LOCUS       NM_030255               2360 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus apolipoprotein B mRNA editing enzyme, catalytic
            polypeptide 3 (Apobec3), transcript variant 2, mRNA.
ACCESSION   NM_030255
VERSION     NM_030255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Byun,H., Singh,G.B., Xu,W.K., Das,P., Reyes,A., Battenhouse,A.,
            Wylie,D.C., Santiago,M.L., Lozano,M.M. and Dudley,J.P.
  TITLE     Apobec-mediated retroviral hypermutation in vivo is dependent on
            mouse strain
  JOURNAL   PLoS Pathog 20 (8), e1012505 (2024)
   PUBMED   39208378
  REMARK    GeneRIF: Apobec-mediated retroviral hypermutation in vivo is
            dependent on mouse strain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Callahan,J.W., Morales,J.C., Atherton,J.F., Wang,D., Kostic,S. and
            Bevan,M.D.
  TITLE     Movement-related increases in subthalamic activity optimize
            locomotion
  JOURNAL   Cell Rep 43 (8), 114495 (2024)
   PUBMED   39068661
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Sirbulescu,R.F., Nicholson,K., Kawai,K., Hilton,O.M., Sobell,D.,
            Jin,G., Verrill,D.E., Dwyer,L.J., Xiong,Y., Bachanova,P., Kim,S.E.,
            Gallup,S., Gelevski,D., Daley,H., Hernandez Rodriguez,D.E.,
            Negre,H., Sturtevant,O., Nikiforow,S., Ritz,J., Chen,Y.B.,
            Reeves,P.M., Sluder,A.E., Berry,J.D., Sadri-Vakili,G., Cudkowicz,M.
            and Poznansky,M.C.
  TITLE     Allogeneic B cell immunomodulatory therapy in amyotrophic lateral
            sclerosis
  JOURNAL   FASEB J 38 (13), e23796 (2024)
   PUBMED   38967302
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Dautan,D., Monai,A., Maltese,F., Chang,X., Molent,C., Mauro,D.,
            Galbusera,A., Vecchia,D., Antonelli,F., Benedetti,A., Drago,F.,
            Leggio,G.M., Pagani,M., Fellin,T., Gozzi,A., Schumann,G., Manago,F.
            and Papaleo,F.
  TITLE     Cortico-cortical transfer of socially derived information gates
            emotion recognition
  JOURNAL   Nat Neurosci 27 (7), 1318-1332 (2024)
   PUBMED   38769153
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Mao,R., Cavelli,M.L., Findlay,G., Driessen,K., Peterson,M.J.,
            Marshall,W., Tononi,G. and Cirelli,C.
  TITLE     Behavioral and cortical arousal from sleep, muscimol-induced coma,
            and anesthesia by direct optogenetic stimulation of cortical
            neurons
  JOURNAL   iScience 27 (6), 109919 (2024)
   PUBMED   38812551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Miyazawa,M., Nishio,J., Wehrly,K., David,C.S. and Chesebro,B.
  TITLE     Spontaneous recovery from Friend retrovirus-induced leukemia.
            Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC
  JOURNAL   J Immunol 148 (6), 1964-1967 (1992)
   PUBMED   1541833
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Morrey,J.D., Warren,R.P., Okleberry,K.M., Burger,R.A.,
            Johnston,M.I. and Sidwell,R.W.
  TITLE     Effects of zidovudine on Friend virus complex infection in Rfv-3r/s
            genotype-containing mice used as a model for HIV infection
  JOURNAL   J Acquir Immune Defic Syndr (1988) 3 (5), 500-510 (1990)
   PUBMED   2157836
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Chesebro,B., Wehrly,K., Doig,D. and Nishio,J.
  TITLE     Antibody-induced modulation of Friend virus cell surface antigens
            decreases virus production by persistent erythroleukemia cells:
            influence of the Rfv-3 gene
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5784-5788 (1979)
   PUBMED   293683
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Doig,D. and Chesebro,B.
  TITLE     Anti-Friend virus antibody is associated with recovery from viremia
            and loss of viral leukemia cell-surface antigens in leukemic mice.
            Identification of Rfv-3 as a gene locus influencing antibody
            production
  JOURNAL   J Exp Med 150 (1), 10-19 (1979)
   PUBMED   286744
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Chesebro,B. and Wehrly,K.
  TITLE     Identification of a non-H-2 gene (Rfv-3) influencing recovery from
            viremia and leukemia induced by Friend virus complex
  JOURNAL   Proc Natl Acad Sci U S A 76 (1), 425-429 (1979)
   PUBMED   284359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY228556.1, AK153719.1, AK049256.1 and AA288216.1.
