LOCUS       NM_019735                924 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus APAF1 interacting protein (Apip), transcript variant
            1, mRNA.
ACCESSION   NM_019735 XM_001480555
VERSION     NM_019735.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Lim,B., Jung,K., Gwon,Y., Oh,J.G., Roh,J.I., Hong,S.H., Kho,C.,
            Park,W.J., Lee,H.W., Bae,J.W. and Jung,Y.K.
  TITLE     Cardioprotective role of APIP in myocardial infarction through
            ADORA2B
  JOURNAL   Cell Death Dis 10 (7), 511 (2019)
   PUBMED   31263105
  REMARK    GeneRIF: APIP is crucial for cardioprotection against myocardial
            infarction by virtue of binding to and stabilizing ADORA2B, thereby
            dampening ischemic heart injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 924)
  AUTHORS   Hong,S.H., Lee,W.J., Kim,Y.D., Kim,H., Jeon,Y.J., Lim,B., Cho,D.H.,
            Heo,W.D., Yang,D.H., Kim,C.Y., Yang,H.K., Yang,J.K. and Jung,Y.K.
  TITLE     APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer
            formation to promote tumorigenesis
  JOURNAL   Oncotarget 7 (16), 21601-21617 (2016)
   PUBMED   26942872
REFERENCE   6  (bases 1 to 924)
  AUTHORS   Cho,D.H., Lee,H.J., Kim,H.J., Hong,S.H., Pyo,J.O., Cho,C. and
            Jung,Y.K.
  TITLE     Suppression of hypoxic cell death by APIP-induced sustained
            activation of AKT and ERK1/2
  JOURNAL   Oncogene 26 (19), 2809-2814 (2007)
   PUBMED   17086211
REFERENCE   7  (bases 1 to 924)
  AUTHORS   Cho,D.H., Hong,Y.M., Lee,H.J., Woo,H.N., Pyo,J.O., Mak,T.W. and
            Jung,Y.K.
  TITLE     Induced inhibition of ischemic/hypoxic injury by APIP, a novel
            Apaf-1-interacting protein
  JOURNAL   J Biol Chem 279 (38), 39942-39950 (2004)
   PUBMED   15262985
  REMARK    GeneRIF: APIP functions to inhibit muscle ischemic damage by
            binding to Apaf-1 in the Apaf-1/caspase-9 apoptosis pathway.
REFERENCE   8  (bases 1 to 924)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077705.1, AK145450.1 and AV060627.1.
            
            On or before Sep 18, 2009 this sequence version replaced
            XM_001480555.1, NM_019735.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145450.1, AK077705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AK077705.1         2-144
            144-913             AK145450.1         146-915
            914-924             AV060627.1         186-196
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.29 cM"
     gene            1..924
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /note="APAF1 interacting protein"
                     /db_xref="GeneID:56369"
                     /db_xref="MGI:MGI:1926788"
     exon            1..167
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     exon            168..268
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     exon            269..317
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     exon            318..435
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     exon            436..571
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     exon            572..739
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     exon            740..924
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      894..899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /note="hexamer: AATAAA"
     polyA_site      916
                     /gene="Apip"
                     /gene_synonym="APIP2; CGI-29; Mmrp19"
                     /note="major polyA site"
ORIGIN      
        1 gcctctcact cttgctccgc ccccaggctg cccgctctgt cgcctaatag cgttctgccg
       61 gccgctcaga cttggaacga gcgcgggaca gataacggag cagagtcaga accatgtctg
      121 gctgtcaagc tcaaggagac tgttgctcgc ggccgtgtgg cgcgcaggac aaggagcacc
      181 cccgattcct gatcccagaa ctttgcaaac agttttacca tctgggctgg gtcaccggca
      241 ctggaggggg aatcagcttg aagcatggca atgaaatcta cattgctccc tcaggcgtgc
      301 aaaaggaacg cattcagcca gaagacatgt ttgtgtgtga cattaatgag caggacataa
      361 gcgggcctcc agcatctaag aagctgaaaa aaagccagtg cactcctctt ttcatgaatg
      421 cttataccat gagaggagct ggcgcagtga ttcataccca ctctaaagct gctgtgatgg
      481 ctacccttct gtttccagga caggagttta aaattacaca tcaagagatg atcaaaggaa
      541 taaggaaatg tacctcagga ggctattaca gatacgatga tatgttagtg gtacctatta
      601 ttgagaacac tcctgaagag aaggatctca aagaaaggat ggctcatgcc atgaacgagt
      661 acccagactc ctgtgcggtt cttgtccggc gtcatggggt gtacgtgtgg ggagaaacat
      721 gggagaaagc aaaaaccatg tgtgagtgtt atgactacct gtttgacatt gctgtctcca
      781 tgaagaagat gggactcgat ccaacacagc tcccagttgg agaaaatgga attgtgtaag
      841 ccaagtggat gcctaagcat ctccaacaat aaaacaaact caattatgcc ttaaataaaa
      901 ctcagctgct tttaaatgag ttgg
//
