LOCUS       NM_177583               4558 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus aph1 homolog B, gamma secretase subunit (Aph1b), mRNA.
ACCESSION   NM_177583 NM_027169
VERSION     NM_177583.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4558)
  AUTHORS   Ma,T., Tian,X., Zhang,B., Li,M., Wang,Y., Yang,C., Wu,J., Wei,X.,
            Qu,Q., Yu,Y., Long,S., Feng,J.W., Li,C., Zhang,C., Xie,C., Wu,Y.,
            Xu,Z., Chen,J., Yu,Y., Huang,X., He,Y., Yao,L., Zhang,L., Zhu,M.,
            Wang,W., Wang,Z.C., Zhang,M., Bao,Y., Jia,W., Lin,S.Y., Ye,Z.,
            Piao,H.L., Deng,X., Zhang,C.S. and Lin,S.C.
  TITLE     Low-dose metformin targets the lysosomal AMPK pathway through PEN2
  JOURNAL   Nature 603 (7899), 159-165 (2022)
   PUBMED   35197629
REFERENCE   2  (bases 1 to 4558)
  AUTHORS   Gobe,C., Elzaiat,M., Meunier,N., Andre,M., Sellem,E., Congar,P.,
            Jouneau,L., Allais-Bonnet,A., Naciri,I., Passet,B., Pailhoux,E. and
            Pannetier,M.
  TITLE     Dual role of DMXL2 in olfactory information transmission and the
            first wave of spermatogenesis
  JOURNAL   PLoS Genet 15 (2), e1007909 (2019)
   PUBMED   30735494
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4558)
  AUTHORS   Acx,H., Serneels,L., Radaelli,E., Muyldermans,S., Vincke,C.,
            Pepermans,E., Muller,U., Chavez-Gutierrez,L. and De Strooper,B.
  TITLE     Inactivation of gamma-secretases leads to accumulation of
            substrates and non-Alzheimer neurodegeneration
  JOURNAL   EMBO Mol Med 9 (8), 1088-1099 (2017)
   PUBMED   28588032
REFERENCE   4  (bases 1 to 4558)
  AUTHORS   Wang,P., Guan,P.P., Guo,J.W., Cao,L.L., Xu,G.B., Yu,X., Wang,Y. and
            Wang,Z.Y.
  TITLE     Prostaglandin I2 upregulates the expression of anterior
            pharynx-defective-1alpha and anterior pharynx-defective-1beta in
            amyloid precursor protein/presenilin 1 transgenic mice
  JOURNAL   Aging Cell 15 (5), 861-871 (2016)
   PUBMED   27240539
  REMARK    GeneRIF: Prostaglandin I2 accumulation in neuronal cells activates
            PKA/CREB and JNK/c-Jun signaling pathways by phosphorylation, which
            results in APH-1alpha/1beta expression.
REFERENCE   5  (bases 1 to 4558)
  AUTHORS   Biundo,F., Ishiwari,K., Del Prete,D. and D'Adamio,L.
  TITLE     Deletion of the gamma-secretase subunits Aph1B/C impairs memory and
            worsens the deficits of knock-in mice modeling the Alzheimer-like
            familial Danish dementia
  JOURNAL   Oncotarget 7 (11), 11923-11944 (2016)
   PUBMED   26942869
  REMARK    GeneRIF: Loss of Aph1B is associated with memory deficit.
REFERENCE   6  (bases 1 to 4558)
  AUTHORS   Ma,G., Li,T., Price,D.L. and Wong,P.C.
  TITLE     APH-1a is the principal mammalian APH-1 isoform present in
            gamma-secretase complexes during embryonic development
  JOURNAL   J Neurosci 25 (1), 192-198 (2005)
   PUBMED   15634781
REFERENCE   7  (bases 1 to 4558)
  AUTHORS   Fraering,P.C., Ye,W., Strub,J.M., Dolios,G., LaVoie,M.J.,
            Ostaszewski,B.L., van Dorsselaer,A., Wang,R., Selkoe,D.J. and
            Wolfe,M.S.
