LOCUS       NM_011784               3573 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus apelin receptor (Aplnr), mRNA.
ACCESSION   NM_011784
VERSION     NM_011784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Vitali,H.E., Kuschel,B., Sherpa,C., Jones,B.W., Jacob,N.,
            Madiha,S.A., Elliott,S., Dziennik,E., Kreun,L., Conatser,C.,
            Bhetwal,B.P. and Sharma,B.
  TITLE     Hypoxia regulate developmental coronary angiogenesis potentially
            through VEGF-R2- and SOX17-mediated signaling
  JOURNAL   Dev Dyn 254 (2), 174-188 (2025)
   PUBMED   39360476
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Anima,B., Gurusubramanian,G. and Roy,V.K.
  TITLE     Hormonal dependent expression of apelin and apelin receptor in the
            ovary and uterus of mice
  JOURNAL   Reprod Biol 24 (3), 100918 (2024)
   PUBMED   38924877
  REMARK    GeneRIF: Hormonal dependent expression of apelin and apelin
            receptor in the ovary and uterus of mice.
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Das,M., Gurusubramanian,G. and Roy,V.K.
  TITLE     Immunolocalization of apelin receptor (APJ) in mouse seminiferous
            epithelium
  JOURNAL   J Exp Zool A Ecol Integr Physiol 341 (4), 450-457 (2024)
   PUBMED   38390701
  REMARK    GeneRIF: Immunolocalization of apelin receptor (APJ) in mouse
            seminiferous epithelium.
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Ishida,J., Hashimoto,T., Hashimoto,Y., Nishiwaki,S., Iguchi,T.,
            Harada,S., Sugaya,T., Matsuzaki,H., Yamamoto,R., Shiota,N.,
            Okunishi,H., Kihara,M., Umemura,S., Sugiyama,F., Yagami,K.,
            Kasuya,Y., Mochizuki,N. and Fukamizu,A.
  TITLE     Regulatory roles for APJ, a seven-transmembrane receptor related to
            angiotensin-type 1 receptor in blood pressure in vivo
  JOURNAL   J Biol Chem 279 (25), 26274-26279 (2004)
   PUBMED   15087458
  REMARK    GeneRIF: APJ exerts the hypotensive effect in vivo and plays a
            counterregulatory role against the pressor action of angiotensin II
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   Saint-Geniez,M., Masri,B., Malecaze,F., Knibiehler,B. and
            Audigier,Y.
  TITLE     Expression of the murine msr/apj receptor and its ligand apelin is
            upregulated during formation of the retinal vessels
  JOURNAL   Mech Dev 110 (1-2), 183-186 (2002)
   PUBMED   11744380
  REMARK    GeneRIF: Expression of the murine msr/apj receptor and its ligand
            apelin is upregulated during formation of the retinal vessels.
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   De Mota,N., Lenkei,Z. and Llorens-Cortes,C.
  TITLE     Cloning, pharmacological characterization and brain distribution of
            the rat apelin receptor
  JOURNAL   Neuroendocrinology 72 (6), 400-407 (2000)
   PUBMED   11146423
REFERENCE   9  (bases 1 to 3573)
  AUTHORS   O'Carroll,A.M., Selby,T.L., Palkovits,M. and Lolait,S.J.
  TITLE     Distribution of mRNA encoding B78/apj, the rat homologue of the
            human APJ receptor, and its endogenous ligand apelin in brain and
            peripheral tissues
  JOURNAL   Biochim Biophys Acta 1492 (1), 72-80 (2000)
   PUBMED   11004481
REFERENCE   10 (bases 1 to 3573)
  AUTHORS   Devic,E., Rizzoti,K., Bodin,S., Knibiehler,B. and Audigier,Y.
  TITLE     Amino acid sequence and embryonic expression of msr/apj, the mouse
            homolog of Xenopus X-msr and human APJ
  JOURNAL   Mech Dev 84 (1-2), 199-203 (1999)
   PUBMED   10473142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133580.1 and BY444880.1.
