LOCUS       NM_001357698            3727 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus amyloid beta precursor-like protein 2 (Aplp2),
            transcript variant 4, mRNA.
ACCESSION   NM_001357698 XM_006509951
VERSION     NM_001357698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Chen,J., Tang,F., Li,H., Wu,X., Yang,Y., Liu,Z., Huang,X., Wang,J.,
            Zheng,R., Wang,L., Liu,H., Xu,J., Wang,P. and Liu,F.
  TITLE     Mycobacterium tuberculosis suppresses APLP2 expression to enhance
            its survival in macrophage
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111058 (2023)
   PUBMED   37844466
  REMARK    GeneRIF: Mycobacterium tuberculosis suppresses APLP2 expression to
            enhance its survival in macrophage.
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Li,Y.Z., Zhu,Y.B., Ge,A.N., Gao,M., Wang,K.L., Zeng,X.R., Li,J.,
            Li,Y., Xu,J.Y., Bai,H.H. and Wu,S.J.
  TITLE     Reduced expression of APLP2 in spinal GABAergic inhibitory neurons
            contributed to nerve injury-induced microglial activation and pain
            sensitization
  JOURNAL   Neuropharmacology 224, 109334 (2023)
   PUBMED   36442651
  REMARK    GeneRIF: Reduced expression of APLP2 in spinal GABAergic inhibitory
            neurons contributed to nerve injury-induced microglial activation
            and pain sensitization.
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Barthet,G., Moreira-de-Sa,A., Zhang,P., Deforges,S.,
            Castanheira,J., Gorlewicz,A. and Mulle,C.
  TITLE     Presenilin and APP Regulate Synaptic Kainate Receptors
  JOURNAL   J Neurosci 42 (49), 9253-9262 (2022)
   PUBMED   36288945
  REMARK    GeneRIF: Presenilin and APP Regulate Synaptic Kainate Receptors.
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 3727)
  AUTHORS   Thinakaran,G., Kitt,C.A., Roskams,A.J., Slunt,H.H., Masliah,E., von
            Koch,C., Ginsberg,S.D., Ronnett,G.V., Reed,R.R., Price,D.L. et al.
  TITLE     Distribution of an APP homolog, APLP2, in the mouse olfactory
            system: a potential role for APLP2 in axogenesis
  JOURNAL   J Neurosci 15 (10), 6314-6326 (1995)
   PUBMED   7472397
REFERENCE   7  (bases 1 to 3727)
  AUTHORS   Blangy,A., Vidal,F., Cuzin,F., Yang,Y.H., Boulukos,K. and
            Rassoulzadegan,M.
  TITLE     CDEBP, a site-specific DNA-binding protein of the 'APP-like'
            family, is required during the early development of the mouse
  JOURNAL   J Cell Sci 108 (Pt 2), 675-683 (1995)
   PUBMED   7539437
REFERENCE   8  (bases 1 to 3727)
  AUTHORS   Vidal,F., Blangy,A., Rassoulzadegan,M. and Cuzin,F.
  TITLE     A murine sequence-specific DNA binding protein shows extensive
            local similarities to the amyloid precursor protein
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1336-1341 (1992)
   PUBMED   1482349
REFERENCE   9  (bases 1 to 3727)
  AUTHORS   Blangy,A., Leopold,P., Vidal,F., Rassoulzadegan,M. and Cuzin,F.
  TITLE     Recognition of the CDEI motif GTCACATG by mouse nuclear proteins
            and interference with the early development of the mouse embryo
  JOURNAL   Nucleic Acids Res 19 (25), 7243-7250 (1991)
   PUBMED   1766880
REFERENCE   10 (bases 1 to 3727)
  AUTHORS   Clarke,L. and Carbon,J.
  TITLE     The structure and function of yeast centromeres
  JOURNAL   Annu Rev Genet 19, 29-55 (1985)
   PUBMED   3909945
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025678.6 and AC114542.9.