  TITLE     Purification and characterization of the human gamma-secretase
            complex
  JOURNAL   Biochemistry 43 (30), 9774-9789 (2004)
   PUBMED   15274632
REFERENCE   8  (bases 1 to 4558)
  AUTHORS   Culvenor,J.G., Ilaya,N.T., Ryan,M.T., Canterford,L., Hoke,D.E.,
            Williamson,N.A., McLean,C.A., Masters,C.L. and Evin,G.
  TITLE     Characterization of presenilin complexes from mouse and human brain
            using Blue Native gel electrophoresis reveals high expression in
            embryonic brain and minimal change in complex mobility with
            pathogenic presenilin mutations
  JOURNAL   Eur J Biochem 271 (2), 375-385 (2004)
   PUBMED   14717705
REFERENCE   9  (bases 1 to 4558)
  AUTHORS   Lee,S.F., Shah,S., Li,H., Yu,C., Han,W. and Yu,G.
  TITLE     Mammalian APH-1 interacts with presenilin and nicastrin and is
            required for intramembrane proteolysis of amyloid-beta precursor
            protein and Notch
  JOURNAL   J Biol Chem 277 (47), 45013-45019 (2002)
   PUBMED   12297508
REFERENCE   10 (bases 1 to 4558)
  AUTHORS   De Strooper,B., Annaert,W., Cupers,P., Saftig,P., Craessaerts,K.,
            Mumm,J.S., Schroeter,E.H., Schrijvers,V., Wolfe,M.S., Ray,W.J.,
            Goate,A. and Kopan,R.
  TITLE     A presenilin-1-dependent gamma-secretase-like protease mediates
            release of Notch intracellular domain
  JOURNAL   Nature 398 (6727), 518-522 (1999)
   PUBMED   10206645
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC142504.2 and
            AC134429.3.
            
            On May 2, 2007 this sequence version replaced NM_177583.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049828.1, BC079659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC142504.2         55132-55302
            172-342             AC142504.2         56315-56485
            343-413             AC142504.2         59887-59957
            414-536             AC142504.2         60787-60909
            537-664             AC142504.2         65910-66037
            665-4343            AC142504.2         71175-74853
            4344-4558           AC134429.3         1-215
FEATURES             Location/Qualifiers
     source          1..4558
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.12 cM"
     gene            1..4558
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /note="aph1 homolog B, gamma secretase subunit"
                     /db_xref="GeneID:208117"
                     /db_xref="MGI:MGI:3522097"
     exon            1..171
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..832
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /note="APH1B homolog; anterior pharynx defective 1c
                     homolog; anterior pharynx defective 1b homolog"
                     /codon_start=1
                     /product="gamma-secretase subunit APH-1B"
                     /protein_id="NP_808251.1"
                     /db_xref="CCDS:CCDS23307.1"
                     /db_xref="GeneID:208117"
                     /db_xref="MGI:MGI:3522097"
                     /translation="MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLV
                     SLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLK
                     SINPEETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSA
