LOCUS       NM_001198823            3377 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus amyloid beta precursor protein (App), transcript
            variant 1, mRNA.
ACCESSION   NM_001198823
VERSION     NM_001198823.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3377)
  AUTHORS   Sasmita,A.O., Ong,E.C., Nazarenko,T., Mao,S., Komarek,L.,
            Thalmann,M., Hantakova,V., Spieth,L., Berghoff,S.A., Barr,H.J.,
            Hingerl,M., Borensen,F., Hirrlinger,J., Simons,M., Stevens,B.,
            Depp,C. and Nave,K.A.
  TITLE     Parental origin of transgene modulates amyloid-beta plaque burden
            in the 5xFAD mouse model of Alzheimer's disease
  JOURNAL   Neuron (2025) In press
   PUBMED   39837326
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3377)
  AUTHORS   Sasaki,K., Fujita,H., Sato,T., Kato,S., Takahashi,Y., Takeshita,Y.,
            Kanda,T., Saito,T., Saido,T.C., Hattori,S., Hozumi,Y., Yamada,Y.
            and Waki,H.
  TITLE     GLP-1 receptor signaling restores aquaporin 4 subcellular
            polarization in reactive astrocytes and promotes amyloid beta
            clearance in a mouse model of Alzheimer's disease
  JOURNAL   Biochem Biophys Res Commun 741, 151016 (2024)
   PUBMED   39577079
REFERENCE   3  (bases 1 to 3377)
  AUTHORS   Baligacs,N., Albertini,G., Borrie,S.C., Serneels,L., Pridans,C.,
            Balusu,S. and De Strooper,B.
  TITLE     Homeostatic microglia initially seed and activated microglia later
            reshape amyloid plaques in Alzheimer's Disease
  JOURNAL   Nat Commun 15 (1), 10634 (2024)
   PUBMED   39639016
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3377)
  AUTHORS   Miller,S.R., Luxem,K., Lauderdale,K., Nambiar,P., Honma,P.S.,
            Ly,K.K., Bangera,S., Bullock,M., Shin,J., Kaliss,N., Qiu,Y.,
            Cai,C., Shen,K., Mallen,K.D., Yan,Z., Mendiola,A.S., Saito,T.,
            Saido,T.C., Pico,A.R., Thomas,R., Roberson,E.D., Akassoglou,K.,
            Bauer,P., Remy,S. and Palop,J.J.
  TITLE     Machine learning reveals prominent spontaneous behavioral changes
            and treatment efficacy in humanized and transgenic Alzheimer's
            disease models
  JOURNAL   Cell Rep 43 (11), 114870 (2024)
   PUBMED   39427315
REFERENCE   5  (bases 1 to 3377)
  AUTHORS   AlQot,H.E. and Rylett,R.J.
  TITLE     Primate-specific 82-kDa choline acetyltransferase attenuates
            progression of Alzheimer's disease-like pathology in the APPNL-G-F
            knock-in mouse model
  JOURNAL   Sci Rep 14 (1), 27614 (2024)
   PUBMED   39528509
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3377)
  AUTHORS   Violette,S.M., Shashikant,C.S., Salbaum,J.M., Belting,H.G.,
            Wang,J.C. and Ruddle,F.H.
  TITLE     Repression of the beta-amyloid gene in a Hox-3.1-producing cell
            line
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3805-3809 (1992)
   PUBMED   1349171
REFERENCE   7  (bases 1 to 3377)
  AUTHORS   Fukuchi,K., Deeb,S.S., Kamino,K., Ogburn,C.E., Snow,A.D.,
            Sekiguchi,R.T., Wight,T.N., Piussan,H. and Martin,G.M.
  TITLE     Increased expression of beta-amyloid protein precursor and
            microtubule-associated protein tau during the differentiation of
            murine embryonal carcinoma cells
  JOURNAL   J Neurochem 58 (5), 1863-1873 (1992)
   PUBMED   1560239
REFERENCE   8  (bases 1 to 3377)
  AUTHORS   Izumi,R., Yamada,T., Yoshikai,S., Sasaki,H., Hattori,M. and
            Sakaki,Y.
  TITLE     Positive and negative regulatory elements for the expression of the
            Alzheimer's disease amyloid precursor-encoding gene in mouse
  JOURNAL   Gene 112 (2), 189-195 (1992)
   PUBMED   1555768
REFERENCE   9  (bases 1 to 3377)
  AUTHORS   Goate,A., Chartier-Harlin,M.C., Mullan,M., Brown,J., Crawford,F.,
            Fidani,L., Giuffra,L., Haynes,A., Irving,N., James,L. et al.