            
            On May 24, 2009 this sequence version replaced NM_030255.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the coding region, compared to variant 1. The encoded
            isoform (2)is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153719.1, AK049256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY228556.1         1-50
            51-1744             AK153719.1         1-1694
            1745-1825           AK049256.1         1705-1785
            1826-2017           AK153719.1         1776-1967
            2018-2360           AA288216.1         28-370
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..2360
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide 3"
                     /db_xref="GeneID:80287"
                     /db_xref="MGI:MGI:1933111"
     exon            1..162
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            163..310
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..587
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..702
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            703..859
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1121
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1234
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2360
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1813..1818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="hexamer: CATAAA"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="hexamer: AATAAA"
     polyA_site      1832
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="major polyA site"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="hexamer: AAGAAA"
     polyA_site      1844
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="major polyA site"
     polyA_site      1855
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
                     /note="hexamer: AATAAA"
     polyA_site      2028
                     /gene="Apobec3"
                     /gene_synonym="Apobec; Arp3; Cem15; Gm20117; Rfv3"
ORIGIN      
        1 aaggtggggc ctgcattcac ttggcccggg aggtcagttt cacttctggg ggtcttccat
       61 agcctgctca cagaaaatgc aaccccagcg cctggggccc agagctggga tgggaccatt
      121 ctgtctggga tgcagccatc gcaaatgcta ttcaccgatc agaaacctga tatctcaaga
      181 aacattcaag ttccacttta agaacctagg ctatgccaaa ggccggaaag ataccttctt
      241 gtgctatgaa gtgactagaa aggactgcga ttcacccgtc tcccttcacc atggggtctt
      301 taagaacaag gacaacatcc acgctgaaat ctgcttttta tactggttcc atgacaaagt
      361 actgaaagtg ctgtctccga gagaagagtt caagatcacc tggtatatgt cctggagccc
      421 ctgtttcgaa tgtgcagagc agatagtaag gttcctggct acacaccaca acctgagcct
      481 ggacatcttc agctcccgcc tctacaacgt acaggaccca gaaacccagc agaatctttg
      541 caggctggtt caggaaggag cccaggtggc tgccatggac ctatacgaat ttaaaaagtg
      601 ttggaagaag tttgtggaca atggtggcag gcgattcagg ccttggaaaa gactgcttac
      661 aaattttaga taccaggatt ctaagcttca ggagattctg aggcgaatgg acccgctaag
      721 tgaagaggaa ttttactcgc agttttacaa ccaacgagtc aagcatctct gctactacca
      781 ccgcatgaag ccctatctat gctaccagct ggagcagttc aatggccaag cgccactcaa
      841 aggctgcctg ctaagcgaga aaggcaaaca gcatgcagaa atcctcttcc ttgataagat
      901 tcggtccatg gagctgagcc aagtgacaat cacctgctac ctcacctgga gcccctgccc
      961 aaactgtgcc tggcaactgg cggcattcaa aagggatcgt ccagatctaa ttctgcatat
     1021 ctacacctcc cgcctgtatt tccactggaa gaggcccttc cagaaggggc tgtgttctct
     1081 gtggcaatca gggatcctgg tggacgtcat ggacctccca cagtttactg actgctggac
     1141 aaactttgtg aacccgaaaa ggccgttttg gccatggaaa ggattggaga taatcagcag
     1201 gcgcacacaa aggcggctcc gcaggatcaa ggagtcctgg ggtctgcaag atttggtgaa
     1261 tgactttgga aacctacagc ttggaccccc gatgtcttga gaggcaagaa gagattcaag
     1321 aaggtctttt ggtgaccccc ccacccaacc ccaagtctag gagacctttt gttctcctgt
     1381 ttgtttcccc ttttgtttta tcttttgttg ttttgctttg ttttgaagac agagtctcac
     1441 tgggtagctt gctactctgg aactcactac tagactaagc tggccttaaa ctctaaaatc
     1501 cacctgccag tgccttctga gagccaggct taaggtgtgc gctgcccact cccagcctta
     1561 acccactgtg gcttttcctt cctctttctt ttattatctt tttatctccc ctcaccctcc
     1621 cgccatcaat aggtacttaa ttttgtactt gaaattttta agttgggcca ggcatggtgg
     1681 agcagcgtgc ctctaatcgc aggcaggagg atttccacga gcttgaggct agcctgatct
     1741 acatagtggg ctccaggaca gccagaacta cacagagacc ctgtctcaaa aataaattta
     1801 gatagataaa tacataaata aatggaagaa gtcaaagaaa gaaagacaag attaagttgt
     1861 gcatgattgg gtcatatgtg tttgaggcag gaggattgcc acatcctggg ctatacaatg
     1921 agaccctgtc tcaaacaaaa caaaacaaaa cacaccaaaa gaacagtttt taaatcccca
     1981 aacctgaatt cttttctaat aaagtggaca accaggcagg ccccctcacc catcagagtg
     2041 tgaacatcaa ggaagggagc cagcaaactg gctcacaggt gagcaagctg actgcacctg
     2101 aagatcagag ttcagatccc agcacccacc tcctgtagct cacaattgat ctaactctag
     2161 ctccagggta cctggtgccc tctcctggac tccatggcac cccatatata tgtatgtgtg
     2221 tttatgtatg tataatgtgt acattatata tgcatacatg caatatataa tttatatgtg
     2281 tgtgtatata tatatataat gtatatatta tatatctccc tgtagttgca acccaaccca
     2341 gttccctcta catagggtgt
//
