LOCUS       NM_001164640            2292 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus apolipoprotein L 7a (Apol7a), transcript variant 2,
            mRNA.
ACCESSION   NM_001164640
VERSION     NM_001164640.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772386.4, AK085956.1, BC139138.1 and AK018646.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085956.1, SRR5189685.188819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL772386.4         25438-25461
            25-870              AK085956.1         2-847
            871-1552            BC139138.1         750-1431
            1553-2287           AK018646.1         1655-2389
            2288-2292           AL772386.4         36327-36331
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.4 cM"
     gene            1..2292
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /note="apolipoprotein L 7a"
                     /db_xref="GeneID:75761"
                     /db_xref="MGI:MGI:1923011"
     exon            1..173
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /inference="alignment:Splign:2.1.0"
     exon            174..261
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1505
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /note="apolipoprotein L 3"
                     /codon_start=1
                     /product="apolipoprotein L 7a"
                     /protein_id="NP_001158112.1"
                     /db_xref="CCDS:CCDS37125.1"
                     /db_xref="GeneID:75761"
                     /db_xref="MGI:MGI:1923011"
                     /translation="MDTPDRECFVESVVNYLLDTWSTEDLRLLLTEEETWKHFVAEVD
                     LSREEEAALQESLAEIFADPDGEDEDELQNDLQDKNERKEEDSLSEDLGESVADTDVE
                     DEDGDAEDEDSDTEDEDRDIEDENSNREDEDSDTEDEDSDTEGEDSNTEDEEEIQNDL
                     WHKERFLDAYPQVKLELEEIIRKLHALADKVDKVHRDCTISRVVASSSSAVSGVLIIL
                     GLSLAPVTAGVSLALSATGLGLGAAAAVTSVSTSIVEKVSVVSAEDEASKLVPTNKDT
                     MKGMKEVLDQSGPRLLSLSTDTIQRLQGIQKCINAIPLAKANTRLANNAKRLMTTGKI
                     SARNTKQVQKAFGGTALAMTKGARIMGAATAGFFLLQDVISLVEDSKHLHEGAKSQTA
                     AELRKQAQDLEQKLQELKEVHDSLTK"
     exon            262..388
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /inference="alignment:Splign:2.1.0"
     exon            389..493
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..2292
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2265..2270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="Apol7a"
                     /gene_synonym="9130022K13Rik; Apol3"
                     /note="major polyA site"
ORIGIN      
        1 gctcttgccg gcttgccgca cctcactagc aagtccgttt ctacaatggc actaggattc
       61 cagagtgtac taaaaaccag ctgagacatc cagccctgtg gactgagcag ctacgggagt
      121 ctccaacctg ccatgcgtag acagcctttg ttggactagc taaaccagag tctcctggtc
      181 acctggtgag ctgtaaggaa cagctagctg tcaagtcctc tgcctgacac ctagacctgg
      241 cagctgccat ggacacccca gacagagaat gctttgttga gagtgtggtt aactacctcc
      301 tggacacatg gagcacagag gacctgcggc tcctgctgac agaagaagaa acctggaaac
      361 actttgtggc agaagttgat ttgtccaggg aagaggaagc tgccttgcag gaatctcttg
      421 ctgagatctt tgcagatcct gatggagaag atgaagatga gctccaaaat gaccttcagg
      481 acaagaacga gaggaaagag gaagattcct tgagtgaaga tcttggtgag agtgtagctg
      541 atactgatgt agaagatgaa gatggtgatg cagaagatga agatagtgat acagaagatg
      601 aagatagaga tatagaagat gaaaatagta atagagaaga tgaagatagt gatacagaag
      661 atgaagatag tgatacagaa ggtgaagata gtaatacgga agatgaagag gagatccaaa
      721 atgatctgtg gcacaaggaa aggttcttgg atgcttatcc tcaggtgaaa ctggagcttg
      781 aggagatcat caggaagctc cacgccctgg cagacaaggt tgacaaggtg cacagggact
      841 gcaccatctc acgggtggtg gccagctcca gcagtgctgt gtctggagtc ctgatcatcc
      901 ttggtctgtc tctggcacct gtgacagcag gagtcagtct ggcattgtca gccactggct
      961 tggggctggg ggcagcagcg gctgtgacta gtgtttccac aagcattgtg gaaaaggtaa
     1021 gtgtggtgtc tgctgaagat gaagccagca agctggtgcc aaccaacaaa gacacaatga
     1081 agggcatgaa agaagttttg gatcagagtg gtcccagact tctttcttta tctacagaca
     1141 ccattcagag attgcaaggc attcagaaat gcattaatgc cattccgctg gccaaagcca
     1201 acactcgcct agcaaataat gccaagcgtc tcatgaccac agggaagata tctgcccgaa
     1261 acactaaaca ggtgcagaaa gcctttggag gtaccgctct ggcaatgacc aaaggagccc
     1321 gaatcatggg tgcagccact gcaggtttct tccttctgca ggatgtgatc agccttgtgg
     1381 aagactcgaa gcatttgcat gaaggtgcta agtcacagac tgctgcagag ctgaggaagc
     1441 aagctcagga cctggagcag aagttacagg agctcaaaga ggttcatgac agcctgacta
     1501 agtgacctct tcatcttctg tgcagctcag atgactgggg agggagtgtg ctggacagag
     1561 ccatgaacac atgggagccc ctgactgtac ccctcacagc agtgcctgct aaagggagag
     1621 ggcacattaa aatacaggaa gccagaacag agatgggaca atctcatgac cacttaccag
     1681 actccagctc ttagatccat caacttccca attaacagcc aagctcccaa gctggggagc
     1741 gcatccaagt cctgactaag ccacatggct gctcctaagc tttgcccact gcactgctcc
     1801 cagctgaggc tcaccaacct caccatccac tgagctgtca atcttcccac tgctttgtga
     1861 ttggtggcac agagaccttc tcttttcttc ttctgcctca ttgtgtgttt ttccaaatat
     1921 ttctcaatct tacaatcaga ttctggttgt gaacgtcatt tcctgttctt ggttttgggt
     1981 cacatgggtg ctgttggtga aaagctcaag actagaaaga ggggatgctg ggaataccac
     2041 ctgtccaatc atcacaagtt cttggccttc catgccactg tggatgttaa ggaaaggaga
     2101 ggtgacattg tacgactggt gagttcttct ctctgctacc agactccagg gaaccatcaa
     2161 taggcacaat ttttaatgcc tattgatgtt taaaatctgc cgtaattgga tgagatctgc
     2221 caagatgaac aagaagggct acacttggtc cataattttc gtagaataaa tttgtgaaaa
     2281 ttgacctaga ca
//
