LOCUS       NM_027977               2234 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus adipocyte plasma membrane associated protein (Apmap),
            transcript variant 1, mRNA.
ACCESSION   NM_027977
VERSION     NM_027977.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Gerber,H., Mosser,S., Boury-Jamot,B., Stumpe,M., Piersigilli,A.,
            Goepfert,C., Dengjel,J., Albrecht,U., Magara,F. and Fraering,P.C.
  TITLE     The APMAP interactome reveals new modulators of APP processing and
            beta-amyloid production that are altered in Alzheimer's disease
  JOURNAL   Acta Neuropathol Commun 7 (1), 13 (2019)
   PUBMED   30704515
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Pessentheiner,A.R., Huber,K., Pelzmann,H.J., Prokesch,A.,
            Radner,F.P.W., Wolinski,H., Lindroos-Christensen,J., Hoefler,G.,
            Rulicke,T., Birner-Gruenberger,R., Bilban,M. and
            Bogner-Strauss,J.G.
  TITLE     APMAP interacts with lysyl oxidase-like proteins, and disruption of
            Apmap leads to beneficial visceral adipose tissue expansion
  JOURNAL   FASEB J 31 (9), 4088-4103 (2017)
   PUBMED   28559441
  REMARK    GeneRIF: These data suggest that APMAP is a novel regulator of
            extracellular matrix components, and establish that APMAP is a
            potential target to mitigate obesity-associated insulin resistance.
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Bogner-Strauss,J.G., Prokesch,A., Sanchez-Cabo,F., Rieder,D.,
            Hackl,H., Duszka,K., Krogsdam,A., Di Camillo,B., Walenta,E.,
            Klatzer,A., Lass,A., Pinent,M., Wong,W.C., Eisenhaber,F. and
            Trajanoski,Z.
  TITLE     Reconstruction of gene association network reveals a transmembrane
            protein required for adipogenesis and targeted by PPARgamma
  JOURNAL   Cell Mol Life Sci 67 (23), 4049-4064 (2010)
   PUBMED   20552250
  REMARK    GeneRIF: Data demonstrate that APMAP contains a functional
            PPARgamma binding site, and that APMAP translocates from the
            endoplasmatic reticulum to the plasma membrane during adipocyte
            differentiation
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Albrektsen,T., Richter,H.E., Clausen,J.T. and Fleckner,J.
  TITLE     Identification of a novel integral plasma membrane protein induced
            during adipocyte differentiation
  JOURNAL   Biochem J 359 (Pt 2), 393-402 (2001)
   PUBMED   11583587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY230335.1 and AK009057.1.
            
            On Oct 5, 2017 this sequence version replaced NM_027977.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154266.1, SRR1660821.76456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY230335.1         1-44
            45-2234             AK009057.1         2-2191
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.68 cM"
     gene            1..2234
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /note="adipocyte plasma membrane associated protein"
                     /db_xref="GeneID:71881"
                     /db_xref="MGI:MGI:1919131"
     exon            1..180
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1336
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="adipocyte plasma membrane-associated protein
                     isoform 1"
                     /protein_id="NP_082253.1"
                     /db_xref="CCDS:CCDS16858.1"
                     /db_xref="GeneID:71881"
                     /db_xref="MGI:MGI:1919131"
                     /translation="MSEADGLRQRRPLRPQVVTDDGQVPEVKEGSSFSGRVFRMTFLM
                     LAVSLAIPLLGAMMLLESPIDPQSFSFKEPPFMFGVLHPNTKLRQAERLFENQLSGPE
                     SIVNIGDVLFTGTADGRVVKLENGEIETIARFGSGPCKTRDDEPTCGRPLGIRAGPNG
