LOCUS       NM_001109045            1483 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus aquaporin 8 (Aqp8), transcript variant 2, mRNA.
ACCESSION   NM_001109045
VERSION     NM_001109045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Hao,Z., Huajun,S., Zhen,G., Yu,X., Qian,L., Ziling,C., Zihao,S.,
            Qingqian,X. and Shujuan,Z.
  TITLE     AQP8 promotes glioma proliferation and growth, possibly through the
            ROS/PTEN/AKT signaling pathway
  JOURNAL   BMC Cancer 23 (1), 516 (2023)
   PUBMED   37280594
  REMARK    GeneRIF: AQP8 promotes glioma proliferation and growth, possibly
            through the ROS/PTEN/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Huang,B., Jin,L., Zhang,L., Cui,X., Zhang,Z., Lu,Y., Yu,L., Ma,T.
            and Zhang,H.
  TITLE     Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell
            autophagy
  JOURNAL   Front Cell Dev Biol 10, 897666 (2022)
   PUBMED   36081911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Okada,N., Kawakita,T., Ito,M. and Tsubota,K.
  TITLE     Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal
            Gland Cells
  JOURNAL   Biomed Res Int 2021, 6888494 (2021)
   PUBMED   34540996
  REMARK    GeneRIF: Aquaporins 8 and 9 as Possible Markers for Adult Murine
            Lacrimal Gland Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Luo,H., Liu,Y., Song,Y., Hua,Y. and Zhu,X.
  TITLE     Aquaporin 1 affects pregnancy outcome and regulates aquaporin 8 and
            9 expressions in the placenta
  JOURNAL   Cell Tissue Res 381 (3), 543-554 (2020)
   PUBMED   32542408
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Calamita,G., Spalluto,C., Mazzone,A., Rocchi,M. and Svelto,M.
  TITLE     Cloning, structural organization and chromosomal localization of
            the mouse aquaporin-8 water channel gene (Aqp8)
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 237-241 (1999)
   PUBMED   10449905
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Koyama,N., Ishibashi,K., Kuwahara,M., Inase,N., Ichioka,M.,
            Sasaki,S. and Marumo,F.
  TITLE     Cloning and functional expression of human aquaporin8 cDNA and
            analysis of its gene
  JOURNAL   Genomics 54 (1), 169-172 (1998)
   PUBMED   9806845
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Verkman,A.S.
  TITLE     Role of aquaporin water channels in kidney and lung
  JOURNAL   Am J Med Sci 316 (5), 310-320 (1998)
   PUBMED   9822113
  REMARK    Review article
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Ma,T., Yang,B. and Verkman,A.S.
  TITLE     Cloning of a novel water and urea-permeable aquaporin from mouse
            expressed strongly in colon, placenta, liver, and heart
  JOURNAL   Biochem Biophys Res Commun 240 (2), 324-328 (1997)
   PUBMED   9388476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713653.1, CF617211.1, AK146660.1 and AV374360.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ948906.1, BQ932329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BY713653.1         6-101
            97-886              CF617211.1         3-792
            887-1478            AK146660.1         569-1160
            1479-1483           AV374360.1         234-238
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 67.42 cM"
     gene            1..1483
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /note="aquaporin 8"
                     /db_xref="GeneID:11833"
                     /db_xref="MGI:MGI:1195271"
     exon            1..165
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            166..410
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            411..537
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            538..752
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            753..887
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1483
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /note="putative"
     polyA_site      1478
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /note="putative"
ORIGIN      
        1 gctttctgga cacctttggt gaatgtcccc agtcctttaa aagcgcagag tccgctagac
       61 tctacctcca gtctgtgacc tagagataag tgagtacaat ctagggcagc cggcgaagct
      121 cctggtagct ctggctcgga tcttcttgag cagatgtctg gggagacacc aatgtgtagt
      181 atggacctac ctgaggtcaa ggtgaagacc agcatggctg gcagatgccg tgtgttctgg
      241 tatgagcaat acgtacaacc atgtatagtg gaacttgtgg gctccgctct cttcatcttc
      301 atcggatgtc tatcggtcat tgagaatagt ccgaatactg ggctcctgca gcctgccttg
      361 gctcatgggc tggccttggg gctcatcatt gctaccttgg ggaacatcag cggtggacac
      421 ttcaaccctg ctgtgtcgct ggcagtcaca gtgatcggag gcctcaagac catgctgcta
      481 attccctatt ggatctccca gctatttgga gggctgattg gggctgcctt ggctaaagtg
      541 gtgagtccag aggaaagatt ctggaatgca tctggggcag cctttgccat cgtccaggag
      601 caggagcagg tggcagaagc cctggggata gagatcattc tgacaatgct gttggtattg
      661 gctgtgtgta tgggtgctgt caatgagaag acaatgggcc ctttagcccc attctccatt
      721 ggcttctctg tcattgtgga catcctggca ggtggtagca tctctggagc ctgcatgaac
      781 cctgctcgtg cctttggacc tgctgtgatg gctggctact gggacttcca ttggatctac
      841 tggctgggcc ccctcctggc tggcctcttt gtaggactgc tcattaggct cctcatcgga
      901 gatgagaaaa cccgcctaat tctaaagtcg aggtgaagaa gaactgctgg cgacgttccc
      961 actgcctgga gtcctcagct gcttgtccta agttgaggac ggaacaattc cattatctcc
     1021 tgcaggacct gagctaacag gagtcaccat gacagcagct gacctaggcc tggcttctca
     1081 ggcaggcagg caggcaggcg gctgctgctc tgtcctgagc atgctcctgg aaacctggaa
     1141 tttctctgtg ctcatggagt gggcctgggg cccagcctaa agacaggtag agaccgcata
     1201 gaaaaagagg gtaggcctct tttcttgcga gagggcaggg attagaaggg ctgagaaggt
     1261 ggagaatgca cactgtccat ttcttcagtc ctctttcttt tttactaggt tgggtttgga
     1321 acccaattca tgcacactag gtgagcactt tgctactgag cccctgctct ccacaccctc
     1381 ttttctcttg attacagtta cagaaggtct ttcaggagcc caaagatctt gcttcctcag
     1441 ctcccaatct gactttgtaa taaatggctt agcatttcat ccc
//
