LOCUS       NM_173743               1509 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus apolipoprotein L 9b (Apol9b), transcript variant 2,
            mRNA.
ACCESSION   NM_173743
VERSION     NM_173743.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1509)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1509)
  AUTHORS   Kreit,M., Paul,S., Knoops,L., De Cock,A., Sorgeloos,F. and
            Michiels,T.
  TITLE     Inefficient type I interferon-mediated antiviral protection of
            primary mouse neurons is associated with the lack of apolipoprotein
            l9 expression
  JOURNAL   J Virol 88 (7), 3874-3884 (2014)
   PUBMED   24453359
  REMARK    GeneRIF: Authors identified a new antiviral protein induced by
            interferon, ApoL9b, whose lack of expression in primary neurons
            likely contributes to the high sensitivity of these cells to viral
            infection.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050167.1 and BF148017.1.
            
            On Dec 12, 2009 this sequence version replaced NM_173743.3.
            
            Transcript Variant: This variant (2) uses a different splice site
            and segment for its 5' UTR compared to variant 1. Both variants
            encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050167.1, BI694000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1129              AK050167.1         3-1131
            1130-1509           BF148017.1         1-380               c
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.75 cM"
     gene            1..1509
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /note="apolipoprotein L 9b"
                     /db_xref="GeneID:71898"
                     /db_xref="MGI:MGI:1919148"
     exon            1..77
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            78..203
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1053
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /codon_start=1
                     /product="apolipoprotein L 9b"
                     /protein_id="NP_776104.1"
                     /db_xref="CCDS:CCDS27604.1"
                     /db_xref="GeneID:71898"
                     /db_xref="MGI:MGI:1919148"
                     /translation="MASSGYLYSLVAEDGAWQAFVSKAKLSRERAVALHKALRELTAL
                     LAIADRGRLQKGLKGREKFLKVFPRLKAELVEHISQLHALADHAEKLHRGCTISNVVA
                     DSFSAASDILSLLGLFLAPVTAEGSLVLSATGLGLGVAATVTDVATSIVEETSRVLDE
                     VEAALTGTHVLGEAGTSVARIVNKIPQATRDITRDLEALEQHMNALRLVRANPRLEED
                     ARILATTGSISAQRAMQVRARLEGTPLAMSNEARIQRAATAGAALWSDVDSLVKESKH
                     LYEGSASESAEALRKLARELEEKLEGLMEFYKTI"
     exon            204..1497
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1473..1478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="Apol9b"
                     /gene_synonym="2310016F22Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggctgctt tccttgtgac tcagaggtgc agctgccaac tgcatctgcg aagccaaggc
       61 catctgggtc ctgttagaga gcagacacac catccaggga gccactgggt atctcagaac
      121 atggcaagca gtggatacct gtatagcctg gtggctgaag atggagcctg gcaggcgttt
      181 gtatccaagg ccaagttgtc cagggagaga gcagtggccc tccacaaagc tctgagggaa
      241 ctgacagcgc tcttggccat agcagacaga ggcagacttc aaaaaggtct gaaaggcagg
      301 gagaagtttt tgaaagtctt tcctcgcttg aaagcagagc tggtggagca tatcagtcag
      361 ctccatgccc tggctgacca cgctgagaaa ctacacaggg gctgcaccat ctccaacgtg
      421 gtggctgact ccttcagtgc tgcctctgac atcctgagcc tccttggtct ctttctggca
      481 cctgtgacag cagagggaag tctggtgctc tcagcaactg gcttggggct gggggtagca
      541 gctactgtga ctgatgttgc tacctcaatc gtggaggaaa caagcagggt tttggatgaa
      601 gttgaagctg ctctgactgg cactcatgtg ctgggggagg ctggcacaag tgtagctagg
      661 attgtcaaca agatccctca ggctaccaga gacatcacca gagacctgga agcccttgag
      721 cagcacatga atgccctcag gctggttaga gctaaccctc gtttagaaga agatgccagg
      781 atcctggcca ccacaggaag catctctgcc caacgggcta tgcaggtgcg ggccaggctg
      841 gaaggaaccc ctctggcaat gagcaatgaa gcccggatcc aacgtgccgc caccgcaggt
      901 gccgccctct ggagtgacgt ggacagcctt gtcaaagagt caaagcatct gtacgaaggg
      961 tctgcgtcag agtcggctga agcactgagg aagctggctc gagagctgga ggagaagcta
     1021 gaggggctca tggaattcta caagacgatc tgatcaggcc ccagtcagtc accccatccc
     1081 caagacaggc agaggtcagg ggggaggacc tggacagagg agagcaagac tgcagtcagg
     1141 tccgagagac ccagtgtgta ggcctgctgc tgaacacagc acaatcaggt gagaccccct
     1201 ggtgcctgag acgagagacc aaaggatgtg ctgctgtgag agggactgga aagattgaac
     1261 tctggactaa acacggaaga agccagttaa gagaaggact agaaagccct ccccagctga
     1321 gctactgcaa acaagacccc acaaaaggca aaccagagag aaaggtgtgt gctctttaaa
     1381 cacatcatga gccccatccc tgtgctttag agcctgtgct tctccccagc tccccagccg
     1441 acacccatcc tcaggcatgt catggtcccc taaataaacc gtttctgttg ttcctcaaaa
     1501 aaaaaaaaa
//
