LOCUS       NM_133997               2327 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus apolipoprotein F (Apof), mRNA.
ACCESSION   NM_133997
VERSION     NM_133997.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   Shen,X., Chen,M., Zhang,J., Lin,Y., Gao,X., Tu,J., Chen,K., Zhu,A.
            and Xu,S.
  TITLE     Unveiling the Impact of ApoF Deficiency on Liver and Lipid
            Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis
            in Mice
  JOURNAL   Genes (Basel) 15 (3), 347 (2024)
   PUBMED   38540406
  REMARK    GeneRIF: Unveiling the Impact of ApoF Deficiency on Liver and Lipid
            Metabolism: Insights from Transcriptome-Wide m6A Methylome Analysis
            in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2327)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2327)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2327)
  AUTHORS   Korstanje,R., Li,R., Howard,T., Kelmenson,P., Marshall,J.,
            Paigen,B. and Churchill,G.
  TITLE     Influence of sex and diet on quantitative trait loci for HDL
            cholesterol levels in an SM/J by NZB/BlNJ intercross population
  JOURNAL   J Lipid Res 45 (5), 881-888 (2004)
   PUBMED   14993241
REFERENCE   7  (bases 1 to 2327)
  AUTHORS   Korstanje,R., Albers,J.J., Wolfbauer,G., Li,R., Tu,A.Y.,
            Churchill,G.A. and Paigen,B.J.
  TITLE     Quantitative trait locus mapping of genes that regulate
            phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (1), 155-160 (2004)
   PUBMED   14592843
REFERENCE   8  (bases 1 to 2327)
  AUTHORS   Wu,T., Lee,C.G., Buckler-White,A. and Kozak,C.A.
  TITLE     Genetic control of a mouse serum lipoprotein factor that
            inactivates murine leukemia viruses: evaluation of apolipoprotein F
            as a candidate
  JOURNAL   J Virol 76 (5), 2279-2286 (2002)
   PUBMED   11836406
REFERENCE   9  (bases 1 to 2327)
  AUTHORS   Yotsumoto,S., Shimada,T., Cui,C.Y., Nakashima,H., Fujiwara,H. and
            Ko,M.S.
  TITLE     Expression of adrenomedullin, a hypotensive peptide, in the
            trophoblast giant cells at the embryo implantation site in mouse
  JOURNAL   Dev Biol 203 (2), 264-275 (1998)
   PUBMED   9808778
REFERENCE   10 (bases 1 to 2327)
  AUTHORS   Gwynn,B., Eicher,E.M. and Peters,L.L.
  TITLE     Genetic localization of Cd63, a member of the transmembrane 4
            superfamily, reveals two distinct loci in the mouse genome
  JOURNAL   Genomics 35 (2), 389-391 (1996)
   PUBMED   8661157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135859.4.
            
            On Feb 22, 2019 this sequence version replaced NM_133997.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022795.1, AI528157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC135859.4         38707-38777         c
            72-2327             AC135859.4         36226-38481         c
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.5 cM"
     gene            1..2327
                     /gene="Apof"
                     /gene_synonym="LVIF"
                     /note="apolipoprotein F"
                     /db_xref="GeneID:103161"
                     /db_xref="MGI:MGI:104539"
     exon            1..71
                     /gene="Apof"
                     /gene_synonym="LVIF"
                     /inference="alignment:Splign:2.1.0"
     exon            72..2327
                     /gene="Apof"
                     /gene_synonym="LVIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1036
                     /gene="Apof"
                     /gene_synonym="LVIF"
                     /note="leukemia virus-inactivating factor"
                     /codon_start=1
                     /product="apolipoprotein F precursor"
                     /protein_id="NP_598758.2"
                     /db_xref="CCDS:CCDS24268.2"
