LOCUS       NM_007470               2074 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus apolipoprotein D (Apod), transcript variant 1, mRNA.
ACCESSION   NM_007470 XM_994687 XM_994704
VERSION     NM_007470.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2074)
  AUTHORS   Zhang,H., Liang,X., Li,D., Zhang,C., Wang,W., Tang,R., Zhang,H.,
            Kiflu,A.B., Liu,C., Liang,J., Li,X. and Luo,T.R.
  TITLE     Apolipoprotein D facilitates rabies virus propagation by
            interacting with G protein and upregulating cholesterol
  JOURNAL   Front Immunol 15, 1392804 (2024)
   PUBMED   38868762
  REMARK    GeneRIF: Apolipoprotein D facilitates rabies virus propagation by
            interacting with G protein and upregulating cholesterol.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2074)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2074)
  AUTHORS   Dani,N., Herbst,R.H., McCabe,C., Green,G.S., Kaiser,K., Head,J.P.,
            Cui,J., Shipley,F.B., Jang,A., Dionne,D., Nguyen,L., Rodman,C.,
            Riesenfeld,S.J., Prochazka,J., Prochazkova,M., Sedlacek,R.,
            Zhang,F., Bryja,V., Rozenblatt-Rosen,O., Habib,N., Regev,A. and
            Lehtinen,M.K.
  TITLE     A cellular and spatial map of the choroid plexus across brain
            ventricles and ages
  JOURNAL   Cell 184 (11), 3056-3074 (2021)
   PUBMED   33932339
REFERENCE   4  (bases 1 to 2074)
  AUTHORS   Wilkerson,B.A., Zebroski,H.L., Finkbeiner,C.R., Chitsazan,A.D.,
            Beach,K.E., Sen,N., Zhang,R.C. and Bermingham-McDonogh,O.
  TITLE     Novel cell types and developmental lineages revealed by single-cell
            RNA-seq analysis of the mouse crista ampullaris
  JOURNAL   Elife 10, e60108 (2021)
   PUBMED   34003106
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2074)
  AUTHORS   Jimenez-Palomares,M., Cozar-Castellano,I., Ganfornina,M.D.,
            Sanchez,D. and Perdomo,G.
  TITLE     Genetic deficiency of apolipoprotein D in the mouse is associated
            with nonfasting hypertriglyceridemia and hyperinsulinemia
  JOURNAL   Metabolism 60 (12), 1767-1774 (2011)
   PUBMED   21632073
  REMARK    GeneRIF: The findings underscore the importance of ApoD in the
            regulation of plasma insulin levels and triglyceride metabolism,
            suggesting that ApoD plays an important role in the pathogenesis of
            dyslipidemia.
REFERENCE   6  (bases 1 to 2074)
  AUTHORS   Yoshida,K., Cleaveland,E.S., Nagle,J.W., French,S., Yaswen,L.,
            Ohshima,T., Brady,R.O., Pentchev,P.G. and Kulkarni,A.B.
  TITLE     Molecular cloning of the mouse apolipoprotein D gene and its
            upregulated expression in Niemann-Pick disease type C mouse model
  JOURNAL   DNA Cell Biol 15 (10), 873-882 (1996)
   PUBMED   8892759
REFERENCE   7  (bases 1 to 2074)
  AUTHORS   Cofer,S. and Ross,S.R.
  TITLE     The murine gene encoding apolipoprotein D exhibits a unique
            expression pattern as compared to other species
  JOURNAL   Gene 171 (2), 261-263 (1996)
   PUBMED   8666283
REFERENCE   8  (bases 1 to 2074)
  AUTHORS   Seguin,D., Desforges,M. and Rassart,E.
  TITLE     Molecular characterization and differential mRNA tissue
            distribution of mouse apolipoprotein D
  JOURNAL   Brain Res Mol Brain Res 30 (2), 242-250 (1995)
   PUBMED   7637575
REFERENCE   9  (bases 1 to 2074)
  AUTHORS   Flower,D.R.
  TITLE     The lipocalin protein family: a role in cell regulation
  JOURNAL   FEBS Lett 354 (1), 7-11 (1994)
   PUBMED   7957904
  REMARK    Review article
REFERENCE   10 (bases 1 to 2074)
  AUTHORS   Warden,C.H., Diep,A., Taylor,B.A. and Lusis,A.J.
  TITLE     Localization of the gene for apolipoprotein D on mouse chromosome
            16
  JOURNAL   Genomics 12 (4), 851-852 (1992)
   PUBMED   1572665
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC130815.4, AK135046.1,
            AK162392.1 and BY596441.1.
            
            On Aug 13, 2014 this sequence version replaced NM_007470.3.
