LOCUS       NP_035914                377 aa            linear   ROD 11-MAR-2025
DEFINITION  apelin receptor [Mus musculus].
ACCESSION   NP_035914
VERSION     NP_035914.1
DBSOURCE    REFSEQ: accession NM_011784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 377)
  AUTHORS   Vitali,H.E., Kuschel,B., Sherpa,C., Jones,B.W., Jacob,N.,
            Madiha,S.A., Elliott,S., Dziennik,E., Kreun,L., Conatser,C.,
            Bhetwal,B.P. and Sharma,B.
  TITLE     Hypoxia regulate developmental coronary angiogenesis potentially
            through VEGF-R2- and SOX17-mediated signaling
  JOURNAL   Dev Dyn 254 (2), 174-188 (2025)
   PUBMED   39360476
REFERENCE   2  (residues 1 to 377)
  AUTHORS   Anima,B., Gurusubramanian,G. and Roy,V.K.
  TITLE     Hormonal dependent expression of apelin and apelin receptor in the
            ovary and uterus of mice
  JOURNAL   Reprod Biol 24 (3), 100918 (2024)
   PUBMED   38924877
  REMARK    GeneRIF: Hormonal dependent expression of apelin and apelin
            receptor in the ovary and uterus of mice.
REFERENCE   3  (residues 1 to 377)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (residues 1 to 377)
  AUTHORS   Das,M., Gurusubramanian,G. and Roy,V.K.
  TITLE     Immunolocalization of apelin receptor (APJ) in mouse seminiferous
            epithelium
  JOURNAL   J Exp Zool A Ecol Integr Physiol 341 (4), 450-457 (2024)
   PUBMED   38390701
  REMARK    GeneRIF: Immunolocalization of apelin receptor (APJ) in mouse
            seminiferous epithelium.
REFERENCE   5  (residues 1 to 377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 377)
  AUTHORS   Ishida,J., Hashimoto,T., Hashimoto,Y., Nishiwaki,S., Iguchi,T.,
            Harada,S., Sugaya,T., Matsuzaki,H., Yamamoto,R., Shiota,N.,
            Okunishi,H., Kihara,M., Umemura,S., Sugiyama,F., Yagami,K.,
            Kasuya,Y., Mochizuki,N. and Fukamizu,A.
  TITLE     Regulatory roles for APJ, a seven-transmembrane receptor related to
            angiotensin-type 1 receptor in blood pressure in vivo
  JOURNAL   J Biol Chem 279 (25), 26274-26279 (2004)
   PUBMED   15087458
  REMARK    GeneRIF: APJ exerts the hypotensive effect in vivo and plays a
            counterregulatory role against the pressor action of angiotensin II
REFERENCE   7  (residues 1 to 377)
  AUTHORS   Saint-Geniez,M., Masri,B., Malecaze,F., Knibiehler,B. and
            Audigier,Y.
  TITLE     Expression of the murine msr/apj receptor and its ligand apelin is
            upregulated during formation of the retinal vessels
  JOURNAL   Mech Dev 110 (1-2), 183-186 (2002)
   PUBMED   11744380
  REMARK    GeneRIF: Expression of the murine msr/apj receptor and its ligand
            apelin is upregulated during formation of the retinal vessels.
REFERENCE   8  (residues 1 to 377)
  AUTHORS   De Mota,N., Lenkei,Z. and Llorens-Cortes,C.
  TITLE     Cloning, pharmacological characterization and brain distribution of
            the rat apelin receptor
  JOURNAL   Neuroendocrinology 72 (6), 400-407 (2000)
   PUBMED   11146423
REFERENCE   9  (residues 1 to 377)
  AUTHORS   O'Carroll,A.M., Selby,T.L., Palkovits,M. and Lolait,S.J.
  TITLE     Distribution of mRNA encoding B78/apj, the rat homologue of the
            human APJ receptor, and its endogenous ligand apelin in brain and
            peripheral tissues
  JOURNAL   Biochim Biophys Acta 1492 (1), 72-80 (2000)
   PUBMED   11004481
REFERENCE   10 (residues 1 to 377)
  AUTHORS   Devic,E., Rizzoti,K., Bodin,S., Knibiehler,B. and Audigier,Y.
  TITLE     Amino acid sequence and embryonic expression of msr/apj, the mouse
            homolog of Xenopus X-msr and human APJ
  JOURNAL   Mech Dev 84 (1-2), 199-203 (1999)
   PUBMED   10473142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133580.1 and BY444880.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK133580.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     Protein         1..377
                     /product="apelin receptor"
                     /note="MSR; G-protein coupled receptor APJ; angiotensin
                     receptor-like 1"
                     /calculated_mol_wt=42135
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          17..318
                     /region_name="7tmA_Apelin_R"
                     /note="apelin receptor, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15190"
                     /db_xref="CDD:341340"
     Site            order(18..22,83,86..87,89,91,108,166,171..175,181,183,196,
                     262,266,269,289,293,297)
                     /site_type="other"
                     /note="peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:341340"
     Region          28..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341340"
     Site            29..52
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          62..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341340"
     Site            63..84
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Site            83
                     /site_type="other"
                     /note="Required for APELA and APLN/apelin-13 interaction
                     and signaling. /evidence=ECO:0000250|UniProtKB:P35414;
                     propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Site            98..123
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          100..130
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341340"
     Region          143..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341340"
     Site            145..162
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Site            166
                     /site_type="other"
                     /note="Required for APELA and APLN/apelin-13 interaction
                     and signaling. /evidence=ECO:0000250|UniProtKB:P35414;
                     propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Site            173
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          196..225
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341340"
     Site            197..221
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          239..269
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341340"
     Site            245..268
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          286..311
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341340"
     Site            288..310
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     Region          334..377
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV08.1)"
     CDS             1..377
                     /gene="Aplnr"
                     /gene_synonym="Agtrl1; APJ; msr/apj"
                     /coded_by="NM_011784.3:274..1407"
                     /db_xref="CCDS:CCDS16201.1"
                     /db_xref="GeneID:23796"
                     /db_xref="MGI:MGI:1346086"
ORIGIN      
        1 meddgynyyg adnqsecdya dwkpsgalip aiymlvfllg ttgnglvlwt vfrtsrekrr
       61 sadifiasla vadltfvvtl plwatytyre fdwpfgtfsc klssylifvn myasvfcltg
      121 lsfdrylaiv rpvanarlrl rvsgavatav lwvlaallav pvmvfrstda sengtkiqcy
      181 mdysmvatsn sewawevglg vsstavgfvv pftimltcyf fiaqtiaghf rkerieglrk
      241 rrrllsiivv lvvtfalcwm pyhlvktlym lgsllhwpcd fdiflmnvfp yctcisyvns
      301 clnpflyaff dprfrqacts mlccdqsgck gtphsssaek sasyssghsq gpgpnmgkgg
      361 eqmheksipy sqetlvd
//
