LOCUS       NM_080434               2323 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus apolipoprotein A-V (Apoa5), transcript variant 1,
            mRNA.
ACCESSION   NM_080434
VERSION     NM_080434.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Chen,H., Luo,S., Deng,X., Li,S., Mao,Y., Yan,J., Cheng,Y., Liu,X.,
            Pan,J. and Huang,H.
  TITLE     Pre-eclamptic foetal programming predisposes offspring to hepatic
            steatosis via DNA methylation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167189 (2024)
   PUBMED   38648899
REFERENCE   2  (bases 1 to 2323)
  AUTHORS   Yang,Y., Beigneux,A.P., Song,W., Nguyen,L.P., Jung,H., Tu,Y.,
            Weston,T.A., Tran,C.M., Xie,K., Yu,R.G., Tran,A.P., Miyashita,K.,
            Nakajima,K., Murakami,M., Chen,Y.Q., Zhen,E.Y., Kim,J.R., Kim,P.H.,
            Birrane,G., Tontonoz,P., Ploug,M., Konrad,R.J., Fong,L.G. and
            Young,S.G.
  TITLE     Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts
            of lipoprotein lipase in the capillary lumen
  JOURNAL   J Clin Invest 133 (23), e172600 (2023)
   PUBMED   37824203
  REMARK    GeneRIF: Hypertriglyceridemia in Apoa5-/- mice results from reduced
            amounts of lipoprotein lipase in the capillary lumen.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2323)
  AUTHORS   Ress,C., Dobner,J., Rufinatscha,K., Staels,B., Hofer,M., Folie,S.,
            Radlinger,B., Adolph,T.E., Rubin,E.M., Roden,M., Tilg,H. and
            Kaser,S.
  TITLE     Apolipoprotein A5 controls fructose-induced metabolic dysregulation
            in mice
  JOURNAL   Nutr Metab Cardiovasc Dis 31 (3), 972-978 (2021)
   PUBMED   33549451
  REMARK    GeneRIF: Apolipoprotein A5 controls fructose-induced metabolic
            dysregulation in mice.
REFERENCE   4  (bases 1 to 2323)
  AUTHORS   Takanashi,M., Kimura,T., Li,C., Tanaka,M., Matsuhashi,A.,
            Yoshida,H., Noda,A., Xu,P., Takase,S., Okazaki,S., Iizuka,Y.,
            Kumagai,H., Ikeda,Y., Gotoda,T., Takahashi,M., Yagyu,H.,
            Ishibashi,S., Yamauchi,T., Kadowaki,T., Liang,G. and Okazaki,H.
  TITLE     Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced
            Hypertriglyceridemia of Apo AV Deficiency
  JOURNAL   Arterioscler Thromb Vasc Biol 39 (3), 373-386 (2019)
   PUBMED   30700132
REFERENCE   5  (bases 1 to 2323)
  AUTHORS   Li,H., Feng,J.C., Li,G.L., Wang,X., Li,M.Z. and Liu,H.F.
  TITLE     [The effect of lnc-RAP3 on 3T3-L1 preadipocyte differentiation in
            mouse]
  JOURNAL   Yi Chuan 40 (9), 758-766 (2018)
   PUBMED   30369479
  REMARK    GeneRIF: lnc-RAP3 suppress 3T3-L1 preadipocyte differentiation by
            affecting the expression of the genes involved in adipogenic
            differentiation.
REFERENCE   6  (bases 1 to 2323)
  AUTHORS   Sehayek,E., Duncan,E.M., Yu,H.J., Petukhova,L. and Breslow,J.L.
  TITLE     Loci controlling plasma non-HDL and HDL cholesterol levels in a
            C57BL /6J x CASA /Rk intercross
  JOURNAL   J Lipid Res 44 (9), 1744-1750 (2003)
   PUBMED   12810823
REFERENCE   7  (bases 1 to 2323)
  AUTHORS   Pennacchio,L.A. and Rubin,E.M.