  TITLE     Segregation of a missense mutation in the amyloid precursor protein
            gene with familial Alzheimer's disease
  JOURNAL   Nature 349 (6311), 704-706 (1991)
   PUBMED   1671712
REFERENCE   10 (bases 1 to 3377)
  AUTHORS   McAdam,K.P., Anders,R.F., Aiken,G. and Takitaki,F.F.
  TITLE     Secondary amyloidosis and the serum amyloid precursor in leprosy:
            geographical variation and association with leukocytosis
  JOURNAL   Int J Lepr Other Mycobact Dis 45 (2), 150-157 (1977)
   PUBMED   561759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK128971.1, AK159718.1, BC070409.1 and BP753972.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY267348.1, SRR11927932.2802707.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AK128971.1         1-79
            80-2058             AK159718.1         66-2044
            2059-3350           BC070409.1         1830-3121
            3351-3377           BP753972.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..3377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 46.92 cM"
     gene            1..3377
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /note="amyloid beta precursor protein"
                     /db_xref="GeneID:11820"
                     /db_xref="MGI:MGI:88059"
     exon            1..206
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2462
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; appican; amyloid beta A4 protein; amyloidogenic
                     glycoprotein; alzheimer disease amyloid A4 protein
                     homolog; protease nexin II; amyloid precursor protein;
                     beta-amyloid precursor protein; alzheimer disease amyloid
                     protein; amyloid beta (A4) precursor protein"
                     /codon_start=1
                     /product="amyloid-beta precursor protein isoform 1
                     precursor"
                     /protein_id="NP_001185752.1"
                     /db_xref="CCDS:CCDS88958.1"
                     /db_xref="GeneID:11820"
                     /db_xref="MGI:MGI:88059"
                     /translation="MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMH
                     MNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
                     KQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSE
                     KSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSVDSADAEEDDSDVWWGGADTDYA
                     DGGEDKVVEVAEEEEVADVEEEEADDDEDVEDGDEVEEEAEEPYEEATERTTSTATTT
                     TTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCVPFFYGGCGGNRNNFDTE
                     EYCMAVCGSVSTQSLLKTTSEPLPQDPDKLPTTAASTPDAVDKYLETPGDENEHAHFQ
                     KAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER
                     QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHT
                     LKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELL
                     QKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPF
                     GVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFE
                     VRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDA
                     AVTPEERHLSKMQQNGYENPTYKFFEQMQN"
     exon            207..374
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            375..504
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            505..617
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            618..811
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1014
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1182
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1239
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1373
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1448
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1607
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1736
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1836
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2058
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2112
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2213
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2360
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..3357
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /note="hexamer: AATAAA"
     regulatory      3336..3341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3350
