LOCUS       NM_175087               2260 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus aquaporin 6 (Aqp6), mRNA.
ACCESSION   NM_175087 XM_912579
VERSION     NM_175087.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2260)
  AUTHORS   Okada,N., Kawakita,T., Ito,M. and Tsubota,K.
  TITLE     Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal
            Gland Cells
  JOURNAL   Biomed Res Int 2021, 6888494 (2021)
   PUBMED   34540996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2260)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2260)
  AUTHORS   Tanahashi,H., Tian,Q.B., Hara,Y., Sakagami,H., Endo,S. and
            Suzuki,T.
  TITLE     Polyhydramnios in Lrp4 knockout mice with bilateral kidney
            agenesis: Defects in the pathways of amniotic fluid clearance
  JOURNAL   Sci Rep 6, 20241 (2016)
   PUBMED   26847765
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2260)
  AUTHORS   Snitow,M.E., Li,S., Morley,M.P., Rathi,K., Lu,M.M., Kadzik,R.S.,
            Stewart,K.M. and Morrisey,E.E.
  TITLE     Ezh2 represses the basal cell lineage during lung endoderm
            development
  JOURNAL   Development 142 (1), 108-117 (2015)
   PUBMED   25516972
REFERENCE   6  (bases 1 to 2260)
  AUTHORS   Offenberg,H., Barcroft,L.C., Caveney,A., Viuff,D., Thomsen,P.D. and
            Watson,A.J.
  TITLE     mRNAs encoding aquaporins are present during murine preimplantation
            development
  JOURNAL   Mol Reprod Dev 57 (4), 323-330 (2000)
   PUBMED   11066060
REFERENCE   7  (bases 1 to 2260)
  AUTHORS   Edashige,K., Sakamoto,M. and Kasai,M.
  TITLE     Expression of mRNAs of the aquaporin family in mouse oocytes and
            embryos
  JOURNAL   Cryobiology 40 (2), 171-175 (2000)
   PUBMED   10788316
REFERENCE   8  (bases 1 to 2260)
  AUTHORS   Krane,C.M., Towne,J.E. and Menon,A.G.
  TITLE     Cloning and characterization of murine Aqp5: evidence for a
            conserved aquaporin gene cluster
  JOURNAL   Mamm Genome 10 (5), 498-505 (1999)
   PUBMED   10337625
REFERENCE   9  (bases 1 to 2260)
  AUTHORS   Verkman,A.S.
  TITLE     Lessons on renal physiology from transgenic mice lacking aquaporin
            water channels
  JOURNAL   J Am Soc Nephrol 10 (5), 1126-1135 (1999)
   PUBMED   10232700
  REMARK    Review article
REFERENCE   10 (bases 1 to 2260)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139317.4 and AK082699.1.
            
            On Mar 28, 2018 this sequence version replaced NM_175087.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082699.1, SRR7652917.65166.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AC139317.4         100167-100366       c
            201-1434            AK082699.1         2-1235
            1435-2260           AC139317.4         96089-96914         c
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..2260
                     /gene="Aqp6"
                     /note="aquaporin 6"
                     /db_xref="GeneID:11831"
                     /db_xref="MGI:MGI:1341204"
     exon            1..601
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1090
                     /gene="Aqp6"
                     /note="AQP-6"
                     /codon_start=1
                     /product="aquaporin-6"
                     /protein_id="NP_780296.1"
                     /db_xref="CCDS:CCDS27824.1"
                     /db_xref="GeneID:11831"
                     /db_xref="MGI:MGI:1341204"
                     /translation="MEPGLCSRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLP
                     WPVALPSVLQIAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAMAYIA
