LOCUS       NM_007473               2524 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus aquaporin 7 (Aqp7), transcript variant 2, mRNA.
ACCESSION   NM_007473 XM_982564 XM_982593
VERSION     NM_007473.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Hirako,S., Wakayama,Y., Kim,H., Iizuka,Y., Wada,N., Kaibara,N.,
            Okabe,M., Arata,S. and Matsumoto,A.
  TITLE     Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in
            db/db Mice
  JOURNAL   Zoolog Sci 40 (6), 455-462 (2023)
   PUBMED   38064372
  REMARK    GeneRIF: Association of Aquaporin 7 and 9 with Obesity and Fatty
            Liver in db/db Mice.
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Liu,M., Mi,Y.J. and Dai,J.
  TITLE     Aquaporin 7 is upregulated through the PI3K-Akt pathway and
            modulates decidualisation of endometrial stromal cells
  JOURNAL   Reprod Fertil Dev 35 (14), 669-675 (2023)
   PUBMED   37879294
  REMARK    GeneRIF: Aquaporin 7 is upregulated through the PI3K-Akt pathway
            and modulates decidualisation of endometrial stromal cells.
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Ma,Y., Zhang,J., Li,Y., Hu,H., Ye,Q., Yang,C., Yang,L., Zhang,B.
            and Ma,T.
  TITLE     Aquaporin-7 Facilitates Proliferation and Adipogenic
            Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by
            Regulating Hydrogen Peroxide Transport
  JOURNAL   Stem Cell Rev Rep 19 (7), 2378-2390 (2023)
   PUBMED   37432580
  REMARK    GeneRIF: Aquaporin-7 Facilitates Proliferation and Adipogenic
            Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by
            Regulating Hydrogen Peroxide Transport.
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Ishihama,S., Yoshida,S., Yoshida,T., Mori,Y., Ouchi,N., Eguchi,S.,
            Sakaguchi,T., Tsuda,T., Kato,K., Shimizu,Y., Ohashi,K., Okumura,T.,
            Bando,Y.K., Yagyu,H., Wettschureck,N., Kubota,N., Offermanns,S.,
            Kadowaki,T., Murohara,T. and Takefuji,M.
  TITLE     LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and
            prevents cardiac dysfunction during ischemia
  JOURNAL   FASEB J 35 (12), e22048 (2021)
   PUBMED   34807469
  REMARK    GeneRIF: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia
            and prevents cardiac dysfunction during ischemia.
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Okada,N., Kawakita,T., Ito,M. and Tsubota,K.
  TITLE     Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal
            Gland Cells
  JOURNAL   Biomed Res Int 2021, 6888494 (2021)
   PUBMED   34540996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Edashige,K., Sakamoto,M. and Kasai,M.
  TITLE     Expression of mRNAs of the aquaporin family in mouse oocytes and
            embryos
  JOURNAL   Cryobiology 40 (2), 171-175 (2000)
   PUBMED   10788316
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Verkman,A.S.
  TITLE     Lessons on renal physiology from transgenic mice lacking aquaporin
            water channels
  JOURNAL   J Am Soc Nephrol 10 (5), 1126-1135 (1999)
   PUBMED   10232700
  REMARK    Review article
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Verkman,A.S.
  TITLE     Role of aquaporin water channels in kidney and lung
  JOURNAL   Am J Med Sci 316 (5), 310-320 (1998)
   PUBMED   9822113
  REMARK    Review article
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Ishibashi,K., Yamauchi,K., Kageyama,Y., Saito-Ohara,F., Ikeuchi,T.,
            Marumo,F. and Sasaki,S.
  TITLE     Molecular characterization of human Aquaporin-7 gene and its
            chromosomal mapping
  JOURNAL   Biochim Biophys Acta 1399 (1), 62-66 (1998)
   PUBMED   9714739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU945845.1, AK131744.1 and AL837521.6.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_007473.5.
