LOCUS       NM_001277944             727 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus apolipoprotein C2 (Apoc2), transcript variant 1, mRNA.
ACCESSION   NM_001277944 NM_009695 XM_987120
VERSION     NM_001277944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 727)
  AUTHORS   Wolska,A., Lo,L., Sviridov,D.O., Pourmousa,M., Pryor,M.,
            Ghosh,S.S., Kakkar,R., Davidson,M., Wilson,S., Pastor,R.W.,
            Goldberg,I.J., Basu,D., Drake,S.K., Cougnoux,A., Wu,M.J.,
            Neher,S.B., Freeman,L.A., Tang,J., Amar,M., Devalaraja,M. and
            Remaley,A.T.
  TITLE     A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist
            peptide lowers plasma triglycerides
  JOURNAL   Sci Transl Med 12 (528) (2020)
   PUBMED   31996466
REFERENCE   2  (bases 1 to 727)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 727)
  AUTHORS   Sakurai,T., Sakurai,A., Vaisman,B.L., Amar,M.J., Liu,C.,
            Gordon,S.M., Drake,S.K., Pryor,M., Sampson,M.L., Yang,L.,
            Freeman,L.A. and Remaley,A.T.
  TITLE     Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and
            Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic
            Peptide
  JOURNAL   J Pharmacol Exp Ther 356 (2), 341-353 (2016)
   PUBMED   26574515
  REMARK    GeneRIF: A novel mouse model of apoC-II deficiency was created with
            an apoC-II peptide that reverses the hypertriglyceridemia.
REFERENCE   4  (bases 1 to 727)
  AUTHORS   Walker,E.M., Thompson,C.A. and Battle,M.A.
  TITLE     GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation
            during development
  JOURNAL   Dev Biol 392 (2), 283-294 (2014)
   PUBMED   24929016
REFERENCE   5  (bases 1 to 727)
  AUTHORS   Seth,A., Ye,J., Yu,N., Guez,F., Bedford,D.C., Neale,G.A., Cordi,S.,
            Brindle,P.K., Lemaigre,F.P., Kaestner,K.H. and Sosa-Pineda,B.
  TITLE     Prox1 ablation in hepatic progenitors causes defective hepatocyte
            specification and increases biliary cell commitment
  JOURNAL   Development 141 (3), 538-547 (2014)
   PUBMED   24449835
REFERENCE   6  (bases 1 to 727)
  AUTHORS   Purcell-Huynh,D.A., Weinreb,A., Castellani,L.W., Mehrabian,M.,
            Doolittle,M.H. and Lusis,A.J.
  TITLE     Genetic factors in lipoprotein metabolism. Analysis of a genetic
            cross between inbred mouse strains NZB/BINJ and SM/J using a
            complete linkage map approach
  JOURNAL   J Clin Invest 96 (4), 1845-1858 (1995)
   PUBMED   7560076
REFERENCE   7  (bases 1 to 727)
  AUTHORS   van Eck,M.M., Hoffer,M.J., Havekes,L.M., Frants,R.R. and
            Hofker,M.H.
  TITLE     The apolipoprotein C2-linked (Acl) gene: a new gene within the
            mouse apolipoprotein e-c1-c2 gene cluster
  JOURNAL   Genomics 21 (1), 110-115 (1994)
   PUBMED   8088778
REFERENCE   8  (bases 1 to 727)
  AUTHORS   Hoffer,M.J., van Eck,M.M., Havekes,L.M., Hofker,M.H. and
            Frants,R.R.
  TITLE     Structure and expression of the mouse apolipoprotein C2 gene
  JOURNAL   Genomics 17 (1), 45-51 (1993)
   PUBMED   7691714
REFERENCE   9  (bases 1 to 727)
  AUTHORS   Hoffer,M.J., Hofker,M.H., van Eck,M.M., Havekes,L.M. and
            Frants,R.R.
  TITLE     Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene
            cluster: structure and genetic variability in inbred mice
  JOURNAL   Genomics 15 (1), 62-67 (1993)
   PUBMED   7916738
REFERENCE   10 (bases 1 to 727)
  AUTHORS   Mahley,R.W., Innerarity,T.L., Rall,S.C. Jr. and Weisgraber,K.H.
  TITLE     Plasma lipoproteins: apolipoprotein structure and function
  JOURNAL   J Lipid Res 25 (12), 1277-1294 (1984)
   PUBMED   6099394
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149282.2 and BG085960.2.
            
            On May 1, 2013 this sequence version replaced NM_009695.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024697.1, BF385571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC149282.2         83187-83262         c
            77-157              AC149282.2         82125-82205         c
            158-727             BG085960.2         1-570
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.94 cM"
     gene            1..727
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /note="apolipoprotein C2"
                     /db_xref="GeneID:11813"
                     /db_xref="MGI:MGI:88054"
     exon            1..76
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /inference="alignment:Splign:2.1.0"
     exon            77..239
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /inference="alignment:Splign:2.1.0"
     exon            240..306
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..545
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /note="apolipoprotein C-II"
                     /codon_start=1
                     /product="apolipoprotein C-II precursor"
                     /protein_id="NP_001264873.1"
                     /db_xref="CCDS:CCDS39801.1"
                     /db_xref="GeneID:11813"
                     /db_xref="MGI:MGI:88054"
                     /translation="MGSRFFLALFLVILMLGNEVQGNQEDDSGSLALLGTVQGSLLSY
                     WTSAKEVAKDLYQKTYPISMDEKLRDMYSKSSAAMSTYAGIFTDQLLTLLRGE"
     exon            307..457
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /inference="alignment:Splign:2.1.0"
     exon            458..727
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      703..708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /note="hexamer: AATAAA"
     polyA_site      722
                     /gene="Apoc2"
                     /gene_synonym="apo-CII; apoC-II"
                     /note="major polyA site"
ORIGIN      
        1 cacaggttcc ggcttgatga gaacaggaga cttccaggca ccaggtcaga tgcaggaggc
       61 aaagtcttag aggccggcct gccaccccac ccccctgtgg ctttgttggc caggactttg
      121 gcctaggaca gagcagctgc ctgatatgga aggagggggc cctccagagc tataaagcct
      181 gccaacccac tggagtactg gagtgagcca ggatagtccc ttcctgccac tacattcagg
      241 tcccagacag catggggtct cggttcttcc tggctctatt cctggtcatc ctgatgttgg
      301 gaaatgaggt ccaggggaac caggaagatg actcgggcag cctggctctg ctgggcacgg
      361 tgcagggctc cctcttaagt tactggacct ctgccaagga ggttgccaaa gacctgtacc
      421 agaagacata cccgatcagc atggatgaga aactcaggga catgtacagc aaaagctcgg
      481 cggccatgag cacttacgca ggcattttta cagaccagct ccttactctc ctgaggggag
      541 agtagctgcc aggcaagccc caagttaggg gaaaggaaaa cctgatgaca gacaccgcgc
      601 ctctttgctc gcatcaccag accaggatgg tcctacacca ccctgtccca gctgctcccg
      661 ccttcctgct cccaactaga gcccagagtc tttcagtgaa agaataaatg agtccaggtt
      721 cactggc
//
