LOCUS       NM_001297554             957 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus apelin receptor early endogenous ligand (Apela),
            transcript variant 1, mRNA.
ACCESSION   NM_001297554
VERSION     NM_001297554.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 957)
  AUTHORS   Chen,Z., Wang,Z., Hu,Y., Lin,H., Yin,L., Kong,J., Zhang,Y., Hu,B.,
            Li,T., Zheng,X., Yang,Q., Ye,S., Wang,S., Zhou,Q. and Zheng,C.
  TITLE     ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by
            Regulating AMPK/NLRP3 Pathway
  JOURNAL   Inflammation 46 (6), 2343-2358 (2023)
   PUBMED   37540330
  REMARK    GeneRIF: ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial
            Injury by Regulating AMPK/NLRP3 Pathway.
REFERENCE   2  (bases 1 to 957)
  AUTHORS   Li,W., Xu,P., Kong,L., Feng,S., Shen,N., Huang,H., Wang,W., Xu,X.,
            Wang,X., Wang,G., Zhang,Y., Sun,W., Hu,W. and Liu,X.
  TITLE     Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in
            cerebral ischemia/reperfusion injury
  JOURNAL   Transl Res 257, 78-92 (2023)
   PUBMED   36813109
  REMARK    GeneRIF: Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway
            in cerebral ischemia/reperfusion injury.
REFERENCE   3  (bases 1 to 957)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 957)
  AUTHORS   Jin,L., Li,Q., Li,J., Pan,Y., Zou,J., Wu,X. and Wang,Z.
  TITLE     Apela inhibits systemic and renal inflammatory reactions in mice
            with type I cardiorenal syndrome
  JOURNAL   FASEB J 35 (10), e21907 (2021)
   PUBMED   34516679
  REMARK    GeneRIF: Apela inhibits systemic and renal inflammatory reactions
            in mice with type I cardiorenal syndrome.
REFERENCE   5  (bases 1 to 957)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   6  (bases 1 to 957)
  AUTHORS   Pauli,A., Norris,M.L., Valen,E., Chew,G.L., Gagnon,J.A.,
            Zimmerman,S., Mitchell,A., Ma,J., Dubrulle,J., Reyon,D., Tsai,S.Q.,
            Joung,J.K., Saghatelian,A. and Schier,A.F.
  TITLE     Toddler: an embryonic signal that promotes cell movement via Apelin
            receptors
  JOURNAL   Science 343 (6172), 1248636 (2014)
   PUBMED   24407481
REFERENCE   7  (bases 1 to 957)
  AUTHORS   Redshaw,N., Camps,C., Sharma,V., Motallebipour,M., Guzman-Ayala,M.,
            Oikonomopoulos,S., Thymiakou,E., Ragoussis,J. and Episkopou,V.
  TITLE     TGF-beta/Smad2/3 signaling directly regulates several miRNAs in
            mouse ES cells and early embryos
  JOURNAL   PLoS One 8 (1), e55186 (2013)
   PUBMED   23390484
REFERENCE   8  (bases 1 to 957)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   9  (bases 1 to 957)
  AUTHORS   Hassan,A.S., Hou,J., Wei,W. and Hoodless,P.A.
  TITLE     Expression of two novel transcripts in the mouse definitive
            endoderm
  JOURNAL   Gene Expr Patterns 10 (2-3), 127-134 (2010)
   PUBMED   20153842
  REMARK    GeneRIF: Ende was expressed dynamically and in specific populations
            of the definitive endoderm from E7.0 to E8.5.
REFERENCE   10 (bases 1 to 957)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102287.16.
            
            On Jan 7, 2022 this sequence version replaced NM_001297554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014119.1, BY713104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC102287.16        36380-36417         c
            39-292              AC102287.16        35989-36242         c
            293-382             AC102287.16        34764-34853         c
            383-957             AC102287.16        27516-28090         c
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 32.52 cM"
     gene            1..957
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /note="apelin receptor early endogenous ligand"
                     /db_xref="GeneID:100038489"
                     /db_xref="MGI:MGI:3642370"
     exon            1..38
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /inference="alignment:Splign:2.1.0"
     exon            39..292
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..381
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /note="Protein Elabela; protein Toddler"
                     /codon_start=1
                     /product="apelin receptor early endogenous ligand
                     precursor"
                     /protein_id="NP_001284483.1"
                     /db_xref="CCDS:CCDS80883.1"
                     /db_xref="GeneID:100038489"
                     /db_xref="MGI:MGI:3642370"
                     /translation="MRFQPLFWVFFIFAMSLLFISEQKPVNFPRRRKLYRHNCFRRRC
                     IPLHSRVPFP"
     exon            293..382
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /inference="alignment:Splign:2.1.0"
     exon            383..957
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /inference="alignment:Splign:2.1.0"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /note="hexamer: ATTAAA"
     polyA_site      957
                     /gene="Apela"
                     /gene_synonym="Ela; Elabela; Ende; Gm10664"
                     /note="major polyA site"
ORIGIN      
        1 gcagagactt cccgcttaag ttactgcgtg cctgaatgga aaaggcagct ggcagccctc
       61 tgagttctgg ccataggatg tggggtgagc cggacagata ctgcgattta cagacgattt
      121 ctctacttga agagctattg ttcacttgcg tgtaagaaaa aagaaaaaca aaaggaaaga
      181 aaaagaagaa aagaaaaaag agaaagaaaa gaaaagatgc gattccagcc ccttttttgg
      241 gtatttttta tttttgccat gagtctcctt tttatcagtg aacagaaacc agttaacttt
      301 cccaggagaa gaaaactata cagacacaac tgctttcgca ggagatgcat tccacttcat
      361 tctcgagtgc ccttcccatg agaaaacctc taatttcctt ggctctacca gaagaagggt
      421 gaaagcaaag atacccaatc accggaaaaa caacctcagg atggcaacag gatggcagct
      481 caggagttac tacgcaacag aggctgtttc agagtaccgt ggatggcttt tcagactgct
      541 cttcctggat tctctttgac aagaaaatga tagaaaggga aaacagacga ggttaaagca
      601 catgcgtttg tctgaataac aatctctcct gctgttctgc acgttctttg cgtataatgt
      661 atgaattaca catagtggtg ggtttcacaa aggcatttac ataccagtac atcacgtcct
      721 atggccgtct ttccacacat gtgcatcata tacaccgatt ctttacaggc atgcatgcca
      781 tatacactga ctacatttgc acacacatac cttccccttt ctctcccctc accctcctgc
      841 aggtctcttt tattcacctg ggcagttttg tttctatttt aatggtttgt acacatgaat
      901 gattttattg cacattatta ttcttacatg gattaaaaag aaaactactt taatata
//
