LOCUS       NM_009701               1551 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus aquaporin 5 (Aqp5), mRNA.
ACCESSION   NM_009701 XM_912555
VERSION     NM_009701.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1551)
  AUTHORS   Liu,S., Li,Y., Huang,D., Liu,M., Zhang,X., Zhao,H., Liu,H., Li,Q.
            and Chen,Z.
  TITLE     Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1
            Expression During Salivary Gland Development
  JOURNAL   J Cell Physiol 240 (1), e31487 (2025)
   PUBMED   39587709
REFERENCE   2  (bases 1 to 1551)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1551)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1551)
  AUTHORS   Ge,H., Di,G., Li,B., Han,W., Song,P., Han,S., Wang,D. and Chen,P.
  TITLE     Reticulated Retinoic Acid Synthesis is Implicated in the
            Pathogenesis of Dry Eye in Aqp5 Deficiency Mice
  JOURNAL   Invest Ophthalmol Vis Sci 65 (8), 25 (2024)
   PUBMED   39017635
  REMARK    GeneRIF: Reticulated Retinoic Acid Synthesis is Implicated in the
            Pathogenesis of Dry Eye in Aqp5 Deficiency Mice.
REFERENCE   5  (bases 1 to 1551)
  AUTHORS   Wrynn,T., Min,S., Horeth,E., Osinski,J., Sinha,S. and Romano,R.A.
  TITLE     DeltaNp63 regulates Sfrp1 expression to direct salivary gland
            branching morphogenesis
  JOURNAL   PLoS One 19 (5), e0301082 (2024)
   PUBMED   38722977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1551)
  AUTHORS   Verkman,A.S.
  TITLE     Role of aquaporin water channels in kidney and lung
  JOURNAL   Am J Med Sci 316 (5), 310-320 (1998)
   PUBMED   9822113
  REMARK    Review article
REFERENCE   7  (bases 1 to 1551)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
REFERENCE   8  (bases 1 to 1551)
  AUTHORS   Ishida,N., Hirai,S.I. and Mita,S.
  TITLE     Immunolocalization of aquaporin homologs in mouse lacrimal glands
  JOURNAL   Biochem Biophys Res Commun 238 (3), 891-895 (1997)
   PUBMED   9325187
REFERENCE   9  (bases 1 to 1551)
  AUTHORS   Lee,M.D., Bhakta,K.Y., Raina,S., Yonescu,R., Griffin,C.A.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Preston,G.M. and Agre,P.
  TITLE     The human Aquaporin-5 gene. Molecular characterization and
            chromosomal localization
  JOURNAL   J Biol Chem 271 (15), 8599-8604 (1996)
   PUBMED   8621489
REFERENCE   10 (bases 1 to 1551)
  AUTHORS   Steinman,R.M., Gutchinov,B., Witmer,M.D. and Nussenzweig,M.C.
  TITLE     Dendritic cells are the principal stimulators of the primary mixed
            leukocyte reaction in mice
  JOURNAL   J Exp Med 157 (2), 613-627 (1983)
   PUBMED   6185614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139317.4 and AK009302.1.
            
            On Nov 14, 2006 this sequence version replaced NM_009701.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087654.1, AK009302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC139317.4         110423-110538       c
            117-1543            AK009302.1         2-1428
            1544-1551           AC139317.4         106737-106744       c
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..1551
                     /gene="Aqp5"
                     /note="aquaporin 5"
                     /db_xref="GeneID:11830"
                     /db_xref="MGI:MGI:106215"
     exon            1..607
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1042
                     /gene="Aqp5"
                     /note="AQP-5"
                     /codon_start=1
                     /product="aquaporin-5"
                     /protein_id="NP_033831.1"
                     /db_xref="CCDS:CCDS27823.1"
                     /db_xref="GeneID:11830"
                     /db_xref="MGI:MGI:106215"
                     /translation="MKKEVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQ
                     ISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAIFYVAAQLVGAIAGA
                     GILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVGS
                     PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAVLAA
                     ILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH"
     exon            608..772
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     exon            773..856
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1551
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1526..1531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp5"
                     /note="hexamer: AATAAA"
     polyA_site      1544
                     /gene="Aqp5"
                     /note="major polyA site"
ORIGIN      
        1 cgctccctgc gcgctgcgct ggcctctggg cgcgggagcc gcccccggcc cccccgcgct
       61 ctgcccgccg cggggcgcgc gccctctata tagcgcgccc ctgcccggtc cgcgccaggc
      121 cgcctgccac ggagtgggca ccgcacgtcg cgcagagccc cgcagacaga cgcccgccgc
      181 tgccagcgcc gccccgacgg ccgccccgcg acgcagccgc tgccaccggg cccccaaggc
      241 caccatgaag aaggaggtgt gttcagttgc cttcttcaag gccgtgttcg cagagttcct
      301 ggccaccctc atcttcgtct tctttggcct gggctcggca ctcaagtggc cctcggcgct
      361 gcccaccatt ctgcagatct ccatagcctt tggcctggcc ataggtacct tggcccaagc
      421 cctgggacct gtgagtggtg gccacatcaa tccggccatt actctggccc tcttaatagg
      481 caaccagatc tctctgctcc gagccatctt ctacgtggca gcccagctgg tgggtgccat
      541 tgctggagca ggcatcctgt actggttggc gccaggcaat gcccggggta acctggccgt
      601 caatgcgctc agcaacaaca caacaccagg caaggccgtg gtggtggagt taatcttgac
      661 tttccagctg gccctctgca tcttctcctc cacggactcc cgccgcacca gcccggtggg
      721 ctccccagcc ttatccattg gcttgtcggt cacactgggc catcttgtgg ggatctactt
      781 caccggctgt tccatgaacc cagcccgatc tttcggccct gcggtggtca tgaatcggtt
      841 cagcccctct cactgggtct tctgggtagg accgatcgtg ggggccgtcc tggctgcaat
      901 cctctacttc tacttgcttt tcccctcctc gctgagcctc cacgaccgtg tggctgtggt
      961 caaaggcaca tatgagccag aggaggactg ggaagatcat agagaggagc ggaagaagac
     1021 catcgagctg acggcacact gaccggcacc gggcaggggc cagtccctca gcccctggac
     1081 cactggagaa aaggaagacg aagagtttgg agcacctctc cctagcatcc tctcagctgg
     1141 agaggcagca ttggatcccc atgccgcaca cggggatggg atgggagcag aagcccatga
     1201 tgggacactt gggtgtgggc cagggacagg gcctctttgg aattaggcag aacgactgcc
     1261 acagctcaga cctcagagat tgtgaaggca gtgccaagct cacagcagtt caggaccatc
     1321 ccagaaaggg gtgatagccc tgtttatctc tccaacccag tatctcatgt gccaaagcct
     1381 tcccccaggt agacagaggg gacattgcct gagagctctt caggagagag atagatggtt
     1441 cgtcgagtgc catcttattt atttctggtt aagatggggc ggaggatggg ggggacgctg
     1501 ctggtattcg ggttgggcgt ttcccaataa accaccaatc ttcatattgt g
//
