LOCUS       NM_023114                527 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus apolipoprotein C-III (Apoc3), transcript variant 3,
            mRNA.
ACCESSION   NM_023114
VERSION     NM_023114.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Xiao,Q., Wang,L., Wang,J., Wang,M., Wang,D.W. and Ding,H.
  TITLE     A novel lncRNA GM47544 modulates triglyceride metabolism by
            inducing ubiquitination-dependent protein degradation of APOC3
  JOURNAL   Mol Metab 88, 102011 (2024)
   PUBMED   39173944
  REMARK    GeneRIF: A novel lncRNA GM47544 modulates triglyceride metabolism
            by inducing ubiquitination-dependent protein degradation of APOC3.
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Cervantes,J., Koska,J., Kramer,F., Akilesh,S., Alpers,C.E.,
            Mullick,A.E., Reaven,P. and Kanter,J.E.
  TITLE     Elevated apolipoprotein C3 augments diabetic kidney disease and
            associated atherosclerosis in type 2 diabetes
  JOURNAL   JCI Insight 9 (12), e177268 (2024)
   PUBMED   38743496
  REMARK    GeneRIF: Elevated apolipoprotein C3 augments diabetic kidney
            disease and associated atherosclerosis in type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 527)
  AUTHORS   Pu,Z., Wang,W., Xie,H. and Wang,W.
  TITLE     Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of
            macrophages through mitochondrial damage by accelerating of the
            interaction between SCIMP and SYK pathway in acute lung injury
  JOURNAL   Int Immunopharmacol 128, 111537 (2024)
   PUBMED   38232538
  REMARK    GeneRIF: Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated
            pyroptosis of macrophages through mitochondrial damage by
            accelerating of the interaction between SCIMP and SYK pathway in
            acute lung injury.
REFERENCE   4  (bases 1 to 527)
  AUTHORS   Bornfeldt,K.E.
  TITLE     Apolipoprotein C3: form begets function
  JOURNAL   J Lipid Res 65 (1), 100475 (2024)
   PUBMED   37972731
  REMARK    GeneRIF: Apolipoprotein C3: form begets function.
            Review article
REFERENCE   5  (bases 1 to 527)
  AUTHORS   Zhou,J., Mo,H., Feng,Q., Li,L. and La,J.
  TITLE     ApoC3 is expressed in oocytes and increased expression is
            associated with PCOS progression
  JOURNAL   J Ovarian Res 16 (1), 188 (2023)
   PUBMED   37689737
  REMARK    GeneRIF: ApoC3 is expressed in oocytes and increased expression is
            associated with PCOS progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 527)
  AUTHORS   Chen,M., Breslow,J.L., Li,W. and Leff,T.
  TITLE     Transcriptional regulation of the apoC-III gene by insulin in
            diabetic mice: correlation with changes in plasma triglyceride
            levels
  JOURNAL   J Lipid Res 35 (11), 1918-1924 (1994)
   PUBMED   7868970
REFERENCE   7  (bases 1 to 527)
  AUTHORS   Maeda,N., Li,H., Lee,D., Oliver,P., Quarfordt,S.H. and Osada,J.
  TITLE     Targeted disruption of the apolipoprotein C-III gene in mice
            results in hypotriglyceridemia and protection from postprandial
            hypertriglyceridemia
  JOURNAL   J Biol Chem 269 (38), 23610-23616 (1994)
   PUBMED   8089130
REFERENCE   8  (bases 1 to 527)
  AUTHORS   Januzzi,J.L., Azrolan,N., O'Connell,A., Aalto-Setala,K. and
            Breslow,J.L.
  TITLE     Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene
            locus: genomic, mRNA, and protein sequences with comparisons to
            other species
  JOURNAL   Genomics 14 (4), 1081-1088 (1992)
   PUBMED   1478650
REFERENCE   9  (bases 1 to 527)
  AUTHORS   Kobayashi,E., Tachibana,M., Ikadai,H., Imamichi,T. and Kunieda,T.