  TITLE     Apolipoprotein A5, a newly identified gene that affects plasma
            triglyceride levels in humans and mice
  JOURNAL   Arterioscler Thromb Vasc Biol 23 (4), 529-534 (2003)
   PUBMED   12615678
  REMARK    GeneRIF: Review. APOA5 represents a newly discovered gene involved
            in triglyceride metabolism in both humans and mice whose mechanism
            of action remains to be deciphered.
            Review article
REFERENCE   8  (bases 1 to 2323)
  AUTHORS   van der Vliet,H.N., Schaap,F.G., Levels,J.H., Ottenhoff,R.,
            Looije,N., Wesseling,J.G., Groen,A.K. and Chamuleau,R.A.
  TITLE     Adenoviral overexpression of apolipoprotein A-V reduces serum
            levels of triglycerides and cholesterol in mice
  JOURNAL   Biochem Biophys Res Commun 295 (5), 1156-1159 (2002)
   PUBMED   12135615
  REMARK    GeneRIF: a role of ApoA-V in regulating levels of circulating
            triglycerides and cholesterol.
REFERENCE   9  (bases 1 to 2323)
  AUTHORS   van der Vliet,H.N., Sammels,M.G., Leegwater,A.C., Levels,J.H.,
            Reitsma,P.H., Boers,W. and Chamuleau,R.A.
  TITLE     Apolipoprotein A-V: a novel apolipoprotein associated with an early
            phase of liver regeneration
  JOURNAL   J Biol Chem 276 (48), 44512-44520 (2001)
   PUBMED   11577099
REFERENCE   10 (bases 1 to 2323)
  AUTHORS   Pennacchio,L.A., Olivier,M., Hubacek,J.A., Cohen,J.C., Cox,D.R.,
            Fruchart,J.C., Krauss,R.M. and Rubin,E.M.
  TITLE     An apolipoprotein influencing triglycerides in humans and mice
            revealed by comparative sequencing
  JOURNAL   Science 294 (5540), 169-173 (2001)
   PUBMED   11588264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050280.1 and AC164105.4.
            
            On Feb 8, 2017 this sequence version replaced NM_080434.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050280.1, AF327059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2321              AK050280.1         2-2322
            2322-2323           AC164105.4         173151-173152       c
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.37 cM"
     gene            1..2323
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /note="apolipoprotein A-V"
                     /db_xref="GeneID:66113"
                     /db_xref="MGI:MGI:1913363"
     exon            1..12
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            13..69
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1136
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /note="apolipoprotein A5; regeneration-associated protein
                     3"
                     /codon_start=1
                     /product="apolipoprotein A-V precursor"
                     /protein_id="NP_536682.2"
                     /db_xref="CCDS:CCDS23143.1"
                     /db_xref="GeneID:66113"
                     /db_xref="MGI:MGI:1913363"
                     /translation="MAAVITWALALLAVFASTQARKSLWDYFSQNSWSKGVMGQPQKL
                     AQENLKGSFEQDLYNMNNYLEKLGPLRGPGKEPPLLAQDPEGIRKQLQQELGEVSSRL
                     EPYMAAKHQQVGWNLEGLRQQLKPYTAELMEQVGLSVQELQEQLRVVGEDTKAQLLGG
                     VDEALNLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAAASPAR
                     LSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSAFIRVSTDGAEDGDSLDPQALSE
                     EVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKAL
                     SRLQSRLDDLWEDIAYGLQDQGHSHLSDPEGHSG"
