LOCUS       NM_009692                988 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus apolipoprotein A-I (Apoa1), mRNA.
ACCESSION   NM_009692
VERSION     NM_009692.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Yao,X., Redekar,N.R., Keeran,K.J., Qu,X., Jeffries,K.R.,
            Soria-Florido,M.T., Saxena,A., Dagur,P.K., Lin,W.C., McCoy,J.P. and
            Levine,S.J.
  TITLE     Neutrophil Heterogeneity Is Modified during Acute Lung Inflammation
            in Apoa1-/- Mice
  JOURNAL   J Immunol 213 (4), 456-468 (2024)
   PUBMED   38912868
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Fung,K.Y.Y., Ho,T.W.W., Xu,Z., Neculai,D., Beauchemin,C.A.A.,
            Lee,W.L. and Fairn,G.D.
  TITLE     Apolipoprotein A1 and high-density lipoprotein limit low-density
            lipoprotein transcytosis by binding SR-B1
  JOURNAL   J Lipid Res 65 (4), 100530 (2024)
   PUBMED   38479648
  REMARK    GeneRIF: Apolipoprotein A1 and high-density lipoprotein limit
            low-density lipoprotein transcytosis by binding SR-B1.
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Wang,Z.Y., Chen,R.X., Wang,J.F., Liu,S.C., Xu,X., Zhou,T.,
            Chen,Y.A.L., Zhang,Y.D., Li,X.C. and Li,C.X.
  TITLE     Apolipoprotein A-1 Accelerated Liver Regeneration Through
            Regulating Autophagy Via AMPK-ULK1 Pathway
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (4), 539-551 (2024)
   PUBMED   38122985
  REMARK    GeneRIF: Apolipoprotein A-1 Accelerated Liver Regeneration Through
            Regulating Autophagy Via AMPK-ULK1 Pathway.
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Wang,S.S., Shi,W., Wang,X., Velky,L., Greenlee,S., Wang,M.T.,
            Drake,T.A. and Lusis,A.J.
  TITLE     Mapping, genetic isolation, and characterization of genetic loci
            that determine resistance to atherosclerosis in C3H mice
  JOURNAL   Arterioscler Thromb Vasc Biol 27 (12), 2671-2676 (2007)
   PUBMED   17916774
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Mezdour,H., Larigauderie,G., Castro,G., Torpier,G., Fruchart,J.,
            Nowak,M., Fruchart,J.C., Rouis,M. and Maeda,N.
  TITLE     Characterization of a new mouse model for human apolipoprotein
            A-I/C-III/A-IV deficiency
  JOURNAL   J Lipid Res 47 (5), 912-920 (2006)
   PUBMED   16497661
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Plump,A.S., Azrolan,N., Odaka,H., Wu,L., Jiang,X., Tall,A.,
            Eisenberg,S. and Breslow,J.L.
  TITLE     ApoA-I knockout mice: characterization of HDL metabolism in
            homozygotes and identification of a post-RNA mechanism of apoA-I
            up-regulation in heterozygotes
  JOURNAL   J Lipid Res 38 (5), 1033-1047 (1997)
   PUBMED   9186920
REFERENCE   7  (bases 1 to 988)
  AUTHORS   Stoffel,W., Muller,R., Binczek,E. and Hofmann,K.
  TITLE     Mouse apolipoprotein AI. cDNA-derived primary structure, gene
            organisation and complete nucleotide sequence
  JOURNAL   Biol Chem Hoppe Seyler 373 (4), 187-193 (1992)
   PUBMED   1596360
REFERENCE   8  (bases 1 to 988)
  AUTHORS   Miller,J.C., Barth,R.K., Shaw,P.H., Elliott,R.W. and Hastie,N.D.
  TITLE     Identification of a cDNA clone for mouse apoprotein A-1 (apo A-1)
            and its use in characterization of apo A-1 mRNA expression in liver
            and small intestine
  JOURNAL   Proc Natl Acad Sci U S A 80 (6), 1511-1515 (1983)
   PUBMED   6572912
REFERENCE   9  (bases 1 to 988)
  AUTHORS   Hakansson,E.M., Juneja,R.K. and Lundin,L.G.
  TITLE     Gene for a serum protein on chromosome 9 in the mouse
  JOURNAL   Genet Res 33 (2), 147-152 (1979)
   PUBMED   478292
REFERENCE   10 (bases 1 to 988)
  AUTHORS   Elliott,R.W.
