LOCUS       NM_013475               1202 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus apolipoprotein H (Apoh), mRNA.
ACCESSION   NM_013475
VERSION     NM_013475.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1202)
  AUTHORS   He,X., Zhang,J., Huang,M., Wang,J., Yang,S., Yu,X., Xu,Y. and
            Yang,W.
  TITLE     Serum apolipoprotein H determines ferroptosis resistance by
            modulating cellular lipid composition
  JOURNAL   Cell Death Dis 15 (10), 718 (2024)
   PUBMED   39353906
  REMARK    GeneRIF: Serum apolipoprotein H determines ferroptosis resistance
            by modulating cellular lipid composition.
            Erratum:[Cell Death Dis. 2024 Dec 3;15(12):875. doi:
            10.1038/s41419-024-07181-9.. PMID: 39627207]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1202)
  AUTHORS   Phinney,N.Z., Huang,X., Toombs,J.E. and Brekken,R.A.
  TITLE     Development of betabodies: The next generation of
            phosphatidylserine targeting agents
  JOURNAL   J Biol Chem 300 (9), 107681 (2024)
   PUBMED   39159812
REFERENCE   3  (bases 1 to 1202)
  AUTHORS   Dasgupta,S.K., Gollamudi,J., Rivera,S., Poche,R.A., Rumbaut,R.E.
            and Thiagarajan,P.
  TITLE     beta2-glycoprotein I promotes the clearance of circulating
            mitochondria
  JOURNAL   PLoS One 19 (1), e0293304 (2024)
   PUBMED   38271349
  REMARK    GeneRIF: beta2-glycoprotein I promotes the clearance of circulating
            mitochondria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1202)
  AUTHORS   Liu,Y., Zhao,Y., Liu,Q., Li,B., Daniel,P.V., Chen,B. and Wu,Z.
  TITLE     Effects of apolipoprotein H downregulation on lipid metabolism,
            fatty liver disease, and gut microbiota dysbiosis
  JOURNAL   J Lipid Res 65 (1), 100483 (2024)
   PUBMED   38101620
  REMARK    GeneRIF: Effects of apolipoprotein H downregulation on lipid
            metabolism, fatty liver disease, and gut microbiota dysbiosis.
REFERENCE   5  (bases 1 to 1202)
  AUTHORS   Liu,Y., Wu,Z., Zhang,Y., Chen,B., Yu,S., Li,W. and Ren,J.
  TITLE     Alcohol-dependent downregulation of apolipoprotein H exacerbates
            fatty liver and gut microbiota dysbiosis in mice
  JOURNAL   Lipids Health Dis 21 (1), 89 (2022)
   PUBMED   36123743
  REMARK    GeneRIF: Alcohol-dependent downregulation of apolipoprotein H
            exacerbates fatty liver and gut microbiota dysbiosis in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1202)
  AUTHORS   George,J., Shoenfeld,Y. and Harats,D.
  TITLE     The involvement of beta2-glycoprotein I (beta2-GPI) in human and
            murine atherosclerosis
  JOURNAL   J Autoimmun 13 (1), 57-60 (1999)
   PUBMED   10441168
REFERENCE   7  (bases 1 to 1202)
  AUTHORS   Okkels,H., Rasmussen,T.E., Sanghera,D.K., Kamboh,M.I. and
            Kristensen,T.
  TITLE     Structure of the human beta2-glycoprotein I (apolipoprotein H) gene
  JOURNAL   Eur J Biochem 259 (1-2), 435-440 (1999)
   PUBMED   9914524
REFERENCE   8  (bases 1 to 1202)
  AUTHORS   Sheng,Y., Herzog,H. and Krilis,S.A.
  TITLE     Cloning and characterization of the gene encoding the mouse beta
            2-glycoprotein I
  JOURNAL   Genomics 41 (1), 128-130 (1997)
   PUBMED   9126494
REFERENCE   9  (bases 1 to 1202)
  AUTHORS   Sellar,G.C., Steel,D.M., Zafiropoulos,A., Seery,L.T. and
            Whitehead,A.S.
  TITLE     Characterization, expression and evolution of mouse beta
            2-glycoprotein I (apolipoprotein H)
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1521-1528 (1994)
   PUBMED   7514402
REFERENCE   10 (bases 1 to 1202)
  AUTHORS   Nonaka,M., Matsuda,Y., Shiroishi,T., Moriwaki,K., Nonaka,M. and
            Natsuume-Sakai,S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY143138.1, AK010926.1, AA273732.1 and BU756628.1.
