LOCUS       NM_001409470            2320 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus apolipoprotein B mRNA editing enzyme, catalytic
            polypeptide 1 (Apobec1), transcript variant 6, mRNA.
ACCESSION   NM_001409470 XM_006505401
VERSION     NM_001409470.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Nargis,T., Lin,X., Giordano,E., Ijaz,L., Suhail,S., Gurzenda,E.M.,
            Kiefer,D., Quadro,L., Hanna,N. and Hussain,M.M.
  TITLE     Characterization of lipoproteins in human placenta and fetal
            circulation as well as gestational changes in lipoprotein assembly
            and secretion in human and mouse placentas
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (9), 159357 (2023)
   PUBMED   37315736
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Ozawa,K., Packwood,W., Varlamov,O., Muller,M., Xie,A., Wu,M.D.,
            Abraham-Fan,R.J., Lopez,J.A. and Lindner,J.R.
  TITLE     Elevated LDL Cholesterol Increases Microvascular Endothelial VWF
            and Thromboinflammation After Myocardial Infarction
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), 1041-1053 (2023)
   PUBMED   37128919
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Sandovici,I., Georgopoulou,A., Perez-Garcia,V., Hufnagel,A.,
            Lopez-Tello,J., Lam,B.Y.H., Schiefer,S.N., Gaudreau,C., Santos,F.,
            Hoelle,K., Yeo,G.S.H., Burling,K., Reiterer,M., Fowden,A.L.,
            Burton,G.J., Branco,C.M., Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     The imprinted Igf2-Igf2r axis is critical for matching placental
            microvasculature expansion to fetal growth
  JOURNAL   Dev Cell 57 (1), 63-79 (2022)
   PUBMED   34963058
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Newberry,E.P., Hall,Z., Xie,Y., Molitor,E.A., Bayguinov,P.O.,
            Strout,G.W., Fitzpatrick,J.A.J., Brunt,E.M., Griffin,J.L. and
            Davidson,N.O.
  TITLE     Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis,
            Fibrosis, and Hepatocellular Cancer
  JOURNAL   Hepatology 74 (3), 1203-1219 (2021)
   PUBMED   33638902
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Morrison,J.R., Paszty,C., Stevens,M.E., Hughes,S.D., Forte,T.,
            Scott,J. and Rubin,E.M.
  TITLE     Apolipoprotein B RNA editing enzyme-deficient mice are viable
            despite alterations in lipoprotein metabolism
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7154-7159 (1996)
   PUBMED   8692961
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Hirano,K., Young,S.G., Farese,R.V. Jr., Ng,J., Sande,E.,
            Warburton,C., Powell-Braxton,L.M. and Davidson,N.O.
  TITLE     Targeted disruption of the mouse apobec-1 gene abolishes
            apolipoprotein B mRNA editing and eliminates apolipoprotein B48
  JOURNAL   J Biol Chem 271 (17), 9887-9890 (1996)
   PUBMED   8626621
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Innerarity,T.L., Boren,J., Yamanaka,S. and Olofsson,S.O.
  TITLE     Biosynthesis of apolipoprotein B48-containing lipoproteins.
            Regulation by novel post-transcriptional mechanisms
  JOURNAL   J Biol Chem 271 (5), 2353-2356 (1996)
   PUBMED   8576187
  REMARK    Review article
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Osuga,J., Inaba,T., Harada,K., Yagyu,H., Shimada,M., Yazaki,Y.,
            Yamada,N. and Ishibashi,S.
  TITLE     Cloning and structural analysis of the mouse apolipoprotein B mRNA
            editing protein gene
  JOURNAL   Biochem Biophys Res Commun 214 (2), 653-662 (1995)
   PUBMED   7677778
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Nakamuta,M., Oka,K., Krushkal,J., Kobayashi,K., Yamamoto,M.,
            Li,W.H. and Chan,L.
  TITLE     Alternative mRNA splicing and differential promoter utilization
            determine tissue-specific expression of the apolipoprotein B
            mRNA-editing protein (Apobec1) gene in mice. Structure and
            evolution of Apobec1 and related nucleoside/nucleotide deaminases
  JOURNAL   J Biol Chem 270 (22), 13042-13056 (1995)
   PUBMED   7768898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158651.12.
