LOCUS       NM_007467               2345 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus amyloid beta precursor like protein 1 (Aplp1), mRNA.
ACCESSION   NM_007467 XM_994141
VERSION     NM_007467.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Mao,X., Gu,H., Kim,D., Kimura,Y., Wang,N., Xu,E., Kumbhar,R.,
            Ming,X., Wang,H., Chen,C., Zhang,S., Jia,C., Liu,Y., Bian,H.,
            Karuppagounder,S.S., Akkentli,F., Chen,Q., Jia,L., Hwang,H.,
            Lee,S.H., Ke,X., Chang,M., Li,A., Yang,J., Rastegar,C.,
            Sriparna,M., Ge,P., Brahmachari,S., Kim,S., Zhang,S., Shimoda,Y.,
            Saar,M., Liu,H., Kweon,S.H., Ying,M., Workman,C.J., Vignali,D.A.A.,
            Muller,U.C., Liu,C., Ko,H.S., Dawson,V.L. and Dawson,T.M.
  TITLE     Aplp1 interacts with Lag3 to facilitate transmission of pathologic
            alpha-synuclein
  JOURNAL   Nat Commun 15 (1), 4663 (2024)
   PUBMED   38821932
  REMARK    Erratum:[Nat Commun. 2024 Jul 30;15(1):6413. doi:
            10.1038/s41467-024-50640-2.. PMID: 39080298]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Cha,H.J., Shen,J. and Kang,J.
  TITLE     Regulation of gene expression by the APP family in the adult
            cerebral cortex
  JOURNAL   Sci Rep 12 (1), 66 (2022)
   PUBMED   34997052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Zhang,S., Liu,Y.Q., Jia,C., Lim,Y.J., Feng,G., Xu,E., Long,H.,
            Kimura,Y., Tao,Y., Zhao,C., Wang,C., Liu,Z., Hu,J.J., Ma,M.R.,
            Liu,Z., Jiang,L., Li,D., Wang,R., Dawson,V.L., Dawson,T.M.,
            Li,Y.M., Mao,X. and Liu,C.
  TITLE     Mechanistic basis for receptor-mediated pathological
            alpha-synuclein fibril cell-to-cell transmission in Parkinson's
            disease
  JOURNAL   Proc Natl Acad Sci U S A 118 (26) (2021)
   PUBMED   34172566
  REMARK    GeneRIF: Mechanistic basis for receptor-mediated pathological
            alpha-synuclein fibril cell-to-cell transmission in Parkinson's
            disease.
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Steubler,V., Erdinger,S., Back,M.K., Ludewig,S., Fassler,D.,
            Richter,M., Han,K., Slomianka,L., Amrein,I., von Engelhardt,J.,
            Wolfer,D.P., Korte,M. and Muller,U.C.
  TITLE     Loss of all three APP family members during development impairs
            synaptic function and plasticity, disrupts learning, and causes an
            autism-like phenotype
  JOURNAL   EMBO J 40 (12), e107471 (2021)
   PUBMED   34008862
  REMARK    GeneRIF: Loss of all three APP family members during development
            impairs synaptic function and plasticity, disrupts learning, and
            causes an autism-like phenotype.
REFERENCE   6  (bases 1 to 2345)
  AUTHORS   Beher,D., Hesse,L., Masters,C.L. and Multhaup,G.
  TITLE     Regulation of amyloid protein precursor (APP) binding to collagen
            and mapping of the binding sites on APP and collagen type I
  JOURNAL   J Biol Chem 271 (3), 1613-1620 (1996)
   PUBMED   8576160
REFERENCE   7  (bases 1 to 2345)
  AUTHORS   Lorent,K., Overbergh,L., Moechars,D., De Strooper,B., Van Leuven,F.
            and Van den Berghe,H.
  TITLE     Expression in mouse embryos and in adult mouse brain of three
            members of the amyloid precursor protein family, of the
            alpha-2-macroglobulin receptor/low density lipoprotein
            receptor-related protein and of its ligands apolipoprotein E,
            lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular
            weight receptor-associated protein
  JOURNAL   Neuroscience 65 (4), 1009-1025 (1995)
   PUBMED   7542371
REFERENCE   8  (bases 1 to 2345)
  AUTHORS   Blangy,A., Vidal,F., Cuzin,F., Yang,Y.H., Boulukos,K. and
            Rassoulzadegan,M.
