LOCUS       NM_007468               1666 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus apolipoprotein A-IV (Apoa4), mRNA.
ACCESSION   NM_007468
VERSION     NM_007468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Wang,F., Ko,C.W., Qu,J., Wu,D., Zhu,Q., Liu,M. and Tso,P.
  TITLE     Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background Are
            Susceptible to Obesity and Glucose Intolerance
  JOURNAL   Nutrients 15 (22), 4840 (2023)
   PUBMED   38004234
  REMARK    GeneRIF: Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background
            Are Susceptible to Obesity and Glucose Intolerance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Liu,X.H., Zhang,Y., Chang,L., Wei,Y., Huang,N., Zhou,J.T.,
            Cheng,C., Zhang,J., Xu,J., Li,Z. and Li,X.
  TITLE     Apolipoprotein A-IV reduced metabolic inflammation in white adipose
            tissue by inhibiting IKK and JNK signaling in adipocytes
  JOURNAL   Mol Cell Endocrinol 559, 111813 (2023)
   PUBMED   36341820
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Liu,X.H., Zhou,J.T., Yan,C.X., Cheng,C., Fan,J.N., Xu,J., Zheng,Q.,
            Bai,Q., Li,Z., Li,S. and Li,X.
  TITLE     Single-cell RNA sequencing reveals a novel inhibitory effect of
            ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells
  JOURNAL   Front Immunol 13, 1038401 (2022)
   PUBMED   36426356
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Cheng,C., Liu,X.H., He,J., Gao,J., Zhou,J.T., Fan,J.N., Jin,X.,
            Zhang,J., Chang,L., Xiong,Z., Yu,J., Li,S. and Li,X.
  TITLE     Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via
            SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling
  JOURNAL   Mol Nutr Food Res 66 (18), e2101034 (2022)
   PUBMED   35909347
  REMARK    GeneRIF: Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis
            via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt
            Signaling.
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Reue,K. and Leete,T.H.
  TITLE     Genetic variation in mouse apolipoprotein A-IV due to insertion and
            deletion in a region of tandem repeats
  JOURNAL   J Biol Chem 266 (19), 12715-12721 (1991)
   PUBMED   1648102
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Frank,S.L., Taylor,B.A. and Lusis,A.J.
  TITLE     Linkage of the mouse LDL receptor gene on chromosome 9
  JOURNAL   Genomics 5 (3), 646-648 (1989)
   PUBMED   2575592
REFERENCE   8  (bases 1 to 1666)
  AUTHORS   Williams,S.C., Bruckheimer,S.M., Lusis,A.J., LeBoeuf,R.C. and
            Kinniburgh,A.J.
  TITLE     Mouse apolipoprotein A-IV gene: nucleotide sequence and induction
            by a high-lipid diet
  JOURNAL   Mol Cell Biol 6 (11), 3807-3814 (1986)
   PUBMED   3796595
REFERENCE   9  (bases 1 to 1666)
  AUTHORS   Buchberg,A.M. and Kinniburgh,A.J.
  TITLE     Induction of liver apolipoprotein A-IV mRNA in porphyric mice
  JOURNAL   Nucleic Acids Res 13 (6), 1953-1963 (1985)
   PUBMED   4000948
REFERENCE   10 (bases 1 to 1666)
  AUTHORS   Mahley,R.W., Innerarity,T.L., Rall,S.C. Jr. and Weisgraber,K.H.
  TITLE     Plasma lipoproteins: apolipoprotein structure and function
  JOURNAL   J Lipid Res 25 (12), 1277-1294 (1984)
   PUBMED   6099394
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF660098.1 and AK168687.1.