            
            On Nov 18, 2008 this sequence version replaced NM_011784.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK133580.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2191              AK133580.1         2-2192
            2192-3562           AK133580.1         2194-3564
            3563-3573           BY444880.1         418-428
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..3573
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; APJ; msr/apj"
                     /note="apelin receptor"
                     /db_xref="GeneID:23796"
                     /db_xref="MGI:MGI:1346086"
     exon            1..3564
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; APJ; msr/apj"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1407
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; APJ; msr/apj"
                     /note="MSR; G-protein coupled receptor APJ; angiotensin
                     receptor-like 1"
                     /codon_start=1
                     /product="apelin receptor"
                     /protein_id="NP_035914.1"
                     /db_xref="CCDS:CCDS16201.1"
                     /db_xref="GeneID:23796"
                     /db_xref="MGI:MGI:1346086"
                     /translation="MEDDGYNYYGADNQSECDYADWKPSGALIPAIYMLVFLLGTTGN
                     GLVLWTVFRTSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKL
                     SSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAV
                     PVMVFRSTDASENGTKIQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFTIMLTC
                     YFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLH
                     WPCDFDIFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCDQSGCKGTPH
                     SSSAEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVD"
     regulatory      3546..3551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; APJ; msr/apj"
                     /note="hexamer: AATAAA"
     polyA_site      3564
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; APJ; msr/apj"
                     /note="major polyA site"
ORIGIN      
        1 ggagacagag actctggagg gtgcaaggaa gtgtctttag ctgagctggg ctgggctggg
       61 acgggaaggt agactgaagc tgcctgaact gctcatcccg ctgggtctga gctcccagtg
      121 gggcggttcg catgcctgga aggactctaa gcaccctcag acctcttact ctgaggttca
      181 agccaatcct tcagggtgct tgctgagttg gtgacccatc tctggaactg gtgtccctgg
      241 gactcactgc ccagcttcac ttcattcagc accatggaag atgatggtta caactactat
      301 ggggctgaca accagtctga atgcgactac gcagactgga agccctctgg agcgctcatt
      361 cctgccatct acatgttggt ttttcttcta ggcaccacag gcaatggcct ggtgctctgg
      421 accgtgtttc gaaccagccg cgaaaagaga cgctcagctg acatcttcat tgccagcctg
      481 gcagtggctg acttgacctt tgtggtgact ttgccactgt gggccactta tacctaccgg
      541 gagtttgact ggccttttgg aaccttctct tgcaagctca gcagctacct catctttgtc
      601 aacatgtacg ccagtgtctt ttgcctcacc ggcctcagct ttgaccgata cctggccatt
      661 gtcaggccgg tggccaatgc tcggctaagg ctgcgagtca gcggggccgt ggccacagca
      721 gtcttatggg tgctggctgc ccttctagct gtgcctgtca tggtgttccg ttccacagac
      781 gcctcggaaa atggcaccaa gatccagtgc tacatggact actctatggt ggccacttca
      841 aactcagagt gggcctggga ggtgggcctt ggggtgtcct ccactgccgt gggctttgtg
      901 gtgcccttca ccatcatgct gacatgttac ttcttcattg cccaaaccat cgctggccat
