LOCUS       NM_177587               1088 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus aquaporin 12 (Aqp12), transcript variant 1, mRNA.
ACCESSION   NM_177587
VERSION     NM_177587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1088)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1088)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 1088)
  AUTHORS   Okada,N., Kawakita,T., Ito,M. and Tsubota,K.
  TITLE     Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal
            Gland Cells
  JOURNAL   Biomed Res Int 2021, 6888494 (2021)
   PUBMED   34540996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1088)
  AUTHORS   Tanahashi,H., Tian,Q.B., Hara,Y., Sakagami,H., Endo,S. and
            Suzuki,T.
  TITLE     Polyhydramnios in Lrp4 knockout mice with bilateral kidney
            agenesis: Defects in the pathways of amniotic fluid clearance
  JOURNAL   Sci Rep 6, 20241 (2016)
   PUBMED   26847765
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1088)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1088)
  AUTHORS   Ohta,E., Itoh,T., Nemoto,T., Kumagai,J., Ko,S.B., Ishibashi,K.,
            Ohno,M., Uchida,K., Ohta,A., Sohara,E., Uchida,S., Sasaki,S. and
            Rai,T.
  TITLE     Pancreas-specific aquaporin 12 null mice showed increased
            susceptibility to caerulein-induced acute pancreatitis
  JOURNAL   Am J Physiol Cell Physiol 297 (6), C1368-C1378 (2009)
   PUBMED   19726746
  REMARK    GeneRIF: AQP12 may function in the mechanisms that control the
            proper secretion of pancreatic fluid following rapid and intense
            stimulation.
REFERENCE   7  (bases 1 to 1088)
  AUTHORS   Parreira,K.S., Debaix,H., Cnops,Y., Geffers,L. and Devuyst,O.
  TITLE     Expression patterns of the aquaporin gene family during renal
            development: influence of genetic variability
  JOURNAL   Pflugers Arch 458 (4), 745-759 (2009)
   PUBMED   19367412
REFERENCE   8  (bases 1 to 1088)
  AUTHORS   Itoh,T., Rai,T., Kuwahara,M., Ko,S.B., Uchida,S., Sasaki,S. and
            Ishibashi,K.
  TITLE     Identification of a novel aquaporin, AQP12, expressed in pancreatic
            acinar cells
  JOURNAL   Biochem Biophys Res Commun 330 (3), 832-838 (2005)
   PUBMED   15809071
  REMARK    GeneRIF: a role of AQP12 in digestive enzyme secretion such as
            maturation and exocytosis of secretory granules
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131815.1 and AB084104.1.
            
            On Apr 25, 2009 this sequence version replaced NM_177587.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB084104.1, BC107213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               AK131815.1         2-677
            677-1085            AB084104.1         740-1148
            1086-1088           AK131815.1         1084-1086
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.72 cM"
     gene            1..1088
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
                     /note="aquaporin 12"
                     /db_xref="GeneID:208760"
                     /db_xref="MGI:MGI:2664636"
     exon            1..676
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..942
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AQP-12"
                     /codon_start=1
                     /product="aquaporin-12 isoform 1"
                     /protein_id="NP_808255.1"
                     /db_xref="CCDS:CCDS15183.1"
                     /db_xref="GeneID:208760"
                     /db_xref="MGI:MGI:2664636"
                     /translation="MASLNVSLCFFFATCAICEVARRASKALLPAGTYASFARGAVGA
                     AQLAACCLEMRVLVELGPWAGGFGPDLLLTLVFLLFLVHGVTFDGASANPTVALQEFL
                     MVEASLPNTLLKLSAQVLGAQAACALTQRCWAWELSELHLLQSLMAAHCSSTLRTSVL
                     QGMLVEGACTFFFHLSLLHLQHSLLVYRVPALALLVTLMAYTAGPYTSAFFNPALAAS
                     VTFHCPGNTLLEYAHVYCLGPVAGMILAVLLHQGHLPRLFQRNLFYRQKSKYRTPRGK
                     LSPGSVDAKMHKGE"
     exon            677..793
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1088
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1069..1074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
     polyA_site      1088
                     /gene="Aqp12"
                     /gene_synonym="mAQP12"
ORIGIN      
        1 ccttgggctg tgggaccagc cagtctccca cacgtcacca ggtccttgct ccttgtagaa
       61 cccagactga tggccagtct gaatgtgtcc ctctgtttct tttttgctac ttgtgccatc
      121 tgtgaggtgg ctagaagggc atctaaagcc ctgcttccag caggtaccta tgccagtttt
      181 gcccgggggg cagtaggcgc agcccagctg gcagcctgct gcctggagat gcgagtgttg
      241 gtggagcttg gcccctgggc agggggcttc ggacccgacc tgttgctgac cctggtcttc
      301 ctgcttttcc tggtacatgg ggtcaccttc gatggggcct ctgccaaccc caccgtggcc
      361 ctgcaggagt tcctcatggt ggaggcatcg ctgcccaaca ctctgctgaa actgtcggcc
      421 caggtgctgg gtgcacaggc tgcctgtgcc ctgacccagc gctgctgggc ctgggagctc
      481 agcgaactac acttactaca gagcctcatg gctgcacact gcagctcaac cctgcgtaca
      541 tccgtgctgc agggcatgct cgtggagggt gcctgcacct tcttcttcca tctgagcctc
      601 ctccacctgc agcacagcct tcttgtctac agggtgcctg ccctggccct gctggtcact
      661 ctcatggcct acacagcagg gccctacaca tctgccttct tcaatcctgc cctggctgcc
      721 tctgtcacat tccactgccc tgggaacacc ttgctggagt atgcccacgt gtactgcctg
      781 ggtcctgtcg cagggatgat cctggctgtc ctcctccatc agggccacct tccccgcctt
      841 ttccagagaa atctgttcta ccggcagaaa agcaaatacc gaactcccag ggggaagctg
      901 tccccaggtt ctgtggacgc caagatgcac aaaggggagt agtggcaaag ggccgtgccc
      961 tacaggtgcc agggcagcag ccactggggt ccagctgcgc tgtctcactc accgcagctt
     1021 cactcgcctc ctgagaggtc tggtctccct gccacaaaat catttgccaa taaaccactg
     1081 ttaagatc
//