                     /db_xref="GeneID:103161"
                     /db_xref="MGI:MGI:104539"
                     /translation="MHSLRLILMSIQLLCYLLLCPVDATSHGEATSVSTVLPPSKLGY
                     QMQTSDKPLSCQMLLPKSLPGFTYMPPVSKFLVGLALRNALEAAGCQAEVWALQLQLY
                     RLGGVEATQALIHHLQELQKSGHTDREVSVDALSSALQLLAWEQPGPKRAKRSISNTD
                     CDNDQEQSVHNVVDLLPAVGTYYNLGTALYYAIKNCSDKAKERGRDGAIDLGYDLLMA
                     MVGASGGPAGAVITAALKPAMKAGVQRLIQYYYDEKEVTTPQPEVTTHQPETGKDATT
                     DIGVVEEIAMSNFVSEVESTTSNWEWPLLKNYGVLAYKR"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apof"
                     /gene_synonym="LVIF"
                     /note="hexamer: ATTAAA"
     polyA_site      1230
                     /gene="Apof"
                     /gene_synonym="LVIF"
                     /note="major polyA site"
ORIGIN      
        1 aaacaggagc aggattgtgg aactaccgaa gctacccagg gactcttact tctcaatggc
       61 cggactgtat gggtgctcag ctcctgacat gcatagcctc cgactcatcc tgatgtcaat
      121 ccagctgctt tgctatctcc tgctgtgtcc tgtggatgcc acttcacacg gagaggcaac
      181 cagtgtctct acggtgctcc ctccctcgaa gttgggatac cagatgcaga cctcagacaa
      241 gcccttgtcc tgccagatgc tgctccccaa gtccctgcct ggcttcactt acatgccccc
      301 tgtctccaaa ttcctggtag gcctggctct aaggaatgct ctggaggcag ctggctgcca
      361 ggctgaggtc tgggctcttc agcttcagct ttaccgatta ggaggtgtgg aggctacaca
      421 agccctcatc caccatctcc aggagctcca gaagagtgga cacacagacc gggaagtgtc
      481 tgtggatgcc ctgtcctctg ctctgcagct cttagcctgg gagcagccag gtccaaagag
      541 ggccaaacgt tcgatttcca acacagactg cgacaatgat caggaacaga gtgtccacaa
      601 tgtggttgac ctactaccag cagtaggcac ctactacaac ctaggcacag ctttgtatta
      661 cgccattaag aactgctctg acaaggccaa ggaacgaggt cgagatgggg ccatagatct
      721 gggttatgat ctcttgatgg ccatggtagg cgcgtcaggg ggcccagctg gtgcggtgat
      781 cacggctgct cttaagccag cgatgaaggc tggggttcag cggctgatcc agtattatta
      841 tgatgagaaa gaggtgacca cccctcagcc agaggtgacc acccatcagc cagagaccgg
      901 aaaggatgcc accacagata tcggtgttgt ggaagaaata gccatgtcta attttgtgtc
      961 agaagttgaa agtacaactt ctaactggga gtggccttta ttaaagaact atggtgtctt
     1021 ggcgtacaag agatagtaac aaaacaacca ataagtggaa aattctgaca agagaagtgt
     1081 agatggatgg atgggtgggt ggatggtttg ggatactgtc atcgcttgcc agtaatttcc
     1141 ttcttgaaac ttagattttt acactctaat ggggctggct aacttccacc tgaacaagtg
     1201 attatagaaa ttaaaaagcg ttatcatgaa cccacagtat ttatcattca tatcctcaaa
     1261 aataccttat tacctcagct cttccctccc tatcctaagg gacgcaggtc ccaccctttc
     1321 tatggagtcc taggtgcctt cacgcaccct ggtttcagtt tcctttccct agaactcacg
     1381 gttcggttcg ggtaaatcag ctgctagaat tcctggctaa gactttagtt gggctccgcc
     1441 cgactagggg ggcgggagcg ggcactaacg agcttctccc tctccgccaa tcactgaagt
     1501 cggcggtgtg gtttcaagca gcttgtccag cccagcgctg aacggggttg tgtttcagcc
     1561 aatgagagtg acacgcgggg agggcgtggc taagctttcg gtcgccccac cgatcccgga
     1621 acgccgagcg tccacagccg ggtgatccat tccgccagcc gggtgaccca ttccgctgtt
     1681 cgctatcttg gtccgccgga gtcgggggag ggtggaaaac gggtccttga accgcttgga
     1741 gaattggaag ttgcagcgag agcactggaa ggagcggcac tggaccctca gaaggtacag
     1801 gccccgaaag ggtgtgcgga gcggggcgga ggtgccagcc ggttcccggg aagggctgct
     1861 gccccgggtg atgcccctgt agacaaggct tctgctctct ggctgaagtc gaacaccctg
     1921 caggatgctg caccgctgca cagttctact tctcaaccct gtcgacttcc ttccaaaact
     1981 cctccgcaac ccttgcagct gctctatgta cccattatga tccttgtcat aagccaaagc
     2041 tttaacctct gctctgcgaa tctatttact tatttgtttg cttccttatt atatttttaa
     2101 aatttgtatg catgttgtgt ttatgtacta ggtgcgtgcc tgaattggcc agaagagggc
     2161 cgaatttact aggactggag ttaagatggt tgtgagcagc catgtggggg ctgggaaccg
     2221 aacccaggtc ctctggaaga gcagccagtg ctcttaacca tggagccatc tctcgaggcc
     2281 ctttacataa tttttgatcc ttgcacaaat aaataaataa ataagaa
//
