LOCUS       NM_001305549             518 bp    mRNA    linear   ROD 25-JUL-2023
DEFINITION  Mus musculus apolipoprotein A-II (Apoa2), transcript variant 2,
            mRNA.
ACCESSION   NM_001305549 XM_006496625
VERSION     NM_001305549.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Miyahara H, Dai J, Li Y, Cui X, Takeuchi H, Hachiya N, Kametani F,
            Yazaki M, Mori M and Higuchi K.
  TITLE     Macrophages in the reticuloendothelial system inhibit early
            induction stages of mouse apolipoprotein A-II amyloidosis
  JOURNAL   Amyloid 30 (2), 225-238 (2023)
   PUBMED   36495239
  REMARK    GeneRIF: Macrophages in the reticuloendothelial system inhibit
            early induction stages of mouse apolipoprotein A-II amyloidosis.
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Cui X, Sawashita J, Dai J, Liu C, Igarashi Y, Mori M, Miyahara H
            and Higuchi K.
  TITLE     Exercise suppresses mouse systemic AApoAII amyloidosis through
            enhancement of the p38 MAPK signaling pathway
  JOURNAL   Dis Model Mech 15 (3) (2022)
   PUBMED   35099007
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Jung H, Park H, Choi Y, Kang H, Lee E, Kweon H, Roh JD, Ellegood J,
            Choi W, Kang J, Rhim I, Choi SY, Bae M, Kim SG, Lee J, Chung C, Yoo
            T, Park H, Kim Y, Ha S, Um SM, Mo S, Kwon Y, Mah W, Bae YC, Kim H,
            Lerch JP, Paik SB and Kim E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   4  (bases 1 to 518)
  AUTHORS   Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H,
            Sawashita J and Higuchi K.
  TITLE     Apolipoprotein A-II induces acute-phase response associated AA
            amyloidosis in mice through conformational changes of plasma
            lipoprotein structure
  JOURNAL   Sci Rep 8 (1), 5620 (2018)
   PUBMED   29618729
  REMARK    GeneRIF: High Apolipoprotein A-II is associated with acute-phase
            response and AA amyloidosis by conformational changes of plasma
            lipoprotein structure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Gillombardo CB, Darrah R, Dick TE, Moore M, Kong N, Decker MJ, Han
            F, Yamauchi M, Dutschmann M, Azzam S and Strohl KP.
  TITLE     C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea
  JOURNAL   Respir Physiol Neurobiol 235, 88-94 (2017)
   PUBMED   27756649
  REMARK    GeneRIF: Study reports a deterministic role for the B6 apoa2 gene
            polymorphism in respiratory rhythmogenesis. The in vivo inheritance
            pattern discloses a recessive effect of the B6 allele on the apnea
            phenotype, as the presence of both B6 alleles in the brain is
            required for transcript and trait expression; in contrast, apoa2
            mRNA expression in the liver requires only one allele.
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Januzzi JL, Azrolan N, O'Connell A, Aalto-Setala K and Breslow JL.
  TITLE     Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene
            locus: genomic, mRNA, and protein sequences with comparisons to
            other species
  JOURNAL   Genomics 14 (4), 1081-1088 (1992)
   PUBMED   1478650
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Srivastava RA, Tang J, Krul ES, Pfleger B, Kitchens RT and
            Schonfeld G.
  TITLE     Dietary fatty acids and dietary cholesterol differ in their effect
            on the in vivo regulation of apolipoprotein A-I and A-II gene
            expression in inbred strains of mice
  JOURNAL   Biochim Biophys Acta 1125 (3), 251-261 (1992)
   PUBMED   1596514
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Hwa JJ, Zollman S, Warden CH, Taylor BA, Edwards PA, Fogelman AM
            and Lusis AJ.
  TITLE     Genetic and dietary interactions in the regulation of HMG-CoA
            reductase gene expression
  JOURNAL   J Lipid Res 33 (5), 711-725 (1992)
   PUBMED   1352323
REFERENCE   9  (bases 1 to 518)
  AUTHORS   Higuchi K, Kitagawa K, Naiki H, Hanada K, Hosokawa M and Takeda T.
