LOCUS       NM_145221               6933 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus adaptor protein, phosphotyrosine interaction, PH
            domain and leucine zipper containing 1 (Appl1), mRNA.
ACCESSION   NM_145221 XM_975639
VERSION     NM_145221.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6933)
  AUTHORS   Du,Y., Duan,Y., Zhao,J., Liu,C., Zhang,Z., Zhang,J., Meng,Z.,
            Wang,X., Lau,W.B., Xie,D., Lopez,B.L., Christopher,T.A., Gao,E.,
            Koch,W.W., Liu,H., Liu,D., Ma,X.L., Gu,G. and Wang,Y.
  TITLE     Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic
            Vascular Injury
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (12), e491-e508 (2023)
   PUBMED   37795615
  REMARK    GeneRIF: Dysfunctional APPL1-Mediated Epigenetic Regulation in
            Diabetic Vascular Injury.
            Erratum:[Arterioscler Thromb Vasc Biol. 2024 May;44(5):e171. doi:
            10.1161/ATV.0000000000000171.. PMID: 38657036]
REFERENCE   2  (bases 1 to 6933)
  AUTHORS   Mukherjee,S., Chakraborty,M., Msengi,E.N., Haubner,J., Zhang,J.,
            Jellinek,M.J., Carlson,H.L., Pyles,K., Ulmasov,B., Lutkewitte,A.J.,
            Carpenter,D., McCommis,K.S., Ford,D.A., Finck,B.N.,
            Neuschwander-Tetri,B.A. and Chakraborty,A.
  TITLE     Ube4A maintains metabolic homeostasis and facilitates insulin
            signaling in vivo
  JOURNAL   Mol Metab 75, 101767 (2023)
   PUBMED   37429524
REFERENCE   3  (bases 1 to 6933)
  AUTHORS   Hua,S.S., Ding,J.J., Sun,T.C., Guo,C., Zhang,Y., Yu,Z.H., Cao,Y.Q.,
            Zhong,L.H., Wu,Y., Guo,L.Y., Luo,J.H., Cui,Y.H. and Qiu,S.
  TITLE     NMDA Receptor-Dependent Synaptic Potentiation via APPL1 Signaling
            Is Required for the Accessibility of a Prefrontal Neuronal Assembly
            in Retrieving Fear Extinction
  JOURNAL   Biol Psychiatry 94 (3), 262-277 (2023)
   PUBMED   36842495
  REMARK    GeneRIF: NMDA Receptor-Dependent Synaptic Potentiation via APPL1
            Signaling Is Required for the Accessibility of a Prefrontal
            Neuronal Assembly in Retrieving Fear Extinction.
REFERENCE   4  (bases 1 to 6933)
  AUTHORS   Zhang,Y., Liu,W., Yuan,W., Cai,Z., Ye,G., Zheng,G., Xu,C., Wang,X.,
            Zeng,C., Mi,R., Feng,P., Chen,F., Wu,Y., Shen,H. and Wang,P.
  TITLE     Impairment of APPL1/Myoferlin facilitates adipogenic
            differentiation of mesenchymal stem cells by blocking autophagy
            flux in osteoporosis
  JOURNAL   Cell Mol Life Sci 79 (9), 488 (2022)
   PUBMED   35984564
  REMARK    GeneRIF: Impairment of APPL1/Myoferlin facilitates adipogenic
            differentiation of mesenchymal stem cells by blocking autophagy
            flux in osteoporosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6933)
  AUTHORS   Wu,K.K.L., Long,K., Lin,H., Siu,P.M.F., Hoo,R.L.C., Ye,D., Xu,A.
            and Cheng,K.K.Y.
  TITLE     The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through
            early endosomal-dependent mitophagy in macrophages
  JOURNAL   Nat Commun 12 (1), 6637 (2021)
   PUBMED   34789781
  REMARK    GeneRIF: The APPL1-Rab5 axis restricts NLRP3 inflammasome
            activation through early endosomal-dependent mitophagy in
            macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6933)
  AUTHORS   Cheng,K.K., Iglesias,M.A., Lam,K.S., Wang,Y., Sweeney,G., Zhu,W.,
            Vanhoutte,P.M., Kraegen,E.W. and Xu,A.
