LOCUS       NM_009694               1218 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus apolipoprotein B mRNA editing enzyme, catalytic
            polypeptide 2 (Apobec2), mRNA.
ACCESSION   NM_009694
VERSION     NM_009694.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1218)
  AUTHORS   Lorenzo,J.P., Molla,L., Amro,E.M., Ibarra,I.L., Ruf,S., Neber,C.,
            Gkougkousis,C., Ridani,J., Subramani,P.G., Boulais,J., Harjanto,D.,
            Vonica,A., Di Noia,J.M., Dieterich,C., Zaugg,J.B. and
            Papavasiliou,F.N.
  TITLE     APOBEC2 safeguards skeletal muscle cell fate through binding
            chromatin and regulating transcription of non-muscle genes during
            myoblast differentiation
  JOURNAL   Proc Natl Acad Sci U S A 121 (17), e2312330121 (2024)
   PUBMED   38625936
  REMARK    GeneRIF: APOBEC2 safeguards skeletal muscle cell fate through
            binding chromatin and regulating transcription of non-muscle genes
            during myoblast differentiation.
REFERENCE   2  (bases 1 to 1218)
  AUTHORS   Florkowska,A., Meszka,I., Nowacka,J., Granica,M., Jablonska,Z.,
            Zawada,M., Truszkowski,L., Ciemerych,M.A. and Grabowska,I.
  TITLE     PAX7 Balances the Cell Cycle Progression via Regulating Expression
            of Dnmt3b and Apobec2 in Differentiating PSCs
  JOURNAL   Cells 10 (9), 2205 (2021)
   PUBMED   34571854
  REMARK    GeneRIF: PAX7 Balances the Cell Cycle Progression via Regulating
            Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1218)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1218)
  AUTHORS   Sato,Y., Ohtsubo,H., Nihei,N., Kaneko,T., Sato,Y., Adachi,S.I.,
            Kondo,S., Nakamura,M., Mizunoya,W., Iida,H., Tatsumi,R., Rada,C.
            and Yoshizawa,F.
  TITLE     Apobec2 deficiency causes mitochondrial defects and mitophagy in
            skeletal muscle
  JOURNAL   FASEB J 32 (3), 1428-1439 (2018)
   PUBMED   29127187
  REMARK    GeneRIF: Apobec2 deficiency causes mitochondrial defects that
            increase muscle mitophagy, leading to myopathy and atrophy.
            Findings demonstrate that Apobec2 is required for mitochondrial
            homeostasis to maintain normal skeletal muscle function.
REFERENCE   5  (bases 1 to 1218)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1218)
  AUTHORS   Mariani,R., Chen,D., Schrofelbauer,B., Navarro,F., Konig,R.,
            Bollman,B., Munk,C., Nymark-McMahon,H. and Landau,N.R.
  TITLE     Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif
  JOURNAL   Cell 114 (1), 21-31 (2003)
   PUBMED   12859895
REFERENCE   7  (bases 1 to 1218)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (bases 1 to 1218)
  AUTHORS   Dance,G.S., Beemiller,P., Yang,Y., Mater,D.V., Mian,I.S. and
            Smith,H.C.
  TITLE     Identification of the yeast cytidine deaminase CDD1 as an orphan
            C-->U RNA editase
  JOURNAL   Nucleic Acids Res 29 (8), 1772-1780 (2001)
   PUBMED   11292850
REFERENCE   9  (bases 1 to 1218)
  AUTHORS   Liao,W., Hong,S.H., Chan,B.H., Rudolph,F.B., Clark,S.C. and Chan,L.
  TITLE     APOBEC-2, a cardiac- and skeletal muscle-specific member of the
            cytidine deaminase supergene family
  JOURNAL   Biochem Biophys Res Commun 260 (2), 398-404 (1999)
   PUBMED   10403781
REFERENCE   10 (bases 1 to 1218)
  AUTHORS   Hirano,K., Young,S.G., Farese,R.V. Jr., Ng,J., Sande,E.,
            Warburton,C., Powell-Braxton,L.M. and Davidson,N.O.
  TITLE     Targeted disruption of the mouse apobec-1 gene abolishes
            apolipoprotein B mRNA editing and eliminates apolipoprotein B48
  JOURNAL   J Biol Chem 271 (17), 9887-9890 (1996)
   PUBMED   8626621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165291.2 and AC166164.2.