            
            Summary: The protein encoded by this gene is a component of
            high-density lipoprotein (HDL), but is unique in that it shares
            greater structural similarity to lipocalin than to other members of
            the apolipoprotein family, and has a wider tissue expression
            pattern. The encoded protein is involved in lipid metabolism, and
            ablation of this gene results in defects in triglyceride
            metabolism. Elevated levels of this gene product have been observed
            in multiple tissues of Niemann-Pick disease mouse models, as well
            as in some tumors. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162392.1, AK135046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AC130815.4         10738-10949
            213-1615            AK135046.1         1-1403
            1616-1939           AK162392.1         1404-1727
            1940-1940           BY596441.1         307-307
            1941-2074           AK162392.1         1729-1862
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.41 cM"
     gene            1..2074
                     /gene="Apod"
                     /note="apolipoprotein D"
                     /db_xref="GeneID:11815"
                     /db_xref="MGI:MGI:88056"
     exon            1..257
                     /gene="Apod"
                     /inference="alignment:Splign:2.1.0"
     exon            258..327
                     /gene="Apod"
                     /inference="alignment:Splign:2.1.0"
     exon            328..478
                     /gene="Apod"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..925
                     /gene="Apod"
                     /codon_start=1
                     /product="apolipoprotein D precursor"
                     /protein_id="NP_031496.2"
                     /db_xref="CCDS:CCDS28105.1"
                     /db_xref="GeneID:11815"
                     /db_xref="MGI:MGI:88056"
                     /translation="MVTMLMFLATLAGLFTTAKGQNFHLGKCPSPPVQENFDVKKYLG
                     RWYEIEKIPASFEKGNCIQANYSLMENGNIEVLNKELSPDGTMNQVKGEAKQSNVSEP
                     AKLEVQFFPLMPPAPYWILATDYENYALVYSCTTFFWLFHVDFVWILGRNPYLPPETI
                     TYLKDILTSNGIDIEKMTTTDQANCPDFL"
     exon            479..600
                     /gene="Apod"
                     /inference="alignment:Splign:2.1.0"
     exon            601..689
                     /gene="Apod"
                     /inference="alignment:Splign:2.1.0"
     exon            690..2074
                     /gene="Apod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apod"
                     /note="hexamer: AATAAA"
     polyA_site      1147
                     /gene="Apod"
                     /note="major polyA site"
     regulatory      1597..1602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apod"
                     /note="hexamer: ATTAAA"
     polyA_site      1629
                     /gene="Apod"
ORIGIN      
        1 acaaacaata tctcattgtt tcttcctcag ggagcagctg tgaaggaaac taagtgaggg
       61 gacagacaca gcatcccatc tttgtgcccc acacagagct cagctttgag gccagtttcc
      121 cccaagctgt ggtgggtgtg gcatgcctga ctatcaaagg gcaagggcct gatgggagcc
      181 tataaagtga cttgggagaa gccacacacc tcacttggag gattctgggt ggaaacttca
      241 gtcatctgat ctgagagtta gaaactgaca gtgagcacca actgaaggct tttacaggct
      301 ccatctcatt ttcctcagac ttctaaggcc tctcctgcag ccaccccacc ccaagatggt
      361 gaccatgctg atgttcctgg ccacgctggc gggtctcttc accacagcca aaggacaaaa
      421 tttccatctt gggaaatgcc cgtctcctcc tgtgcaagag aattttgacg tgaaaaagta
      481 tcttggaaga tggtacgaaa ttgagaagat cccagcgagc tttgagaaag gaaactgcat
      541 tcaagccaac tactcgctga tggagaacgg aaacatcgaa gtgctaaaca aggagctgag
      601 tcctgatgga accatgaacc aagtaaaggg tgaagccaaa cagagcaacg tctcagagcc
      661 agccaagctg gaagtccagt tcttcccgtt gatgccaccg gcaccctact ggatcctggc
      721 caccgattat gaaaactatg ccctcgtgta ctcctgcacc accttcttct ggctcttcca
      781 tgtggatttt gtttggattc ttggaagaaa tccttatctc cctccagaaa caataaccta
      841 cctaaaagat atccttactt ctaatggcat cgacatcgaa aaaatgacaa caacagatca
      901 agcgaactgc ccggacttcc tgtaaagggg gcgggggggg aaaaccacac caggttattt
      961 ctttgctttg cgttccctgg ctccaccccc cacgcctctt aagtaccaag caaccatggc
     1021 aggcactaga gggagagtaa ggctatagaa gccaatggag ggaggggact catggaaagt
     1081 tggcccaaac ccaacctgac cccacactgt caccttgcta gcccaataat aaacattttg
     1141 ctgatcagct gtgtttcctg tggattctga gctaggttta tagtgcaaga gtcatggtcg
     1201 gcagatggtt ggaaaccctt tggctgtagt ttaaaggtag agaaagctga tggccaagtt
     1261 agatcctggt gactcggatc cagggtccct ctccacggca gatgctctgg agggaattct
     1321 gggacgtttt tcacttctgt ctggaggctt ccttgaagct tttactttct catcgggaag
     1381 tcttcggaac agggccgaag catgagcatc ctgaaaatat ctgggaaaag cagacagcct
     1441 gtgaggaaaa gacaaaggtt gtttgtttgg ttggtttgtt ttgttttttc gacatagggt
     1501 ttctctgtat agccctggct gtcaggggac tcactttgta gaccatgctg gcctcgaact
     1561 cagaaacccg tctgcctctg cctcccgagt gctgggatta aaggcgtgcg ccaccatgcc
     1621 tggcttcaac ggtgtttgtt tgtttgtttg tttgtttgtt taatgatgca aattttctct
     1681 ttcactcaga atttactgag gtccaattgc attccagtca gtgaaaaaaa aaatttagaa
     1741 tccctgacca ccgctctcct tgcccccaag cgtcaactca gtccagtgat agaaataaga
     1801 cagagcaaca tagagggcat cacgggaaat cagagaacat cccaccctct tcaagacaca
     1861 ggctcaagtt atccagtatc cagtctgtct tcaagccttg gcactcccat gcctctgctc
     1921 cagtagcaag ccagaaacca cctggtgttg ttcttttctg atcttgtgac ttttaaaacc
     1981 aaaaacccag atttatcacc ccacaagttc acttagttcc tgttgtatag tctgttgtat
     2041 gcttttcatt taattaaaaa aaaaaaaaaa actc
//