            
            On Jul 18, 2022 this sequence version replaced XM_006505401.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR12282455.26104001.1,
                                    SRR13862101.636499.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849382, SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC158651.12        108947-109249       c
            304-371             AC158651.12        108766-108833       c
            372-517             AC158651.12        105340-105485       c
            518-635             AC158651.12        99795-99912         c
            636-663             AC158651.12        96853-96880         c
            664-1061            AC158651.12        90061-90458         c
            1062-1180           AC158651.12        89396-89514         c
            1181-2320           AC158651.12        86504-87643         c
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.68 cM"
     gene            1..2320
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide 1"
                     /db_xref="GeneID:11810"
                     /db_xref="MGI:MGI:103298"
     exon            1..303
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..371
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..517
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..635
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     CDS             620..1309
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /EC_number="3.5.4.36"
                     /note="isoform a is encoded by transcript variant 6;
                     C->U-editing enzyme APOBEC-1; apolipoprotein B editing
                     complex 1; mRNA(cytosine(6666)) deaminase 1"
                     /codon_start=1
                     /product="C->U-editing enzyme APOBEC-1 isoform a"
                     /protein_id="NP_001396399.1"
                     /db_xref="GeneID:11810"
                     /db_xref="MGI:MGI:103298"
                     /translation="MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINW
                     GGRHSVWRHTSQNTSNHVEVNFLEKFTTERYFRPNTRCSITWFLSWSPCGECSRAITE
                     FLSRHPYVTLFIYIARLYHHTDQRNRQGLRDLISSGVTIQIMTEQEYCYCWRNFVNYP
                     PSNEAYWPRYPHLWVKLYVLELYCIILGLPPCLKILRRKQPQLTFFTITLQTCHYQRI
                     PPHLLWATGLK"
     exon            636..663
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..1061
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1180
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..2320
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="hexamer: ACTAAA"
     polyA_site      1410
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="major polyA site"
     regulatory      2285..2290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="hexamer: AAGAAA"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="hexamer: AGTAAA"
     polyA_site      2316
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="major polyA site"
     polyA_site      2320
                     /gene="Apobec1"
                     /gene_synonym="APOBEC-1; Cdar1"
                     /note="major polyA site"
ORIGIN      
        1 gaatagccaa ctaatgagaa tcggataagt gtgccacaaa gacatattct ctttccctaa
       61 atccgactgg tggaataggg agaagtcctc tatccctaaa tcctgattgg tgggatgact
      121 tggcagagac ttaaaacctg caacattctg gctcagggtt gcagttcagc tctggcggag
      181 tttgttctgg ggccctgatc gaccagtagt ggtctgcata caatacagtc ttgccatctg
      241 cttaaatact tattaaaatg cagattcagt catcccctga gtctctgctg ttgtacctga
      301 ttggactgcc cgtggttgat ttgttctgct cctggattct tcatattagc tctgaggaca
      361 tcatgagcca ggactgctag acacactgga gagaagctgc ttccgtctgc cctgcgtctg
      421 tagagtgtcc agcatcctga cccatgaatc agagactact gtctgatttg ccttgactca
      481 gagagtctga acctgacctt cagctaacct cacacaggtg gctgtgggca cacctgagga
      541 aacaaagtcc ggcacacagc tggcagaagc catcgcagca acataagctc ccgaggaagg
      601 cgtccagaga cagagcaaga tgagttccga gacaggccct gtagctgttg atcccactct
      661 gaggagaaga attgagcccc acgagtttga agtcttcttt gacccccggg agcttcggaa
      721 agagacctgt ctgctgtatg agatcaactg gggtggaagg cacagtgtct ggcgacacac
      781 gagccaaaac accagcaacc acgttgaagt caacttctta gaaaaattta ctacagaaag
      841 atactttcgt ccgaacacca gatgctccat tacctggttc ctgtcctgga gtccctgcgg
      901 ggagtgctcc agggccatta cagagtttct gagccgacac ccctatgtaa ctctgtttat
      961 ttacatagca cggctttatc accacacgga tcagcgaaac cgccaaggac tcagggacct
     1021 tattagcagc ggtgtgacta tccagatcat gacagagcaa gagtattgtt actgctggag
     1081 gaatttcgtc aactaccccc cttcaaacga agcttattgg ccaaggtacc cccatctgtg
     1141 ggtgaaactg tatgtactgg agctctactg catcatttta ggacttccac cctgtttaaa
     1201 aattttaaga agaaagcaac ctcaactcac gtttttcaca attactcttc aaacctgcca
     1261 ttaccaaagg ataccacccc atctcctttg ggctacaggg ttgaaatgac ttctgggagt
     1321 tgggcatgga tgaaatgact ccttgtatgt gtattgtctt gacagcaagc attgatgacc
     1381 cactaaagag tgactgccat gaagaatcta gaaattgagc tggaggtgtc attcatgggt
     1441 agggtactag ttacacacga ggcccttggt ttaattccaa gaatgtccag aaaaaaggag
     1501 aatctagaaa ttgagctggg aatggttata cactcctgta atgtcagcaa ttgtgaggca
     1561 gaggcaccag atctctgtga gtttaaggcc agcctggtct acactgcaag acccaggcta
     1621 gccttgaatt acacagtgag accttgtcta aaaaaacccc acccccatca agaatgtaga
     1681 aattgaagag tcaggtaagg tggtgcattc ctgtaagccc agtagttgca tggtggaggc
     1741 aggagaatga caaggtcaaa gtcacttgga gctacacagt aagtctgaag acagcctcaa
     1801 cacatagaaa ttcagtgtgc taaattcctc caggtacacc aggggccaac agccaacacc
     1861 ttgccagctt acatagtata gtcactcaga caagctcagt catttgtctg cctggcctcc
     1921 aaaggctata atggcataca gcagtcccag ggcattaaaa gaagcttaga ccttattaat
     1981 ttctgatgaa gtctggctat acattttaat tttaaaaact gtatctattt actcttatta
     2041 ttgtgtctgt tgagggggtt gtatgtacac actgtggcac tcctgtgaag gtcagaggac
     2101 aacttttaag gtttttgttc tctccatctg ttagccgttc tgaggactga atgcagattg
     2161 tcagctcaaa aaagcaaatt atctcccctg agtggtctca acagccctat gtctatacgt
     2221 aaaaaaaaac aaaacaaaac aaaacaaaaa caaaacaaaa aaaaaaaaaa acaaaggaaa
     2281 agaaaagaaa aaccctgcag taaaagaacc atgtatcaat
//