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
     polyA_site      3355
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtttcc tcggcggcgg gaggcgagag caccgggagc agagcgagcg cggggccacc
       61 ggagacggcg gcggcggcgc ggacacagcc agggcgcggc ggatcttcca ctcgcacacg
      121 gagcactcgg tggcccacgc aggatcacga tgctgcccag cttggcactg ctcctgctgg
      181 ccgcctggac ggttcgggct ctggaggtac ccactgatgg caacgccggg ctgctggcag
      241 aaccccagat cgccatgttc tgtggtaaac tcaacatgca catgaatgtg cagaatggaa
      301 agtgggagtc agacccgtca gggaccaaaa cctgcattgg caccaaggag ggcatcttgc
      361 agtactgcca agaggtctac cctgaactgc agatcacaaa cgtggtggaa gccaaccagc
      421 cagtgaccat ccagaactgg tgcaagcggg gccgcaagca gtgcaagaca cacacccaca
      481 tcgtgattcc ttaccgttgc ctagttggtg agtttgtgag cgacgccctt ctcgtgcccg
      541 acaagtgcaa gttcctacac caggagcgga tggatgtttg tgagacccat cttcactggc
      601 acaccgtcgc caaagagaca tgcagcgaga agagcactaa cttgcacgac tatggcatgc
      661 tgctgccctg cggcatcgac aagttccgag gggtagagtt tgtatgctgc ccgttggccg
      721 aggaaagcga cagcgtggat tctgcggatg cagaggagga tgactctgat gtctggtggg
      781 gtggagcgga cacagactac gctgatggcg gtgaagacaa agtagtagaa gtcgccgaag
      841 aggaggaagt ggctgatgtt gaggaagagg aagctgatga tgatgaggat gtggaggatg
      901 gggacgaggt ggaggaggag gccgaggagc cctacgaaga ggccaccgag agaacaacca
      961 gcactgccac caccaccaca accaccactg agtccgtgga ggaggtggtc cgagaggtgt
     1021 gctctgaaca agccgagacc gggccatgcc gcgcaatgat ctcccgctgg tactttgatg
     1081 tcactgaagg gaagtgtgtc ccattctttt acggcggatg tggcggcaac aggaacaact
     1141 ttgacacgga agagtactgc atggcggtgt gtggcagcgt gtcaacccaa agtttactca
     1201 agactaccag tgaacctctt ccccaagatc ctgataaact tcccacgaca gcagccagca
     1261 cccccgacgc cgtcgacaag tacctggaga cacccgggga cgagaacgag catgcccatt
     1321 tccagaaagc caaagagagg ctggaagcca agcaccgaga gagaatgtcc caggtcatga
     1381 gagaatggga agaggcagag cgtcaagcca agaacttgcc caaagctgac aagaaggccg
     1441 ttatccagca tttccaggag aaagtggaat ctctggaaca ggaagcagcc aatgagagac
     1501 agcagcttgt agagacacac atggccagag ttgaagccat gctcaatgac cgccgccgcc
     1561 tggccctcga gaattacatc actgcactgc aggcggtgcc cccaaggcct catcatgtgt
     1621 tcaacatgct gaagaagtac gtccgtgcgg agcagaaaga cagacagcac accctaaagc
     1681 attttgaaca tgtgcgcatg gtggacccca agaaagctgc tcagatccgg tcccaggtta
     1741 tgacacacct ccgtgtgatc tacgagcgca tgaaccagtc tctgtccctg ctctacaatg
     1801 tccctgcggt ggctgaggag attcaagatg aagtcgatga gctgcttcag aaggagcaga
     1861 actactccga cgatgtcttg gccaacatga tcagtgagcc cagaatcagc tacggaaacg
     1921 acgctctcat gccttcgctg acggaaacca agaccaccgt ggagctcctt cccgtgaatg
     1981 gggaattcag cctggatgac ctccagccgt ggcacccttt tggggtggac tctgtgccag
     2041 ccaataccga aaatgaagtc gagcctgttg acgcccgccc cgctgctgac cgaggactga
     2101 ccactcgacc aggttctggg ctgacaaaca tcaagacgga agagatctcg gaagtgaaga
     2161 tggatgcaga attcggacat gattcaggat ttgaagtccg ccatcaaaaa ctggtgttct
     2221 ttgctgaaga tgtgggttcg aacaaaggcg ccatcatcgg actcatggtg ggcggcgttg
     2281 tcatagcaac cgtgattgtc atcaccctgg tgatgttgaa gaagaaacag tacacatcca
     2341 tccatcatgg cgtggtggag gtcgacgccg ccgtgacccc agaggagcgc catctctcca
     2401 agatgcagca gaacggatat gagaatccaa cttacaagtt ctttgagcaa atgcagaact
     2461 aagccccacc cgcgccacag cagcggcctc tgaacttgga cagcgaaacc attgcttcac
     2521 tacccatcgg tgttcattta taaaataacg tggaaagaaa caaacccttc cgtttattta
     2581 ctcaccctcg gcttttgaca gctgtgctgt aacacaagta gatgcctgaa cttgaattaa
     2641 tatacaaatc agtaatgtat tctcgctttc tctctttaca ttctggtctc tacattacat
     2701 gattcatggg ttttgtgtac tgtaaaaaaa aaaattagct gtatcaaact agtgcatgaa
     2761 tagattctct cctaattatt tatcacatac atagcccctt agcccgttgt atattattct
     2821 tgtggtttgt ggcccggaaa aaactcctac ttgaaatatg ctttaaaaat cgatggggga
     2881 tgcttcttgt gaacgtgggc gtctagctgc ttctcctacg tattcttttc ctgatcacta
     2941 tgcattttga acattttttt aagtattcca aatgacttag aaaattcttt ttccatgact
     3001 gcatcttact gtacagattg ctgcttctgc tctctttgtg atataggaat aagaggatac
     3061 acattgattt ctttgtgcct gttttatgtg cacacattag gcattgagaa tttgaacatt
     3121 ttttttgtcc atgtatcttt ggatctttga taaaaaaaaa ttaaaaaaaa attatccctg
     3181 ttcatcataa gcacttttac gggtgggggg agggagtgtt ctgctggtct ccaattacca
     3241 agaattctcc aaaaattaat tttctgcagg atgattgtac agaatcattg cttatgccat
     3301 gatagctttc tacactgtat tacataaata aattaaataa aataactcca ggcaagaaaa
     3361 aaaaaaaaaa aaaaaaa
//