  TITLE     Use of two-dimensional electrophoresis to identify and map new
            mouse genes
  JOURNAL   Genetics 91 (2), 295-308 (1979)
   PUBMED   447069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116503.17 and AK076187.1.
            
            On Dec 5, 2013 this sequence version replaced NM_009692.3.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            cleaved to yield a signal peptide and a proproptein that is
            subsequently processed to generate the active mature peptide. The
            encoded protein is the major protein component of plasma high
            density lipoprotein (HDL). This protein facilitates the removal of
            cholesterol and other fats from tissues by transporting them to the
            liver for excretion. This protein is a cofactor for lecithin
            cholesterolacyltransferase, an enzyme that catalyzes the conversion
            of free cholesterol to cholesteryl esters. Mutations in this gene
            in humans causes familial HDL deficiency, Tangier disease and
            familial visceral amyloidosis. Similar clinical features are
            exhibited by mice with mutations in this gene. This gene is
            clustered with three other apolipoprotein genes on chromosome 9.
            [provided by RefSeq, Dec 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149576.1, AK161536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC116503.17        172428-172506
            80-976              AK076187.1         3-899
            977-988             AC116503.17        174256-174267
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.36 cM"
     gene            1..988
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /note="apolipoprotein A-I"
                     /db_xref="GeneID:11806"
                     /db_xref="MGI:MGI:88049"
     exon            1..107
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /inference="alignment:Splign:2.1.0"
     exon            108..169
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..921
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /note="apolipoprotein A1"
                     /codon_start=1
                     /product="apolipoprotein A-I preproprotein"
                     /protein_id="NP_033822.2"
                     /db_xref="CCDS:CCDS40610.1"
                     /db_xref="GeneID:11806"
                     /db_xref="MGI:MGI:88049"
                     /translation="MKAVVLAVALVFLTGSQAWHVWQQDEPQSQWDKVKDFANVYVDA
                     VKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKET
                     DWVRQEMNKDLEEVKQKVQPYLDEFQKKWKEDVELYRQKVAPLGAELQESARQKLQEL
                     QGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSNPTLNEYHTRAK
                     THLKTLGEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ"
     exon            170..323
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..988
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      964..969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /note="hexamer: AATAAA"
     polyA_site      985
                     /gene="Apoa1"
                     /gene_synonym="Alp-1; apo-AI; Apoa-1; apoA-I; Brp-14;
                     Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2"
                     /note="major polyA site"
ORIGIN      
        1 agggccaggc tgagcttatc agtctcccag cccagcccct gcccacacac atatatagac
       61 cagggaagaa gagctggaca cccagactgt cggagagctc cggggaggtc acccacaccc
      121 ttcaggatga aagctgtggt gctggccgtg gctctggtct tcctgacagg gagccaggct
      181 tggcacgtat ggcagcaaga tgaaccccag tcccaatggg acaaagtgaa ggatttcgct
      241 aatgtgtatg tggatgcggt caaagacagc ggcagagact atgtgtccca gtttgaatcc
      301 tcctccttgg gccaacagct gaacctgaat ctcctggaaa actgggacac tctgggttca
      361 accgttagtc agctgcagga acggctgggc ccattgactc gggacttctg ggataacctg
      421 gagaaagaaa cagattgggt gagacaggag atgaacaagg acctagagga agtgaaacag
      481 aaggtgcagc cctacctgga cgaattccag aagaaatgga aagaggatgt ggagctctac
      541 cgccagaagg tggcgcctct gggcgccgag ctgcaggaga gcgcgcgcca gaagctgcag
      601 gagctgcaag ggagactgtc ccctgtggct gaggaatttc gcgaccgcat gcgcacacac
      661 gtagactctc tgcgcacaca gctagcgccc cacagcgaac agatgcgcga gagcctggcc
      721 cagcgcctgg ctgagctcaa gagcaaccct accttgaacg agtaccacac cagggccaaa
      781 acccacctga agacacttgg cgagaaagcc agacctgcgc tggaggacct gcgccatagt
      841 ctgatgccca tgctggagac gcttaagacc caagtccaga gtgtgatcga caaggccagc
      901 gagactctga ctgcccagtg aggtgcccgc ttccactccc cacccccgca ttggctttct
      961 tacaataaac ctttccaaaa tggaatag
//