  TITLE     APPL1 potentiates insulin-mediated inhibition of hepatic glucose
            production and alleviates diabetes via Akt activation in mice
  JOURNAL   Cell Metab 9 (5), 417-427 (2009)
   PUBMED   19416712
  REMARK    GeneRIF: Overexpression of APPL1 protein in the liver of db/db
            obese mice suppressed the interaction between Proto-Oncogene
            Proteins c-akt and TRB3 protein.
REFERENCE   7  (bases 1 to 6933)
  AUTHORS   Mao,X., Kikani,C.K., Riojas,R.A., Langlais,P., Wang,L., Ramos,F.J.,
            Fang,Q., Christ-Roberts,C.Y., Hong,J.Y., Kim,R.Y., Liu,F. and
            Dong,L.Q.
  TITLE     APPL1 binds to adiponectin receptors and mediates adiponectin
            signalling and function
  JOURNAL   Nat Cell Biol 8 (5), 516-523 (2006)
   PUBMED   16622416
  REMARK    GeneRIF: APPL1 interacts with adiponectin receptors in mammalian
            cells and the interaction is stimulated by adiponectin.
            Erratum:[Nat Cell Biol. 2006 Jun;8(6):642]
REFERENCE   8  (bases 1 to 6933)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 6933)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 6933)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124603.5.
            
            On Jan 4, 2022 this sequence version replaced NM_145221.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146356.1, SRR10223970.16727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC124603.5         85142-85262         c
            122-220             AC124603.5         79600-79698         c
            221-280             AC124603.5         78388-78447         c
            281-352             AC124603.5         77547-77618         c
            353-440             AC124603.5         75692-75779         c
            441-482             AC124603.5         74166-74207         c
            483-541             AC124603.5         73194-73252         c
            542-688             AC124603.5         67719-67865         c
            689-771             AC124603.5         66176-66258         c
            772-930             AC124603.5         65293-65451         c
            931-1119            AC124603.5         64183-64371         c
            1120-1162           AC124603.5         61862-61904         c
            1163-1219           AC124603.5         60286-60342         c
            1220-1311           AC124603.5         58653-58744         c
            1312-1494           AC124603.5         57389-57571         c
            1495-1547           AC124603.5         54985-55037         c
            1548-1722           AC124603.5         43300-43474         c
            1723-1759           AC124603.5         43181-43217         c
            1760-1906           AC124603.5         42470-42616         c
            1907-1957           AC124603.5         40700-40750         c
            1958-2047           AC124603.5         40158-40247         c
            2048-6933           AC124603.5         33727-38612         c
FEATURES             Location/Qualifiers
     source          1..6933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.09 cM"
     gene            1..6933
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /note="adaptor protein, phosphotyrosine interaction, PH
                     domain and leucine zipper containing 1"
                     /db_xref="GeneID:72993"
                     /db_xref="MGI:MGI:1920243"
     exon            1..121
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2191
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /note="adaptor protein APPL like; dip13-alpha; adapter
                     protein containing PH domain, PTB domain and leucine
                     zipper motif 1; DIP13 alpha"
                     /codon_start=1
                     /product="DCC-interacting protein 13-alpha"
                     /protein_id="NP_660256.1"
