LOCUS       NM_026673                935 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus apolipoprotein O (Apoo), transcript variant 1, mRNA.
ACCESSION   NM_026673 XM_904889
VERSION     NM_026673.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Chen,J., Hu,J., Guo,X., Yang,Y., Qin,D., Tang,X., Huang,Z.,
            Wang,F., Hu,D., Peng,D. and Yu,B.
  TITLE     Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3
            independent of LDL receptor
  JOURNAL   Cell Death Dis 15 (6), 389 (2024)
   PUBMED   38830896
  REMARK    GeneRIF: Apolipoprotein O modulates cholesterol metabolism via
            NRF2/CYB5R3 independent of LDL receptor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 935)
  AUTHORS   Tang,X., Huang,Z., Wang,F., Chen,J., Qin,D., Peng,D. and Yu,B.
  TITLE     Macrophage-specific deletion of MIC26 (APOO) mitigates advanced
            atherosclerosis by increasing efferocytosis
  JOURNAL   Atherosclerosis 386, 117374 (2023)
   PUBMED   37995600
  REMARK    GeneRIF: Macrophage-specific deletion of MIC26 (APOO) mitigates
            advanced atherosclerosis by increasing efferocytosis.
REFERENCE   4  (bases 1 to 935)
  AUTHORS   Guo,X., Hu,J., He,G., Chen,J., Yang,Y., Qin,D., Li,C., Huang,Z.,
            Hu,D., Wei,C., Wang,F. and Yu,B.
  TITLE     Loss of APOO (MIC26) aggravates obesity-related whitening of brown
            adipose tissue via PPARalpha-mediated functional interplay between
            mitochondria and peroxisomes
  JOURNAL   Metabolism 144, 155564 (2023)
   PUBMED   37088120
  REMARK    GeneRIF: Loss of APOO (MIC26) aggravates obesity-related whitening
            of brown adipose tissue via PPARalpha-mediated functional interplay
            between mitochondria and peroxisomes.
REFERENCE   5  (bases 1 to 935)
  AUTHORS   Mostofa,M.G., Tran,M., Gilling,S., Lee,G., Fraher,O., Jin,L.,
            Kang,H., Park,Y.K., Lee,J.Y., Wang,L. and Shin,D.J.
  TITLE     MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O
            functions to modulate lipid homeostasis in alcoholic fatty liver
            disease
  JOURNAL   J Biol Chem 298 (6), 101966 (2022)
   PUBMED   35460694
  REMARK    GeneRIF: MicroRNA-200c coordinates HNF1 homeobox B and
            apolipoprotein O functions to modulate lipid homeostasis in
            alcoholic fatty liver disease.
REFERENCE   6  (bases 1 to 935)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   7  (bases 1 to 935)
  AUTHORS   Turkieh,A., Caubere,C., Barutaut,M., Desmoulin,F., Harmancey,R.,
            Galinier,M., Berry,M., Dambrin,C., Polidori,C., Casteilla,L.,
            Koukoui,F., Rouet,P. and Smih,F.
  TITLE     Apolipoprotein O is mitochondrial and promotes lipotoxicity in
            heart
  JOURNAL   J Clin Invest 124 (5), 2277-2286 (2014)
   PUBMED   24743151
  REMARK    GeneRIF: APOO represents a link between impaired mitochondrial
            function and cardiomyopathy onset, and targeting APOO-dependent
            metabolic remodeling has potential as a strategy to adjust heart
            metabolism and protect the myocardium from impaired contractility.
REFERENCE   8  (bases 1 to 935)
  AUTHORS   Nijstad,N., de Boer,J.F., Lagor,W.R., Toelle,M., Usher,D.,
            Annema,W., der Giet,Mv., Rader,D.J. and Tietge,U.J.
  TITLE     Overexpression of apolipoprotein O does not impact on plasma HDL
            levels or functionality in human apolipoprotein A-I transgenic mice
  JOURNAL   Biochim Biophys Acta 1811 (4), 294-299 (2011)
   PUBMED   21296681
  REMARK    GeneRIF: Overexpression of apolipoprotein O does not impact on
            plasma HDL levels or functionality in human apolipoprotein A-I
            transgenic mice.
