LOCUS       NM_007472               2760 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus aquaporin 1 (Aqp1), mRNA.
ACCESSION   NM_007472
VERSION     NM_007472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Lv,W., Liao,J., Li,C., Liu,D., Luo,X., Diao,R., Wang,Y. and Jin,Y.
  TITLE     Aquaporin 1 is renoprotective in septic acute kidney injury by
            attenuating inflammation, apoptosis and fibrosis through inhibition
            of P53 expression
  JOURNAL   Front Immunol 15, 1443108 (2024)
   PUBMED   39238634
  REMARK    GeneRIF: Aquaporin 1 is renoprotective in septic acute kidney
            injury by attenuating inflammation, apoptosis and fibrosis through
            inhibition of P53 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2760)
  AUTHORS   Ma,Y.S., Deng,S.Q., Zhang,P., Thomsen,J.S., Andreasen,A.,
            Chang,S.J., Zhang,J., Gu,L. and Zhai,X.Y.
  TITLE     Identification of countercurrent tubule-vessel arrangements in the
            early development of mouse kidney based on immunohistochemistry and
            computer-assisted 3D visualization
  JOURNAL   PLoS One 19 (8), e0307223 (2024)
   PUBMED   39137214
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2760)
  AUTHORS   Taki,S., Boron,W.F. and Moss,F.J.
  TITLE     Novel RPTPgamma and RPTPzeta splice variants from mixed
            neuron-astrocyte hippocampal cultures as well as from the
            hippocampi of newborn and adult mice
  JOURNAL   Front Physiol 15, 1406448 (2024)
   PUBMED   38952869
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2760)
  AUTHORS   Huang,B., Zeng,Z., Kim,S., Fausto,C.C., Koppitch,K., Li,H., Li,Z.,
            Chen,X., Guo,J., Zhang,C.C., Ma,T., Medina,P., Schreiber,M.E.,
            Xia,M.W., Vonk,A.C., Xiang,T., Patel,T., Li,Y., Parvez,R.K.,
            Der,B., Chen,J.H., Liu,Z., Thornton,M.E., Grubbs,B.H., Diao,Y.,
            Dou,Y., Gnedeva,K., Ying,Q., Pastor-Soler,N.M., Fei,T.,
            Hallows,K.R., Lindstrom,N.O., McMahon,A.P. and Li,Z.
  TITLE     Long-term expandable mouse and human-induced nephron progenitor
            cells enable kidney organoid maturation and modeling of plasticity
            and disease
  JOURNAL   Cell Stem Cell 31 (6), 921-939 (2024)
   PUBMED   38692273
REFERENCE   5  (bases 1 to 2760)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   6  (bases 1 to 2760)
  AUTHORS   Ma,T., Yang,B., Gillespie,A., Carlson,E.J., Epstein,C.J. and
            Verkman,A.S.
  TITLE     Severely impaired urinary concentrating ability in transgenic mice
            lacking aquaporin-1 water channels
  JOURNAL   J Biol Chem 273 (8), 4296-4299 (1998)
   PUBMED   9468475
REFERENCE   7  (bases 1 to 2760)
  AUTHORS   Moon,C., King,L.S. and Agre,P.
  TITLE     Aqp1 expression in erythroleukemia cells: genetic regulation of
            glucocorticoid and chemical induction
  JOURNAL   Am J Physiol 273 (5), C1562-C1570 (1997)
   PUBMED   9374641
REFERENCE   8  (bases 1 to 2760)
  AUTHORS   Ruiz,A. and Bok,D.
  TITLE     Characterization of the 3' UTR sequence encoded by the AQP-1 gene
            in human retinal pigment epithelium
  JOURNAL   Biochim Biophys Acta 1282 (2), 174-178 (1996)
   PUBMED   8703970
REFERENCE   9  (bases 1 to 2760)
  AUTHORS   Moon,C., Williams,J.B., Preston,G.M., Copeland,N.G., Gilbert,D.J.,
            Nathans,D., Jenkins,N.A. and Agre,P.
  TITLE     The mouse aquaporin-1 gene
  JOURNAL   Genomics 30 (2), 354-357 (1995)
   PUBMED   8586439
REFERENCE   10 (bases 1 to 2760)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850287.1 and AK081886.1.
