LOCUS       NM_025825               2407 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus amyloid beta precursor protein binding protein 2
            (Appbp2), mRNA.
ACCESSION   NM_025825
VERSION     NM_025825.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Wang,Q., Li,H., Tajima,K., Verkerke,A.R.P., Taxin,Z.H., Hou,Z.,
            Cole,J.B., Li,F., Wong,J., Abe,I., Pradhan,R.N., Yamamuro,T.,
            Yoneshiro,T., Hirschhorn,J.N. and Kajimura,S.
  TITLE     Post-translational control of beige fat biogenesis by PRDM16
            stabilization
  JOURNAL   Nature 609 (7925), 151-158 (2022)
   PUBMED   35978186
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Reynard,L.N., Cocquet,J. and Burgoyne,P.S.
  TITLE     The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an
            abundant spermatid protein that interacts with a histone
            acetyltransferase and an acrosomal protein
  JOURNAL   Biol Reprod 81 (2), 250-257 (2009)
   PUBMED   19176879
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Darbinian,N., Cui,J., Basile,A., Del Valle,L., Otte,J.,
            Miklossy,J., Sawaya,B.E., Amini,S., Khalili,K. and Gordon,J.
  TITLE     Negative regulation of AbetaPP gene expression by pur-alpha
  JOURNAL   J Alzheimers Dis 15 (1), 71-82 (2008)
   PUBMED   18780968
  REMARK    GeneRIF: amyloid beta precursor protein gene is associated with
            Alzheimer's disease
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Yang,J. and Li,T.
  TITLE     The ciliary rootlet interacts with kinesin light chains and may
            provide a scaffold for kinesin-1 vesicular cargos
  JOURNAL   Exp Cell Res 309 (2), 379-389 (2005)
   PUBMED   16018997
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 2407)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL596183.11.
            
            On Mar 21, 2007 this sequence version replaced NM_025825.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019152.1, AK133853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AL596183.11        136463-136911       c
            450-538             AL596183.11        118227-118315       c
            539-690             AL596183.11        116901-117052       c
            691-814             AL596183.11        116027-116150       c
            815-983             AL596183.11        111731-111899       c
            984-1073            AL596183.11        106025-106114       c
            1074-1141           AL596183.11        103394-103461       c
            1142-1247           AL596183.11        103207-103312       c
            1248-1372           AL596183.11        102085-102209       c
            1373-1458           AL596183.11        99857-99942         c
            1459-1649           AL596183.11        97857-98047         c
            1650-1815           AL596183.11        96366-96531         c
            1816-2407           AL596183.11        93099-93690         c
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..2407
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /note="amyloid beta precursor protein binding protein 2"
                     /db_xref="GeneID:66884"
                     /db_xref="MGI:MGI:1914134"
     exon            1..449
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2069
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /note="APP-BP2; amyloid beta precursor protein
                     (cytoplasmic tail) binding protein 2"
                     /codon_start=1
                     /product="amyloid protein-binding protein 2"
                     /protein_id="NP_080101.1"
                     /db_xref="CCDS:CCDS25193.1"
                     /db_xref="GeneID:66884"
                     /db_xref="MGI:MGI:1914134"
                     /translation="MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVY
                     YKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFS
                     RRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWF
                     RAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFA
                     KSHYDEAYKWCVEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLA
                     RDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHE
