LOCUS       NM_175105               1322 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus aquaporin 11 (Aqp11), mRNA.
ACCESSION   NM_175105
VERSION     NM_175105.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Okada,N., Kawakita,T., Ito,M. and Tsubota,K.
  TITLE     Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal
            Gland Cells
  JOURNAL   Biomed Res Int 2021, 6888494 (2021)
   PUBMED   34540996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Koike,S., Tanaka,Y., Morishita,Y. and Ishibashi,K.
  TITLE     Effects of osmolality on the expression of brain aquaporins in
            AQP11-null mice
  JOURNAL   Biochimie 188, 2-6 (2021)
   PUBMED   33794341
  REMARK    GeneRIF: Effects of osmolality on the expression of brain
            aquaporins in AQP11-null mice.
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Hoshino,Y., Sonoda,H., Nishimura,R., Mori,K., Ishibashi,K. and
            Ikeda,M.
  TITLE     Involvement of the NADPH oxidase 2 pathway in renal oxidative
            stress in Aqp11-/- mice
  JOURNAL   Biochem Biophys Rep 17, 169-176 (2019)
   PUBMED   30656220
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Tchekneva,E.E., Khuchua,Z., Davis,L.S., Kadkina,V., Dunn,S.R.,
            Bachman,S., Ishibashi,K., Rinchik,E.M., Harris,R.C., Dikov,M.M. and
            Breyer,M.D.
  TITLE     Single amino acid substitution in aquaporin 11 causes renal failure
  JOURNAL   J Am Soc Nephrol 19 (10), 1955-1964 (2008)
   PUBMED   18701606
  REMARK    GeneRIF: mutation causing single amino acid substitution in
            aquaporin 11 causes renal failure in sudden juvenile death syndrome
            mutant mice
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Okada,S., Misaka,T., Tanaka,Y., Matsumoto,I., Ishibashi,K.,
            Sasaki,S. and Abe,K.
  TITLE     Aquaporin-11 knockout mice and polycystic kidney disease animals
            share a common mechanism of cyst formation
  JOURNAL   FASEB J 22 (10), 3672-3684 (2008)
   PUBMED   18606867
  REMARK    GeneRIF: These results provide new insights into the physiological
            roles of AQP11.
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Yakata,K., Hiroaki,Y., Ishibashi,K., Sohara,E., Sasaki,S.,
            Mitsuoka,K. and Fujiyoshi,Y.
  TITLE     Aquaporin-11 containing a divergent NPA motif has normal water
            channel activity
  JOURNAL   Biochim Biophys Acta 1768 (3), 688-693 (2007)
   PUBMED   17178102
  REMARK    Erratum:[Biochim Biophys Acta. 2008 Jun;1778(6):1525]
REFERENCE   9  (bases 1 to 1322)
  AUTHORS   Morishita,Y., Matsuzaki,T., Hara-chikuma,M., Andoo,A., Shimono,M.,
            Matsuki,A., Kobayashi,K., Ikeda,M., Yamamoto,T., Verkman,A.,
            Kusano,E., Ookawara,S., Takata,K., Sasaki,S. and Ishibashi,K.
  TITLE     Disruption of aquaporin-11 produces polycystic kidneys following
            vacuolization of the proximal tubule
  JOURNAL   Mol Cell Biol 25 (17), 7770-7779 (2005)
   PUBMED   16107722
  REMARK    GeneRIF: AQP11 is essential for the proximal tubular function
REFERENCE   10 (bases 1 to 1322)
  AUTHORS   Rinchik,E.M. and Carpenter,D.A.
  TITLE     N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the
            Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557
            gametes and deletion mapping and complementation analysis of 31
            mutations
  JOURNAL   Genetics 152 (1), 373-383 (1999)
   PUBMED   10224267
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK075757.1.
