LOCUS       NM_001110009             432 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus apolipoprotein C-I (Apoc1), transcript variant 2,
            mRNA.
ACCESSION   NM_001110009
VERSION     NM_001110009.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Yang,Z., Yang,L., Sun,Z., Rong,Y., Bai,C., Dong,Q. and Jian,L.
  TITLE     miRNA-660-3p inhibits malignancy in glioblastoma via negative
            regulation of APOC1-TGFbeta2 signaling pathway
  JOURNAL   Cancer Biol Ther 24 (1), 2281459 (2023)
   PUBMED   37981873
  REMARK    GeneRIF: miRNA-660-3p inhibits malignancy in glioblastoma via
            negative regulation of APOC1-TGFbeta2 signaling pathway.
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Yu,K., Li,S., Wang,C., Zhang,Y., Li,L., Fan,X., Fang,L., Li,H.,
            Yang,H., Sun,J. and Yang,X.
  TITLE     APOC1 as a novel diagnostic biomarker for DN based on machine
            learning algorithms and experiment
  JOURNAL   Front Endocrinol (Lausanne) 14, 1102634 (2023)
   PUBMED   36891052
  REMARK    GeneRIF: APOC1 as a novel diagnostic biomarker for DN based on
            machine learning algorithms and experiment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 432)
  AUTHORS   Li,R.X., Ding,Y.B., Zhao,S.L., Xiao,Y.Y., Li,Q.R., Xia,F.Y.,
            Sun,L., Lin,X., Wu,J.R., Liao,K. and Zeng,R.
  TITLE     Secretome-derived isotope tags (SDIT) reveal adipocyte-derived
            apolipoprotein C-I as a predictive marker for cardiovascular
            disease
  JOURNAL   J Proteome Res 11 (5), 2851-2862 (2012)
   PUBMED   22404376
  REMARK    GeneRIF: Apolipoprotein C-I was significantly increased in obese
            mice plasma.
REFERENCE   4  (bases 1 to 432)
  AUTHORS   Berbee,J.F., Vanmierlo,T., Abildayeva,K., Blokland,A., Jansen,P.J.,
            Lutjohann,D., Gautier,T., Sijbrands,E., Prickaerts,J., Hadfoune,M.,
            Ramaekers,F.C., Kuipers,F., Rensen,P.C. and Mulder,M.
  TITLE     Apolipoprotein CI knock-out mice display impaired memory functions
  JOURNAL   J Alzheimers Dis 23 (4), 737-747 (2011)
   PUBMED   21157034
  REMARK    GeneRIF: The absence of ApoC-I results in impaired memory
            functions, which is, together with previous data, suggestive of an
            important, bell-shaped gene-dose dependent role for ApoC-I in
            appropriate brain functioning
REFERENCE   5  (bases 1 to 432)
  AUTHORS   Westerterp,M., Berbee,J.F., Delsing,D.J., Jong,M.C., Gijbels,M.J.,
            Dahlmans,V.E., Offerman,E.H., Romijn,J.A., Havekes,L.M. and
            Rensen,P.C.
  TITLE     Apolipoprotein C-I binds free fatty acids and reduces their
            intracellular esterification
  JOURNAL   J Lipid Res 48 (6), 1353-1361 (2007)
   PUBMED   17339654
  REMARK    GeneRIF: Data suggest that apoC-I binds free fatty acids (FFA),
            thereby reducing the blood FFA for uptake by cells, and this
            mechanism can serve as an additional mechanism for the resistance
            to obesity and the cutaneous abnormalities of APOC1(+/+) mice.
REFERENCE   6  (bases 1 to 432)
  AUTHORS   Gautier,T., Masson,D., Jong,M.C., Duverneuil,L., Le Guern,N.,
            Deckert,V., Pais de Barros,J.P., Dumont,L., Bataille,A., Zak,Z.,
            Jiang,X.C., Tall,A.R., Havekes,L.M. and Lagrost,L.
  TITLE     Apolipoprotein CI deficiency markedly augments plasma lipoprotein
            changes mediated by human cholesteryl ester transfer protein (CETP)
            in CETP transgenic/ApoCI-knocked out mice
  JOURNAL   J Biol Chem 277 (35), 31354-31363 (2002)
   PUBMED   12070157
  REMARK    GeneRIF: present observations provide direct support for a potent
            specific inhibition of CETP by plasma apoCI in vivo
REFERENCE   7  (bases 1 to 432)
  AUTHORS   Hoffer,M.J., van Eck,M.M., Havekes,L.M., Hofker,M.H. and
            Frants,R.R.