  TITLE     CDEBP, a site-specific DNA-binding protein of the 'APP-like'
            family, is required during the early development of the mouse
  JOURNAL   J Cell Sci 108 (Pt 2), 675-683 (1995)
   PUBMED   7539437
REFERENCE   9  (bases 1 to 2345)
  AUTHORS   Wasco,W., Brook,J.D. and Tanzi,R.E.
  TITLE     The amyloid precursor-like protein (APLP) gene maps to the long arm
            of human chromosome 19
  JOURNAL   Genomics 15 (1), 237-239 (1993)
   PUBMED   8432545
REFERENCE   10 (bases 1 to 2345)
  AUTHORS   Wasco,W., Bupp,K., Magendantz,M., Gusella,J.F., Tanzi,R.E. and
            Solomon,F.
  TITLE     Identification of a mouse brain cDNA that encodes a protein related
            to the Alzheimer disease-associated amyloid beta protein precursor
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10758-10762 (1992)
   PUBMED   1279693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149067.3.
            
            On Jan 14, 2022 this sequence version replaced NM_007467.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154992.1, BC021877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC149067.3         254021-254234       c
            215-358             AC149067.3         253017-253160       c
            359-491             AC149067.3         251791-251923       c
            492-604             AC149067.3         251497-251609       c
            605-738             AC149067.3         251179-251312       c
            739-929             AC149067.3         250869-251059       c
            930-1060            AC149067.3         250341-250471       c
            1061-1135           AC149067.3         249754-249828       c
            1136-1294           AC149067.3         248843-249001       c
            1295-1423           AC149067.3         248634-248762       c
            1424-1523           AC149067.3         246877-246976       c
            1524-1631           AC149067.3         245486-245593       c
            1632-1655           AC149067.3         244878-244901       c
            1656-1726           AC149067.3         244672-244742       c
            1727-1789           AC149067.3         244445-244507       c
            1790-1933           AC149067.3         244175-244318       c
            1934-2345           AC149067.3         243679-244090       c
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.32 cM"
     gene            1..2345
                     /gene="Aplp1"
                     /note="amyloid beta precursor like protein 1"
                     /db_xref="GeneID:11803"
                     /db_xref="MGI:MGI:88046"
     exon            1..214
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2032
                     /gene="Aplp1"
                     /note="amyloid-like protein 1; APLP; APLP-1; amyloid beta
                     (A4) precursor-like protein 1"
                     /codon_start=1
                     /product="amyloid beta precursor like protein 1 precursor"
                     /protein_id="NP_031493.2"
                     /db_xref="CCDS:CCDS21092.1"
                     /db_xref="GeneID:11803"
                     /db_xref="MGI:MGI:88046"
                     /translation="MGPTSPAARGQGRRWRPPPLPLLLPLSLLLLRAQLAVGNLAVGS
                     PSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPEL
                     HIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLH
                     QERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNP
                     SGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPP
                     PSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMR
                     EWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQR
                     RAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMR
                     FQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSS
                     EDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHS
                     SDIQRDELAPSGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVD
                     PMLTLEEQQLRELQRHGYENPTYRFLEERP"
     exon            215..358
