LOCUS       NM_009699               1416 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus aquaporin 2 (Aqp2), mRNA.
ACCESSION   NM_009699
VERSION     NM_009699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Ide,H., Miike,K., Ohmori,T., Maruyama,K., Izumi,Y., Tanigawa,S. and
            Nishinakamura,R.
  TITLE     Mouse embryonic kidney transplantation identifies maturation
            defects in the medulla
  JOURNAL   Sci Rep 14 (1), 30293 (2024)
   PUBMED   39639083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Yano-Sakamoto,K., Kitai,Y., Toriu,N., Yamamoto,S., Mizuta,K.,
            Saitou,M., Tsukiyama,T., Taniuchi,I., Osato,M. and Yanagita,M.
  TITLE     Expression pattern of Runt-related transcription factor (RUNX)
            family members and the role of RUNX1 during kidney development
  JOURNAL   Biochem Biophys Res Commun 722, 150155 (2024)
   PUBMED   38795454
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Ma,Y.S., Deng,S.Q., Zhang,P., Thomsen,J.S., Andreasen,A.,
            Chang,S.J., Zhang,J., Gu,L. and Zhai,X.Y.
  TITLE     Identification of countercurrent tubule-vessel arrangements in the
            early development of mouse kidney based on immunohistochemistry and
            computer-assisted 3D visualization
  JOURNAL   PLoS One 19 (8), e0307223 (2024)
   PUBMED   39137214
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Song,R. and Yosypiv,I.V.
  TITLE     Deletion of the prorenin receptor in the ureteric bud in mice
            inhibits Dot1/H3K79 pathway
  JOURNAL   Pediatr Res 95 (7), 1754-1757 (2024)
   PUBMED   38287105
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   Tsilosani,A., Gao,C., Chen,E., Lightle,A.R., Shehzad,S., Sharma,M.,
            Tran,P.V., Bates,C.M., Wallace,D.P. and Zhang,W.
  TITLE     Pkd2 Deficiency in Embryonic Aqp2 + Progenitor Cells Is Sufficient
            to Cause Severe Polycystic Kidney Disease
  JOURNAL   J Am Soc Nephrol 35 (4), 398-409 (2024)
   PUBMED   38254271
  REMARK    GeneRIF: Pkd2 Deficiency in Embryonic Aqp2 + Progenitor Cells Is
            Sufficient to Cause Severe Polycystic Kidney Disease.
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Frokiaer,J., Marples,D., Valtin,H., Morris,J.F., Knepper,M.A. and
            Nielsen,S.
  TITLE     Low aquaporin-2 levels in polyuric DI +/+ severe mice with
            constitutively high cAMP-phosphodiesterase activity
  JOURNAL   Am J Physiol 276 (2), F179-F190 (1999)
   PUBMED   9950948
REFERENCE   7  (bases 1 to 1416)
  AUTHORS   Verkman,A.S.
  TITLE     Role of aquaporin water channels in kidney and lung
  JOURNAL   Am J Med Sci 316 (5), 310-320 (1998)
   PUBMED   9822113
  REMARK    Review article
REFERENCE   8  (bases 1 to 1416)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
REFERENCE   9  (bases 1 to 1416)
  AUTHORS   Rai,T., Uchida,S., Marumo,F. and Sasaki,S.
  TITLE     Cloning of rat and mouse aquaporin-2 gene promoters and
            identification of a negative cis-regulatory element
  JOURNAL   Am J Physiol 273 (2 Pt 2), F264-F273 (1997)
   PUBMED   9277587
REFERENCE   10 (bases 1 to 1416)
  AUTHORS   Horton,C.E. Jr., Davisson,M.T., Jacobs,J.B., Bernstein,G.T.,
            Retik,A.B. and Mandell,J.
  TITLE     Congenital progressive hydronephrosis in mice: a new recessive
            mutation
  JOURNAL   J Urol 140 (5 Pt 2), 1310-1315 (1988)
   PUBMED   3184310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142567.1.
            
            On Nov 16, 2007 this sequence version replaced NM_009699.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142567.1, BM454092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1416              AK142567.1         2-1417
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..1416
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
                     /note="aquaporin 2"
                     /db_xref="GeneID:11827"
                     /db_xref="MGI:MGI:1096865"
     exon            1..457
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
                     /inference="alignment:Splign:2.1.0"
     exon            458..622
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
                     /inference="alignment:Splign:2.1.0"
     exon            623..703
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1416
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1397..1402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
ORIGIN      
        1 gaggcccaga ggaagagaga agagaaagag agagggaggg aggaagagcc acccccgtgg
       61 cccagaccac tggccagcgc tcagaaggcc gagcagcatg tgggaactcc ggtccatagc
      121 gttctcccga gcggtgctgg ccgagttcct ggccacgctc cttttcgtct tctttggcct
      181 tggctcagcc ctccagtggg ccagctcccc accctctgtg ctccagattg ccgtggcctt
      241 tggtctgggc attggcaccc tggttcaggc tctgggccat gtcagcgggg cccacatcaa
      301 ccctgctgtg actgtggcgt gcctggtggg ttgccatgtc tccttccttc gagctgcctt
      361 ctacgtggct gcccagctgc tgggggccgt ggccggggcc gccatcctcc atgagattac
      421 ccctgtagaa atccgcgggg acctggctgt caatgctctc cacaacaatg caacagccgg
      481 ccaggcggtg actgtggagc tcttcctgac catgcagctg gtgctgtgca tctttgcctc
      541 cactgatgag cgccgcagtg acaacctggg tagccctgct ctctccattg gtttctctgt
      601 taccctgggc cacctccttg ggatctattt caccggctgc tccatgaatc cagcccgctc
      661 cctggctcca gcagttgtca ctggcaagtt tgatgatcac tgggtcttct ggatcggacc
      721 cctggtgggc gccgtcatcg gttccctcct ctacaactac ctgctgttcc cctcgaccaa
      781 gagcctgcag gagcgcctgg cggtgctcaa gggcctggag ccggacactg actgggagga
      841 acgcgaagtg cggcggcggc agtcggtgga gctgcactct ccgcagagcc tgccgcgcgg
      901 cagcaaggcc tgagcgcccc ggcagcgcag tgcagcgcag ccggccgacg gctcgccccc
      961 tccctctccc tggcccgccg tcggttccca gtgcagggta gctagctgct cctgcgcctg
     1021 cgagcgcggt gagcctcaag aaggggctcg cccgggaacc tggcagtacc tcggccccga
     1081 agccctggcc ccagctaccc tcgagctcgc cccttgcagg gaaccagaca cttggggatc
     1141 gtggcagtgg ggagacggag agctctggag agcccgctct ggtgcctagg gagaggtgca
     1201 tagagaccac cctggagagg ggggtctgtg gttagtgcat ctaattttat tagggtgtaa
     1261 aagtgctcgt ccatctctgc gtgtttcttt cctcacgtgc agagactgca tgttcctgag
     1321 ggtgaccccg agtgcccgtg gtgatacggg gcgggggact ttcattcttg ctttggcctt
     1381 cccctcctgt acctgcaata aatccacttc ctctgc
//