      961 ttccgaaagg agcgcattga gggcctgcgg aagaggcgcc ggctgctcag cattatcgtg
     1021 gtgcttgtag tgacctttgc cctgtgctgg atgccttacc acctggtgaa gactctctac
     1081 atgctgggca gtttgctgca ctggccctgt gactttgaca tcttcctcat gaatgtcttt
     1141 ccgtactgca cctgcatcag ttatgtcaac agctgcctca acccctttct ctatgccttc
     1201 tttgaccccc gatttcgcca agcctgcacc tccatgctct gctgtgatca gagcgggtgc
     1261 aaaggcaccc ctcacagcag tagtgctgag aagtcagcca gttattcttc cgggcacagc
     1321 cagggccctg gccccaacat gggaaaggga ggagagcaga tgcatgagaa atcgattccc
     1381 tatagtcaag aaacccttgt ggactagggc tgggaccaga gggaagcctg gtgcagcggg
     1441 tctgacccaa actttatcct cacgctctga gaatcaggta gcatggctgt actttctccc
     1501 ggattcctcg ctccgttctc ttgctcatct ccgagttctg ccttgcccct ctcagatgtt
     1561 tgtggtttag cggaaaggga tggagccttg caaacagctc agctgttcaa catttctgag
     1621 gttgagcttg cacaagtctc ttaacttcct taaacttcag tttctttgtt tataataaat
     1681 gagggaaggt tatatggacc ctaaaatgtt gaagtatgag tcctgatcta atttgcttca
     1741 ttctgccatt ttttccctca gctctctagc accccttttt gctttctctg ctggagaaat
     1801 tatttctgtc aactactcac ttgctagatc taactctttc tcttctagtg ggtcccttcc
     1861 cctcaaacct tcctgtctgt accccagcgc cttcttccct gctggactct taagggttaa
     1921 gtaccctgaa acttgaagag taacttatcc tttgagttct tgtcctgttt tctgagaacc
     1981 agcaggtggc tgtatgtagg caaagaatta gtgctctagt ccccagcgcc aggagctctg
     2041 tatctttcaa aaaagttgga tcagttcatt gttggtccag gcaccagggc tagatgaatt
     2101 tttgaatagc aatttctctt tggcagaatc tctgtgatgc ttagtgaatc ctaccaataa
     2161 cccagtatcc ttcccatcat tttttttttt taaaactgtc tgtgagaatc tcaaggcaac
     2221 aggactgaag aagctgtgga ttgtcctgtc cctctgaagg ggggagttgg gaagggacaa
     2281 cagagaaagg attagagggg agtctgtatt tagtttgtat gctgcttgcc tcccctatcc
     2341 caatcctcat ccctccacct cctacagaac tgtgaactgt agagctgatc tttctcctgt
     2401 ctcctccccc accccaccat ctctataggt tttggtgcta cttggcacca agagtcactc
     2461 acttggttag gtaaggctat ttgctttttg tctatatggg tgtatataaa ggtatatcaa
     2521 tgtgcacatg catgtgtgtg tacacacaca catacacaag tatcacataa actttatcga
     2581 tgaaggacta gggtgaaccc cccactcact ttcccctgtg cctctgtagg tctcagagtc
     2641 cacttgggga agaatggacc tatggaggta gaatagatcc attgtggatc cacccccact
     2701 ggatttgggg aactccgacg gctggtccgt atctaggaaa gaagtctatg tttgtgctag
     2761 gatttctgta gggagctgtt ttctcagtgg catctggtcc taaggctgga gaagtctgga
     2821 gctgggcccc agttcctctc ccagttccac agtagcaaga agagacttac agactatata
     2881 tagcagggcc cttctcctct gtccctccct gcctctgact tttttctcac ccctctcact
     2941 ctctttaggg gtcttgagga ggccactttc ttgccacagg atgatgaaaa aagggtgagc
     3001 ttttgtgatc ctctccatca ggactgagcc tcctggatcc tctttctcct ttagggggga
     3061 gtaagtttgg gaaagagtga ctggagcctc tgtggggatc tccaggacaa aatcaatagt
     3121 ggggcctttg tgagctggac atgggtgtgc atattccggg ttttgttctt ggagggctct
     3181 ggacaccaag gacaagacat attccatgga aacaggaaga gcccagcttg atgcggttgg
     3241 accatctctg gcagagatcc tgctcctgga gtaggaaagg gggttgtggt ggtgggggat
     3301 ggagaaagca gctcctctta gctgagctct gcatatctca ggccagaaac tttcacacag
     3361 ctactttctc cgccaggcca ttctcaaagc agccagttcg agctgcagga ggcttctggg
     3421 agacaacaaa ctcaaccaca gcatgggaca gatagcagca gaggcagctt ttcctcaccc
     3481 ccaccccttc ttcaggatgc gctttttttt ttttaaatga tcttgttact cactgtggtt
     3541 catcaaataa aactgttttg tgtaaaaaaa aaa
//