            
            On Nov 4, 2017 this sequence version replaced XM_006509951.3.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (d).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1169841.1,
                                           SRR9219382.83256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               CT025678.6         88425-88650
            227-400             CT025678.6         122195-122368
            401-524             CT025678.6         123132-123255
            525-637             CT025678.6         128227-128339
            638-834             CT025678.6         129640-129836
            835-1043            CT025678.6         131357-131565
            1044-1211           CT025678.6         132545-132712
            1212-1342           AC114542.9         233258-233388       c
            1343-1417           AC114542.9         232061-232135       c
            1418-1576           AC114542.9         230474-230632       c
            1577-1705           AC114542.9         229942-230070       c
            1706-1805           AC114542.9         227214-227313       c
            1806-1958           AC114542.9         226410-226562       c
            1959-1994           AC114542.9         224905-224940       c
            1995-2080           AC114542.9         222129-222214       c
            2081-2155           AC114542.9         221028-221102       c
            2156-2311           AC114542.9         220552-220707       c
            2312-3727           AC114542.9         218272-219687       c
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.66 cM"
     gene            1..3727
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /note="amyloid beta precursor-like protein 2"
                     /db_xref="GeneID:11804"
                     /db_xref="MGI:MGI:88047"
     exon            1..226
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2413
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /note="isoform d precursor is encoded by transcript
                     variant 4; amyloid-like protein 2; CDE1-binding protein
                     CDEBP; CDEI box-binding protein; amyloid protein homolog;
                     sperm membrane protein YWK-II; amyloid beta (A4)
                     precursor-like protein 2"
                     /codon_start=1
                     /product="amyloid beta precursor like protein 2 isoform d
                     precursor"
                     /protein_id="NP_001344627.1"
                     /db_xref="GeneID:11804"
                     /db_xref="MGI:MGI:88047"
                     /translation="MAATGTAAAAATGKLLVLLLLGLTAPAAALAGYIEALAANAGTG
                     FAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITN
                     VMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVC
                     EKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQTKTVDSDSTMSKE
                     EEEEEEDEEDEEEDYDLDKSEFPTEADLEDFTEAAADEEEEDEEEGEEVVEDRDYYYD
                     PFKGDDYNEENPTEPSSEGTISDKEIVHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGK
                     CVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQK
                     AKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKTERQTLIQHFQAMVKALEKEAASEKQ
                     QLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTI
                     RHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQ
                     EQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPLHPFPSLSENEDTQPELYHPMKK
                     GSGMAEQDGGLIGAEEKVINSKNKMDENMVIDETLDVKEMIFNAERVGGLEEEPESVG
                     PLREDFSLSSNALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEER
                     HLNKMQNHGYENPTYKYLEQMQI"
     exon            227..400
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            401..524
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            525..637
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            638..834
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1043
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1211
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1342
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1417
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1576
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1705
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1805
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1958
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..1994
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2080
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2155
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2311
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..3727
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /note="hexamer: AATAAA"
     polyA_site      3727