            
            On Apr 27, 2007 this sequence version replaced NM_007472.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081886.1, AK158389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               BB850287.1         2-134
            134-2760            AK081886.1         2-2628
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.38 cM"
     gene            1..2760
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /note="aquaporin 1"
                     /db_xref="GeneID:11826"
                     /db_xref="MGI:MGI:103201"
     exon            1..576
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            577..741
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            742..822
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            823..2760
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /note="hexamer: AATAAA"
     polyA_site      2760
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /note="major polyA site"
ORIGIN      
        1 agagccctgt ctgcatccat cgcagcgagg aggctcgtgt ggtgtggggc gggccaggag
       61 caaggagagg ccttcctccc tttgtgctcc ccccacccag ccctataaat aggcccagcc
      121 caggctgtgg ctcagctctt ggagggagtt gagcaccagg catccagcgg ttaagtcgag
      181 gtccctgcca gcatggccag tgaaatcaag aagaagctct tctggagggc tgtggtggct
      241 gagttcctgg ccatgaccct cttcgtcttc atcagcattg gttctgccct aggcttcaat
      301 tacccactgg agagaaacca gacgctggtc caggacaacg tgaaggtgtc gctggccttt
      361 ggtttgagca tcgctactct ggcccaaagt gtgggtcaca tcagcggtgc tcacctcaac
      421 cctgcggtca cactggggct cctgctcagc tgtcagatca gcatcctccg ggctgtcatg
      481 tacatcatcg cccagtgtgt gggagccatc gtcgccacgg ccattctctc gggcatcacc
      541 tcctccctag tcgacaattc acttggccgc aatgacctgg ctcacggtgt gaactctggc
      601 cagggcctgg gcattgagat cattggcact ctgcagctgg tactgtgcgt tctggccacc
      661 actgaccgga ggcgccgaga cttaggtggc tcagccccgc ttgccattgg cttgtctgtg
      721 gcccttggac acctgctggc gattgactac actggctgcg gtatcaaccc tgcccggtca
      781 tttggctctg ctgtgctcac ccgcaacttc tcaaaccact ggattttctg ggtggggccg
      841 ttcattgggg gtgccctggc agtgctcatc tatgacttca tcctggcccc acgcagcagc
      901 gacttcacag accgcatgaa ggtgtggacc agtggccagg tggaggagta tgacctggat
      961 gctgacgaca tcaactccag ggtggagatg aagcccaaat agaggaggct tggcctgggc
     1021 atctatatgg gggtggggca gggatgggcg gagggagggg agggccgaaa tcatattgta
     1081 gacactctga caagctgacc aaagtcactc cccaagacct gcctgaccca catggtctag
     1141 ccttgtctgg ggcagtaata tcactgtctt tctttctgtt tcctggtctc agagcttcct
     1201 ggggaccaag atttatcaac tcagcacccc actcctttga catcatggag gagtgaaagt
     1261 gagggaccca cctgctagtt gtcccctcag agtgtgctag gaagtccccc tcattccaaa
     1321 gctgcccagc aagtccccca ccttaggtgc ctgggattct gccaatgtcg ctttgtgcct
     1381 ttgaccgcag ccttccttgg ggtaggcacc ttatctccaa aggcactttg agggagagga
     1441 ggtcccctaa ctttcccctt tggtctgact tacctccagg acccttcccc ttgaactcac
     1501 tctaagacct tggaattgtc cctgtgctga ggcctcagtg atcacatctg taaagtggca
     1561 aggaagggac agctttgggg attctgtaag tgtggacatg ccacaggttc tagaagggac
     1621 agtcttgaca gcactgcttt gtgtacccgg cctgtactct ttcccagcgt ccacagccca
     1681 cgagcacacg tggatgggcc acggatcaga gaatcagtgt gggatgcaag acgtgcctgt
     1741 tcacacacac agccttcctg gaggcgggtt agctgtagca gaacgaaggt cattttgtgg
     1801 tagaagaaga gctcacacta tcttacctag ctctagtggg tctgcccgtg taacatggcc
     1861 ccgactggat gtttatttcg gtcctccagt ctcccttgca gtatagatct ggtgtgtgtg
     1921 tgtttgttaa agagcattgg gctatgtgca gtgtcatgtc tgaggagaga agcagctagc
     1981 tatgcaacag accctggaca gatgcccatg ctgggcacac aagggtttgg atgcccttag
     2041 ttcatcatga gcaaggaggt cactctggcc ctggcttgtg agctcctggc tggatgagtg
     2101 tgaccggagc ctggacaatc tgcagaggct cactctgtgc ctccaggcac agtcttctct
     2161 ctgcattggc ccaatgctac agcttgtgtt gcagcccaag gacagctcag agtgcagtca
     2221 gctcaggggt tgcatttagc tctaggtcat tccattggat cccatcaatc cagagtggct
     2281 ctaccactgt gcccttaacc acattgtgaa ccgagagcca cattcttcag gtgcttagaa
     2341 gcagcagaag agtcaggagg ccactgacca ctggcatatc acagctgcac actcgtctcc
     2401 gttccctagc agacactgta cccacttaac agataagggc actgaggacc catatgctca
     2461 actgtatcat attggatcaa gcttagcagt caaggccatg tttggccacc ccatggtcaa
     2521 tgacgtggac tcctctcacc tccagcttct cagtttctgc ctgggcaatg gctaagggcc
     2581 aggggtgagg gtgggggtgg aggtggtgag agctttgctg gagaggggca gggcaggccc
     2641 atcccacctg gttctggcca ttgtgaacca ggaccttgta tctgtctgct ctgtgtatgt
     2701 ttctttgcaa ttgaatttca tcttatggta agaaaataaa ggacaatgac ttgtaaggtc
//