  TITLE     Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains
            of mice. Relationship between the molecular type of apoA-II and
            mouse senile amyloidosis
  JOURNAL   Biochem J 279 (Pt 2) (Pt 2), 427-433 (1991)
   PUBMED   1683229
REFERENCE   10 (bases 1 to 518)
  AUTHORS   Higuchi,K., Yonezu,T., Tsunasawa,S., Sakiyama,F. and Takeda,T.
  TITLE     The single proline-glutamine substitution at position 5 enhances
            the potency of amyloid fibril formation of murine apo A-II
  JOURNAL   FEBS Lett 207 (1), 23-27 (1986)
   PUBMED   3095143
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY780589.1, X62772.1 and
            AC084821.26.
            
            On Mar 20, 2015 this sequence version replaced XM_006496625.1.
            
            Summary: This gene encodes a component of high density lipoproteins
            (HDL). Mice lacking the encoded protein have low HDL-cholesterol
            levels, smaller HDL particles, increased clearance of
            triglyceride-rich lipoproteins and insulin hypersensitivity.
            Transgenic mice overexpressing the encoded protein have elevated
            levels of HDL-cholesterol and show increased susceptibility to
            atherosclerosis. Alternative splicing of this gene results in
            multiple variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB947382.1, BY780589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               BY780589.1         2-335
            335-517             X62772.1           286-468
            518-518             AC084821.26        119149-119149       c
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.22 cM"
     gene            1..518
                     /gene="Apoa2"
                     /gene_synonym="Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII;
                     Hdl-1"
                     /note="apolipoprotein A-II"
                     /db_xref="GeneID:11807"
                     /db_xref="MGI:MGI:88050"
     exon            1..68
                     /gene="Apoa2"
                     /gene_synonym="Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII;
                     Hdl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..148
                     /gene="Apoa2"
                     /gene_synonym="Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII;
                     Hdl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..405
                     /gene="Apoa2"
                     /gene_synonym="Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII;
                     Hdl-1"
                     /note="apolipoprotein A2"
                     /codon_start=1
                     /product="apolipoprotein A-II preproprotein"
                     /protein_id="NP_001292478.1"
                     /db_xref="CCDS:CCDS35773.1"
                     /db_xref="GeneID:11807"
                     /db_xref="MGI:MGI:88050"
                     /translation="MKLLAMVALLVTICSLEGALVKRQADGPDMQSLFTQYFQSMTDY
                     GKDLMEKAKTSEIQSQAKAYFEKTHEQLTPLVRSAGTSLVNFFSSLMNLEEKPAPAAK
                     "
     exon            149..281
                     /gene="Apoa2"
                     /gene_synonym="Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII;
                     Hdl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            282..518
                     /gene="Apoa2"
                     /gene_synonym="Alp-2; Apo-AII; Apoa-2; ApoA-II; ApoAII;
                     Hdl-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgtgtat atagccccta cctccagtca agcccagagt agacgggaag gactgcagca
       61 cagaatcgca ctgttcctag gccatagtct gccatcatga agctgctcgc aatggtcgca
      121 ctgctggtca ccatctgtag cctggaagga gctttggtta agagacaggc agacggaccg
      181 gatatgcaga gcctgttcac tcaatacttt cagagcatga ctgattatgg caaagatttg
      241 atggagaagg ccaagacctc agagattcag agccaggcca aggcatactt tgagaagaca
      301 cacgagcagc tgacacccct tgtcaggtca gcaggaacta gtctggtgaa cttcttcagc
      361 agtttaatga accttgagga gaaaccggct cctgcggcta agtgagatgt gccaggccca
      421 gtcttcccac cccagctgct ccactggcca ccgctagagc ccctctccct accttctgcc
      481 tgttttctcc aataaatgcg gaaggagtta aacttcat
//