                     DLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAID
                     CHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEE
                     MHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGE
                     GYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSSSPQS
                     TEEVVQSFLMAQNVEGPSC"
     exon            450..538
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..690
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..814
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..983
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1073
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1141
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1247
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1372
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1458
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1649
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1815
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..2407
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="Appbp2"
                     /gene_synonym="1300003O07Rik; PAT1"
                     /note="major polyA site"
ORIGIN      
        1 ccgcccatgc agagctgaga gcctggacgg aactgggctc gctctcctgt tgggaatgtg
       61 aggctctcgg tacggtcgtg gtctgcgttc gtccggatct tccgtggccg ccgctaccgc
      121 cgctaccgcc agcaccatct gccctcaggc cgcgcgcgca cgcagaggcc cggcagccgg
      181 gtccgagagg cgcgcgcacg cccgctcgcc cgcgtggtcg ccgcccctcg gaagcctccg
      241 gagcctcaca cgggttcgct acggagggag gcggaggcct gcgggaggag gcggaggagg
      301 agcgagggaa gatggcggcc gtggagctcg agtggatccc ggagacgctc tacaacaccg
      361 ccatctccgc tgtcgtggac aactacatcc gctcgcgccg cgacatccgc tccttgccgg
      421 agaatatcca gttcgacgtt tactacaagc tttaccaaca gggacgcttg tgtcagctcg
      481 gcagtgaatt ctgtgaattg gaagtttttg ctaaagtttt gagagctttg gataaaagac
      541 atttgctcca ccactgtttt caggctctga tggaccatgg cgttaaggta gcttccgtct
      601 tggcctactc cttcagtaga cggtgctctt acatagcaga gtccgacgct gcagtaaagg
      661 agaaggccat ccaggttggc tttgtcttag gtggctttct ttctgatgca ggctggtaca
      721 gtgatgctga aaaggttttt ctgtcctgcc ttcagttgtg tacgctacat gatgagatgc
      781 tccactggtt ccgagcagtg gagtgttgtg tgaggttgct tcatgtgcga aatggaaatt
      841 gtaaatatca tctaggtgaa gaaacattta aattagctca gacatacatg gataagctgt
      901 ctaaacatgg ccagcaagca aatagagctg ctctctacgg agaactatgt gcactcctgt
      961 ttgcaaaaag ccactatgat gaggcataca agtggtgcgt tgaggcaatg aaggaaatta
     1021 cagcaggctt accagtcaaa gttgtggtgg atgttttaag acaagcttct aaggcttgtg
     1081 tagtcaaacg tgaatttaag aaggcagaac agttaattaa acatgcagtg tatttggcac
     1141 gagatcattt cggatccaaa cacccaaaat actctgacac actgctagat tatgggttct
     1201 acttactcaa tgtagacaat atctgtcagt ctgttgcaat ttaccaggca gccctcgaca
     1261 ttcgacagtc agtgtttggt ggcaaaaata ttcatgtagc aacagctcat gaagacctgg
     1321 cctactcttc ctacgttcac cagtacagct ctggaaaatt cgacaatgca ctatttcatg
     1381 cagaaagagc cattggtatc attactcaca tcctacctga agatcatctt cttctggctt
     1441 cttcaaagag ggtgaaagca cttattctag aggagattgc gattgactgt cacaacaagg
     1501 agacggagca gcggctgctt caggaggcac acgacttgca cttgtcttcg ctgcagctgg
     1561 ctaagaaagc atttggggaa tttaatgtac agactgcaaa gcactatggg aacctcggaa
     1621 ggctctatca gtcaatgaga aaatttaagg aagctgaaga aatgcacata aaagcaattc
     1681 agattaagga gcagctcctt ggccaagaag attatgaagt ggccctttca gtgggacacc
     1741 tggcatctct gtataattat gacatgaatc agtatgaaaa tgctgagaaa ctgtacctgc
     1801 ggtcgatagc cattgggaag aaactgtttg gtgaaggcta cagtggacta gaatatgatt
     1861 accggggcct cattaaactt tacaactcca ttgggaatta tgagaaagtg ttcgagtatc
     1921 acaacgttct gtctaactgg aaccggttgc gagatcgaca gtattcagtg accgatgccc
     1981 ttgaagacgt cagcagcagc ccccagtcca ctgaagaagt ggtgcagtcc tttctgatgg
     2041 ctcagaatgt tgagggacca agctgctgag ggacagcctc agctaacaat tacctttccc
     2101 agattccggg gaattcatac tgtgaaatca aaccatgttg tttttagggc tggcatttgc
     2161 attgaaacac tggtccagtc cacccaagac cctatttcgg gtagtcctgt attgcagttc
     2221 ctgtagaata agcatatatt gagttatatc agcatgtgcc gcgtgtataa gtagtcccac
     2281 attctcaccc cagtagaaca acaggaaacc gttttttttt tctttttaaa aaataattcg
     2341 tttttcagaa agtctgaaag aaaaaaaaaa aaagaacccc taaataaaac tatttaagag
     2401 tttaaaa
//