            
            On Jul 14, 2006 this sequence version replaced NM_007468.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169277.1, BC010769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               BF660098.1         13-229
            218-1666            AK168687.1         2-1450
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.36 cM"
     gene            1..1666
                     /gene="Apoa4"
                     /gene_synonym="apo-AIV; Apoa-4; apoA-IV"
                     /note="apolipoprotein A-IV"
                     /db_xref="GeneID:11808"
                     /db_xref="MGI:MGI:88051"
     exon            1..359
                     /gene="Apoa4"
                     /gene_synonym="apo-AIV; Apoa-4; apoA-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            360..486
                     /gene="Apoa4"
                     /gene_synonym="apo-AIV; Apoa-4; apoA-IV"
                     /inference="alignment:Splign:2.1.0"
     exon            487..1666
                     /gene="Apoa4"
                     /gene_synonym="apo-AIV; Apoa-4; apoA-IV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoa4"
                     /gene_synonym="apo-AIV; Apoa-4; apoA-IV"
                     /note="putative"
     polyA_site      1666
                     /gene="Apoa4"
                     /gene_synonym="apo-AIV; Apoa-4; apoA-IV"
                     /note="putative"
ORIGIN      
        1 ctatccttcc cagcctcttg gacagggtgg agccaactca agaagactgc ttccctctgc
       61 tgcctgtgtg ctgtcagctt ccacgttgtc ttagggccac taaagtccaa gaggcctcct
      121 gggagtgtgt caccttccaa cgtggagtca cactggggag gaggcgggga gagagggctg
      181 gaggggcttt aaatgagtgg ctggccttgc ctgcagtcaa tctgcacagg gacacaggta
      241 caccgtttct tctgactccg ggaaacatcc agtgtagccg aaactgtccc agcccagtga
      301 ggagcccagg atgttcctga aggctgcggt gctgaccctg gccctggtgg ccatcaccgg
      361 cacccgggct gaggtcactt cggaccaggt ggccaatgtg gtgtgggatt actttaccca
      421 gctaagcaac aatgccaagg aggctgtaga acagtttcag aagacggatg tcactcagca
      481 gctcagtacc ctcttccagg acaaacttgg ggatgctagt acgtatgctg atggggtgca
      541 caacaagctg gtgccctttg tcgtacagct gagtgggcat ctagcccagg aaactgagag
      601 ggtgaaggaa gagatcaaga aggagctgga ggacctacgt gaccgcatga tgccccatgc
      661 caacaaagta acccagacgt tcggggagaa catgcagaag ttgcaggagc acctgaagcc
      721 ctatgccgtg gacctgcaag atcagatcaa cacacagacc caggaaatga agctccagct
      781 gaccccatac atccagcgca tgcagaccac gatcaaggag aatgtggaca acctgcacac
      841 ctcgatgatg ccccttgcca ccaacttaaa ggacaagttt aacaggaata tggaagagct
      901 caaggggcac ctaacccccc gtgccaacga gctgaaggcc acgatcgacc agaacctgga
      961 ggatctgcgc cgcagcctgg cccctctgac ggtgggcgtg caggagaaac tcaaccatca
     1021 gatggagggc ctggccttcc agatgaagaa gaacgcggag gagctccaga ccaaggtctc
     1081 cgcaaaaatc gaccagctgc agaagaatct ggccccgctg gtggaagacg tgcagagcaa
     1141 ggtgaagggc aacacggaag ggctgcagaa gtctctggaa gacctgaaca ggcagctgga
     1201 gcagcaggtg gaggagttcc gacgcactgt ggagcccatg ggagagatgt tcaacaaggc
     1261 tctggtgcag cagctggaac agttcagaca gcagctgggt cccaattcgg gggaggtgga
     1321 aagccacttg agcttcctgg agaagagcct gagggagaag gtcaactcct ttatgagcac
     1381 cctggaaaaa aaggggagcc cagaccagcc tcaagccctc cccctcccgg agcaggccca
     1441 ggagcaggct caggagcagg ctcaggagca ggtgcagccc aaacctctgg agagctgagc
     1501 tgtccctggt gccctcagcc catcacagca gcagacacct gtcctgcccc accacctgtc
     1561 tgtcactctg tccccaggca cttcttgtac cagcttgagg acacatgtcc tgtgggaggt
     1621 gaagccacat ctcgctactc aataaagcaa ctgagaaatt agcccc
//