                     TLFVVDAYKGLFEVNPQKRSVKLLLSSETPIEGKKMSFVNDLTVTRDGRKIYFTDSSS
                     KWQRRDYLLLVMEATDDGRLLEYDTVTKEVKVLLDQLQFPNGVQLSPEEDFVLVAETT
                     MARIRRVYVSGLMKGGADMFVENMPGFPDNIRPSSSGGYWVAAATIRANPGFSMLDFL
                     SDKPFIKRMIFKMFSQETVMKFVPRYSLVLEVSDSGAFRRSLHDPDGQVVTYVSEAHE
                     HDGYLYLGSFRSPFICRLSLQSI"
     exon            181..297
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            298..413
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..506
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            507..623
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..798
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..933
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1126
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..2234
                     /gene="Apmap"
                     /gene_synonym="2310001A20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcatttcct cgcgccaggg agtagttctg aaacccgcgt tgctgagtgt caaggcgctg
       61 ttggaggtgt cagtggagag gcggcagaat gagcgaagcg gacgggctgc ggcagcgtcg
      121 gcccctgcgg ccgcaggtcg tcacggacga tggccaggtc ccggaggtca aggagggcag
      181 ttcctttagt ggcagagtct tcagaatgac cttcttgatg ctggctgtgt cccttgccat
      241 tcccctactt ggagccatga tgctgttgga gtcccccata gatcctcaga gtttcagctt
      301 caaagaaccc cctttcatgt ttggtgttct gcatccaaat acgaagttgc ggcaagcaga
      361 aaggctattt gaaaaccaac ttagtggacc agaatccata gtaaatattg gggatgtgct
      421 gtttactggt acagcagatg gccgagttgt aaaacttgaa aatggagaaa tagagaccat
      481 cgctcggttc ggttcaggcc cttgcaaaac ccgagatgat gaacctacct gtgggagacc
      541 cctgggcatc cgggcagggc ccaatgggac tctttttgtg gttgatgcgt acaagggact
      601 gttcgaagta aatcctcaga aacgttcagt gaaactgctg ctatcctctg agacgcccat
      661 tgagggcaag aagatgtcct ttgtgaatga cctcactgtt actcgggatg gaaggaagat
      721 ttatttcacg gattccagca gcaagtggca gagacgagac tacctgcttc tggtgatgga
      781 ggccactgat gatgggcgcc tgttagagta tgatactgtg acgaaagaag tgaaggtttt
      841 gttggaccag ttgcagttcc ctaatggagt tcagctctct cctgaggaag actttgtcct
      901 agtggcagag acaactatgg ccaggatacg aagagtctat gtgtctggcc tgatgaaagg
      961 aggggcagat atgtttgtgg agaacatgcc tggatttcct gacaatatcc ggcctagcag
     1021 ctctggcgga tactgggttg ctgctgcaac cattcgtgct aaccctgggt tttccatgtt
     1081 ggatttctta tctgacaagc cttttattaa gagaatgatt tttaagatgt tcagtcagga
     1141 gacagtgatg aagtttgtgc cacgatatag cctggtccta gaagtcagtg acagtggtgc
     1201 cttccggaga agcctgcatg atcctgatgg acaggtggtc acctatgtga gtgaggcgca
     1261 tgaacatgat ggatacctgt acctgggctc cttcagatct cccttcatct gcagactcag
     1321 tctccagtct atttagccag cccagcagct gcccccactg tgcatgccag aaatcatcac
     1381 actcagtcac ataggtctgg aaggagccat ggacatatag ctctgtccct gtgttcctgc
     1441 tagtccttgg aagtgtggga gtagctgctg taacctggag aaggtatgaa ccttacccat
     1501 actttctccc aagacgtgcc tctcacctgg acttgatgtc atttttagag ggaaatagtg
     1561 tatctgctat ggggaagaca aatcatggaa agccatttct ctttaaaaaa acatgctaag
     1621 tacaagaatt ctctagtacc tggaaaattt aatacacctg tgacagggct cagggtttga
     1681 tgattagagc aggggattag ctgtgcaggg acctttgtat tgccattggc tctatctgac
     1741 acttgtatct tcattctaaa gggggtcatg cttttggggg tggtattgcg gtatgccatg
     1801 gaagtggtaa tgcatgtgtt gaggcaggga ttattcaagc tgaaacttgt tctcaggggc
     1861 cgtgtgagat gtgtgagaat acctggactt ctggtatttc tccacagaaa aggtgtgctc
     1921 tcccaccctc tacaagcctc tttccatgcc agagggtttt caagactcct gttttagtgg
     1981 ccaggaggat ttcattgggt ttctttctga ctgccttctc cactggaatt gggtgaccca
     2041 gtgagtttgt acctgcacag gggtgtttta gaaatgccct tttatggctt gattcctttt
     2101 agacctacag atgtgattag tgaactgttg atgtaatgtt tgtgctaatg taataagctc
     2161 aaagttgctt atttcttggc aagtatgttt atacactggt cttaattttg ataataataa
     2221 atcatattaa accc
//