                     FMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYI
                     IMVLMGIWAFYVAGGSCRSLKLCLLCQDKDFLLYNQRSR"
     exon            172..342
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            343..413
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            414..536
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            537..664
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /inference="alignment:Splign:2.1.0"
     exon            665..4558
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1185..1190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /note="hexamer: AGTAAA"
     polyA_site      1206
                     /gene="Aph1b"
                     /gene_synonym="APH-1b; aph-1beta"
                     /note="major polyA site"
ORIGIN      
        1 gctgtccatt gggcactgca gggccctcgg gcccccgcga ctggctcccg aggtcgtcat
       61 gacggctgcg gtgttctttg gttgcgcctt catcgccttc gggcccgcgc tcgctcttta
      121 tgtcttcacc atcgccaccg accctttgcg agtcatcttc ctcatcgccg gtgctttctt
      181 ctggttggtg tctctcctgc tgtcatccgt tttttggttc ctagtgagag tcattactga
      241 caacagagat ggaccagtac agaattacct gctcatcttc ggagtgttgc tctctgtctg
      301 tatccaagag ctgttcaggc tcgcatatta taagctgtta aaaaaagcca gtgagggttt
      361 gaaaagcata aaccctgagg agacagcacc ctcgatgcga ctgttggcct atgtttctgg
      421 cttgggcttt ggaatcatga gtggagtgtt ttcctttgtg aacaccctgt ctaactcctt
      481 ggggccaggc acagtgggca ttcatggtga ttctcctcag ttcttcctta attcagcttt
      541 catgacactg gtcgtcataa tgctgcacgt gttctggggc gttgtgttct ttgatggctg
      601 tgagaagaat aagtggtaca ccctcctcac ggttctcctg acgcatctgg tggtgtccac
      661 ccagactttt ctaagtcctt attatgaagt gaatctggta acagcatata taatcatggt
      721 gctcatgggc atctgggcat tttatgttgc cggaggcagc tgccgaagct tgaaactctg
      781 cctgctctgc caagacaagg attttcttct ttacaaccaa cgctccagat aacctctgac
      841 catcagcacc tctaagcagc agcctgtgtc tttagaggaa gcacaactgg gccctgttct
      901 aaaaagaccc ctgtatcttg gaacttggaa gccacagaac tgtccagcct ggaactgtcc
      961 tgtgctttca tgcagcagcc tctggaagag ctgcagtgta gcctgcagcc tggctgcaca
     1021 tttgaagcat ctggggaaac aaggattgat gcttctgggc ttctccagac ttgattatcc
     1081 tggatgtgca ggacagctga gagtcactgg ggtccaatgg ggagttcgag aaaacaccca
     1141 aaagctgttc agtgttggtc ttctaaacca acttcagctg agcaagtaaa tatctgaatg
     1201 tggtaaccag cgtagcccct gtctttttat gtactgatgt cacagactcc agggctgttc
     1261 tgtctgtgga tgggtttgct agccttcacc agcatcatag gctgtgcctt taaatgcagt
     1321 aacctacact ggcattataa cttagccaag gtaaggtcca tgtagaacct gtatttttct
     1381 cattatttta tcaattttaa gtttttcttc ctcaggcact agattattta tttgagtata
     1441 aattcaggct ctttaggatt aattatatgc tgacttcctt gggagagtct aaaattatgt
     1501 gctgaattcc ttggaagaaa ttagcagtgc aatttctttg gattccgtaa gtttattcat
     1561 tataaaatac taacagcaac atagattcct cagttttaag ctgctgtgtg tgctgtctga
     1621 aactggcttg tctagggaaa actcaccttt tttatctctg agaagctggg cagggagatg
     1681 aatgatggac ctttgggaga tcttctcttt gtgagagtgt agctaaacca caaagtagtg
     1741 tgacattgac acttctcatt tgctactgtg acaccaaaca gtgccatcac cctaatggta
     1801 cagggtaaag ttggagatag accaaatttc aagctggcat ggaacttttc atcttcagca
     1861 gttcgcctgg gttctggtta ctgtgagaca aacagcattc ccttttcagg actacgcaag
     1921 ggctttgtta gtcttccaga taaggcctct ggcttcctct gtaagaggaa tgctactgca