                     AQLAGATAGAALLYGVTPGGIRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASM
                     DGRQTLASPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPL
                     TGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTECLT
                     SPCEEAVRSFSFTLGLC"
     exon            602..760
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     exon            761..841
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1027
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..2260
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp6"
                     /note="hexamer: ATTAAA"
     polyA_site      2240
                     /gene="Aqp6"
ORIGIN      
        1 agacacgcac aatgccatca gctggctccc catgaatctg agcagcttgt ttctaaggcc
       61 agcagtgtgc tgggggcacc ttagctggct ggggaagctg ccacagaaag ggaggccagg
      121 agagctgggg aggggtcaag agacctgagg gaacagaacg aatcagggag aagaggcagc
      181 agacctgaag gcaagcaggt gacaagacat ggagccaggg ctgtgtagca gggcttacct
      241 tctggttggc gggctttgga ccgccatcag caaggcgctt tttgctgagt tcctggccac
      301 ggggctgtac gttttctttg gtgtgggctc tgttctgccc tggcctgtgg cgcttccctc
      361 tgtgctccag atcgccatca ccttcaatct ggccacagcc acagccgtgc agatctcctg
      421 gaagaccagc ggggcccacg ccaaccctgc tgtgaccctg gcctacctcg tgggatccca
      481 tatctctctg cctcgggcta tggcctatat cgctgcgcag ctggctgggg ccacagctgg
      541 ggctgctctt ctttacgggg taactccagg aggtattcga gagacccttg gggtcaacgt
      601 ggtccacaac agcacatcaa ctggccaggc ggtggccgtg gagctggttc tgacgctgca
      661 gctggtgctc tgtgtctttg cttccatgga tggccggcag accttggcgt ccccagctgc
      721 catgattgga acctctgtgg cactgggcca cctcattggg atctacttca ctggctgttc
      781 catgaaccca gcccgctcct tcggccctgc cgtcattgtt gggaagttcg cagtccattg
      841 gatcttctgg gtaggaccgc tcacaggggc tgtcctggct tcgctgatct acaactttat
      901 cttgttccct gacaccaaga ctgtagccca gcgattggcc atccttgtgg gcaccacaaa
      961 ggtggagaaa gtggtagacc tggagcccca gaagaaagaa tcacagacaa actctgagga
     1021 cacagaatgt ttgacttctc cgtgtgagga ggctgtccgg tcattttcat tcacgcttgg
     1081 cctttgctga tcccctccct ggctcccctc ccagtacctc ctggccactt cctgctggtc
     1141 ctcaccttac cctcccaagg ccctccactt ctgctgtaat gttgctttca tgtttcctgt
     1201 tttctgttgc cctcttcccc cagcctcccc agtctcccct gtccagtcct ctccctagtt
     1261 atccagtcta ccccagtccc ctctccttag ttccctcaat ctactccagt cccctctccc
     1321 tggtcccccc agactacccc agtacccctg gtcccctctc cctagccccc tcaatctacc
     1381 ccagtccccc cagcccctct ccctcatccc cccagataac cccagtaccc ctggtcccct
     1441 ctccctagcc ccctcaatct accccagtcc tcccagcccc tctccctcgt cctctcagcc
     1501 tctcccatgt gccttcttcc tgctcccatg gtcaaggttc tagtttcctg acccttttct
     1561 gtttcttaac ggcaagagca cagggaggca gaaaccacac agcaggaccc cagtgggcat
     1621 cctgggccgc tggatccctg tcttggagaa aggggaattg ggtcccaaat atccattctg
     1681 cttggactct gatgaaggag cttcagagcc cactaagatg gggcaatacc agttttaggg
     1741 attgcctgag cttcttgaaa gatttctctg tcctaggtgt ggtttggggt ttcctgagga
     1801 caaaggtcgc tcttccaaaa ggtctctctg ttcccaaatg ctcaggaaga tctctacctg
     1861 ggacaaggtg atacagagga agcccacgtc cccaccccac ccccatgcca cactcggtct
     1921 ataccctggg ccagaagcct ctaaggtctg attttcaaca ccttggtccc tgttaaatag
     1981 tgaggctata gagtggccca gaaagtagag actacaggct tagtgcctct aaaagaccct
     2041 gggagttgaa ttgtttttgc tacacattga aggccactgc acatctactc ggctaatcaa
     2101 agggggtcgt ggggtggtgg ggtatcctct ctggatttca gcttatccac tgtagaatgg
     2161 gcatacttct ccctccctcc ggggtgctgt ggcaacgatg agaatgcttt ggggaattaa
     2221 atgctggtag aacactccaa taaatgatga ttgttgttgc
//