                     /db_xref="CCDS:CCDS26883.1"
                     /db_xref="GeneID:72993"
                     /db_xref="MGI:MGI:1920243"
                     /translation="MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAM
                     HRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAV
                     LSTQLADAMMFPISQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVK
                     YEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENL
                     NGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPINRN
                     LTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVD
                     CEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQ
                     SALEAVTPSPSFQQRHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDT
                     PIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGS
                     MEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFP
                     LPCVVLYATHQENKRLFGFVLRTSGGRSESNLSSVCYIFESNNEGEKICDSVGLAKQI
                     ALHAELDRRASEKQKEIERVKEKQQKELSKQKQIEKDLEEQSRLIAASSRPNQAGSEG
                     QLVLSSSQSEESDLGEEGKKRESEA"
     exon            122..220
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            221..280
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            281..352
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            353..440
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            441..482
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            483..541
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            542..688
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            689..771
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            772..930
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1119
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1162
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1219
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1311
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1494
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1547
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1722
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1759
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1906
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1957
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2047
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..6933
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6907..6912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /note="hexamer: AATAAA"
     polyA_site      6933
                     /gene="Appl1"
                     /gene_synonym="2900057D21Rik; 7330406P05Rik; DIP13"
                     /note="major polyA site"
ORIGIN      
        1 aggcggggcc acgcgcggag ctgtgggcgg ctgccgagtg tcctgccgcc gcccagcctt
       61 cgccacgatg ccggggatcg acaagctgcc cattgaagag accctggagg acagtccgca
      121 gacaaggtct ttacttggtg tatttgaaga agatgctact gctatttcaa attatatgaa
      181 ccaattgtat caagctatgc atcggattta tgatgcacag aatgaattga gtgcagcaac
      241 acacctgact tcgaaacttt tgaaagaata tgaaaaacag cgttttcctt tggggggtga
      301 tgatgaagtt atgagctcta ctttgcagca gttttccaag gtcatagatg agcttagttc
      361 ttgtcatgca gtactttcaa ctcaacttgc tgatgccatg atgttcccca tttcccagtt
      421 taaagaaaga gatctgaaag aaatattgac actaaaggag gtatttcaaa ttgctagtaa
      481 tgatcatgat gccgcaatta ataggtacag tcggttgtca aaaaagagag aaaatgacaa
      541 ggtaaaatat gaagttacag aggatgtata tacttccagg aaaaaacaac accagaccat
      601 gatgcattat ttttgtgcac taaatactct tcagtacaag aagaaaatag ctttgttaga
      661 acctctactg ggatacatgc aggctcagat aagtttcttt aagatgggtt ctgaaaatct
      721 caatggacaa ctggaagaat tcttagctaa cattggaaca agtgtacaga atgttcgaag
      781 agaaatggat ggtgatgtag agaccatgca gcagacaata gaagacttgg aggtagccag