     1981 ttgggagtct gctgtggaga ctgttcccaa tccaagtctt ttgggaacag agtgtaaagt
     2041 agcaatgacc tcttggtgga agtgatgcct tggtgatccc agcacacatg tgcactgtct
     2101 ataagaacca ggggcagcag tgagagggtt tggcagtgac acttaagatg aattacccag
     2161 gaactaaacc ttaattgatg aacttccacc atgcttaaaa tatttgagtg tctatgtaga
     2221 gatgcaagac ttataaagct tctagcaaga atatagatta cctgagaaac cactgtttct
     2281 ccttaaaggt tacttcagct ctaaatcatg ttagtgcctc tgctggagtt tattggttgt
     2341 atcttcatat aagatttccc ctggactaga aggacaaaga catagaaagc aaacagtaaa
     2401 cttcacttta cagagccaag aacaagaaga tgcccacagg gctgggatgt gttcctccct
     2461 gagcatggtt actactgctg tcttatacac cttgtatgga gatattccga taaaatgttt
     2521 gcttgtccga ggcatggaga acctgagaat ttgactgtta ttatacttga gctctaagca
     2581 aattctctga gtataccaca atattagaaa tgaggctatt atacaatctc aattaattaa
     2641 aaaaactcag atgaatggct gggaagatgg ctcactggct aagcacacat actgctcttt
     2701 cagaggatcc aagttcagtt ccaagaaccc cctttgagca gctcacaacc acttctaact
     2761 acagctctag gagatccaat gcatctggcc ttcaactgcg actgtattca tatgcccaca
     2821 caggcaggac catacatatt caaaaacaga accaacacac atgagaagga aatttgccta
     2881 gtgaaactca gttgaattat tgaatagtcc ttgtttgcct gtggttgttc ttatactgtg
     2941 agtgctgctg tgtagctcag gcagagctgt ttccgtagcc tgctttgcac cttacctagg
     3001 aagcctgagg gaggtggagt cttacacata cacattgaag tgctgctctt attaataatt
     3061 gaaaaggagt agcctggatg ttgtatgctg tgttccacac aggttttctg tgaagagaga
     3121 gaaaatgcac ataaaattga ccttgggatt ttgaatattg ttttagtgct tgagtaacag
     3181 agatgcattg accatgtgaa tagccgggat agattcagtt gtaatttcac ataagccaca
     3241 tttatcctta gtttgtttga accagtgctc ttcactggag gtgtgtccac ctgtctgtcc
     3301 tttcgcttgc cgggctagca gtgcagcagt agtgacattt tcagaacatc ttgatgaaat
     3361 gtgctccagg gaagtgagga cagtgtcttc agactgctca gaagatagct tttgttccca
     3421 gtaaacataa gtactgtgag agagattttt ttctctccct agttcttgtt tcagtagctt
     3481 cagccctgtg tcaaaacagg tgttaacagt agttgtgagc actgaagcct tgctagggct
     3541 tataggcatg tgccaccacg cctagctaaa ggatctcatt atgattacaa tatttatctt
     3601 tttgtttaat aacaggcttt actttagtcc tttctaatgt ttagaggaaa tggacaccat
     3661 ctctctgtat catctgtaac atttttacat gttaaccctt tatgacccgt atgacctgcc
     3721 tttatgacct gtagcagcaa accttccagg cctgtgtttt tcccaatgga cagcaaaaac
     3781 attatttaac atttcattct ctagatatcc ctcatttgga gtagaccatc tttcagtatc
     3841 tgttagtata gttattgcct tgtttgaaac ttggctgtac attctgttgt ttgttactga
     3901 ttagttgcga gactttcaaa gtgaagttca ttagctaatt tacaacccac aacgcatgta
     3961 tcatttctct gtattcagaa tcaatttggc acaaagatgt tccttgtggc ttcttaatcc
     4021 aagtagagaa aaaaaaaaaa aacctcaaag atcttggagc tttactttga aaaatctcta
     4081 agtaattgtg aaagagtgaa cttacaaaac atcacagagc agtagctgaa gacagaagcc
     4141 ggtgaaatta accatgattt agcttctact tggcagcttt gaatagctta gtcttgtcac
     4201 tttccctccc cttagagagg agacgaagca cctgagaggt tgtgtgtggc ctttaccctc
     4261 agacaggagg ttcaggaaac tgggaggatc tatcactgga atcagttggc tctgtttgaa
     4321 tgaggctgct ccaggtttat actgatcatc ttcccggatg atccagcttc agggccaata
     4381 cctctgagcc tgtaacacag gtgaggaggg gcacatttcc caagtcagct cagagtcggc
     4441 tacagtctct ttggcccttt ctcaataaag ttgtgagtct tgctagatgt cattatttga
     4501 ggattagtta gaatggagat ttcctgatga ccaccctcag atgtgagaat cctctatt
//
