LOCUS       NM_007385                518 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus apolipoprotein C-IV (Apoc4), mRNA.
ACCESSION   NM_007385
VERSION     NM_007385.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Rong,R., Wei,Y., Li,L., Wang,T., Zhu,H., Xiao,G. and Wang,Y.
  TITLE     Image-based quantification of histological features as a function
            of spatial location using the Tissue Positioning System
  JOURNAL   EBioMedicine 94, 104698 (2023)
   PUBMED   37453365
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Wei,Y., Wang,Y.G., Jia,Y., Li,L., Yoon,J., Zhang,S., Wang,Z.,
            Zhang,Y., Zhu,M., Sharma,T., Lin,Y.H., Hsieh,M.H., Albrecht,J.H.,
            Le,P.T., Rosen,C.J., Wang,T. and Zhu,H.
  TITLE     Liver homeostasis is maintained by midlobular zone 2 hepatocytes
  JOURNAL   Science 371 (6532) (2021)
   PUBMED   33632817
  REMARK    Erratum:[Science. 2021 Sep 3;373(6559):eabl8195. doi:
            10.1126/science.abl8195.. PMID: 34516857]
REFERENCE   4  (bases 1 to 518)
  AUTHORS   Luo,X., Liao,R., Hanley,K.L., Zhu,H.H., Malo,K.N., Hernandez,C.,
            Wei,X., Varki,N.M., Alderson,N., Chu,C., Li,S., Fan,J., Loomba,R.,
            Qiu,S.J. and Feng,G.S.
  TITLE     Dual Shp2 and Pten Deficiencies Promote Non-alcoholic
            Steatohepatitis and Genesis of Liver Tumor-Initiating Cells
  JOURNAL   Cell Rep 17 (11), 2979-2993 (2016)
   PUBMED   27974211
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Kotite,L., Zhang,L.H., Yu,Z., Burlingame,A.L. and Havel,R.J.
  TITLE     Human apoC-IV: isolation, characterization, and immunochemical
            quantification in plasma and plasma lipoproteins
  JOURNAL   J Lipid Res 44 (7), 1387-1394 (2003)
   PUBMED   12700345
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Mak,P.A., Laffitte,B.A., Desrumaux,C., Joseph,S.B., Curtiss,L.K.,
            Mangelsdorf,D.J., Tontonoz,P. and Edwards,P.A.
  TITLE     Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene
            cluster in murine and human macrophages. A critical role for
            nuclear liver X receptors alpha and beta
  JOURNAL   J Biol Chem 277 (35), 31900-31908 (2002)
   PUBMED   12032151
  REMARK    GeneRIF: regulated exprsesion of gene cluster in macrophages
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Allan,C.M., Walker,D., Segrest,J.P. and Taylor,J.M.
  TITLE     Identification and characterization of a new human gene (APOC4) in
            the apolipoprotein E, C-I, and C-II gene locus
  JOURNAL   Genomics 28 (2), 291-300 (1995)
   PUBMED   8530039
REFERENCE   9  (bases 1 to 518)
  AUTHORS   van Eck,M.M., Hoffer,M.J., Havekes,L.M., Frants,R.R. and
            Hofker,M.H.
  TITLE     The apolipoprotein C2-linked (Acl) gene: a new gene within the
            mouse apolipoprotein e-c1-c2 gene cluster
  JOURNAL   Genomics 21 (1), 110-115 (1994)
   PUBMED   8088778
REFERENCE   10 (bases 1 to 518)
  AUTHORS   Hoffer,M.J., van Eck,M.M., Havekes,L.M., Hofker,M.H. and
            Frants,R.R.
  TITLE     Structure and expression of the mouse apolipoprotein C2 gene
  JOURNAL   Genomics 17 (1), 45-51 (1993)
   PUBMED   7691714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC100593.1, BB872041.1 and AC149282.2.
            
            On Jan 3, 2013 this sequence version replaced NM_007385.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: W13915.1, BC024657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BC100593.1         1-3
            4-384               BB872041.1         2-382
            385-518             AC149282.2         83405-83538         c
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.94 cM"
     gene            1..518
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /note="apolipoprotein C-IV"
                     /db_xref="GeneID:11425"
                     /db_xref="MGI:MGI:87878"
     exon            1..156
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..455
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /note="apolipoprotein C2-linked; apolipoprotein C4"
                     /codon_start=1
                     /product="apolipoprotein C-IV precursor"
                     /protein_id="NP_031411.1"
                     /db_xref="CCDS:CCDS20910.1"
                     /db_xref="GeneID:11425"
                     /db_xref="MGI:MGI:87878"
                     /translation="MSLLRCRPRDLPSVSLSVLFLVSFVASMSTESLSPTPGPESSRW
                     SLVRARVLEMVEPLVTRTRDRWQWFWGPGAVQGFMQTYYEDHLKDLGPRTQAWLQSSR
                     DHLLNKTHSLCPRLLCKDRTQG"
     exon            157..289
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            290..518
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /note="hexamer: AATAAA"
     polyA_site      508
                     /gene="Apoc4"
                     /gene_synonym="Acl; apo-CIV; apoC-IV"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgcct gtcccttccc cggtgaaaga gtggagtaca gcaggaggga cagagataga
       61 gagggaccaa gtccccagaa atgtccctgc tgaggtgcag gccacgggac ctgccatcag
      121 tctccctttc tgtgctgttc ttggtcagct ttgtagcatc catgtctaca gaaagcctga
      181 gccccacgcc tggccctgag agcagccgct ggagcctggt aagggccagg gtgttggaga
      241 tggtggagcc actggtgacc agaaccaggg acagatggca gtggttctgg ggccctggag
      301 ctgtccaggg ctttatgcag acctactatg aagatcacct gaaagacctg ggtccccgaa
      361 ctcaggcctg gctgcagagc tccagagacc acctcctaaa caagacccac agcctgtgtc
      421 ccagactgct ctgcaaagac cggactcagg gttaaagtgc cacgtacctc cctcccctgg
      481 cacccacaat aaaggtgttt gttcttgatc tgtgtcac
//
