LOCUS       NM_009687               1307 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus apurinic/apyrimidinic endonuclease 1 (Apex1), mRNA.
ACCESSION   NM_009687
VERSION     NM_009687.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Xiao,X., Du,Y., Sun,S., Su,X., Xing,J., Wang,G., Elzein,S.M.,
            Zou,D., Minze,L.J., Mao,Z., Ghobrial,R.M., Connor,A.A., Chen,W.,
            Zhang,Z. and Li,X.C.
  TITLE     Apex1 safeguards genomic stability to ensure a cytopathic T cell
            fate in autoimmune disease models
  JOURNAL   J Clin Invest (2024) In press
   PUBMED   39739423
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Diao,J., Fan,H., Zhang,J., Fu,X., Liao,R., Zhao,P., Huang,W.,
            Huang,S., Liao,H., Yu,J., Pan,D., Wang,M., Xiao,W. and Wen,X.
  TITLE     Activation of APE1 modulates Nrf2 protected against acute liver
            injury by inhibit hepatocyte ferroptosis and promote hepatocyte
            autophagy
  JOURNAL   Int Immunopharmacol 128, 111529 (2024)
   PUBMED   38244516
  REMARK    GeneRIF: Activation of APE1 modulates Nrf2 protected against acute
            liver injury by inhibit hepatocyte ferroptosis and promote
            hepatocyte autophagy.
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Liu,L., Wu,Q., Wang,Z., Niu,B., Jiao,Y. and An,H.
  TITLE     APE1 promotes embryonic stem cell proliferation and teratoma
            formation by regulating GDNF/GFRalpha1 axis
  JOURNAL   Reprod Biol 23 (3), 100792 (2023)
   PUBMED   37523789
  REMARK    GeneRIF: APE1 promotes embryonic stem cell proliferation and
            teratoma formation by regulating GDNF/GFRalpha1 axis.
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Zaunz,S., De Smedt,J., Lauwereins,L., Cleuren,L., Laffeber,C.,
            Bajaj,M., Lebbink,J.H.G., Marteijn,J.A., De Keersmaecker,K. and
            Verfaillie,C.
  TITLE     APEX1 Nuclease and Redox Functions are Both Essential for Adult
            Mouse Hematopoietic Stem and Progenitor Cells
  JOURNAL   Stem Cell Rev Rep 19 (6), 2052-2072 (2023)
   PUBMED   37266894
  REMARK    GeneRIF: APEX1 Nuclease and Redox Functions are Both Essential for
            Adult Mouse Hematopoietic Stem and Progenitor Cells.
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Moreli,J.B., Santos,M.R.D., Calderon,I.M.P., Hebeda,C.B.,
            Farsky,S.H.P., Bevilacqua,E. and Oliani,S.M.
  TITLE     The Role of Annexin A1 in DNA Damage Response in Placental Cells:
            Impact on Gestational Diabetes Mellitus
  JOURNAL   Int J Mol Sci 24 (12), 10155 (2023)
   PUBMED   37373303
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Takiguchi,Y. and Chen,D.J.
  TITLE     Genomic structure of the mouse apurinic/apyrimidinic endonuclease
            gene
  JOURNAL   Mamm Genome 5 (11), 717-722 (1994)
   PUBMED   7533013
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Wilson,T.M., Carney,J.P. and Kelley,M.R.
  TITLE     Cloning of the multifunctional rat apurinic/apyrimidinic
            endonuclease (rAPEN)/redox factor from an immature T cell line
  JOURNAL   Nucleic Acids Res 22 (3), 530-531 (1994)
   PUBMED   7510394
REFERENCE   8  (bases 1 to 1307)
  AUTHORS   Zhao,B., Grandy,D.K., Hagerup,J.M., Magenis,R.E., Smith,L.,
            Chauhan,B.C. and Henner,W.D.
  TITLE     The human gene for apurinic/apyrimidinic endonuclease (HAP1):
            sequence and localization to chromosome 14 band q12
  JOURNAL   Nucleic Acids Res 20 (15), 4097-4098 (1992)
   PUBMED   1380694
REFERENCE   9  (bases 1 to 1307)
  AUTHORS   Seki,S., Akiyama,K., Watanabe,S., Hatsushika,M., Ikeda,S. and
            Tsutsui,K.