REFERENCE   9  (bases 1 to 935)
  AUTHORS   Lamant,M., Smih,F., Harmancey,R., Philip-Couderc,P., Pathak,A.,
            Roncalli,J., Galinier,M., Collet,X., Massabuau,P., Senard,J.M. and
            Rouet,P.
  TITLE     ApoO, a novel apolipoprotein, is an original glycoprotein
            up-regulated by diabetes in human heart
  JOURNAL   J Biol Chem 281 (47), 36289-36302 (2006)
   PUBMED   16956892
  REMARK    GeneRIF: apolipoprotein O is the first chondroitin sulfate chain
            containing apolipoprotein
REFERENCE   10 (bases 1 to 935)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EL957008.1, CB595096.1, BU534555.1 and DV662362.1.
            
            On Dec 4, 2010 this sequence version replaced NM_026673.3.
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring transcript. Variant 1 encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: C88728.1, CV674789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                EL957008.1         1-24
            25-740              CB595096.1         14-729
            741-917             BU534555.1         171-347
            918-935             DV662362.1         602-619
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 41.56 cM"
     gene            1..935
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /note="apolipoprotein O"
                     /db_xref="GeneID:68316"
                     /db_xref="MGI:MGI:1915566"
     exon            1..53
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..641
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MICOS complex subunit Mic23; MICOS complex
                     subunit Mic26"
                     /codon_start=1
                     /product="MICOS complex subunit Mic26 isoform 1 precursor"
                     /protein_id="NP_080949.2"
                     /db_xref="CCDS:CCDS53136.1"
                     /db_xref="GeneID:68316"
                     /db_xref="MGI:MGI:1915566"
                     /translation="MFKVIQRSVGPASLSLLTFRVYAAPKKDSPHKSYMKIDELSLYS
                     VPEGQSKYVEEPRTQLEENISQLRHHCEPYTSFCQEIYSHTKPKVDHFVQWGVDNYNY
                     LQNAPPGFFPRLGVIGFAGFVGLLFARGSKIKKLVYPPFFMGLGASVYYPQQAITIAQ
                     ITGEKLYDWGLRGYIVIEDLWKQNFQKPGNVKNSPGNK"
     exon            54..161
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            162..281
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            282..336
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            337..432
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            433..524
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            525..605
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            606..671
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
     exon            672..923
                     /gene="Apoo"
                     /gene_synonym="0610008C08Rik; 1110019O03Rik; Micos26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaagggag gggtgaccct gccggagccg cggctgccag cgacatgttc aaggtaattc
       61 agagatctgt ggggccagcc agcctgagcc tgctcacctt cagagtctat gcagcaccca
      121 aaaaggactc gcctcacaaa agttacatga agatcgatga gctttcactc tactcagttc
      181 ctgagggtca atctaaatat gtggaggagc caaggactca acttgaagaa aacatctcac
      241 aactccgaca tcattgtgag ccatatacaa gtttctgtca ggaaatatac tcccatacta
      301 aacccaaggt ggatcacttt gtccagtggg gagtagacaa ctataactat cttcaaaatg
      361 cgcctcctgg atttttccca agactcggtg ttattggttt tgctggtttt gttggactcc
      421 tttttgctag aggttcaaaa ataaagaagc tggtgtatcc tccttttttc atgggattag
      481 gtgcctctgt ctattaccca caacaagcca tcaccattgc ccagatcact ggggagaagt
      541 tatatgactg gggattacga gggtacatag ttatagaaga tttgtggaag caaaattttc
      601 agaagccagg aaatgtgaag aattcacctg gaaataaata gaaaactcca tgctctgccc
      661 atttcaatca gttataggta aacattggaa acttcagaca gtaaatcagt atttctacag
      721 acaaatggcg aaatcagtat tggatatagt aaactggctt tcttcaggaa aaacaacact
      781 aagccttttt gctcttttgg gtgatgccat attacaggcc aactaatctg caatctttca
      841 catggaaata atgtacaagc cttagaactc ctcattctta taccactatt tatgtacata
      901 attaaactcc agattccaac aaaaaaaaaa aaaaa
//