  TITLE     The mouse apolipoprotein C1 gene: structure and expression
  JOURNAL   Genomics 18 (1), 37-42 (1993)
   PUBMED   8276416
REFERENCE   8  (bases 1 to 432)
  AUTHORS   Kushwaha,R.S., Hasan,S.Q., McGill,H.C. Jr., Getz,G.S., Dunham,R.G.
            and Kanda,P.
  TITLE     Characterization of cholesteryl ester transfer protein inhibitor
            from plasma of baboons (Papio sp.)
  JOURNAL   J Lipid Res 34 (8), 1285-1297 (1993)
   PUBMED   8409763
REFERENCE   9  (bases 1 to 432)
  AUTHORS   Simonet,W.S., Bucay,N., Pitas,R.E., Lauer,S.J. and Taylor,J.M.
  TITLE     Multiple tissue-specific elements control the apolipoprotein E/C-I
            gene locus in transgenic mice
  JOURNAL   J Biol Chem 266 (14), 8651-8654 (1991)
   PUBMED   2026582
REFERENCE   10 (bases 1 to 432)
  AUTHORS   Mahley,R.W., Innerarity,T.L., Rall,S.C. Jr. and Weisgraber,K.H.
  TITLE     Plasma lipoproteins: apolipoprotein structure and function
  JOURNAL   J Lipid Res 25 (12), 1277-1294 (1984)
   PUBMED   6099394
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC149282.2 and BC094638.1.
            
            On Dec 6, 2013 this sequence version replaced NM_001110009.1.
            
            Summary: This gene encodes a precursor plasma protein that is
            cleaved to yield a signal peptide and two alternatively processed
            mature peptides. The encoded protein, which is a component of
            chylomicrons, very low density lipoproteins and high density
            lipoproteins, transports lipids from the intestines to other
            locations in the body. This protein binds to free fatty acids
            preventing their uptake by cells. This protein is a cofactor for
            lecithin cholesterol acyltransferase, an enzyme that catalyzes the
            conversion of free cholesterol to cholesteryl esters. The encoded
            protein inhibits the activity of the cholesteryl ester transfer
            protein which promotes the exchange of neutral lipids between
            lipoproteins. In humans this gene is associated with risk of
            coronary artery disease and age-associated memory impairment. Mice
            lacking this gene demonstrate impaired memory. This gene is
            clustered with three other apolipoprotein genes on chromosome 7.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: W98909.1, AA033335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC149282.2         97941-97980         c
            41-431              BC094638.1         10-400
            432-432             AC149282.2         94801-94801         c
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.94 cM"
     gene            1..432
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /note="apolipoprotein C-I"
                     /db_xref="GeneID:11812"
                     /db_xref="MGI:MGI:88053"
     exon            1..51
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /inference="alignment:Splign:2.1.0"
     exon            52..127
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /inference="alignment:Splign:2.1.0"
     exon            128..275
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /inference="alignment:Splign:2.1.0"
     exon            276..432
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      408..413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /note="hexamer: AATAAA"
     polyA_site      431
                     /gene="Apoc1"
                     /gene_synonym="apo-CI; Apo-CIB; apoC-I; ApoC-IB"
                     /note="major polyA site"
ORIGIN      
        1 gtgcaggatc ctcccaccgc catgggcctc ctgagagatc cttagatcca gggtgcccct
       61 ccaaccagga tgaggctctt catcgctctt cctgtcctga ttgtggtcgt agccatgacc
      121 ttggaaggcc cagcccccgc ccaggcggcc ccggatttgt ccggaacatt ggagagcata
      181 ccggataaac tgaaggagtt tgggaacact ttggaagaca aggcccgggc agccattgaa
      241 catatcaaac agaaggaaat tttgaccaag acccgggcct ggttctcaga ggcatttggc
      301 aaagtgaagg agaagttgaa gaccacgttc tcctgagcac ctggcgggcc acctcgaagc
      361 atcaaggaca tccacgtaat gtgccaggtc cctcttcatc acagaccaat aaaaaacgtg
      421 tagaaggcaa ac
//