  TITLE     cDNA and deduced amino acid sequence of a mouse DNA repair enzyme
            (APEX nuclease) with significant homology to Escherichia coli
            exonuclease III
  JOURNAL   J Biol Chem 266 (31), 20797-20802 (1991)
   PUBMED   1939131
REFERENCE   10 (bases 1 to 1307)
  AUTHORS   Seki,S., Ikeda,S., Watanabe,S., Hatsushika,M., Tsutsui,K.,
            Akiyama,K. and Zhang,B.
  TITLE     A mouse DNA repair enzyme (APEX nuclease) having exonuclease and
            apurinic/apyrimidinic endonuclease activities: purification and
            characterization
  JOURNAL   Biochim Biophys Acta 1079 (1), 57-64 (1991)
   PUBMED   1716153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027184.15 and BC052401.1.
            
            On Mar 19, 2011 this sequence version replaced NM_009687.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052401.1, D90374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC027184.15        2359-2387           c
            30-1258             BC052401.1         1-1229
            1259-1307           AC027184.15        148-196             c
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.3 cM"
     gene            1..1307
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /note="apurinic/apyrimidinic endonuclease 1"
                     /db_xref="GeneID:11792"
                     /db_xref="MGI:MGI:88042"
     exon            1..81
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..193
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1092
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /EC_number="3.1.11.2"
                     /note="DNA-(apurinic or apyrimidinic site) lyase; APEN;
                     APEX nuclease; AP endonuclease 1; redox factor-1;
                     DNA-(apurinic or apyrimidinic site) endonuclease"
                     /codon_start=1
                     /product="DNA repair nuclease/redox regulator APEX1"
                     /protein_id="NP_033817.1"
                     /db_xref="CCDS:CCDS27027.1"
                     /db_xref="GeneID:11792"
                     /db_xref="MGI:MGI:88042"
                     /translation="MPKRGKKAAADDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLY
                     EDPPDQKTSPSGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENK
                     LPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAE
                     FESFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEID
                     LRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKN
                     VGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL"
     exon            194..381
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..574
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..1307
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /note="hexamer: AATAAA"
     polyA_site      1258
                     /gene="Apex1"
                     /gene_synonym="APE; Apex; HAP1; Ref-1"
                     /note="major polyA site"
ORIGIN      
        1 cacgtgacca caccaatcgc ccacgtggga acaggcagac tccattcttt gtgccgtgag
       61 ggtctctggc ttcgttggga ggcagcgcag taaacactgc ttcggtgctc caggagccta
      121 agggctttcg tcacagcgat gccaaagcgg ggaaagaaag cggcggccga cgacggggaa
      181 gaacccaagt cggagccaga gaccaagaag agtaaggggg cagcaaagaa aaccgagaag
      241 gaggccgcgg gagagggccc tgtcctgtac gaggaccctc cagatcagaa aacctcaccc
      301 agtggcaaat ctgccacact caagatatgc tcctggaatg tggatgggct tcgagcctgg
      361 attaaaaaga aaggtttgga ttgggtaaag gaagaagcac cagatatctt gtgcctccaa
      421 gagaccaagt gctcggagaa caaactcccg gctgaactgc aagagctgcc tggactcacc
      481 catcagtact ggtcagctcc gtcagacaaa gaaggataca gtggtgtggg cctactttcc
      541 cgccagtgcc cgctaaaagt ctcttatggc attggcgagg aagaacatga tcaagaaggc
      601 cgggtgattg tggctgaatt tgagtccttt gtcctggtaa cagcctatgt tcccaatgca
      661 ggcaggggtc tggtaagact ggaataccga cagcgttggg atgaagcctt ccgaaagttt
      721 ctaaaggact tggcttccag aaagcctctt gtgctatgtg gggatctcaa tgtggctcat
      781 gaagaaattg acctccgtaa ccccaaagga aacaaaaaga atgctggctt tactccccag
      841 gagcgccaag gttttgggga actgctacaa gctgtaccat tggctgacag cttccggcat
      901 ctctacccca acactgctta cgcttacact ttctggactt acatgatgaa tgcccgctct
      961 aagaatgttg gttggcgcct tgattacttt ttgctttccc actctctttt acctgcattg
     1021 tgtgacagca agatccggtc caaggctctt ggcagtgacc actgtcccat caccctttac
     1081 ctagcactgt gataccctcc tgcagtagct tcctgcctgg gagatggctc tctctgcaga
     1141 agtctggtgt tttagccttc aggtgtttgg ttttgtatgt gctccctcat tttaaacatt
     1201 aaaccaaact tctggtttcc tttagacaat ccaagagaaa taaaaggccc tactttcagc
     1261 ttggctttct ttgtcccttt gtgaaaacta catattccct ttttcat
//