                     /gene="Aplp2"
                     /gene_synonym="APLP-2; CDEBP"
                     /note="major polyA site"
ORIGIN      
        1 gtaaaacccc cggggcggcg gcgaacgggc ttcagacgct tctgggtcgc ggtagggaag
       61 cgctgtagcc tggctgtgcg agagacgggg agagcccagc gccacagcga cctggagaag
      121 gatggcggcc accgggaccg cggccgctgc ggccaccggc aagcttcttg tcctgctgct
      181 gctcgggctc acggcgcccg ctgcggctct ggctggctac atagaggctc ttgcagccaa
      241 tgctggaaca ggcttcgctg ttgctgagcc tcagattgcg atgttctgtg ggaagctgaa
      301 tatgcatgtg aacattcaga ctggcaaatg ggagcctgac ccaacaggca ccaagagctg
      361 ccttggaaca aaggaggagg ttcttcagta ctgccaggag atatatccag agctgcagat
      421 cacaaatgtg atggaagcaa accagccagt caatattgat agttggtgcc gaagggacaa
      481 aaggcagtgc aagagtcaca ttgttatacc attcaagtgt cttgtgggtg aatttgtaag
      541 tgatgtcctg ctagttccag ataactgcca gtttttccac caagagcgga tggaggtgtg
      601 tgagaagcac cagcgctggc acacgttagt caaggaggca tgtctgactg aggggctgac
      661 cttatatagc tatggcatgc tgctgccctg cggggtagac cagttccatg gcaccgagta
      721 tgtgtgctgc cctcagacaa agactgttga ctcggactcg actatgtcca aagaagagga
      781 ggaagaggaa gaggatgaag aggacgaaga ggaagactat gatcttgata aaagtgaatt
      841 tcctactgaa gcagatttgg aagacttcac agaagcagca gcagatgagg aagaagagga
      901 tgaggaggaa ggggaggaag tggtggaaga ccgtgactac tactatgacc cctttaaagg
      961 agacgattac aatgaggaga atccaaccga acccagcagc gagggcacca tttcagacaa
     1021 ggagattgtt cacgatgtta aagctgtctg ctcccaggag gccatgacgg ggccctgccg
     1081 ggctgtgatg cctcgttggt acttcgacct ctccaaggga aagtgcgtac gctttatata
     1141 tggcggctgc ggcggcaaca ggaacaattt tgagtctgag gattattgta tggctgtgtg
     1201 taaagcgatg attcccccga ctcccctgcc aaccaatgat gttgatgtgt attttgagac
     1261 ctcagcggat gataatgagc acgcccgctt ccagaaggct aaggaacagc tggaaattcg
     1321 acatcgaaac cgaatggaca gggtaaagaa ggaatgggaa gaggcagaac ttcaagccaa
     1381 gaacctcccc aagacagaaa gacagaccct catccagcat ttccaagcta tggttaaagc
     1441 tttagagaaa gaagcagcca gtgagaagca gcagcttgtg gaaacccatc tggcccgagt
     1501 agaagccatg ctgaatgacc gccgacgcat agctctggaa aattacctgg ctgccctgca
     1561 gtctgaccca cctcggccac atcgcattct tcaagctctt cgtcgttacg tccgtgctga
     1621 gaacaaagat cgcctgcata ccattcgtca ttaccaacac gtgttggctg ttgacccaga
     1681 aaaggccgcc cagatgaaat cccaggtgat gacacacctc catgtgattg aagaaagaag
     1741 gaaccaaagt ctttctcttc tgtacaaagt tccttatgtt gctcaagaaa ttcaagagga
     1801 aattgatgag ctccttcagg aacagcgagc ggatatggac caatttacct cctccatctc
     1861 agagaaccct gtggatgtcc gggtgagctc tgaggagagt gaggagatcc cgccgttcca
     1921 ccctctccat cccttcccat ccttgtctga gaatgaagac actcagccgg agttgtacca
     1981 cccaatgaaa aaaggctctg gaatggcaga acaagacggg ggactgattg gtgcagaaga
     2041 aaaagtgatt aacagcaaga ataaaatgga tgaaaatatg gtcattgacg agactctgga
     2101 tgttaaggaa atgattttca atgctgagag agttggaggc cttgaggaag agccggaatc
     2161 ggtgggacct ttaagggagg atttcagttt gagcagcaat gcccttattg gcttgctggt
     2221 tatcgcagtg gccattgcta cggtcatcgt tatcagcctg gtgatgctga ggaagaggca
     2281 gtacggcacc atcagccacg ggattgtgga ggttgaccca atgctcaccc cagaagagcg
     2341 tcacctgaac aagatgcaga accatggtta tgaaaaccca acctacaaat acctggagca
     2401 gatgcagatt taaggacagc gtgtgtgaca ccctggctga ggctgctgca ggtgggctgg
     2461 aagaggctca gcgtttgtgc ttgactgctg accaccagtg gtgccagaag gcctcatcct
     2521 acatcctgct ctcctggatt gttaagacta taaagtacta ctgtaggatt gcaatttcca
     2581 ttcttttaaa tgggttaaaa agatgttaat ataacaatat atgatatata aaccttaagt
     2641 gaaatgaaag aaaaagatct attgcagata tctgatggat gtagttttct ttttttaaat
     2701 tagaaatgcc acttctattg tattgtctca cacatgctct atataaatgg gaaatgttga
     2761 tttttttgat gatagactat atacacaggc tgttcccgtt atgtaagtca gttcttcagg
     2821 ctcatttgct gtgctggttt tactattatt tgttttcaat gtataaaggc agtatttccc
     2881 ttttcaggtt gctgagaaat gtaagaggag ctgaagtaca ttgtatgcag ttactgactg
     2941 ctttaggcat agtctccgca gaagcctcgt gtgtccagtg ctgggtgttt gggtgcttct
     3001 gtaccagccg tccccaagca gggctaaggc accttgaact agccagatgc aaacatagat
     3061 tcactgtgct ttcctttcaa atccagttct tccacagcaa ctagcccata gtcagtctgt
     3121 gttcttccac agttgtttac ggtagccttt tcctatccac ttcccttacc aagtgtatcc
     3181 aagcgtgcac ccacctcctc attggatggc tccctccatg cactgaccct ctgcctgcct
     3241 ttgtacctca ctcacctcca ccgctctcca gcccctctga tggccactca gagaatacca
     3301 taataaacat ggctgaggac ccaggagagt tcacgggagg cttcatcata tgaaaggaca
     3361 atgttctggg ttgtgcatga aattggatct gtagacactg tggaaacgtt tgaaagtgtt
     3421 tgtttccttc atatgaacct gtaaaatgct gtgtagctgg agttcacgct cacagccttt
     3481 agcgctttgt tgcttgtttt gttttaatct gaaggttctg gtaacctgtt tttgtttgtt
     3541 tgtttatttg ttttggtttg gtttttgtac ttttctgtga ctcacctgcc cttccttccc
     3601 cccttggccc tagccgtgcc tcgtcccact atgcacagat tgaaacttca cctacaaacc
     3661 tgttagtgtg atctgtggag aatgtacaga acttaactac atcaataaac actttaacgt
     3721 cccctga
//