      841 tgacccttta tatctgcctg acccggatcc caccaagttt cccatcaatc gaaatttaac
      901 ccgaaaggct ggatacctaa atgctaggaa taaaacaggc ttggtgtcat ctacctggga
      961 tagacagttt tacttcacgc agggtggaaa cttaatgagt caagcccgtg gagatgtggc
     1021 aggaggccta gccatggaca tagacaactg ttcagtgatg gctgtggact gtgaagacag
     1081 acgatactgt tttcagatca cttcttttga tggaaaaaaa tcttcaatat tgcaagcaga
     1141 gagtaaaaaa gaccatgaag agtggatctg tacaataaac aacatatcta aacaaatata
     1201 tttgagtgaa aatccagagg aaactgctgc acgagtgaat cagtctgctc tagaagctgt
     1261 cactccttcc ccatctttcc agcagagaca cgagagcctg cgtccaggag gacaatctcg
     1321 gccaccaaca gctcgaacca gcagttcagg atccttggga tcagagtcta caaatttggc
     1381 tgccctctct ctagattctc ttgttgctcc ggatacacca atacagtttg atataatttc
     1441 tcctgtgtgt gaagatcagc ctggccaggc aaaagccttt ggtcaaggag gcaggcgtac
     1501 aaatccattt ggagaatctg gaggaagcac aaaatcagaa acagaagact ctattcttca
     1561 tcagttattt attgtccgat tccttggttc tatggaggta aagtcagatg accatccaga
     1621 tgttgtctat gaaacaatgc gccagatctt agctgctcgg gccatccaca acatctttcg
     1681 tatgacagaa tcacatttat tagtcacttg tgactgcttg aagttaattg atccgcagac
     1741 ccaagttaca aggctcacat ttccattgcc gtgtgtagtt ctgtatgcta cgcaccagga
     1801 aaataaacga ctttttggat ttgttctccg gacatcaggc ggaagaagtg agagtaattt
     1861 gtcatcagtc tgctatatat ttgaatcaaa caatgaggga gaaaagattt gtgattctgt
     1921 tggactggca aaacagatag ctttgcatgc tgaactggat cgtagggcat cagaaaaaca
     1981 aaaagaaata gagagagtaa aagagaaaca gcagaaagag ctcagcaaac agaaacagat
     2041 tgagaaggac ttggaagaac agagtcggtt gatagctgcc tccagtagac caaaccaggc
     2101 tggtagtgag ggccagcttg ttcttagcag tagccaatca gaggagagtg atttgggaga
     2161 agaagggaaa aaaagagagt cggaagcata aacttgttgc tgctttttga gttctcattt
     2221 ccctgggatg tggcacagcg tatccatgct gaagatcatg gaagagataa gctttacagt
     2281 agtgtgcttc agcttcattt aaaaagactg aacttgataa ccggttatag cgaacatttc
     2341 cccgtaaaaa taaaatacta tgcattgtca tccaactctg ctttcctaaa caagacctgc
     2401 ttacttttct gtagtagatt gctgaggaat tacaggtctt caagatattt ttcctttaaa
     2461 ttgtgaacat tttatcttgc actgtaattg gctgtctcca taaggaatga tttattcttg
     2521 gattctgaca ttcctgtgta tactctccct ttcattagga atgttttatt ggtagtgagg
     2581 gagggctcaa ttgagtgagc ttaacatcct ttatgtggag aattctataa gtgtgcaagt
     2641 gttgtaacaa tattgagtgt gcaatagaat ttgcacaaaa tcacaaggac ggggcaggtg
     2701 gtgctgttga cttcaggatg ttttgtggct tgctccattt ctctgatgta ctagatcatg
     2761 gcagtgggag acctcaagtg tctgttggtg tttgtgtggc acttggtatt ttgttaccat
     2821 cttctcagtt ctcaggttgg gactttactt attgctgcag aacaggaaag gttagagagt
     2881 aagacttcag aatttattga gattgttgtt gttcaaacat tttatattag aattgacatg
     2941 taaagggagt gttgtagact gatacattgt attttctgta ttgtgaaata atttttaaat
     3001 gacaatgagt gacatttcaa aagatgttct ataacaatta tgtttattgc ttaaataaaa
     3061 atgtgcagtt tagtttagaa aacaatcttt tgaatttcag actgataacc ccagtatttt
     3121 cataatccca cattttgata atgtattgaa ttgccacttt ttatccataa aggcaaataa
     3181 ctaatttgag tgtagaataa tttgcactaa taattgtaaa tacttttact tttcaaatga
     3241 gtaaaaggtc taattccatg aaagactgaa aaggaactga acacctcata tagtgcagga
     3301 cagagttagc gtgtactgag ggtgattctg tcaaaacttt ctttactagg actttaaact
     3361 gtgtttacag attttatttt cattcattct acatgaaaag gtgtgtgtgt gtgtgtgtgt
     3421 atatatacac acacatatgt atacaggtta aatatattga ttagtatttt acatagtcat
     3481 acatttagag attttcaaaa ggttaaccac taatttcaca agtagtttct ctttgttctg
     3541 aattagaagt tttagttttc agcttatagc tccgtttcac actctgtaag tacactgttt
     3601 tctgtaggaa caagataacg atatatatag gatcatattc tttttctcca tttgccaaat
     3661 gagactaatg gttatttact actcttcaaa gtcttctgtt acccaaacat acagttaata
     3721 attatcaatt tatggagtgc atttggctaa aagtctgttt tgggcttact aaagggaatg
     3781 ccttcatagt aagtagtgtt tcctctgtta aaactgtgaa ctgctgtggt tagaccgtga
     3841 ttagtggtga caagtcttgc ttttaaaact ttttttgata ttggtaaggc ttcttgtttt