            
            On Apr 17, 2007 this sequence version replaced NM_007473.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB056091.1, AK131744.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BU945845.1         4-36
            34-1433             AK131744.1         2-1401
            1434-2524           AL837521.6         152294-153384       c
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.83 cM"
     gene            1..2524
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /note="aquaporin 7"
                     /db_xref="GeneID:11832"
                     /db_xref="MGI:MGI:1314647"
     exon            1..264
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     exon            265..403
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     exon            404..539
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..1352
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /note="isoform 2 is encoded by transcript variant 2;
                     AQP-7; aquaglyceroporin-7"
                     /codon_start=1
                     /product="aquaporin-7 isoform 2"
                     /protein_id="NP_031499.1"
                     /db_xref="CCDS:CCDS18055.1"
                     /db_xref="GeneID:11832"
                     /db_xref="MGI:MGI:1314647"
                     /translation="MAPRSVLETIQSVLQKNMVREFLAEFLSTYVMMVFGLGSVAHMV
                     LGENSGSYLGVNLGFGFGVTMGVHVAGGISGAHMNAAVTFTNCALGRMTWKKFPVYVL
                     GQFLGSFSAAATTYLIFYGAINHFAGGDLLVTGSKATANIFATYLPEYMTLWRGFLDE
                     AFVTGMLQLCLFAITDKKNSPALQGTEPLVIGILVTVLGVSLGMNSGYAINPSRDLPP
                     RLFTFIAGWGKQVFRAGNNWWWVPVVAPLLGAYLGGIVYLGLIHPSIPQDPQRLENFT
                     ARDQKVTASYKNAASANISGSVPLEHF"
     exon            540..663
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     exon            664..801
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     exon            802..920
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1138
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..2524
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
     polyA_site      2524
                     /gene="Aqp7"
                     /gene_synonym="AQP7L; AQPap"
ORIGIN      
        1 aagaacagag atgctatttt gggcagtgtg tatggacttg gcttaagtgg catgggccaa
       61 acccctgccc tactgacctc tcccctggag aagcacaaca gaactcacag ccaccctggg
      121 gagggcccag aggcaggctc aagtgaggac tcggagaccg cagagctaca gttcagttgc
      181 agcttgagtc tgcctccctg atagagaaac ggaatcaaga ccagctgtga gacggaggct
      241 gaaagacaca gagcacttca gagaacctac ttcataagac cagcaactcg acgccgggtg
      301 aaaattacca tctccgcact gcacctccag cctctctcgt cttcctgtgg gtctcagctc
      361 agacaggggt ccccttctcc tcggctccag ccagaagtca aggcttggtc tgctgcttca
      421 ggtccaccca caactccaca atggccccca ggtctgtgct ggagaccata caatcagtgc
      481 tacagaagaa tatggtgcga gagtttctgg cagagttcct gagtacctat gtcatgatgg
      541 tgtttggcct tggttccgtg gctcacatgg ttttaggaga aaactctggc agctatctcg
      601 gtgtcaactt gggttttgga ttcggagtga ccatgggagt ccatgtagca ggcggcatct
      661 ctggggccca catgaatgcc gcagtgactt tcaccaattg tgcactaggc cgaatgacct
      721 ggaagaagtt ccctgtatat gtgctgggtc agttcctggg ctccttctca gctgcagcta
      781 ccacctactt aattttctat ggtgccatta accactttgc aggcggagac ctgttggtga
      841 caggttccaa ggccactgca aacatttttg ccacctatct tcctgaatac atgacactgt
      901 ggcggggctt cctggatgag gcattcgtga ctgggatgct gcagctgtgt ctcttcgcca
      961 tcaccgacaa gaagaacagt ccagcacttc aagggaccga gcccctcgtg ataggcatcc
     1021 ttgttaccgt ccttggggtg tcgctaggca tgaactccgg atatgcaatc aacccatccc
     1081 gtgacctgcc tccccggttg ttcactttca ttgctggctg gggcaaacaa gtgttcagag
     1141 ccggaaacaa ctggtggtgg gtgccggtgg tggcaccact tctgggcgcc tacctaggtg
     1201 gtattgtata cctgggttta attcacccca gcataccaca ggatcctcag agactggaga
     1261 attttacagc aagagaccag aaggtaactg catcatacaa gaatgcagct tctgcaaaca
     1321 taagtggctc tgtgcctcta gagcacttct aagtagagct tctctttgac cacaaccgta
     1381 ctgcaataaa gcacaccacc tatcagcggt cccccactcc ttgggatctc ctgcagctga
     1441 actccctcct aggtttttct gggagcttct gagttattcc agcctggtac ttgtcgtgga
     1501 gagcaggctg gccttgaact tgtgatcttc ttgcctcttt ctcctgagtg ctggggatac
     1561 aggcatttac taccctgctt ggcatattcc agggtgattc tgggctcttt tctgaggact
     1621 agagcatagg gtcagaagac tccagctctt tccagttcta ggaggtgggg tgtcaagggg
     1681 gaatgtctac tttgggggct cagggtgagt gatataaagg gctttcgtgc atcagtatgt
     1741 gtgttggggg aacagtgaga aaaagaccgg aggtagctga tgggagatca gatttggggg
     1801 tctttgacgg ttttctggat aggagtacag gatctcctgg cttctccctt cctctagttt
     1861 tgagccagag aaggtaaggc taagagttta catcagaatt cctcaacttt tttttttttt
     1921 ttttgttaat gacttcctca gtggccttgt agttctccac ccctgttttt cttaaaatta
     1981 tgtagcccag gctagccttg actggaactc ttatataact aagtttagcc atgaactctg
     2041 gattgtctgg cctccacctc ctgagttctg ggattacagg tgcgcaccac cattcccagt
     2101 ttatatgtgg tgctgggatc aaacccaagg ccttgtgtat gctaggtaat atccataact
     2161 aacttaaatc ccagctcccc agttttttct tttcttgtct tttctctttc tttctctctt
     2221 tctttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttcttcttt
     2281 ctttccttcc ttccttcctt ccttccttcc ttccttcctt cctttctttt tttttttctt
     2341 tttttggttt ttcaagacag ggtttctcgg tgtagccctg gctgtcctgg aactcacttt
     2401 gtagactagg ctggcctcga actcagaaat ccgcctgcct ctgcctccca agtgctggga
     2461 ttaaaggcgt gcgccaccac tgcccggccc aaattttttc ttaattaaaa attttaatac
     2521 caca
//