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..491
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..604
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..738
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..929
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1060
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1135
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1294
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1423
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1523
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1631
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1655
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1726
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1789
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1933
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2345
                     /gene="Aplp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aplp1"
                     /note="hexamer: AATAAA"
     polyA_site      2345
                     /gene="Aplp1"
                     /note="major polyA site"
ORIGIN      
        1 ctgtcaccgc tggggccggg tagggccggg cgggagcgca ggggacgtga gggcccgagg
       61 cccggacatg gggcccacca gccccgccgc tcgcggtcag ggtcgccgct ggcgaccgcc
      121 gccgctgccg ctgttgctgc cactgtcatt gctgcttctg cgcgcgcagc tcgccgtcgg
      181 gaacctggct gttgggagcc ccagcgcggc cgaggctccg gggtcggctc aagtggctgg
      241 actatgtggg cgtctaaccc ttcaccggga cctgcgcacc ggccgctggg aaccagaccc
      301 acagcgatca cgacgctgtc ttctggaccc gcagcgcgtg ctggagtact gcagacagat
      361 gtaccccgag ctgcacatag cacgcgtgga gcaggctgca caggccatcc cgatggagcg
      421 ctggtgtggg ggtacccgga gtggcagatg cgcccacccc caccatgagg ttgtgccctt
      481 ccattgcctg cctggcgaat tcgtgagtga agccctgcta gtgcccgaag gctgtcggtt
      541 cttgcaccag gagcgtatgg accagtgtga gagttcaacc aggaggcatc aggaggctca
      601 ggaggcctgc agctctcagg gcctcatcct gcatggctct ggcatgcttt tgccctgtgg
      661 ctctgatcgg ttccgaggtg tggagtatgt atgctgtcca cctcctgcaa ctcccaaccc
      721 atctgggatg gcagctggtg acccctctac ccggtcctgg cccctggggg gcagagcaga
      781 gggaggtgag gatgaagagg aggtggaatc tttccctcag ccagtagacg attacttcgt
      841 agagccccct caggctgaag aagaagagga agaggaggaa gaaagggccc cacctcccag
      901 ctcccacacc cctgtcatgg ttagcagagt cactcccacc ccaaggccta ctgatggtgt
      961 ggatgtttac tttggcatgc ctggggaaat cggcgagcat gagggtttcc tgagggccaa
     1021 gatggacctg gaggagcgta ggatgcgcca gattaatgag gtgatgcgtg aatgggccat
     1081 ggctgacagc caatctaaga acctgccaaa ggcggacagg caggccctga atgagcactt
     1141 ccagtccatt ctgcagaccc tggaagaaca agtgtctggt gaacggcaac gcctggtgga
     1201 gacccacgcc accagagtca tcgctctgat caacgaccag cgccgagcag ccctggaagg
     1261 tttcctggca gccttacagg gcgatccgcc tcaggctgag cgagttctga tggccctgag
     1321 gcgctacctg cgcgccgagc agaaagagca gaggcacact ctgaggcact accagcacgt
     1381 ggccgcagtg gatcctgaga aggcccagca gatgcgcttt caggtccaga cccaccttca
     1441 ggtgatcgaa gagcgaatga atcagagcct ggggctgctc gaccagaacc ctcacctggc
     1501 tcaggagctg cggccacaga tccaggagct tctccttgct gaacacttgg gtcccagtga
     1561 actggacgcc tctgtgcccg ggagcagcag tgaggacaaa ggtagcctcc agcctcccga
     1621 atccaaggac gatcccccag tgacccttcc aaaagggtcc acagatcaag agtcatcctc
     1681 ctctgggaga gagaagctaa ctccactgga gcagtatgag caaaaggtga atgcatccgc
     1741 cccgaggggg tttcccttcc actcgtcaga tatccagcgg gatgaactgg ctccttccgg
     1801 gactggagtg tcccgagagg ccttgtcagg tctgctgatc atgggagctg gaggaggctc
     1861 cctcattgtc ctatccttgc tgcttctgcg caagaagaaa ccctatggga ctatcagcca
     1921 tggagtggtg gaggtggacc ccatgctgac cctggaggag cagcagctcc gggaacttca
     1981 gaggcatggc tatgagaacc ccacctaccg cttcctggaa gaacgacctt gacccctacc
     2041 ctagctgcct tcagctgagc cctactgccc ttcttccggc cccccaaacc caactcccag
     2101 cttccggtgg gggagggaga tcttgacaaa ttcattcttg tttccccttc ctagttccaa
     2161 attccacacc cttagaaatc cccagctcct gtcccacaaa ggacctcttc accttaattt
     2221 attttacgtt aatttattgc tccttaaggt gacctgggtc ccaggtatgt atgtcactcc
     2281 ctggaattca ccatcccacg tttcttcact aacatcccaa taaagtcctc tttcccaccc
     2341 ggcca
//