            
            On Apr 6, 2007 this sequence version replaced NM_175105.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075757.1, AK137326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1322              AK075757.1         2-1323
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.57 cM"
     gene            1..1322
                     /gene="Aqp11"
                     /gene_synonym="1700015P13Rik; sjds"
                     /note="aquaporin 11"
                     /db_xref="GeneID:66333"
                     /db_xref="MGI:MGI:1913583"
     exon            1..879
                     /gene="Aqp11"
                     /gene_synonym="1700015P13Rik; sjds"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1076
                     /gene="Aqp11"
                     /gene_synonym="1700015P13Rik; sjds"
                     /note="AQP-11; CG12251 gene product"
                     /codon_start=1
                     /product="aquaporin-11"
                     /protein_id="NP_780314.1"
                     /db_xref="CCDS:CCDS21463.1"
                     /db_xref="GeneID:66333"
                     /db_xref="MGI:MGI:1913583"
                     /translation="MSALLGLRPEVQDTCISLGLMLLFVLFVGLARVIARQQLHRPVV
                     HAFVLEFLATFQLCCCTHELQVLSEQDSAHPTWTLTLIYFFSLVHGLTLVGTASNPCG
                     VMMQMILGGMSPEMGAVRLLAQLVSALCSRYCISALWSLSLTKYHYDERILACRNPIH
                     TDMSKAIIIEAICSFIFHSALLHFQEVRTKLRIHLLAALITFLAYAGGSLTGALFNPA
                     LALSLHFPCFDELFYKFFVVYWLAPSVGVLMMILMFSFFLPWLHNNQMTNKKE"
     exon            880..996
                     /gene="Aqp11"
                     /gene_synonym="1700015P13Rik; sjds"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1322
                     /gene="Aqp11"
                     /gene_synonym="1700015P13Rik; sjds"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1322
                     /gene="Aqp11"
                     /gene_synonym="1700015P13Rik; sjds"
                     /note="putative"
ORIGIN      
        1 acagaccgtt gtcccctccg ccagtgccca gggacagctc cctcgccgcc tcctttcccc
       61 cgccctcccc ccctccccgg ctcaggtcac atctgcacag cgcagccggg gaggggagga
      121 gccctccagc gcggaacccg ggctctccac tcggcccgcc cctgaggggc gtgggagggc
      181 ggggcggcgg acttcggact ccagcccccg acgctcctct gtccctgccg ccctcagcca
      241 tccccagcgg tgagggagcc atgtccgcgc tactggggct ccggcccgag gtgcaggaca
      301 cctgcatctc gctggggcta atgctgctgt tcgtgctgtt cgtggggctg gcccgcgtga
      361 tcgcccggca acagctacac aggcccgtgg tccacgcctt cgtcctggag tttctagcta
      421 ccttccagct ctgctgctgc acccacgagc tccaagtgct gagcgagcag gactctgcgc
      481 accccacctg gactctgaca ctgatctact tcttttcctt ggtgcatggc ctgaccctgg
      541 tgggcacagc tagcaacccg tgcggcgtga tgatgcagat gattctgggg ggtatgtccc
      601 ccgaaatggg tgccgtgagg ttgttggctc agctggttag cgccctgtgc agcaggtact
      661 gcataagcgc cctgtggagc ctgagtctga ccaagtacca ttacgacgaa aggatcttag
      721 cttgcaggaa tcccatccac accgacatgt ccaaagcgat catcatagag gccatctgct
      781 cctttatttt ccacagcgct ctactgcact tccaggaggt ccgaaccaag cttcgcatcc
      841 acctgctggc tgcactcatc acctttttgg cctatgcagg agggagcctc acaggagcat
      901 tgtttaaccc agcgctggca ctttctctgc actttccgtg ctttgacgaa ctcttctata
      961 agttttttgt agtatactgg cttgctcctt ctgtaggtgt gctgatgatg atcctcatgt
     1021 tcagtttttt ccttccatgg ctgcataaca atcaaatgac taataaaaaa gagtaaccac
     1081 tcccaaagac tcgaactaag tcccaggaca gtcaagctgg atgcgacaat ctgagcaccc
     1141 tccaaactct ggacgcctcc tgcttcagct ttctctgtgg aaggtgtctt aagtttttac
     1201 tacctggact tcaaattact gtgaaaatga ggtagcctgt atttctcaag ttaagacttg
     1261 ttctcgagtg atgtattaaa tgctgctaga aaaggctcat tcattaaaca tctacctatc
     1321 cc
//