  TITLE     Linkage among esterase-6 (Es-6), neural cell adhesion molecule
            (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8
  JOURNAL   Mamm Genome 3 (11), 656-658 (1992)
   PUBMED   1450516
REFERENCE   10 (bases 1 to 527)
  AUTHORS   Mahley,R.W., Innerarity,T.L., Rall,S.C. Jr. and Weisgraber,K.H.
  TITLE     Plasma lipoproteins: apolipoprotein structure and function
  JOURNAL   J Lipid Res 25 (12), 1277-1294 (1984)
   PUBMED   6099394
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008260.1 and AC116503.17.
            
            On Jan 31, 2014 this sequence version replaced NM_023114.3.
            
            Summary: This gene encodes an apolipoprotein which is the major
            protein component of very-low-density lipoproteins (VLDL) and a
            minor component of high-density lipoproteins (HDL). The encoded
            protein is thought to regulate the metabolism of triglyceride-rich
            lipoproteins and play a role in lipid storage and the mobilization
            of fat cells. This gene is clustered with three other
            apolipoprotein genes on chromosome 9 and is associated with
            coronary disease. Mice lacking this gene have lower levels of total
            cholesterol in the plasma. Mutations in the human genes causes
            hyperalphalipoproteinemia 2, a disorder of lipid metabolism which
            results in a favorable lipid profile (lower LDL-cholesterol, higher
            HDL-cholesterol and lower levels of serum triglycerides when
            fasting and after a meal). Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon compared to variant 1. The encoded isoform
            (b) has a shorter N-terminus compared to isoform a. Variants 2 and
            3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB949799.1, AK008260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AK008260.1         4-515
            513-527             AC116503.17        176848-176862       c
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.36 cM"
     gene            1..527
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /note="apolipoprotein C-III"
                     /db_xref="GeneID:11814"
                     /db_xref="MGI:MGI:88055"
     exon            1..41
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /inference="alignment:Splign:2.1.0"
     exon            42..109
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..354
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; apolipoprotein C3"
                     /codon_start=1
                     /product="apolipoprotein C-III isoform b precursor"
                     /protein_id="NP_075603.1"
                     /db_xref="CCDS:CCDS23141.1"
                     /db_xref="GeneID:11814"
                     /db_xref="MGI:MGI:88055"
                     /translation="MQPRTLLTVALLALLASARAEEVEGSLLLGSVQGYMEQASKTVQ
                     DALSSVQESDIAVVARGWMDNHFRSLKGYWSKFTDKFTGFWDSNPEDQPTPAIES"
     exon            110..233
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /inference="alignment:Splign:2.1.0"
     exon            234..527
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      500..505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /note="hexamer: AATAAA"
     polyA_site      522
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; apoC-III"
                     /note="major polyA site"
ORIGIN      
        1 gcctgctcag ttttatccct agaagcagct agctactcca ggtacgtagg tgccatgcag
       61 ccccggacgc tcctcactgt ggccctcttg gctctcctgg catctgcccg agctgaagag
      121 gtagagggat ccttgctgct gggctctgta cagggctaca tggaacaagc ctccaagacg
      181 gtccaggatg cgctaagtag cgtgcaggag tccgatatag ctgtggtggc caggggctgg
      241 atggacaatc acttcagatc cctgaaaggc tactggagca agtttactga caagttcacc
      301 ggcttctggg attctaaccc tgaggaccaa ccaactccag ctattgagtc gtgagacttc
      361 tgtgttgcag atgtgcctgt tcctccatcc tgctgccccc ctccaggcct gccaggtggc
      421 ccctgaaggt tgctttaagg ggaaagtatg ttctcatgtc ttcacccctc cctagatctc
      481 acctaaacat gctgtcccta ataaagctgg ataagaagct gctgtta
//
