LOCUS       NM_018816                764 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus apolipoprotein M (Apom), mRNA.
ACCESSION   NM_018816
VERSION     NM_018816.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Bisgaard,L.S., Christensen,P.M., Oh,J., Torta,F., Fuchtbauer,E.M.,
            Nielsen,L.B. and Christoffersen,C.
  TITLE     Kidney derived apolipoprotein M and its role in acute kidney injury
  JOURNAL   Front Pharmacol 15, 1328259 (2024)
   PUBMED   38313311
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Kurano,M., Uranbileg,B. and Yatomi,Y.
  TITLE     Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis
            through activating S1P1 and S1P4
  JOURNAL   Biomed Pharmacother 166, 115400 (2023)
   PUBMED   37657263
  REMARK    GeneRIF: Apolipoprotein M bound sphingosine 1-phosphate suppresses
            NETosis through activating S1P1 and S1P4.
REFERENCE   4  (bases 1 to 764)
  AUTHORS   Kurano,M., Tsukamoto,K., Shimizu,T., Hara,M. and Yatomi,Y.
  TITLE     Apolipoprotein M/sphingosine 1-phosphate protects against diabetic
            nephropathy
  JOURNAL   Transl Res 258, 16-34 (2023)
   PUBMED   36805561
  REMARK    GeneRIF: Apolipoprotein M/sphingosine 1-phosphate protects against
            diabetic nephropathy.
REFERENCE   5  (bases 1 to 764)
  AUTHORS   Kuo,A., Checa,A., Niaudet,C., Jung,B., Fu,Z., Wheelock,C.E.,
            Singh,S.A., Aikawa,M., Smith,L.E., Proia,R.L. and Hla,T.
  TITLE     Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is
            required for vascular development and systemic sphingolipid
            homeostasis
  JOURNAL   Elife 11, e78861 (2022)
   PUBMED   36197001
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 764)
  AUTHORS   Faber,K., Axler,O., Dahlback,B. and Nielsen,L.B.
  TITLE     Characterization of apoM in normal and genetically modified mice
  JOURNAL   J Lipid Res 45 (7), 1272-1278 (2004)
   PUBMED   15102887
  REMARK    GeneRIF: apoM mainly associates with HDL in normal mice but also
            with the pathologically increased lipoprotein fraction in
            genetically modified mice; decreased apoM levels in
            apoA-I-deficient mice suggest a connection between apoM and apoA-I
            metabolism.
REFERENCE   7  (bases 1 to 764)
  AUTHORS   Zhang,X.Y., Jiao,G.Q., Hurtig,M., Dong,X., Zheng,L., Luo,G.H.,
            Nilsson-Ehle,P., Ye,Q. and Xu,N.
  TITLE     Expression pattern of apolipoprotein M during mouse and human
            embryogenesis
  JOURNAL   Acta Histochem 106 (2), 123-128 (2004)
   PUBMED   15147633
  REMARK    GeneRIF: ApoM transcripts were detectable in mouse embryos from day
            7.5 to day 18.5
REFERENCE   8  (bases 1 to 764)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   9  (bases 1 to 764)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   10 (bases 1 to 764)
  AUTHORS   Xu,N. and Dahlback,B.
  TITLE     A novel human apolipoprotein (apoM)
  JOURNAL   J Biol Chem 274 (44), 31286-31290 (1999)
   PUBMED   10531326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            On Jan 22, 2019 this sequence version replaced NM_018816.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF207820.1, BC021597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               CR974444.18        67605-67796         c
            193-347             CR974444.18        67190-67344         c
            348-427             CR974444.18        66834-66913         c
            428-526             CR974444.18        66403-66501         c
            527-625             CR974444.18        66075-66173         c
            626-764             CR974444.18        64992-65130         c
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     gene            1..764
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /note="apolipoprotein M"
                     /db_xref="GeneID:55938"
                     /db_xref="MGI:MGI:1930124"
     exon            1..192
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            193..347
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            348..427
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            428..526
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            527..625
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /inference="alignment:Splign:2.1.0"
     exon            626..764
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /note="hexamer: AATAAA"
     polyA_site      764
                     /gene="Apom"
                     /gene_synonym="1190010O19Rik; G3a; NG20"
                     /note="major polyA site"
ORIGIN      
        1 agagtagacc gagcggccat cagagaacag ttaaggcgga ggtcccctca actgcagagc
       61 accaactctc atcccgagat gttccaccaa gtttgggcag ctctgctctc tctctatggc
      121 cttctcttta actccatgaa tcagtgccct gagcacagtc aactaactgc gctgggaatg
      181 gacgacacag agaccccaga gccccacctg ggcctgtggt actttattgc gggagcagcc
      241 tccaccacgg aagagttggc aacttttgat ccggtggaca atattgtctt caacatggct
      301 gccggctctg ccccaaggca gctccagctt cgtgctacca tccgcacgaa aagtggggtc
      361 tgtgtgcccc ggaagtggac ataccgattg actgaaggga aaggaaacat ggaactcaga
      421 actgaagggc gcccagacat gaaaacagac ctgttctcca gctcgtgccc aggaggaatc
      481 atgctgaaag agacgggcca gggctaccag cgctttctcc tctacaatcg gtcaccacac
      541 cctccagaga agtgtgtgga ggaattccag tctctgacct cttgcttgga cttcaaagcc
      601 ttcttagtga ctcccaggaa tcaagaggcc tgcccgctgt ccagcaagtg accagtgact
      661 tcacccgtgt cctagacaga caagatagga gcccagcttc gagtggagaa gccagcgact
      721 cctgccccct ctcgtggata ataaagatga tttgtcagtc ctca
//
