LOCUS       NM_001372332            3275 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus aprataxin and PNKP like factor (Aplf), transcript
            variant 3, mRNA.
ACCESSION   NM_001372332 XM_017321755
VERSION     NM_001372332.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3275)
  AUTHORS   Rajam,S.M., Varghese,P.C., Shirude,M.B., Syed,K.M., Devarajan,A.,
            Natarajan,K. and Dutta,D.
  TITLE     Kinase activity of histone chaperone APLF maintains steady state of
            centrosomes in mouse embryonic stem cells
  JOURNAL   Eur J Cell Biol 103 (3), 151439 (2024)
   PUBMED   38968704
  REMARK    GeneRIF: Kinase activity of histone chaperone APLF maintains steady
            state of centrosomes in mouse embryonic stem cells.
REFERENCE   2  (bases 1 to 3275)
  AUTHORS   Varghese,P.C., Rajam,S.M., Nandy,D., Jory,A., Mukherjee,A. and
            Dutta,D.
  TITLE     Histone chaperone APLF level dictates the implantation of mouse
            embryos
  JOURNAL   J Cell Sci 134 (1) (2021)
   PUBMED   33277378
  REMARK    GeneRIF: Histone chaperone APLF level dictates the implantation of
            mouse embryos.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3275)
  AUTHORS   Syed,K.M., Joseph,S., Mukherjee,A., Majumder,A., Teixeira,J.M.,
            Dutta,D. and Pillai,M.R.
  TITLE     Histone chaperone APLF regulates induction of pluripotency in
            murine fibroblasts
  JOURNAL   J Cell Sci 129 (24), 4576-4591 (2016)
   PUBMED   27875275
  REMARK    GeneRIF: the downregulation of histone chaperone Aprataxin PNK-like
            factor (APLF) promotes reprogramming by augmenting the expression
            of E-cadherin.
            Erratum:[J Cell Sci. 2018 Apr 19;131(8):jcs218842. doi:
            10.1242/jcs.218842. PMID: 29674330]
REFERENCE   4  (bases 1 to 3275)
  AUTHORS   Tong,K.I., Ota,K., Komuro,A., Ueda,T., Ito,A., Anne Koch,C. and
            Okada,H.
  TITLE     Attenuated DNA damage repair delays therapy-related myeloid
            neoplasms in a mouse model
  JOURNAL   Cell Death Dis 7 (10), e2401 (2016)
   PUBMED   27711078
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3275)
  AUTHORS   Rulten,S.L., Fisher,A.E., Robert,I., Zuma,M.C., Rouleau,M., Ju,L.,
            Poirier,G., Reina-San-Martin,B. and Caldecott,K.W.
  TITLE     PARP-3 and APLF function together to accelerate nonhomologous
            end-joining
  JOURNAL   Mol Cell 41 (1), 33-45 (2011)
   PUBMED   21211721
  REMARK    GeneRIF: APLF has a role in chromosomal DNA double-strand break
            repair.
REFERENCE   6  (bases 1 to 3275)
  AUTHORS   Danciger,M., Yang,H., Ralston,R., Liu,Y., Matthes,M.T., Peirce,J.
            and Lavail,M.M.
  TITLE     Quantitative genetics of age-related retinal degeneration: a second
            F1 intercross between the A/J and C57BL/6 strains
  JOURNAL   Mol Vis 13, 79-85 (2007)
   PUBMED   17277741
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3275)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158626.6 and AC125171.4.
            
            On Aug 29, 2019 this sequence version replaced XM_017321755.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.625216.1,
                                           SRR13422600.160676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC158626.6         191289-191590
            303-374             AC125171.4         166000-166071       c
            375-547             AC125171.4         161269-161441       c
            548-695             AC125171.4         156425-156572       c
            696-828             AC125171.4         156017-156149       c
            829-1013            AC125171.4         151292-151476       c
            1014-1351           AC125171.4         143598-143935       c
            1352-1477           AC125171.4         139474-139599       c
            1478-1524           AC125171.4         134514-134560       c
            1525-3275           AC125171.4         126009-127759       c
FEATURES             Location/Qualifiers
     source          1..3275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 38.52 cM"
     gene            1..3275
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /note="aprataxin and PNKP like factor"
                     /db_xref="GeneID:72103"
                     /db_xref="MGI:MGI:1919353"
     exon            1..302
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..374
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            375..547
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            548..695
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..828
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1013