            
            On Apr 27, 2007 this sequence version replaced NM_009694.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF161699.1, BC027530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC165291.2         55545-55794         c
            251-815             AC166164.2         4408-4972
            816-1218            AC166164.2         8280-8682
FEATURES             Location/Qualifiers
     source          1..1218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 24.02 cM"
     gene            1..1218
                     /gene="Apobec2"
                     /gene_synonym="Arp1"
                     /note="apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide 2"
                     /db_xref="GeneID:11811"
                     /db_xref="MGI:MGI:1343178"
     exon            1..250
                     /gene="Apobec2"
                     /gene_synonym="Arp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..794
                     /gene="Apobec2"
                     /gene_synonym="Arp1"
                     /EC_number="3.5.4.36"
                     /note="probable C->U-editing enzyme APOBEC-2;
                     apolipoprotein B editing complex 2; mRNA(cytosine(6666))
                     deaminase 2"
                     /codon_start=1
                     /product="C->U-editing enzyme APOBEC-2"
                     /protein_id="NP_033824.1"
                     /db_xref="CCDS:CCDS28868.1"
                     /db_xref="GeneID:11811"
                     /db_xref="MGI:MGI:1343178"
                     /translation="MAQKEEAAEAAAPASQNGDDLENLEDPEKLKELIDLPPFEIVTG
                     VRLPVNFFKFQFRNVEYSSGRNKTFLCYVVEVQSKGGQAQATQGYLEDEHAGAHAEEA
                     FFNTILPAFDPALKYNVTWYVSSSPCAACADRILKTLSKTKNLRLLILVSRLFMWEEP
                     EVQAALKKLKEAGCKLRIMKPQDFEYIWQNFVEQEEGESKAFEPWEDIQENFLYYEEK
                     LADILK"
     exon            251..815
                     /gene="Apobec2"
                     /gene_synonym="Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1218
                     /gene="Apobec2"
                     /gene_synonym="Arp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatccggtcc tctctctgtc atccccagcc aggcttagct gctgacagct gcttgggact
       61 ctgccgccag gcccttggct ggcttgacaa cctctccaca tttcggccac agttcctcca
      121 tggctcagaa ggaagaggcc gctgaggctg cggcgccagc ctctcagaat ggagatgatt
      181 tggagaacct ggaagaccct gagaagctga aagagctgat cgatcttccg cccttcgaga
      241 ttgtcactgg ggtgcggcta ccagtcaact tcttcaagtt tcagttccgg aacgtggaat
      301 acagttccgg gcggaataag acctttctct gctatgtggt cgaagtacag agtaagggcg
      361 gccaagcgca ggcgacgcag ggctacctgg aggatgaaca cgcaggtgcc cacgccgagg
      421 aggctttctt taacaccatc ctgccagctt tcgacccggc cctcaagtac aatgtcacct
      481 ggtatgtgtc ctccagcccc tgtgcagcct gcgctgaccg gattctcaaa accctcagca
      541 agactaagaa ccttcgtctg ctcattctgg tgagccggct cttcatgtgg gaggagccag
      601 aggtccaggc cgctctgaaa aagctgaagg aggccggctg caaacttcgc atcatgaaac
      661 cccaggactt cgagtacatc tggcagaatt ttgtggagca agaagagggt gaatccaagg
      721 cctttgagcc ctgggaggac attcaggaga acttcctata ctatgaggag aagttggcag
      781 acatcctgaa gtaggcaaca gagctcggcc ttccagtttt acctgctgcc actcagagca
      841 atgacccgga tgccatccag gacatacctg gcttcctgat tctacttgga gttggacatc
      901 tgacactaac cagttgcact ggacaagacc ctctctcaga gaactcaaaa catacctcgg
      961 gacgtcattc attcattcaa tcatgccttc tgtaatacgg ctatcagaag aaggaaaatg
     1021 aagacaagaa aaacaactgt gatgtgggca gcaggtacct gggggtggag ggtcttattg
     1081 cctctccagg ggtgctgcct gagacaaaga tcctcagtca aggtacagac ctttgaaata
     1141 cagctagaaa agtgttctga attgggctga ctttttaaaa aagacaaaat agcaacatca
     1201 ataaaggaaa taagtggt
//
