LOCUS       NM_001305258            3704 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus apoptosis inhibitor 5 (Api5), transcript variant 1,
            mRNA.
ACCESSION   NM_001305258 XM_006498588
VERSION     NM_001305258.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Matsuzawa-Ishimoto,Y., Yao,X., Koide,A., Ueberheide,B.M.,
            Axelrad,J.E., Reis,B.S., Parsa,R., Neil,J.A., Devlin,J.C.,
            Rudensky,E., Dewan,M.Z., Cammer,M., Blumberg,R.S., Ding,Y.,
            Ruggles,K.V., Mucida,D., Koide,S. and Cadwell,K.
  TITLE     The gammadelta IEL effector API5 masks genetic susceptibility to
            Paneth cell death
  JOURNAL   Nature 610 (7932), 547-554 (2022)
   PUBMED   36198790
  REMARK    GeneRIF: The gammadelta IEL effector API5 masks genetic
            susceptibility to Paneth cell death.
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3704)
  AUTHORS   Pavlinkova,G., Salbaum,J.M. and Kappen,C.
  TITLE     Maternal diabetes alters transcriptional programs in the developing
            embryo
  JOURNAL   BMC Genomics 10, 274 (2009)
   PUBMED   19538749
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3704)
  AUTHORS   Lang,G., White,J.R., Argent-Katwala,M.J., Allinson,C.G. and
            Weston,K.
  TITLE     Myb proteins regulate the expression of diverse target genes
  JOURNAL   Oncogene 24 (8), 1375-1384 (2005)
   PUBMED   15608679
REFERENCE   5  (bases 1 to 3704)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3704)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 3704)
  AUTHORS   Lu,K.P. and Ramos,K.S.
  TITLE     Identification of genes differentially expressed in vascular smooth
            muscle cells following benzo[a]pyrene challenge: implications for
            chemical atherogenesis
  JOURNAL   Biochem Biophys Res Commun 253 (3), 828-833 (1998)
   PUBMED   9918813
REFERENCE   8  (bases 1 to 3704)
  AUTHORS   Tewari,M., Yu,M., Ross,B., Dean,C., Giordano,A. and Rubin,R.
  TITLE     AAC-11, a novel cDNA that inhibits apoptosis after growth factor
            withdrawal
  JOURNAL   Cancer Res 57 (18), 4063-4069 (1997)
   PUBMED   9307294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672251.10.
            
            On Jan 13, 2022 this sequence version replaced NM_001305258.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167315.1, AK134480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AL672251.10        70336-70557         c
            223-384             AL672251.10        62091-62252         c
            385-478             AL672251.10        60458-60551         c
            479-544             AL672251.10        59924-59989         c
            545-696             AL672251.10        59345-59496         c
            697-903             AL672251.10        58003-58209         c
            904-1008            AL672251.10        57386-57490         c
            1009-1098           AL672251.10        55824-55913         c
            1099-1280           AL672251.10        54709-54890         c
            1281-1374           AL672251.10        53845-53938         c
            1375-1431           AL672251.10        53398-53454         c
            1432-1508           AL672251.10        51283-51359         c
            1509-1645           AL672251.10        50668-50804         c
            1646-3704           AL672251.10        44140-46198         c
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.84 cM"
     gene            1..3704
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /note="apoptosis inhibitor 5"
                     /db_xref="GeneID:11800"
                     /db_xref="MGI:MGI:1888993"
     exon            1..222
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1728
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis inhibitory protein 5"
                     /codon_start=1
                     /product="apoptosis inhibitor 5 isoform 1"
                     /protein_id="NP_001292187.1"
                     /db_xref="GeneID:11800"
                     /db_xref="MGI:MGI:1888993"
                     /translation="MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRL
                     AAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADIL
                     TQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLK
                     TLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVA
                     EQADLEQAFSPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLTTP
                     VEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNE
                     EPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLR
                     LALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVE
                     IGQKRTSEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNLSNFNYEQRGAFRGNRG
                     GRGWGTRGNRSRGRLY"
     exon            223..384
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            385..478
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            479..544
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..696
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            697..903
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1008
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1098