     3901 gttgttgttg ttgctattga ttttattttg tttttgtttg ttgattttcg cagtgatcag
     3961 ttactaaact accacagagc cacaccccca ccccaggttt tcagtttcat gaatcttttc
     4021 ttgatggaag acgtcatgct tgcttcagat gaactgtgtt ttatagtaag agtagtcatc
     4081 aggaggcact tttatttggt tggtgctttg catggtaaca aaatagtgat atttggataa
     4141 aaatttaggc cagaggtaag aattttctaa ttctttttaa gtcatgtttc ataggaactc
     4201 ccccagttgt gttcatgtcc atgggtcaga ccaaaatgtg ttccagtgcc taggacgcat
     4261 tctgagtgga tcagtccgtt tcagtgattt aacttgtatc actattaaac tgtatgcaat
     4321 tctgcacatc agctgtagtc agctctctgc ttgaagaagg ctcctgtcag cttcttccta
     4381 aatgttagta cagatgtcat tctgttatac tatccgccaa gatctcccac aactttttta
     4441 ttttggggga ggcacagaat tgattttctt gttctgagtt tgggttcatt cctgtcacgg
     4501 tcactgagcc aaggcaagta gaccttgcct cttcagtctt agtcctgcgg gcgtctgctc
     4561 agattctctt ccatattcaa aatgccctgg aaaagcttca ctgttttaat acgtcctaga
     4621 tgttcaactg aagcagagcg aagaaatggc cctcccagcc ccatccacct aaaacaaaac
     4681 cagcagctgc tgctacagcc attatgaaaa aataacacaa actcttctta aaaaatagat
     4741 cacacagaaa gaactgaggg cagatgcacc tggggggagg ggggggaggg ctgccccagc
     4801 cacggggaga ggcctgggtg ctgagatgac cctgcagggc tggggtgcta gtaggtggct
     4861 gcctccttcc ttctgcctag cctctgtagt gtgggctgga tcccaggcat cttctgccct
     4921 ctcccctgag ggatcctggc ccctgctgag gactggtacc tatttctcat taaagtggct
     4981 ttgatcagga aatgagatgg acaccaagca tgagtgaggg ccactgcctg gctacatgtc
     5041 tcccagcttt ttagaaatta acaaagttgc tttttaaaaa atgaaattta gcctacctaa
     5101 ttatactctg cattctgtta cctatagcta atcttgtttt tttccattac ttaatgattg
     5161 attggtgttc aatttcaaaa gtgttccaag ctccacagtg ttgggatgag gatgttgccg
     5221 ttatttttga gaaaaggatc gtaagatgtg cataacattg taggtagcat ggttttgtgc
     5281 agtgaacaca caagtaacta caggagctgc actcttcaca gtttgaactg acagtgctgg
     5341 cagaccctta aagcagagtc ttctgacaca cgaatgaaag gaaatatttg cttctaataa
     5401 cagtctgagc atttagatca tacttttaag tatttaaaca caccattgta tatggcaagc
     5461 aaacttttaa ttttattttt agcaagttta tttctctttg aaattgtcat tctacattaa
     5521 taacataaag attttaaact agaaccatac tgaacttttt taatgataag atgaaatgga
     5581 ctttaaagga aaaattattt aaaactttgt taataagcct caatagcata aaatactaat
     5641 gttaatcaaa atacttctaa gtatttttaa agtactttaa aaatctccat cgggctaatt
     5701 cctatgtatt tcttttccag gaatattatt cttaatagca taagcttatt aagactaaat
     5761 ggaagttgaa ggattaggca cacctagagc agtggcttca ccgtttgatt ctcatttctc
     5821 tgtggtttcc acctcttatc aggagctgcc ctggaaagga tccggtcatg ctgcctgcct
     5881 cttttcatct gtcatgatgg atttcatccc tttcacgggc ctctccatcc tctctttcca
     5941 catgggttgt gagcccagca ttcctgtctc tggcttcctg ggccactgct ctaagtttct
     6001 cttcatgctt cttttctttt tgagtcatct tactttctac ttgggcttgc atttccactg
     6061 ctgctcaagc cttctgatca gcaatgtata gtgtttcagc cagtttggca aatttttcac
     6121 ttatatggac catctgaagt cctcttccat cagcagctag ccatttatct aatggaatgg
     6181 tatacccctt agagttcttc cacttggaaa tacaaggagg gattttccac ttctgctgtt
     6241 tctttacagt catcttctga agaggagagt gcattacaag tgcaggagga gatgatggtc
     6301 cctgagggat tttcgtatta actttgaatc ttggatgctc catttggtct ttttgcattt
     6361 ctgctatcca gttaaccctg tttcgctcca gaattgaatg gtactccttc tgatgtggtg
     6421 tgtcactggt gagctgagac atgaaagatg actcattctt tctgagatag ggtttttctg
     6481 tgtagtcctg ggagctctgg aactctagac caggttggcc tagatcacat acccgcttgc
     6541 ctctgtctcc caagtcaaag gcagcaagga gagactactg tccatactga acttttaatg
     6601 agtctctggc tatacttgtg agtaaccagc ttcagttacg tgaatactgg ggactaagtg
     6661 ataatttatg tgtaagactg ctttgtatgt tttgtggttt tgtaatgtaa gtaaattgat
     6721 taacttttat ttcactgata ttaaccaatt gtgcagtgta caattaaaca ttcagtatcc
     6781 ctctttagaa ttgggtttgt gatcatggtg tggcttgtgg agcagaggac ttactttctc
     6841 atttgtcaaa ataggtattt gcagacaagg cttcgagaaa tatgtcgttg gattttttaa
     6901 atgtataata aagtccatga tttttataca gta
//
