LOCUS       NM_016689               1763 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus aquaporin 3 (Aqp3), mRNA.
ACCESSION   NM_016689
VERSION     NM_016689.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Biggs O'May,J., Vanes,L., de Boer,L.L., Lewis,D.A., Hartweger,H.,
            Kunzelmann,S., Hayward,D., Llorian,M., Kochl,R. and
            Tybulewicz,V.L.J.
  TITLE     WNK1-dependent water influx is required for CD4+ T cell activation
            and T cell-dependent antibody responses
  JOURNAL   Nat Commun 16 (1), 1857 (2025)
   PUBMED   39984435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Lin,G., Lin,L., Chen,X., Chen,L., Yang,J., Chen,Y., Qian,D.,
            Zeng,Y. and Xu,Y.
  TITLE     PPAR-gamma/NF-kB/AQP3 axis in M2 macrophage orchestrates lung
            adenocarcinoma progression by upregulating IL-6
  JOURNAL   Cell Death Dis 15 (7), 532 (2024)
   PUBMED   39060229
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Ma,T., Song,Y., Yang,B., Gillespie,A., Carlson,E.J., Epstein,C.J.
            and Verkman,A.S.
  TITLE     Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water
            channels
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4386-4391 (2000)
   PUBMED   10737773
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Verkman,A.S.
  TITLE     Lessons on renal physiology from transgenic mice lacking aquaporin
            water channels
  JOURNAL   J Am Soc Nephrol 10 (5), 1126-1135 (1999)
   PUBMED   10232700
  REMARK    Review article
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Gattone,V.H. 2nd, Maser,R.L., Tian,C., Rosenberg,J.M. and
            Branden,M.G.
  TITLE     Developmental expression of urine concentration-associated genes
            and their altered expression in murine infantile-type polycystic
            kidney disease
  JOURNAL   Dev Genet 24 (3-4), 309-318 (1999)
   PUBMED   10322639
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Ma,T., Yang,B., Gillespie,A., Carlson,E.J., Epstein,C.J. and
            Verkman,A.S.
  TITLE     Generation and phenotype of a transgenic knockout mouse lacking the
            mercurial-insensitive water channel aquaporin-4
  JOURNAL   J Clin Invest 100 (5), 957-962 (1997)
   PUBMED   9276712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145678.1.
            
            On Jan 12, 2007 this sequence version replaced NM_016689.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145678.1, AK160929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1444              AK145678.1         2-1445
            1445-1763           AK145678.1         1447-1765
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.94 cM"
     gene            1..1763
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /note="aquaporin 3"
                     /db_xref="GeneID:11828"
                     /db_xref="MGI:MGI:1333777"
     exon            1..182
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..953
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /note="AQP-3; aquaglyceroporin-3"
                     /codon_start=1
                     /product="aquaporin-3"
                     /protein_id="NP_057898.2"
                     /db_xref="CCDS:CCDS38714.1"
                     /db_xref="GeneID:11828"
                     /db_xref="MGI:MGI:1333777"
                     /translation="MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVA
                     QVVLSRGTHGGFLTINLAFGFAVTLGILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP
                     IYALAQTLGAFLGAGIVFGLYYDAIWAFANNELFVSGPNGTAGIFATYPSGHLDMVNG
                     FFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPAR
                     DFGPRLFTALAGWGSEVFTTGRHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPST
                     EEENVKLAHMKHKEQI"
     exon            183..309
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..447
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..566
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..784
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1763
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /note="putative"
     polyA_site      1763
                     /gene="Aqp3"
                     /gene_synonym="AQP-2"
                     /note="putative"
ORIGIN      
        1 accgctctcg gtgccttgcg ctagctactt tgcactcgta cgccgccgga cctcgccgct
       61 gcctgcctcg cgccatgggt cgacagaagg agttgatgaa tcgttgtggg gagatgcttc
      121 acatccgcta ccggctgctt cgccaggcgc tggcggagtg cctggggacc ctcatccttg
      181 tgatgtttgg ctgtggctcc gtggctcagg tggtgctcag ccgtggcacc catggtggct
      241 tcctcaccat caacttggct tttggcttcg ctgtcaccct tggcatcttg gtggctggcc
      301 aggtgtctgg tgcccacttg aaccccgctg tgaccttcgc aatgtgcttc ctggcacgag
      361 agccctggat caagctgccc atctatgcac tggcacagac actgggggcc ttcttgggcg
      421 ctgggattgt ttttgggctg tactacgatg caatctgggc ctttgccaac aatgagcttt
      481 tcgtctctgg ccccaacggc acagctggaa tctttgccac ctatccctct ggacacttgg
      541 acatggtcaa tggcttcttt gatcagttca taggcacagc cgcccttatt gtgtgtgtac
      601 tggccatcgt tgacccttat aacaaccctg tgccccgtgg cctggaggct ttcactgtgg
      661 gcctggtggt cctggtcatt ggaacctcca tgggcttcaa ttctggctat gccgtcaacc
      721 ctgcccgtga ctttggacct cgcctcttca ccgccctggc tggctggggc tcagaagtct
      781 tcacgactgg ccggcactgg tggtgggtac ccattgtctc cccactcctg ggttccatcg
      841 ctggtgtctt cgtgtaccag ctcatgattg gttgccacct ggagcagccc ccaccctcca
      901 ccgaggaaga gaatgtgaag ctggcccaca tgaaacacaa ggagcagatc tgagtgggca
      961 gcagcccccc tcccccactg tgcactctcc tgagtgtcca ctgactgtgt ggggaccagt
     1021 ccccgaaagc cctttgtgat gcctctctcg ggctaaaccg ctccctgtgt ccacccctgc
     1081 tggatgggcc ctccagaatt tctatgaact ctgcccatta gggcattagg ttcccaccca
     1141 cctttaagcc aaggtaggat agcaaataag atggagagag agagagagag agagagagag
     1201 agagagagag agagagaatg aatgtgtaca tgtgtgctgt tttctaagct gaatgatgca
     1261 aaggcaaggg accaagtttt caaaacaaac tgtagcagct caggggaagg gagcccaggg
     1321 gaagggagaa agtgagtcag gaatgtgcca gagtgtgcat gcttcaggga ctcctccatg
     1381 tggaggtgga cccagaagtg agtttctaag tatgcgtgtg cctactgttt tttttttttt
     1441 ttttgaaatg gacttctagg cttggggagg gggaagggat aagaagggtg tagctcacat
     1501 ctggagctat gacccttgac tgggggctgt gtaatatgtt tctgttataa gatagacatt
     1561 gggaggggct gaagtccagg tcgtaagttt cataatttgt tttttaaata tataaatata
     1621 tacatacata tatgttacag ccctaggaat aggggtggga aactccactt tttaaaaggg
     1681 gtttcctttc tttaatcctc caatcaacaa tgtactgttg ccttttatat ataaaaaaga
     1741 ataaaacgta tacatgctac agg
//