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1351
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1477
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1524
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..3275
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1932..1937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1956
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /note="major polyA site"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3275
                     /gene="Aplf"
                     /gene_synonym="2010301N04Rik"
ORIGIN      
        1 agtttttaag ctgtagtttg gcggtctgtt gacaggtatt ccctgcacga atcacaggct
       61 ctcaaggagt ggggattccg gaaagggaag aagcacactc accaggaaag gagcctcggg
      121 tttcacaccc cttcgggcca tgcccagcgt gcctgaggga ggtggctacg aggtatctcc
      181 tggcgaagga accttctctt accgccatgc cttcggactt ctttctgcag cctctggacg
      241 gcggtccccg cgtgcccgtg gggccggggc agactgtgat aggccgcggg ccgctgctgg
      301 gaataacaga caaaagagta tccagaagac atgccattct tgaagtggtt gatagtcagc
      361 ttcgaatcaa gccaatccat aggaatccat gtttctacca gtcctcggag aagagccaac
      421 actcgccaat ggagacgcaa gtgtggagcc agttgcatcc cggggatagc ttttccctgt
      481 tacttgacaa gtacgctttc cgtgttttct ctgcagaatc tgaagtggag atggagtgta
      541 ctctgagaaa cagtcagatg cttgatgaag atgatatatt gagtgagatg cagaagtccc
      601 ctgtggttaa cttacctgat aagacaactg gtgcctcaca gctgcaagga agccctgaaa
      661 taaccaagac caagtgtccc accatagatc ctatgtcctc ttcaggtgaa tgcagagctt
      721 tcagtgagca ccagccacgt cctacccaga ggaaaagaat cctcccagct tggatgttgg
      781 cggaaagtct aagtgaccag agcctctcca caccagctga ggggggagat aaggatgtca
      841 tccagaggag tggaaaagca ggaacctgtg aagatagaac cccaggaaac acatcatggc
      901 atgggaaaaa gcggcttagt ccatcaggaa attcaaaaag tgtgtcagcg gaacaagacc
      961 ctgggaagaa gtgcagaaag gctgaccaag aaggaccggg tgtttcttct gagaatgttc
     1021 cagaatcatc atcttcaaac atagtaaagg acccagatgt ggatattgtg aagacaaata
     1081 aacagaagga cgggatttta atagaggaac ttggtgaggt ctctaaacat aaagccgcca
     1141 ccaaaccaac cacaaatgaa gagggcgaga gttgtgcacg tgtccaaagc aagtcacctc
     1201 ctgagaaatc tcaaggatgc catcctgagt ctagctctgc tccctccagt cctgatgctt
     1261 tgcacacaga cacagctgac ccagtgctgg gctgttcaga agaaagcaag gtccggagga
     1321 cggcctgcat gtatggggcc aactgctaca ggaggaaccc cctccacttt caacacttca
     1381 gccaccctgg tgacagtgac tatggagagg tacatggcac agatgaaggt gtgattggtg
     1441 acaggcccga gtgtccctat ggagcgtctt gttacaggaa gaacccccag cacaagatgg
     1501 aatataggca cagtgcactt ccagccagag ttgctctgga tgaagatgac gatgatgtcg
     1561 ggcaacccag tgacgatgag gacgaggaag actatgagcc gacagatgaa gattctgatt
     1621 ggcacccagg aaaggacgat gaggagcagg aagatgtgga tgagcttttg aaagaagcaa
     1681 aaaggtttat gagaaggaaa aagtagcgtt tctgcaatga ctcacatttg ctttttttct
     1741 ctgtgggaaa catactcatt ttttttttct tttaatagtt ctttgcactt gaaacattga
     1801 aacaccagcc ttcagtgaaa taggtggatg tatgctattg cctattttgg tgcctattta
     1861 atgtatccat cagtgaaagc aggtaaagag gttgggcagt ctgatatttt ctaaatactt
     1921 tacatactgc gaataaaaag ccataggttg tacaaacctt tgatcttctg ccctgaggtc
     1981 tttatagagc tccctgcaag cttagccagg tgattacaga aaagtggaag agcacaaccc
     2041 cacactgctg ttgaaagagg ccccacaaag ctagacttga acaaatgaca gccagcagtg
     2101 tgccacgtct ctaatatatt agatgtggct ttgtgatttc atttacggct tttgtccttt
     2161 gaatcctggg aagactatta acaaataggt gctgaaaatg atcctgttaa cctatagggc
     2221 agcagtactc gccttgcaag gaaatggttt ttgtgcatcc acaactgcgt atgtatatct
     2281 gtgagagtat aaagaagacg actgcggagc ccttgtgtgg ctctcacacc gccctgcaca
     2341 caccatgccc cgcccacacc atgccccgcc cacaccatgc cccgcccaca ccatgccccg
     2401 cccacaccat gccccgccca caccatgccc cgcccacacc atgccccgcc cacaccatgc
     2461 cccgcccaca ccatgccccg cccgactcct ttgcttgctc tgtgcacctt tacactgagg
     2521 acacgagaag cttcaagcca ctgtcttctc agagggtcac ctgagaggtg cgttctctgc
     2581 tgtggatagg gttctggcct ctgaagaagc ctctgctcca aggatggagc atgtctggtt
     2641 ttaggccagc ttccctctga gcagtctgca gattggggta catcagctcg tgaagcagtg
     2701 tggggagcgg gtgtggcggc agtcccaaag gcgccaggga ctgcagctaa gtcatatgac
     2761 tttcacctga cttcctcata taagacacaa acatcttgag tgctgcttag gtgtaccagg
     2821 atacaggtga atccaatttg gtggagattt gcccctgctg ccctgattag ctgaagcctc
     2881 gtgactggcg agggggcgtg gcctgcggtg catggatgag agagagtata aaaggagtga
     2941 gaggcccagg gttcggggga gatataaaaa caagggagat atataaacaa gggagatata
     3001 aacaagggag atataaacaa gaagaaacag gactgaataa acgtgtgcag aaagatcctg
     3061 ttgcagcgtc gttcttcctg gccagttggg cgcacgcaag aaagcagtga gccagaagct
     3121 ccttgtcatt cttcactcaa gaggaaataa aatgcacatc ttagaacaaa aggggccaca
     3181 tgctttcttc gtatttgtga gtctctccat gtaattgcac agggttaaat ttacttaaac
     3241 tgaagaaaga cagaataaat atttctctat tatca
//
