LOCUS       NM_009698                866 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adenine phosphoribosyl transferase (Aprt), mRNA.
ACCESSION   NM_009698 NM_175704
VERSION     NM_009698.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 866)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 866)
  AUTHORS   Young,G.H., Lin,J.T., Cheng,Y.F., Ho,C.F., Kuok,Q.Y., Hsu,R.C.,
            Liao,W.R., Chen,C.C. and Chen,H.M.
  TITLE     Modulation of adenine phosphoribosyltransferase-mediated salvage
            pathway to accelerate diabetic wound healing
  JOURNAL   FASEB J 35 (3), e21296 (2021)
   PUBMED   33675115
  REMARK    GeneRIF: Modulation of adenine phosphoribosyltransferase-mediated
            salvage pathway to accelerate diabetic wound healing.
REFERENCE   3  (bases 1 to 866)
  AUTHORS   Turker,M.S., Grygoryev,D., Lasarev,M., Ohlrich,A., Rwatambuga,F.A.,
            Johnson,S., Dan,C., Eckelmann,B., Hryciw,G., Mao,J.H.,
            Snijders,A.M., Gauny,S. and Kronenberg,A.
  TITLE     Simulated space radiation-induced mutants in the mouse kidney
            display widespread genomic change
  JOURNAL   PLoS One 12 (7), e0180412 (2017)
   PUBMED   28683078
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 866)
  AUTHORS   Vazquez,B.N., Thackray,J.K., Simonet,N.G., Kane-Goldsmith,N.,
            Martinez-Redondo,P., Nguyen,T., Bunting,S., Vaquero,A.,
            Tischfield,J.A. and Serrano,L.
  TITLE     SIRT7 promotes genome integrity and modulates non-homologous end
            joining DNA repair
  JOURNAL   EMBO J 35 (14), 1488-1503 (2016)
   PUBMED   27225932
REFERENCE   5  (bases 1 to 866)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   6  (bases 1 to 866)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   7  (bases 1 to 866)
  AUTHORS   Tomonari,K., Fairchild,S. and Rosenwasser,O.A.
  TITLE     Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27
  JOURNAL   Immunogenetics 36 (5), 302-305 (1992)
   PUBMED   1322864
REFERENCE   8  (bases 1 to 866)
  AUTHORS   Snyder,F.F., Cruikshank,M.K. and Seegmiller,J.E.
  TITLE     A comparison of purine metabolism and nucleotide pools in normal
            and hypoxanthine-guanine phosphoribosyltransferase-deficient
            neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 543 (4), 556-569 (1978)
   PUBMED   718989
REFERENCE   9  (bases 1 to 866)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 866)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY115322.1 and AK153201.1.
            
            On Dec 2, 2006 this sequence version replaced NM_009698.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153201.1, CK790193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY115322.1         1-36
            37-866              AK153201.1         2-831
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.91 cM"
     gene            1..866
                     /gene="Aprt"
                     /note="adenine phosphoribosyl transferase"
                     /db_xref="GeneID:11821"
                     /db_xref="MGI:MGI:88061"
     exon            1..155
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..618
                     /gene="Aprt"
                     /EC_number="2.4.2.7"
                     /codon_start=1
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="NP_033828.2"
                     /db_xref="CCDS:CCDS40503.1"
                     /db_xref="GeneID:11821"
                     /db_xref="MGI:MGI:88061"
                     /translation="MSEPELKLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIR
                     LLASHLKSTHSGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKQGKLPGPTVSASYS
                     LEYGKAELEIQKDALEPGQRVVIVDDLLATGGTMFAACDLLHQLRAEVVECVSLVELT
                     SLKGRERLGPIPFFSLLQYD"
     exon            156..262
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     exon            263..396
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     exon            397..475
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     exon            476..866
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aprt"
                     /note="putative"
     polyA_site      866
                     /gene="Aprt"
                     /note="putative"
ORIGIN      
        1 ttgttccccc cgggattgac gtgagtttag cgtgctgata cctacctcct ccctgcctcc
       61 tacacgcacg cggccatgtc ggaacctgag ttgaaactgg tggcgcggcg catccgcagc
      121 ttccccgact tcccaatccc gggcgtgctg ttcagggata tctcgcccct cttgaaagac
      181 ccggactcct tccgagcttc catccgcctc ttggccagtc acctgaagtc cacgcacagc
      241 ggcaagatcg actacatcgc aggtctagac tccaggggct tcctgtttgg cccttcccta
      301 gctcaggagc tgggcgtggg ctgtgtgctc atccggaaac aggggaagct gccgggcccc
      361 actgtgtcag cctcctattc tctggagtat gggaaggctg agctggaaat ccagaaagat
      421 gccttggaac ccgggcagag agtggtcatt gtggatgacc tcctggccac aggaggaacc
      481 atgtttgcgg cctgtgacct gctgcaccag ctccgggctg aagtggtgga gtgtgtgagc
      541 ctggtggagc tgacctcgct gaagggcagg gagaggctag gacctatacc attcttctct
      601 ctcctccagt atgactgagg agctggctag atggtcacac ccctgctccc agcagcacca
      661 ggaactgctt ggtggctcag cccaggcgcc taagtgacct ttgtgagcta ccggccgccc
      721 ttttgtgagt gttatcactc attcctttgg tcagctgatc cgccgtgcct gtggacccct
      781 ggatccttgt actttgtaca cgtgccacac accctggagc atagcagagc tgtgctactg
      841 gagatcaata aaccgttttg atatgc
//