     exon            70..169
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            170..2323
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1268..1273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /note="hexamer: ATTACA"
     polyA_site      1295
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /note="hexamer: AATAGA"
     polyA_site      1813
                     /gene="Apoa5"
                     /gene_synonym="1300007O05Rik; Apoav; RAP3"
                     /note="major polyA site"
ORIGIN      
        1 agaaccgagc aggggccatc gtggaaagca tggctgcagt catcacttgg gccctcgccc
       61 tcctcgcagt gttcgcaagc actcaggcac ggaagagcct ctgggactac ttcagccaaa
      121 acagttggag caaaggcgtg atgggccagc cacagaagct ggcacaggag aacctgaaag
      181 gcagcttcga gcaagacctc tacaatatga acaattacct agaaaagctg ggacccttga
      241 gagggcctgg gaaggagcct cctctgctgg cccaggaccc agaaggcatt cggaaacagc
      301 tgcagcagga gctgggggaa gtgagctcgc gcctggagcc ctacatggct gcgaagcacc
      361 agcaggtagg ctggaacttg gagggcctga ggcagcagtt gaaaccctac acggcggagc
      421 tgatggagca ggtgggcctg agtgtgcagg agctgcagga gcagctgcgc gtggtgggag
      481 aagacaccaa ggctcagctc ctggggggcg tggacgaggc gctgaacctg ctgcaggaca
      541 tgcagagtcg agtgctgcac cataccgacc gagtcaaaga gctcttccac ccttacgcag
      601 aacgcttggt gactggaatt gggcaccacg tgcaggagct gcaccgcagt gtcgctcctc
      661 acgcagctgc cagccccgcg cgactcagtc gctgcgtgca gactctgtcc cacaaactca
      721 cacgtaaggc gaaggacctg cacaccagca tccaacgcaa cctggaccag ctgcgcgatg
      781 agctcagtgc cttcatccgc gtcagcacag atggggcgga agatggagat tccctggacc
      841 ctcaggctct ctccgaggag gtccgccaga gactgcaggc ttttcggcat gacacctacc
      901 tgcagattgc tgcatttact caggccattg accaggagac agaggaaatt cagcaccagc
      961 tagccccacc cccgcctagc cacagcgcct tcgctcctga gctgggacac tcagacagta
     1021 ataaggccct gagcagactg cagagccgac tggacgacct gtgggaagat attgcctatg
     1081 gccttcaaga ccagggtcat agtcatttga gtgaccctga gggtcactcc ggttaaccct
     1141 ccagctcatt gtctggaccc tgagccgcta gcatggtcta ttaggcagag ggtggagggt
     1201 cctgcacacc accaaaggtg ctgctgtccc aacctaccca gcctcctcaa ctcccctact
     1261 caggggcatt acactcagta ggctttgcaa acccagcttc tggtactcat ttggcaatcc
     1321 taagtagcaa gagtgaggtg acaggagtgg gagatggtgt gtggggtgac tgaccgcaag
     1381 ccagtgcttg accgtgctgg aaacccatgc cactacaacc tggagttggg ctcctgttaa
     1441 ttctcgcagc ctggtgctgg ctgttacagt tggtccatgg agaggaactc ctgtctcccc
     1501 agggttgtca tgagagcttt tgttggaagg gagcaggagg agagcatgat gcagagaaca
     1561 tgtgatggag tgtgtacgtc cctgccagtg gtcctgctgg tgggtccagt gatgggaccg
     1621 ggcagagccc ctatttcctt agagaactct gaatccagat aaggaactga gccatccaca
     1681 cgatgaagga gggcttctaa aaaaatcctg tacagaacaa actgtgtgcc ttcctcatca
     1741 tacagtccct acctcctgac tctcagggtg gaactgactt ttggttggaa tgaaatagat
     1801 gctcgtgatg gaacgttgtt ggtctggcgt gactctcatt ggaccatgtc tgagagcaat
     1861 tgtttcccct ctgtctcaga acacacccac catccacttg tacccctcac ttgctctttc
     1921 tgtctctttt ccattcttgg tccactctgg gcgagttctg ccgtaggact cctggctaga
     1981 caatggctgt cacatttgat ggggttgggt ggggaggagg ctgtcttgtt ccacagtcta
     2041 cggatcacag gacagcgtgg attaattctc gcagcctggt gctggctgtt acagttggtc
     2101 cacggagagg aactcctgtc tccccagggc tgtcatgaga gcttttgttg gaagggagca
     2161 ggaggagagc atgatgcaga gaacatgtga tggagtgtgt aatggggaaa catgctctcc
     2221 ctgaaatccc tgaaggatcc ccttaccctt ggtcccatgt tccagattcc tcatgcctgc
     2281 ttgactctct tcttgggatt gataaaaact ctctctttga gac
//
