCGSI
                     AQAVLSREKAGGIITINIGFATAVVMALYATFGVSGGHINPAVSFAMCTFGRMEWFKF
                     PFYVGAQLLGAFVGAATVFGIYYDGLMAFADGKLLITGENGTAFIFATYPKPFVSVPG
                     AFVDQVVSTMFLLLIVFAIFDSRNLGVPRGLEPIVIGLLIIVISCSLGLNSGCAMNPA
                     RDLSPRLFTALAGWGFEVFTFGNNFWWIPVVGPMIGAVLGGLIYVLFIQMHHSNPDPE
                     VKAEPAENNLEKHELSVIM"
     exon            318..444
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            445..582
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            583..701
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            702..919
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /inference="alignment:Splign:2.1.0"
     exon            920..2646
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /note="hexamer: AATAAA"
     polyA_site      2646
                     /gene="Aqp9"
                     /gene_synonym="1700020I22Rik; AQP-9"
                     /note="major polyA site"
ORIGIN      
        1 ggattaagtc acagttccta attaggacag gctctctgac acagtcaggt atctctttag
       61 tcgcctccag agatccgtgc agagctaagt gagcttggtt tttttaaaat tcttttttgt
      121 ttggtttggt tttcatgtgg tagtgaaggc aggaaactga gcgagcagac cttggtggaa
      181 agcttacctc tggcagaaac cccaagatgc cttctgagaa ggaccgagcc aagaagaacc
      241 tcgtgcagag gctggccctg aagagctgtc tggctaagga gacactctct gagttcctgg
      301 gcacctttat aatgattgtc cttggatgtg gctctattgc tcaagcagtc ctcagtcgag
      361 aaaaggctgg tgggatcatc actatcaata ttggatttgc aacggcagtt gtgatggctc
      421 tttatgcgac ttttggtgtc tctgggggcc acatcaaccc agcggtgtct tttgcaatgt
      481 gcacctttgg aaggatggag tggttcaagt tcccctttta tgtgggagct cagcttttgg
      541 gagcctttgt cggggctgca actgtctttg gcatttacta tgacggactc atggcctttg
      601 ctgatggaaa gctgctcatc acgggagaaa atggaacggc gttcattttc gcgacatacc
      661 caaaaccatt tgtatccgtg ccaggtgcct ttgtagacca agtggtgtct accatgttcc
      721 tccttctgat tgtctttgcc atctttgact ccagaaacct gggggtcccc agaggcctgg
      781 agcccattgt cattggcctc ctaatcattg tcatttcctg ttctctcgga ctcaactctg
      841 gttgtgccat gaaccctgct cgagacctca gccccaggct cttcactgct ctggcaggat
      901 ggggatttga ggtcttcaca tttggaaata acttctggtg gatacctgtc gtgggcccta
      961 tgattggagc tgtcctggga ggtctcatct atgttctttt tatccaaatg catcactcga
     1021 accccgaccc agaagtgaag gcagaaccag ccgagaacaa tctagaaaaa cacgaactca
     1081 gcgtcatcat gtagtggcat gaccaggtct agagttacca ttcatcctgt tctttcttca
     1141 gaaaagatgg catctgtgtg cctgtgcaga cttggggtgg ggacatctac ccaaccctct
     1201 ctagctgact gggacaaaaa taaatcccaa aggcatccat gaaaaactct accagtcacc
     1261 cctccccaga acagcactaa ctgtttatga tgggtatttg atggaagacc gtactcctag
     1321 gtgattgcta agattttgga aacttgacca tgtgctcggc tggatggcct cagagacttt
     1381 tcttaccctg tatgaaactg tgtgatcaaa ggtgaccaaa ggttctgttt cacaatctat
     1441 aaatacattc taaagctgaa aggccaaaca gtggatgcac ttaacaccta tgaagtgggg
     1501 agcaaagggt taacactcta ccaagctgag cgctaccact aatacccatc ttctcccaac
     1561 ctagggctgg agaaagcagc agacagcagc tggaagaagg cagtggcatt tagaaacctc
     1621 aggacatgag ataaatttgg gaaactgaat ggctttcttt ttaatggaaa ccatttgtca
     1681 gattaatctc ctgctcctct gcattttaga tgacatcaat taatttccag gtctttaagt
     1741 ttataataac ctaaaatacg attataacct tggccgggaa aaatacaccg ctcggtcttt
     1801 tagcactaga gtgagccatt aggagagacc tttttaataa atagttggtg gctactctca
     1861 tccatatccc cagaagccca aactaaaagc tagtggactc tacctggtgg actaaagttg
     1921 gaggtagata aagtccctgg gacaaaagga taaggtcggg ctttaggacc cccggttcca
     1981 cgcgccttat ccagtttgat cccaacagca attgtctgag gtgaatgacc acagcattct
     2041 tctcaaatga gaaattcagg tgacctgagc aagttgccct ttcttctgca gggggctttg
     2101 agtgttgcct tatgccttcc agaagcttgc tagccgactg agggtgtttg agctgagggc
     2161 atcggcagct tccagacggt gtgggctttg tagaagcacc actccgggcc tttgatttcc
     2221 atacgccatg tttactgttt ttattcccag ttttactgag gcacggatga agggacaagg
     2281 tagccgtttg ataatgttca tttgtggaga aacagaggcc tttcttcctt agtggctctc
     2341 tgtctccgtc cctgccagcc ctcctcagcc tctcctggag acatttctct aactgatgtt
     2401 acttccaacc agagaaagaa ctgttctgta tcaggggtgt gccttcactg ccaactgttt
     2461 aaaagcccgg cgttcctcga taacagcaag tttccccagg tgctttgcaa gactaacaga
     2521 acaagacatg aatgagaaac atctgtgata tcctgcgctg tgcaacctat gggcatataa
     2581 attcattttc tgagtctgaa attacctgga tattttctag tttaaataaa tttggaggga
     2641 tattaaaaaa aaaaaaaaaa
//