            
            On Nov 16, 2007 this sequence version replaced NM_013475.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019811.1, Y11356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY143138.1         1-13
            14-439              AK010926.1         2-427
            440-953             AA273732.1         55-568
            954-1177            AK010926.1         942-1165
            1178-1202           BU756628.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.8 cM"
     gene            1..1202
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /note="apolipoprotein H"
                     /db_xref="GeneID:11818"
                     /db_xref="MGI:MGI:88058"
     exon            1..111
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1085
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /note="activated protein C-binding protein; APC inhibitor;
                     apo-H; beta(2)GPI; beta-2-glycoprotein I;
                     beta-2-glycoprotein 1"
                     /codon_start=1
                     /product="beta-2-glycoprotein 1 precursor"
                     /protein_id="NP_038503.4"
                     /db_xref="CCDS:CCDS25574.1"
                     /db_xref="GeneID:11818"
                     /db_xref="MGI:MGI:88058"
                     /translation="MVSPVLALFSAFLCHVAIAGRICPKPDDLPFATVVPLKTSYDPG
                     EQIVYSCKPGYVSRGGMRRFTCPLTGMWPINTLRCVPRVCPFAGILENGIVRYTSFEY
                     PKNISFACNPGFFLNGTSSSKCTEEGKWSPDIPACARITCPPPPVPKFALLKDYRPSA
                     GNNSLYQDTVVFKCLPHFAMIGNDTVMCTEQGNWTRLPECLEVKCPFPPRPENGYVNY
                     PAKPVLLYKDKATFGCHETYKLDGPEEAECTKTGTWSFLPTCRESCKLPVKKATVLYQ
                     GMRVKIQEQFKNGMMHGDKIHFYCKNKEKKCSYTVEAHCRDGTIEIPSCFKEHSSLAF
                     WKTDASELTPC"
     exon            112..288
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     exon            289..385
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     exon            386..462
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     exon            463..651
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     exon            652..831
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1029
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1186
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1160..1165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /note="hexamer: AATAAA"
     polyA_site      1186
                     /gene="Apoh"
                     /gene_synonym="B2GPI; beta-2-GPI; beta2-GPI"
                     /note="major polyA site"
ORIGIN      
        1 ttcagcagaa gacaccactt tggtgaagct ggtgggacgc atccgcaatg gtttccccgg
       61 tgctcgcctt gttctccgcc ttcctctgcc atgttgctat tgcaggacgg atctgtccga
      121 agccggatga cctaccattt gctacggttg tccccttaaa gacatcctac gaccctgggg
      181 agcagattgt ctactcctgc aagccaggct acgtgtccag gggagggatg agacggttta
      241 cctgtcctct cacaggaatg tggcccatca acaccctgag atgtgtcccc agagtatgtc
      301 ctttcgctgg aatcttagaa aatggaattg tacgctacac gagttttgaa tatcccaaga
      361 acatcagttt tgcttgtaac cctgggtttt ttctgaatgg gaccagctca tctaagtgca
      421 cggaggaagg aaaatggagc ccagatattc ctgcttgtgc tcgcatcacc tgcccgccac
      481 caccagttcc aaagtttgca ctccttaagg attataggcc ttcagctggg aacaactctt
      541 tgtatcagga cacagtggtc tttaaatgct tgccacactt tgccatgatc ggaaatgaca
      601 cagtcatgtg cacagaacaa ggaaactgga cccgattgcc agaatgcctg gaagtaaaat
      661 gtcccttccc tccgaggcca gaaaatgggt atgtgaatta tcctgcaaag ccggtgcttc
      721 tatataagga taaagccaca tttggttgcc atgagacata caagctggac ggcccagaag
      781 aagcggaatg taccaagacg ggaacttggt ccttcttgcc gacctgtaga gagtcttgca
      841 aactccccgt taagaaagcc accgtgctgt accaagggat gagggtgaag atccaggaac
      901 agtttaagaa tgggatgatg catggcgaca aaattcactt ctactgcaaa aacaaagaga
      961 agaagtgcag ctacactgtg gaggctcatt gcagagatgg cactatcgag attccctcgt
     1021 gcttcaagga gcacagttct ctggctttct ggaaaacgga tgcatcagaa ctgacaccgt
     1081 gctgaagtcg tttccagaat caaaattgaa tgtcgtattt gtatttctgc ttgtcttagg
     1141 aatccatctg aaatagcaga ataaagttac tggattgcct cagttaaaaa aaaaaaaaaa
     1201 aa
//