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1280
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1374
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1431
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1508
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1645
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..3704
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /note="hexamer: AATAAA"
     polyA_site      3704
                     /gene="Api5"
                     /gene_synonym="AAC-11; API-5"
                     /note="major polyA site"
ORIGIN      
        1 gcggtaccgt gctgtacgcg gtgactggtg gcggcccggc ggcggctccc ggcgtactag
       61 tgcggtcgac ggctcagata agttccgtgg aggcggcggt ggcgccgacg aggtgttggg
      121 cgacgggagc gggcccggaa cttggcgctc agcatgccga cggtggagga gctgtaccgc
      181 aactacggca tcctcgccga tgccacggag caagtgggcc agcataaaga tgcctaccaa
      241 gtgatactgg atggcgtgaa aggcggcacc aaggaaaagc gattagcagc tcagtttata
      301 ccaaaattct ttaagcattt tccagagctg gctgattctg ctatcaatgc acagttagac
      361 ctctgtgagg atgaagatgt gtcaatacga cgtcaagcaa ttaaagagct gcctcagttt
      421 gccacaggag aaaaccttcc tagagtagca gatatactga cccagcttct gcagacagat
      481 gactctgcag aatttaacct ggtgaacaat gctctgctaa gtatatttaa gatggatgca
      541 aaaggaacgt taggtggctt gtttagccag attcttcaag gagaagacat tgttagagaa
      601 cgagcaatta aattcctgtc cacaaaactc aagacgctcc cagatgaggt gttgactaag
      661 gaagtggagg aactcatact cactgagtcc aagaaggtcc tagaagacgt gactggtgaa
      721 gagtttgttt tgttcatgaa gatactgtct gggttgaaaa gcttacagac agtgagtgga
      781 cgacagcagc tggtggagct ggtggcggaa caggctgacc tggagcaggc cttcagcccc
      841 tcagaccccg actgtgtgga cagactactg cagtgcacgc ggcaggctgt gcctctcttc
      901 tccaaaaatg tgcattctac aagatttgtg acgtatttct gtgagcaagt tctccctaac
      961 ctcagcaccc tgaccacccc agtggaaggc ctcgatatac agctggaggt attaaagttg
     1021 ttggcagaga tgagttcatt ttgtggtgac atggaaaaac tagaaacaaa tttaagaaaa
     1081 ctgtttgata agttattgga gtatatgcct ctccctccag aagaagcaga aaatggggag
     1141 aatgctggta atgaggagcc caagctgcag ttcagttatg tggagtgctt attgtacagt
     1201 tttcatcagt tggggcgaaa acttccagac ttcttaacag ccaaactgaa tgcagaaaaa
     1261 ctcaaggatt tcaaaattag gttgcagtac tttgcacggg gcctgcaggt ttatatcaga
     1321 caacttcgct tggctctcca gggtaaaaca ggcgaggcct taaaaacaga ggagaacaag
     1381 ataaaagttg ttgcactgaa aataacaaac aatatcaatg ttttaatcaa ggatctcttc
     1441 cacattcctc cttcttataa gagcacagta acattgtcct ggaaacctgt gcagaaagtt
     1501 gagattgggc aaaagagaac cagtgaagat acaagttcag gttcaccacc taagaagtct
     1561 ccaggaggac caaaaagaga tgccagacag atttataatc ctccgagtgg aaagtacagc
     1621 agcaatctga gcaactttaa ttatgagcag agaggagcct tcaggggaaa tagaggtggc
     1681 cgaggttggg gaacacgagg aaatcgaagt cgaggaagac tctactgatt gtgacgtcac
     1741 attcttcagc attgtcatga gattaatata cttaaatcta ctactcattg gattgccggg
     1801 gatgtccctt taaaaggact gctgccttca gctgaaaatg taatgttctt tctacctttg
     1861 tatgtatgat ctacttttgt aaaagaccat ggttgtgtcc aaggtaaaac cacaacaata
     1921 tttttggatg ctttgtctgc agccttgact tgttttcaca atatcctcac tatccagact
     1981 tcatcttgtg aatcttgctt ttacacatct tgatggtttg tcactgagat ctgactctat
     2041 tggaaaagtc agtctagcct gtgatctggt gaagatcatc actcttgaaa cgttactgtt
     2101 ctcctcccca ttccgttagg tttctgccca acacatggag aagagttaag agcagtctta
     2161 accttctgct ttcattgttt tctaaggaag ctgctaggca gtgttgtcgc attcctgcca
     2221 agtcatagaa atgaagcacc agcttctcac agtgtacagg cgatgccagc cttttagaaa
     2281 gaacttgctt tgcattgccc cttcagtctt ctccatattt tgggatacag ctttgaacac
     2341 agggtcttat tatttgaata ggagtacatg tgcataatat acgtacagac ataagcatat
     2401 gttgtgtgtg tatatatgca tgctatggaa cttgagtgta caaccaatca atacattaaa
     2461 ttctcggaag gggtcctctg acatagcgat tatccctttg aggctgaatc cattactgac
     2521 ttggtatcta ggttttcact ccagtaggga ggaatttcag tcagctgaac ttacagatta
     2581 ttattgttgt ttaaaactaa aaaacaaagg ctgtttttac agagacaaat ttaaagaccc
     2641 ttgttggtga aatacagcca gatctggtgt acatacaggt tcccacagga tctgctagtg
     2701 taatgtagga tttggagact taataaccag ggctacccag gagtgtgact tggtgacata
     2761 gtaccataaa agttgctcac tccgcttgct tttgccactt tcaaatttta acttctcagg
     2821 ttattaatca gattattgtg taagttagcc aatagtcttt agattaaggc aacagacggg
     2881 aggttcgtgg agtgtctcat gttgggcatt tttagtagcc cagactctgt tcttcatttg
     2941 aatgtttcac acatttttgt tcacagttaa tcttccaagt ttactattca agtcagaaat
     3001 tcagatgaca tttctagtgg tttgctgttt tggtttttta tgttttttgg ttttttttga
     3061 ggtttcattt cttacacagg tgtcttcatc accatcactt ctacactggg ggaaaaacaa
     3121 tctcctttgt gagaatcact gcatgtattt atggcgaaaa tatttctgaa agtctagagt
     3181 gatacaagtg agcacaagaa gttggtcagc ttgcctatgg agtgctggca ataaactctg
     3241 aacattccac aagcctgagc tgaacctagg ctcccttgga agctgaacag acataggaac
     3301 atgggattgc cagctgaatc ctgtgaccat ctagttatgg acctcagaga tagatcagcg
     3361 tggcctaaag ccatttcaag tacaaaaatg aattggacta tagcaacata aatttgaaca
     3421 cagtaacttt tcctctttgc ctgagggcat ttgtaaactc ggcagaagta acttgacctc
     3481 atgtctactg cagagctcac tgcattcacc cctcctcatc ctttgcttcc ttccccttgc
     3541 ctagtcagta gttcataact tagtgttcct tttgcttcag aaatctgaaa gaaaatcttc
     3601 atgccatgaa tctttttctt ccgcaaggac acctgtgtct cccttgttta aataaatgta
     3661 aatgctccct tatgcttttg aaataaattt ccttttgtaa tttt
//
